Penilaian Skoring RA
BAB 6. KESIMPULAN DAN SARAN
6.1 Kesimpulan
Pada penelitian kami dijumpai penurunan persen skor rinitis alergi sebelum
diterapi dan sesudah diterapi dengan cetirizin atau loratadin tetapi secara
statisitik tidak dijumpai perbedaan yang signifikan skor rinitis alergi antara
terapi cetirizin dan loratadin yang dievaluasi pada hari ke-3, ke-7 dan ke-14.
Kami juga menilai efek samping dari kedua obat pada hari ke-3, ke-7 dan ke-
14 ternyata secara statistik dijumpai perbedaan yang signifikan efek samping
sakit kepala dan jantung berdebar dengan loratadin.
6.2 Saran
Uji cukit merupakan pemeriksaan yang paling peka untuk reaksi yang
diperantarai oleh IgE dengan pemeriksaan ini alergen penyebab akan dapat
diketahui. Dalam penelitian ini diagnosis rinitis alergi ditegakkan hanya
berdasarkan anamnesis, pemeriksaan THT rutin tanpa pemeriksaan tes kulit
BAB 7. RINGKASAN
Telah dilakukan penelitian secara uji klinis acak tersamar ganda yang
bertujuan membandingkan efikasi loratadin dengan cetirizin pada anak
penderita rinitis alergi. Penelitian dilakukan di SMP Alwasliyah dan SMP
Univa di kota Medan Propinsi Sumatera Utara, dilakukan mulai Oktober
sampai November 2009. Penelitian berlangsung selama 2 minggu. Dari 475
siswa yang diperiksa terdapat penderita rinitis alergi sebanyak 150 orang.
Sampel didapat 100 siswa yang memenuhi kriteria inklusi yaitu anak sekolah
usia 13-16 tahun yang menderita rinitis alergi dan didukung pemeriksaan
hidung dengan alat spekulum untuk menilai anatomi hidung dan mendukung
rinitis alergi, adanya riwayat atopi dalam keluarga dan orang tua mengisi
informed consent.
Sampel dipilih secara acak dengan randomisasi sederhana
menggunakan tabel random. Terdiri dari dua kelompok yaitu 50 anak
mendapat terapi cetirizin 10 mg dan 50 anak mendapat terapi loratadin 10
mg. Gejala klinis di evaluasi pada hari ke-3,-7 dan hari ke-14. Sebelum
pemberian terapi didapatkan jumlah anak penderita rinitis alergi dengan skor
berat pada kelompok cetirizin 29 siswa (58%) dan kelompok loratadin 34
(68%), penderita rinitis alergi dengan skor sedang pada kelompok cetirizin
Pada evaluasi hari ke-14, didapatkan jumlah anak yang tidak
mengalami keluhan lebih banyak pada kedua kelompok terapi, 43 anak
(86%) pada kelompok cetirizin dan 37 anak (74%) pada kelompok loratadin.
Akan tetapi tidak didapatkan perbedaan yang bermakna secara statistik (P = 0.057). Pada studi ini didapatkan efek samping yang lebih besar pada anak
yang diberi terapi loratadin pada hari ketiga dan hari ketujuh dibandingkan
pada kelompok cetirizin (P < 0.05).
Sebagai kesimpulan tidak ada perbedaan efikasi yang bermakna
Summary
A randomized clinical trials research has been done to compare cetirizine and
loratadine efficacy on children suffer from allergic rhinitis. The research are
done in Alwasliyah Junior High School and Univa Junior High School in city of
Medan, North Sumatera, started since October until November 2009. This
study are been held in two weeks time. One hundred fifty were allergic rhinitis
from a total of 475 students. One hundred sample are taken using diagnosed
with which is students aged between 13 until 16 years who suffered from
allergic rhinitis and supported by nose examination with speculum to evaluate
nose anatomy and diagnose with allergic rhinitis, familial atopic history and
parents who are willing to sign the informed consent.
Sample are choosen randomly using simple randomized from a
random table. Sample are divided into two groups, fifty of there were given
cetirizine 10 mg whereas another 50 were given loratadine 10 mg. Clinical
sign was evaluated on day 3,7 and day 14. Before the therapy are given 29
sample (58%) from cetirizine therapy group only 21 sample (42%) from
loratadine therapy group were diagnosed with severe allergic instead. Fourty
two persen cetirizine group were put under moderate score while 32% from
On the 14-day of evaluation there are more children with complaint in
this two group therapy, fourty three childrens (86%) in cetirizine group and 37
children (74%) in loratadine group. But there are no significant difference
statictically (P = 0.057). In this study, there are greater side effect when treated children with loratadine on day-3 and day-7 than treated with cetirizine
group (P < 0.05). For conclusion, there are no significant differente effication between cetirizine and loratadine in decreasing allergic rhinitis symptoms.
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