BAB V. KESIMPULAN DAN SARAN
B. Saran
Perlu dilakukan penelitian lebih lanjut tentang :
1. Uji efek hepatoprotektif ekstrak metanol-air biji Persea americana Mill. pada tikus jantan terinduksi parasetamol.
2. Perlu dilakukan pengembangan lebih lanjut mengenai penggunaan penyari yang berbeda untuk dapat menarik senyawa yang mempunyai aktivitas penangkapan radikal bebas yang lebih kuat.
3. Perlu dilakukan penelitian efek hepatoprotektif ekstrak metanol-air biji
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Lampiran 1. Foto serbuk biji Persea americana Mill.
Lampiran 2. Foto ekstrak metanol-air biji Persea americana Mill.
Lampiran 3. Foto suspensi ekstrak metanol-air biji Persea americana Mill. dalam CMC-Na 1%
Lampiran 5. Surat pengesahan determinasi serbuk biji Persea americana Mill.
Lampiran 6. Surat pengesahan Medical and Health Research Ethics Committee (MHREC)
Lampiran 7. Analisis statistik aktivitas serum ALT dan AST pada uji pendahuluan penentuan dosis hepatotoksin karbon tetraklorida dosis 2
ml/kgBB
NPar Tests (ALT)
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum jam_ke_0 3 68.0000 16.70329 50.00 83.00
One-Sample Kolmogorov-Smirnov Test
jam_ke_0
N 3
Normal Parametersa Mean 68.0000
Std. Deviation 16.70329
Most Extreme Differences Absolute .238
Positive .193
Negative -.238
Kolmogorov-Smirnov Z .412
Asymp. Sig. (2-tailed) .996
a. Test distribution is Normal.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum jam_ke_24 3 2.0333E2 27.53785 185.00 235.00
One-Sample Kolmogorov-Smirnov Test
jam_ke_24
N 3
Normal Parametersa Mean 203.3333
Std. Deviation 27.53785
Most Extreme Differences Absolute .353
Positive .353
Negative -.253
Kolmogorov-Smirnov Z .611
Asymp. Sig. (2-tailed) .850
a. Test distribution is Normal.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum jam_ke_48 3 54.6667 9.45163 44.00 62.00
One-Sample Kolmogorov-Smirnov Test
jam_ke_48
N 3
Normal Parametersa Mean 54.6667
Std. Deviation 9.45163 Most Extreme Differences Absolute .304
Positive .219
Negative -.304
Kolmogorov-Smirnov Z .527
Asymp. Sig. (2-tailed) .944
NPar Tests (AST)
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum jam_ke_0 3 88.3333 6.50641 82.00 95.00
One-Sample Kolmogorov-Smirnov Test
jam_ke_0
N 3
Normal Parametersa Mean 88.3333
Std. Deviation 6.50641 Most Extreme Differences Absolute .187
Positive .187
Negative -.181
Kolmogorov-Smirnov Z .324
Asymp. Sig. (2-tailed) 1.000
a. Test distribution is Normal.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum jam_ke_24 3 4.4633E2 33.50124 410.00 476.00
One-Sample Kolmogorov-Smirnov Test
jam_ke_24
N 3
Normal Parametersa Mean 446.3333
Std. Deviation 33.50124 Most Extreme Differences Absolute .246
Positive .194
Negative -.246
Kolmogorov-Smirnov Z .425
Asymp. Sig. (2-tailed) .994
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum jam_ke_48 3 1.4733E2 13.01281 134.00 160.00
One-Sample Kolmogorov-Smirnov Test
jam_ke_48
N 3
Normal Parametersa Mean 147.3333
Std. Deviation 13.01281 Most Extreme Differences Absolute .187
Positive .181
Negative -.187
Kolmogorov-Smirnov Z .324
Asymp. Sig. (2-tailed) 1.000
Oneway (ALT-AST Serum)
Test of Homogeneity of Variances
Levene Statistic df1 df2 Sig.
