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BAB V. KESIMPULAN DAN SARAN

B. SARAN

1. Perlu dilakukan standarisasi terhadap ekstrak daun petai cina untuk menjamin kualitas sediaan.

2. Perlu dilakukan uji extrudability terhadap gel penyembuh luka ekstrak daun petai cina.

3. Kadar ekstrak daun petai cina pada masing-masing formula perlu disamakan, agar tidak membiaskan hasil percobaan.

DAFTAR PUSTAKA

Admin, 2013, Bioplacenton, http://id.kalbe.co.id/ProdukdanJasa/ObatResep/ProdukAZ/ tabid/267/ID/860/BIOPLACENTON.aspx, diakses tanggal 6 Juni 2013.

Ajizah, A., 2004, Sensitivitas Salmonella Typhimurium Terhadap Ekstrak Daun Psidium Guajava L., Bioscientiae, Vol. 1, No. 1 : 31-8.

Ansel C.Howard, 2005, Introduction to Pharmaceutical Dosage Forms, diterjemahkan oleh Farida Ibrahim, hal 390, Penerbit Universitas Indonesia, Jakarta, Indonesia. Aulton, M.E., 1990, Pharmaceutical Practice, 1st ed., Churchill Livingstone, United

Kingdom, pp.5, 127.

Barry, B.W., 1983, Percutanous Absorption, Marcell Dekker, Inc., New York, pp. 52- 55.

Black Joyce M., Hawks J.H., Keene A.M., 2001, Medical-surgical Nursing: Clinical Management for Positive Outcomes, Volume 2, W.B. Saunders, Michigan, p.315. Bluher, A., Haller, U., Banik, G., dan Thobois, E., 1995, The Applications of

CarbopolTM Poultices, Restaurator, p. 16.

Boateng J.S., Matthews K.H., Stevens H.H.E. dan Eccleston G.M., 2008, Wound

healing dressings and drug delivery systems: A review. Journal of Pharmaceutical Sciences 97, pp. 2892-2923.

C.O. Esimone, E.C. Ibezim and K.F. Chah, 2005,Journal of Pharmaceutical Applied Science, 3 (1), 294 -299.

Centeral Health, 2011, Petai Cina, http://www.centeralhealth.com/petai-cina.htm, diakses 17 April 2012.

Charde, M.S., Fulzele, S.V., Satturwar, P.M., dan Dorle,A.K. (2003) Study of the topical wound healing activity of Darvhi ghrita. Indian Drugs, 40 (2), pp. 115- 118.

Chew, Y. K., Chan, E., W., L., Tan, P., L., Lim, Y., Y., Stanslas, dan J., Goh, J., K., 2011, Assesment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia, BMC Complementary and Alternative Medicine, 11:12, 6.

Depkes RI, 1986, Sediaan Galenik, Departemen Kesehatan Republik Indonesia, pp. 5- 26.

Dirjen POM, 1995, Farmakope Indonesia, edisi IV, Departemen Kesehatan Republik Indonesia, p. 7.

Dukes G.R., 1990, General Considerations for Stability Testing of Topical Pharmaceutical Formulations in Topical Drug Delivery Formulations diedit oleh Osborne dan Amann, Marcell Dekker, Inc., New York, p. 197.

Dwidjoseputro D., 1994. Dasar-Dasar Mikrobiologi. Djambatan, Jakarta.

Faure D., 2002. The Family-3 Glycoside hydrolises: From Housekeeping Function to Host-microbe Interction. Applied and Environmental Microbiology, 64(4):1485- 1490.

Fonder M.A., Lazarus G.S., Cowan D.A., Aronson-Cook B., Kohli A.R., Mamelak A.J., 2008, Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings.Journal of the American Academy of Dermatology 58, 185-206.

Garg A., Aggarwal, D., Garg S., dan Singla A.K., 2002, Spreading of Semisolid Formulation : An Update, Pharmaceutical Technology, September 2002, 84-102, www.pharmtech.com, diakses tanggal 25 September 2008.

Gritter R. J., Bobbitt J. M., dan Schwartin, A., E., 1991, Pengantar Kromatografi, edisi kedua, diterjemahkan oleh Kosasih Padmawinata, Penerbit ITB, Bandung, p. 107. Heather A.E. dan Adam C. Watkinson, 2012, Transdermal and Topical Drug Delivery:

Principles and Practice, A John Wiley & Sons, Inc., New Jersey, pp.265, 281 Hosmani A.H., Thorat Y.S., Kasture, 2006, Carbopol and its Pharmaceutical

Significance: A Review, http://www.pharmainfo.net/reviews/carbopol-and-its- pharmaceutical-significance-review, diakses pada 2 April 2013.

Istyastono E.P., 2012, Mengenal Peranti Lunak R-2.14.0 for Windows : Aplikasi Statistika Gratis dan Open Source, Penerbit Universitas Sanata Dharma, Yogyakarta, p. 21

Kopecek J., 2009, Hydrogels: From soft contact lenses and implants to selfassembled nanomaterials. Journal of Polymer Science 47, pp. 5929-5946.

