LANGUAGE PRODUCTION
4. SUMMARY
1.6. Summary of Recommendations
With the interleaved acquisition mechanism, jaw movement does not occur during data acquisition, resulting in reduced signal drop-out and geometric distortion effects in the derived statistical maps. The data show that reading aloud and reading silently make dif-ferent demands on the inferior frontal gyrus (IFG).
Because of their lengthy TR intervals, interleaved techniques have limited temporal resolution and are optimal for experimental designs requiring imaging of the entire brain at the relatively low sampling rates of six times per minute or less. Two to four seconds are required to image the entire brain utilizing echo-planar imaging. As the hemodynamic response to a brief movement takes ten seconds to complete, it is possible to image the entire cerebrum during the peak of the hemodynamic modulation.
Because of their relative insensitivity to acoustic and motion artifacts, the interleaved techniques produce activity maps that are comparable to or better than those derived using continuous acquisition, possibly because the reduced inter-scan head motion would result in less temporal image misregistration and therefore higher resulting levels of statistical significance. In addition, interleaved techniques employ a longer TR that can result in increased sensitivity to small signal changes due to the improved contrast-to-noise. In Table 1 we present a guide to some of the recent fMRI work using speech responses to study the neural mechanisms of cognitive processing. Both continuous and interleaved techniques are employed using both block and event-related timing arrange-ments.
Aldenkamp, A. P., Boon, P. A., Deblaere, K., Achten, E., Backes, W. H., Boon, P., Hofman, P., Troost, J., Vandemaele, P., Vermeulen, J., Vonck, K., & Wilmink, J. (2003). Usefulness of language and memory testing during intracarotid amobarbital testing: Observations from an fMRI study.
Acta Neurologica Scandinavica, 108, 147–152.
Baciu, M. V., Rubin, C., Decorps, M. A., & Segebarth, C. M. (1999). fMRI assessment of hemispheric language dominance using a simple inner speech paradigm. NMR in Biomedicine, 12, 293–298.
Bandettini, P. A., Jesmanowicz, A., Van Kylen, J., Birn, R. M., & Hyde, J. S. (1998). Functional MRI of brain activation induced by scanner acoustic noise. Magnetic Resonance in Medicine, 39, 410–416.
Barch, D. M., Braver, T. S., Sabb, F. W., & Noll, D. C. (2000). Anterior cingulate and the moni-toring of response conflict: Evidence from an fMRI study of overt verb generation. Journal of Cognitive Neuroscience, 12, 298–309.
Barch, D. M., Sabb, F. W., Carter, C. S., Braver, T. S., Noll, D. C., & Cohen, J. D. (1999). Overt verbal responding during fMRI scanning: Empirical investigations of problems and potential solu-tions. NeuroImage, 10, 642–657.
Barrett, J., Pike, G. B., & Paus, T. (2004). The role of the anterior cingulate cortex in pitch varia-tion during sad affect. European Journal of Neuroscience, 19, 458–464.
Belliveau, J. W., Kennedy, D. N., Jr., McKinstry, R. C., Buchbinder, B. R., Weisskoff, R. M., Cohen, M. S., Vevea, J. M., Brady, T. J., & Rosen, B. R. (1991). Functional mapping of the human visual cortex by magnetic resonance imaging. Science, 254, 716–719.
Birn, R. M., Bandettini, P. A., Cox, R. W., & Shaker, R. (1999). Event–related fMRI of tasks involving brief motion. Human Brain Mapping, 7, 106–114.
Birn, R. M., Cox, R. W., & Bandettini, P. A. (2004). Experimental designs and processing strate-gies for fMRI studies involving overt verbal responses. NeuroImage, 23, 1046–1058.
Biswal, B., DeYoe, A. E., & Hyde, J. S. (1996). Reduction of physiological fluctuations in fMRI using digital filters. Magnetic Resonance in Medicine, 35, 107–113.
Bookheimer, S. Y., Zeffiro, T. A., Blaxton, T., Gaillard, W., & Theodore, W. (1995). Regional cere-bral blood flow during object naming and word reading. Human Brain Mapping, 3, 93–106.
Bookheimer, S. Y., Zeffiro, T. A., Blaxton, T. A., Gaillard, P. W., & Theodore, W. H. (2000).
Activation of language cortex with automatic speech tasks. Neurology, 55, 1151–1157.
Buckner, R. L., Bandettini, P. A., O’Craven, K. M., Savoy, R. L., Petersen, S. E., Raichle, M. E.,
& Rosen, B. R. (1996). Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging. Proceedings of the National Academy of Sciences, USA, 93, 14878–14883.
Burgund, E. D., Lugar, H. M., Miezin, F. M., & Peterson, S. E. (2003). Sustained and transient activity during an object-naming task: A mixed blocked and event-related fMRI study.
NeuroImage, 19, 29–41.