ALT 2.732 2 6 .143
AST 3.169 2 6 .115
ANOVA
Sum of Squares df Mean Square F Sig. ALT Between Groups 40594.667 2 20297.333 54.046 .000
Within Groups 2253.333 6 375.556 Total 42848.000 8 Descriptives N Mean Std. Deviation Std. Error 95% Confidence Interval for Mean
Min Max Lower Bound Upper Bound ALT CCl4 Dosis 2ml/kg BB jam ke-0 3 68.0000 16.70329 9.64365 26.5067 109.4933 50.00 83.00 CCl4 Dosis 2ml/kg BB jam ke-24 3 2.0333E2 27.53785 15.89899 134.9255 271.7412 185.00 235.00 CCl4 Dosis 2ml/kg BB jam ke-48 3 54.6667 9.45163 5.45690 31.1875 78.1458 44.00 62.00 Total 9 1.0867E2 73.18470 24.39490 52.4119 164.9214 44.00 235.00 AST CCl4 Dosis 2ml/kg BB jam ke-0 3 88.3333 6.50641 3.75648 72.1705 104.4961 82.00 95.00 CCl4 Dosis 2ml/kg BB jam ke-24 3 4.4633E2 33.50124 19.34195 363.1116 529.5550 410.00 476.00 CCl4 Dosis 2ml/kg BB jam ke-48 3 1.4733E2 13.01281 7.51295 115.0077 179.6590 134.00 160.00 Total 9 2.2733E2 167.22515 55.74172 98.7927 355.8740 82.00 476.00
AST Between Groups 221046.000 2 110523.000 248.552 .000 Within Groups 2668.000 6 444.667
Total 223714.000 8
Post Hoc Tests
Multiple Comparisons
Scheffe Depen dent Variabl
e (I) kelompok (J) kelompok
Mean Difference
(I-J) Std. Error Sig.
95% Confidence Interval Lower Bound Upper Bound ALT CCl4 Dosis 2ml/kg BB jam ke-0 CCl4 Dosis 2ml/kg BB jam ke-24 -135.33333* 15.82310 .000 -186.0821 -84.5846 CCl4 Dosis 2ml/kg BB jam ke-48 13.33333 15.82310 .715 -37.4154 64.0821 CCl4 Dosis 2ml/kg BB jam ke-24 CCl4 Dosis 2ml/kg BB jam ke-0 135.33333* 15.82310 .000 84.5846 186.0821 CCl4 Dosis 2ml/kg BB jam ke-48 148.66667* 15.82310 .000 97.9179 199.4154 CCl4 Dosis 2ml/kg BB jam ke-48 CCl4 Dosis 2ml/kg BB jam ke-0 -13.33333 15.82310 .715 -64.0821 37.4154 CCl4 Dosis 2ml/kg BB jam ke-24 -148.66667* 15.82310 .000 -199.4154 -97.9179 AST CCl4 Dosis 2ml/kg BB jam ke-0 CCl4 Dosis 2ml/kg BB jam ke-24 -358.00000* 17.21756 .000 -413.2212 - 302.7788 CCl4 Dosis 2ml/kg BB jam ke-48 -59.00000* 17.21756 .039 -114.2212 -3.7788 CCl4 Dosis 2ml/kg BB jam ke-24 CCl4 Dosis 2ml/kg BB jam ke-0 358.00000* 17.21756 .000 302.7788 413.2212 CCl4 Dosis 2ml/kg BB jam ke-48 299.00000* 17.21756 .000 243.7788 354.2212 CCl4 Dosis 2ml/kg BB jam ke-48 CCl4 Dosis 2ml/kg BB jam ke-0 59.00000* 17.21756 .039 3.7788 114.2212
Homogeneous Subsets
ALT
Scheffe
kelompok N
Subset for alpha = 0.05
1 2 CCl4 Dosis 2ml/kg BB jam ke-48 3 54.6667 CCl4 Dosis 2ml/kg BB jam ke-0 3 68.0000 CCl4 Dosis 2ml/kg BB jam ke-24 3 203.3333 Sig. .715 1.000
Means for groups in homogeneous subsets are displayed.