Kurniawan D. W., dan Sulaiman T. N., 2009, Teknologi Sediaan Farmasi, Graha Ilmu, Yogyakarta, pp. 97-99.

Mallefet P., dan Dweck, A.C., 2008, Mechanism of Wound Healing Examined, Personal Care, 9 (3), 75 – 83.

Mario T.P. dan Sujarweni W., 2006, SPSS untuk Paramedis, Penerbit Ardana Media, Yogyakarta, p.55

Masduki I, 1996. Efek Antibakteri Ekstrak Biji Pinang (Areca catechu) terhadap S. aureus dan E. coli., Cermin Dunia Kedokteran 109 : 21-4.

Melani D.H., Purwanti T., Soeratri W., 2005, Korelasi Kadar Propilenglikol dalam Basis dan Pelepasan Dietilammonium Diklofenak dari Basis Gel Carbopol ETD 2020, Majalah Farmasi Airlangga, 5 (1), 1-6.

Monambal E., Arun K. dan Abdul Hasan S.A., 2012, Formulation and Evaluation of pH-triggered in situ Gelling System of Levofloxacin. Indian Journal of Pharmaceutical Education and Research, 2011, Vol 45, Issue 1.

Muth J. E., 1999, Basic Statistics and Pharmaceutical Statistical Applications, Marcel Dekker Inc., New York, pp. 265-266.

NAS, 1977, Leucaena - Promising Forage and Tree Crop for the Tropics, National Academy Press, Washington DC, pp. 115.

Nino M., Calabro G., dan Santoianni P., 2012, Topical Delivery of Active Principles: The field of dermatological research, Dermatology online Journal 16, 4.

Noble W.C., 1993, The Skin Microflora and Microbial Skin Disease, University of Cambridge, Cambridge.

Patel N.A., Patel M., dan Patel P.R., 2011, Formulation and Evaluation of Polyherbal Gel for Wound Healing, International Research J. of Pharmaceuticals, 1(1), 15- 20.

Pauli Aya, 2013, Herbal Medicine Vs. Prescription Medicine, http://www.ehow.com/about_5449289_herbal-medicine-vs-prescription-

medicine.html, diakses pada 22 April 2013.

Penerbit Buku Kedokteran EGC, 1998, Kamus Saku Kedokteran Dorland, edisi 25, Penerbit Buku Kedokteran EGC, Jakarta, Indonesia, p.1203.

Perdhana, E., 2011, Perbedaan Waktu Penyembuhan Luka Insisi Pada Mencit Antara Perasan Daun Lamtoro (Leucaena leucocephala) Dan Betadin (Povidon Iodine), Skripsi, hal 13, Universitas Muhammadiyah Yogyakarta.

Robinson T., 1991, Kandungan Organik Tumbuhan Tingkat Tinggi, ITB, Bandung , p.132.

Rowe R. C., Sheskey, P. J., dan Quinn, M. E., 2009, Handbook of Pharmaceutical Excipients, 6th edition, Pharmaceutical Press and American Pharmacists Association, Washington D. C., pp. 118-121, 467, 468, ,592-594, 625.

Sahoo S., Chakraborti C.K. dan Mishra S.C., 2011, Qualitative analysis of controlled release ciprofloxacin/carbopol 934 mucoadhesive suspension, Journal of Advanced Pharmaceutical Technoloy and Research, 2(3), 195-204.

Sherwood L., 2007, Human Physiology : From cells to systems, 6th Edition, Thomson Brooks, Stamford.

Soeratri W., Purwanti T., 2004, Pengaruh Penambahan Asam Glikolat Terhadap Efektivitas Sediaan Tabir Surya Kombinasi anti UV-A dan anti UV-B dalam Basis Gel, Majalah Farmasi Airlangga, 4(3), 73-75.

Suhartono, 2008., Analisis Data Statistik dengan R, Jurusan Statistika ITS, Surabaya, p.115

Sunilkumar, Parameshwaraiah S., dan Shivakumar H.G.,1998, Evaluation of topical formulations of aqueousextract of Centella asiatica on open wounds in rats. Indian Journal of Experimental Biology, 36, pp. 569-572.

Thomas A.N.S., 1992, Tanaman Obat Tradisional 2, Penerbit Kanisius, Yogyakarta, pp. 90-92.

Voigt, R., 1994, Buku Pelajaran Teknologi Farmasi, diterjemahkan oleh Soewndhi,

S.N. dan Widianto M.B., Gadjah Mada University Press, Yogyakarta.

Wardani, L.P., 2009, Efek Penyembuhan Luka Bakar Gel Ekstrak Etanol Daun Sirih (Piper betle) pada Kulit Punggung Kelinci, Skripsi, Universitas Muhammadiyah Surakarta.

Winfield J.A., Richards R.M.E., 2004, Pharmaceutical Practice, Churchill Livingstone, London, pp. 313-314, 319.

Zats J.L., Kushla, G.P., 1996, Gels, in Lieberman, H.A., Rieger, M.M., Banker, G.S., Pharmaceutical Dosage Forms : Disperse System, Vol. 2, 2 nd Edition, Marcel Dekker Inc., New York, pp 399-421.

5. LAMPIRAN

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