Burton, M. W., Noll, D. C., & Small, S. L. (2001). The anatomy of auditory word processing:
Individual variability. Brain and Language, 77, 119–131.
Cho, Z. H., Chung, S. C., Lim, D. W., & Wong, E. K. (1998). Effects of the acoustic noise of the gradient systems on fMRI: A study on auditory, motor, and visual cortices. Magnetic Resonance in Medicine, 39, 331–335.
Constable, R. T., & Spencer, D. D. (2001). Repetition time in echo planar functional MRI.
Magnetic Resonance in Medicine, 46, 748–755.
de Zubicaray, G. I., McMahon, K. L., Eastburn, M. M., & Wilson, S. J. (2002).
Orthographic/phonological facilitation of naming responses in the picture-word task: An event-related fMRI study using overt vocal responding. NeuroImage, 16, 1084–1093.
de Zubicaray, G. I., Wilson, S. J., McMahon, K. L., & Muthiah, S. (2001). The semantic inter-ference effect in the picture-word paradigm: An event-related fMRI study employing overt responses. Human Brain Mapping, 14, 218–227.
Dietz, N. A., Jones, K. M., Gareau, L., Zeffiro, T. A., & Eden, G. F. (2005). Phonological decod-ing involves left posterior fusiform gyrus. Human Brain Mappdecod-ing, 26, 81–93.
Dietz, N. A., Jones, K. M., Twomey, R., Zeffiro, T. A., & Eden, G. F. (in press). A comparison of continuous versus interleaved fMRI data acquisition for the study of reading aloud.
Eden, G. F., Jones, K. M., Cappell, K., Gareau, L., Wood, F. B., Zeffiro, T. A., Dietz, N. A., Agnew, J. A., & Flowers, D. L. (2004). Neural changes following remediation in adult developmental dyslexia. Neuron, 44, 411–422.
Eden, G. F., Joseph, J. E., Brown, H. E., Brown, C. P., & Zeffiro, T. A. (1999). Utilizing hemo-dynamic delay and dispersion to detect fMRI signal change without auditory interference: The behavior interleaved gradients technique. Magnetic Resonance in Medicine, 41, 13–20.
Edmister, W. B., Talavage, T. M., Ledden, P. J., & Weisskoff, R. M. (1999). Improved auditory cor-tex imaging using clustered volume acquisitions. Human Brain Mapping, 7, 89–97.
Fiez, J. A., Raichle, M. E., Miezin, F. M., Petersen, S. E., Tallal, P., & Katz, W. F. (1995). PET studies of auditory and phonological processing: Effects of stimulus characteristics and task demands. Journal of Cognitive Neuroscience, 7, 357–375.
Frenck-Mestre, C., Anton, J. L., Roth, M., Vaid, J., & Viallet, F. (2005). Articulation in early and late bilinguals’ two languages: Evidence from functional magnetic resonance imaging.
NeuroReport, 16, 761–765.
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S., & Turner, R. (1996). Movement-related effects in fMRI time-series. Magnetic Resonance in Medicine, 35, 346–355.
Frith, C. D., Friston, K., Liddle, P. F., & Frackowiak, R. S. (1991). Willed action and the prefrontal cortex in man: A study with PET. Proceedings of the Royal Society of London, Series B, 244, 241–246.
Glover, P., Hykin, J., Gowland, P., Wright, J., Johnson, I., & Mansfield, P. (1995). An assessment of the intrauterine sound intensity level during obstetric echo-planar magnetic resonance imaging.
British Journal of Radiology, 68, 1090–1094.
Grabowski, T. J., Bauer, M. D., Foreman, D., Mehta, S., Eaton, B. L., Graves, W. W., Defoe, D. L.,
& Bolinger, L. (2006). Adaptive pacing of visual stimulation for fMRI studies involving overt speech. NeuroImage, 29, 1023–1030.
Hall, D. A., Haggard, M. P., Akeroyd, M. A., Palmer, A. R., Summerfield, A. Q., Elliott, M. R., Gurney, E. M., & Bowtell, R. W. (1999). “Sparse” temporal sampling in auditory fMRI. Humam Brain Mapping, 7, 213–223.
Haller, S., Radue, E. W., Erb, M., Grodd, W., & Kircher, T. (2005). Overt sentence production in event-related fMRI. Neuropsychologia, 43, 807–814.
Hashimoto, Y., & Sakai, K. L. (2003). Brain activations during conscious self-monitoring of speech production with delayed auditory feedback: An fMRI study. Human Brain Mapping, 20, 22–28.
Haxby, J. V., Horwitz, B., Ungerleider, L. G., Maisog, J. M., Pietrini, P., & Grady, C. L. (1994).
The functional organization of human extrastriate cortex: A PET-rCBF study of selective attention to faces and locations. The Journal of Neuroscience, 14, 6336–6353.