AST
Scheffe
kelompok N
Subset for alpha = 0.05
1 2 3
CCl4 Dosis 2ml/kg BB jam ke-0 3 88.3333
CCl4 Dosis 2ml/kg BB jam ke-48 3 1.4733E2
CCl4 Dosis 2ml/kg BB jam ke-24 3 4.4633E2
Sig. 1.000 1.000 1.000
Means for groups in homogeneous subsets are displayed. CCl4 Dosis
2ml/kg BB jam ke-24
-299.00000* 17.21756 .000 -354.2212 - 243.7788 *. The mean difference is significant at the
Means
Case Processing Summary
Cases
Included Excluded Total
N Percent N Percent N Percent SGPT * kelompok 9 60.0% 6 40.0% 15 100.0%
Report
ALT
kelompok Mean N Std. Deviation
Std. Error of Mean CCl4 Dosis 2ml/kg BB jam ke-0 68.0000 3 16.70329 9.64365 CCl4 Dosis 2ml/kg BB jam ke-24 2.0333E2 3 27.53785 15.89899 CCl4 Dosis 2ml/kg BB jam ke-48 54.6667 3 9.45163 5.45690 Total 1.0867E2 9 73.18470 24.39490
Case Processing Summary
Cases
Included Excluded Total
N Percent N Percent N Percent AST * kelompok 9 60.0% 6 40.0% 15 100.0%
AST
kelompok Mean N Std. Deviation
Std. Error of Mean CCl4 Dosis 2ml/kg BB jam ke-0 88.3333 3 6.50641 3.75648 CCl4 Dosis 2ml/kg BB jam ke-24 4.4633E2 3 33.50124 19.34195 CCl4 Dosis 2ml/kg BB jam ke-48 1.4733E2 3 13.01281 7.51295 Total 2.2733E2 9 167.22515 55.74172
Lampiran 8. Analisis statistik aktivitas serum ALT perlakuan ekstrak metanol-air biji Persea americana setelah induksi karbon tetraklorida dosis 2
ml/kgBB
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum kontrol_CCl4 5 1.8320E2 11.43241 168.00 197.00 kontrol_olive_oil 5 47.6000 4.39318 43.00 54.00 kontrol_ekstrak 5 45.6000 2.07364 43.00 48.00 kontrol_positif 5 1.0540E2 16.53179 89.00 131.00 dosis_1400 5 52.2000 1.48324 50.00 54.00 dosis_700 5 65.0000 4.84768 60.00 72.00 dosis_350 5 76.6000 4.56070 73.00 84.00
One-Sample Kolmogorov-Smirnov Test
Kontrol CCl4 Kontrol olive oil Kontrol ekstrak Kontrol positif Dosis 1400 Dosis 700 Dosis 350 N 5 5 5 5 5 5 5 Normal Parametersa Mean 183.200 47.6000 45.6000 105.4000 52.2000 65.000 76.600 Std. Deviation 11.4324 4.39318 2.07364 16.53179 1.48324 4.8476 4.5607 Most Extreme Differences Absolute .163 .242 .180 .273 .246 .195 .316 Positive .136 .242 .180 .273 .154 .195 .316 Negative -.163 -.148 -.176 -.161 -.246 -.151 -.215 Kolmogorov-Smirnov Z .363 .541 .402 .610 .551 .437 .706 Asymp. Sig. (2-tailed) .999 .931 .997 .851 .922 .991 .701 a. Test distribution is Normal.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Kruskal-Wallis Test
Ranks
kelompok N Mean Rank
ALT kontrol CCl4 2mL/kgBB 5 33.00
kontrol olive oil 2mL/kgBB 5 7.00
kontrol ekstrak 1400mg/kgBB 5 5.00
kontrol positif curliv 4,05mg/kgBB 5 28.00 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 12.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 18.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 23.00
Total 35
Test Statisticsa,b
ALT Chi-Square 32.218
df 6
Asymp. Sig. .000 a. Kruskal Wallis Test b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks ALT kontrol CCl4 2mL/kgBB 5 8.00 40.00
kontrol olive oil 2mL/kgBB 5 3.00 15.00
Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol CCl4 2mL/kgBB 5 8.00 40.00 kontrol ekstrak 1400mg/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol CCl4 2mL/kgBB 5 8.00 40.00
kontrol positif curliv 4,05mg/kgBB 5 3.00 15.00
ALT Mann-Whitney U .000
Wilcoxon W 15.000
Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol CCl4 2mL/kgBB 5 8.00 40.00 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol CCl4 2mL/kgBB 5 8.00 40.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 Kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
ALT kontrol CCl4 2mL/kgBB 5 8.00 40.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol olive oil 2mL/kgBB 5 6.00 30.00 kontrol ekstrak 1400mg/kgBB 5 5.00 25.00 Total 10 Test Statisticsb ALT Mann-Whitney U 10.000 Wilcoxon W 25.000 Z -.525
Asymp. Sig. (2-tailed) .599 Exact Sig. [2*(1-tailed Sig.)] .690a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol olive oil 2mL/kgBB 5 3.00 15.00 kontrol positif curliv 4,05mg/kgBB 5 8.00 40.00
Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol olive oil 2mL/kgBB 5 4.00 20.00 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 7.00 35.00 Total 10 Test Statisticsb ALT Mann-Whitney U 5.000 Wilcoxon W 20.000 Z -1.581
Asymp. Sig. (2-tailed) .114 Exact Sig. [2*(1-tailed Sig.)] .151a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol olive oil 2mL/kgBB 5 3.00 15.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol olive oil 2mL/kgBB 5 3.00 15.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00
Test Statisticsb
ALT Mann-Whitney U .000
Wilcoxon W 15.000
Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol ekstrak 1400mg/kgBB 5 3.00 15.00 kontrol positif curliv 4,05mg/kgBB 5 8.00 40.00
Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol ekstrak 1400mg/kgBB 5 3.00 15.00 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol ekstrak 1400mg/kgBB 5 3.00 15.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol ekstrak 1400mg/kgBB 5 3.00 15.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00
ALT Mann-Whitney U .000
Wilcoxon W 15.000
Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol positif curliv 4,05mg/kgBB 5 8.00 40.00 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol positif curliv 4,05mg/kgBB 5 8.00 40.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT kontrol positif curliv 4,05mg/kgBB 5 8.00 40.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00
ALT Mann-Whitney U .000
Wilcoxon W 15.000
Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.627
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum ALT 35 82.2286 46.78240 43.00 197.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks
ALT EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 3.00 15.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 8.00 40.00 Total 10 Test Statisticsb ALT Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.619
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
Means
Case Processing Summary
Cases
Included Excluded Total
N Percent N Percent N Percent ALT * kelompok 35 100.0% 0 .0% 35 100.0%
Report
ALT
kelompok Mean N Std. Deviation Std. Error of Mean kontrol CCl4 2mL/kgBB 1.8320E2 5 11.43241 5.11273 kontrol olive oil 2mL/kgBB 47.6000 5 4.39318 1.96469 kontrol ekstrak
1400mg/kgBB 45.6000 5 2.07364 .92736
kontrol positif curliv
4,05mg/kgBB 1.0540E2 5 16.53179 7.39324 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 52.2000 5 1.48324 .66332 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 65.0000 5 4.84768 2.16795 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 76.6000 5 4.56070 2.03961 Total 82.2286 35 46.78240 7.90767 ANOVA Table Sum of Squares df Mean Square F Sig. ALT * kelompok Between Groups (Combined) 72515.771 6 12085.962 178.447 .000 Linearity 13840.457 1 13840.457 204.352 .000 Deviation from Linearity 58675.314 5 11735.063 173.266 .000 Within Groups 1896.400 28 67.729 Total 74412.171 34 Measures of Association
R R Squared Eta Eta Squared ALT * kelompok -.431 .186 .987 .975
Graph
Lampiran 9. Analisis statistik serum AST perlakuan ekstrak metanol-air biji Persea americana Mill. setelah induksi karbon tetraklorida dosis 2 ml/kgBB NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum kontrol_CCl4 5 4.7680E2 31.87789 441.00 521.00 kontrol_olive_oil 5 60.2000 5.26308 55.00 69.00 kontrol_ekstrak 5 80.8000 4.38178 76.00 84.00 kontrol_positif 5 3.7700E2 34.22718 344.00 419.00 dosis_1400 5 1.5680E2 5.31037 149.00 163.00 dosis_700 5 2.6740E2 14.99333 252.00 288.00 dosis_350 5 3.2120E2 15.44992 303.00 336.00
One-Sample Kolmogorov-Smirnov Test kontrol_ CCl4 kontrol_ olive_oil kontrol_ ekstrak kontrol positif Dosis 1400 Dosis 700 Dosis 350 N 5 5 5 5 5 5 5 Normal Parametersa Mean 476.8000 60.2000 80.8000 377.0000 156.8000 267.4000 321.2000 Std. Deviation 31.87789 5.26308 4.38178 34.22718 5.31037 14.99333 15.44992 Most Extreme Differences Absolute .172 .315 .367 .225 .167 .289 .316 Positive .172 .315 .263 .225 .129 .289 .237 Negative -.131 -.162 -.367 -.193 -.167 -.160 -.316 Kolmogorov-Smirnov Z .385 .705 .822 .503 .374 .647 .706 Asymp. Sig. (2-tailed) .998 .703 .510 .962 .999 .797 .702 a. Test distribution is
Normal.
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum AST 35 2.4860E2 147.75062 55.00 521.00 kelompok 35 4.0000 2.02920 1.00 7.00
Kruskal-Wallis Test
Ranks
Kelompok N Mean Rank
AST kontrol CCl4 2mL/kgBB 5 33.00
kontrol olive oil 2mL/kgBB 5 3.00
kontrol ekstrak 1400mg/kgBB 5 8.00
kontrol positif curliv 4,05mg/kgBB 5 28.00 EMBPA 1400 mg/kgBB + CCl4 2ml/kgBB 5 13.00 EMBPA 700 mg/kgBB + CCl4 2ml/kgBB 5 18.00 EMBPA 350 mg/kgBB + CCl4 2ml/kgBB 5 23.00
Test Statisticsa,b
AST Chi-Square 33.357
Df 6
Asymp. Sig. .000 a. Kruskal Wallis Test b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum AST 35 2.4860E2 147.75062 55.00 521.00 Kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
kelompok N Mean Rank Sum of Ranks AST kontrol CCl4 2mL/kgBB 5 8.00 40.00
kontrol olive oil 2mL/kgBB 5 3.00 15.00
Total 10 Test Statisticsb AST Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.611
Asymp. Sig. (2-tailed) .009 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
N Mean Std. Deviation Minimum Maximum AST 35 2.4860E2 147.75062 55.00 521.00 kelompok 35 4.0000 2.02920 1.00 7.00
Mann-Whitney Test
Ranks
Kelompok N Mean Rank Sum of Ranks
AST kontrol CCl4 2mL/kgBB 5 8.00 40.00 kontrol ekstrak 1400mg/kgBB 5 3.00 15.00 Total 10 Test Statisticsb AST Mann-Whitney U .000 Wilcoxon W 15.000 Z -2.652
Asymp. Sig. (2-tailed) .008 Exact Sig. [2*(1-tailed Sig.)] .008a a. Not corrected for ties.
b. Grouping Variable: kelompok
NPar Tests
Descriptive Statistics
N Mean Std. Deviation Minimum Maximum