He, A. G., Tan, L. H., Tang, Y., James, G. A., Wright, P., Eckert, M. A., Fox, P. T., & Liu, Y. (2003).
Modulation of neural connectivity during tongue movement and reading. Human Brain Mapping, 18, 222–232.
Heim, S., Opitz, B., & Friederici, A. D. (2002). Broca’s area in the human brain is involved in the selection of grammatical gender for language production: Evidence from event-related functional magnetic resonance imaging. Neuroscience Letters, 328, 101–104.
Herscovitch, P., Markham, J., & Raichle, M. E. (1983). Brain blood flow measured with intra-venous H215O. I. Theory and error analysis. Journal of Nuclear Medicine, 24, 782–789.
Hu, X., Le, T. H., Parrish, T., & Erhard, P. (1995). Retrospective estimation and correction of physiological fluctuation in functional MRI. Magnetic Resonance in Medicine, 34, 201–212.
Huang, J., Carr, T. H., & Cao, Y. (2002). Comparing cortical activations for silent and overt speech using event-related fMRI. Human Brain Mapping, 15, 39–53.
Jung, K. J., Prasad, P., Qin, Y., & Anderson, J. R. (2005). Extraction of overt verbal response from the acoustic noise in a functional magnetic resonance imaging scan by use of segmented active noise cancellation. Magnetic Resonance in Medicine, 53, 739–744.
Kan, I. P., & Thompson-Schill, S. L. (2004). Effect of name agreement on prefrontal activity dur-ing overt and covert picture namdur-ing. Cognitive, Affect, & Behavioral Neuroscience, 4, 43–57.
Kemeny, S., Xu, J., Park, G. H., Hosey, L. A., Wettig, C. M., & Braun, A. R. (2006). Temporal dis-sociation of early lexical access and articulation using a delayed naming task - An fMRI study.
Cerebral Cortex, 16, 587–595.
Kemeny, S., Ye, F. Q., Birn, R., & Braun, A. R. (2005). Comparison of continuous overt speech fMRI using bold and arterial spin labeling. Human Brain Mapping, 24, 173–183.
Kircher, T. T., Brammer, M. J., Levelt, W., Bartels, M., & McGuire, P. K. (2004). Pausing for thought:
Engagement of left temporal cortex during pauses in speech. NeuroImage, 21, 84–90.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., Turner, R., Cheng, H. -M., Brady, T. J., & Rosen, B. R. (1992). Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proceedings of the National Academy of Sciences, USA, 89, 5675–5679.
Larsen, B., Skinhoj, E., & Lassen, N. A. (1978). Variations in regional cortical blood flow in the right and left hemispheres during automatic speech. Brain, 101, 193–209.
Larsen, B., Skinhoj, E., Soh, K., Endo, H., & Lassen, N. A. (1977). The pattern of cortical activity provoked by listening and speech revealed by rCBF measurements. Acta Neurologica Scandinavica Supplementum, 64, 268–269, 280–281.
Le, T. H., & Hu, X. (1996). Retrospective estimation and correction of physiological artifacts in fmri by direct extraction of physiological activity from MR data. Magnetic Resonance in Medicine, 35, 290–298.
Leger, A., Demonet, J. F., Ruff, S., Aithamon, B., Touyeras, B., Puel, M., Boulanouar, K., &
Cardebat, D. (2002). Neural substrates of spoken language rehabilitation in an aphasic patient: An fMRI study. NeuroImage, 17, 174–183.
Liegeois, F., Baldeweg, T., Connelly, A., Gadian, D. G., Mishkin, M., & Vargha-Khadem, F. (2003).
Language fMRI abnormalities associated with FOXP2 gene mutation. Nature Neuroscience, 6, 1230–1237.
Martin, P. I., Naeser, M. A., Doron, K. W., Bogdan, A., Baker, E. H., Kurland, J., Renshaw, P., &
Yurgelun-Todd, D. (2005). Overt naming in aphasia studied with a functional MRI hemodynamic delay design. NeuroImage, 28, 194–204.
McCarthy, G., Blamire, A. M., Rothman, D. L., Gruetter, R., & Shulman, R. G. (1993). Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proceedings of the National Academy of Sciences, USA, 90, 4952–4956.
Naeser, M. A., Martin, P. I., Baker, E. H., Hodge, S. M., Sczernie, S. E., Nicholas, M., Palumbo, C. L., Goodglass, H., Wingfield, A., Samaraweera, R., Harris, G., Baird, A., Renshaw, P., &
Yurgelun-Todd, D. (2004). Overt propositional speech in chronic nonfluent aphasia studied with the dynamic susceptibility contrast fMRI method. NeuroImage, 22, 29–41.
Nelles, J. L., Lugar, H. M., Coalson, R. S., Miezin, F. M., Petersen, S. E., & Schlaggar, B. L. (2003).
Automated method for extracting response latencies of subject vocalizations in event-related fMRI experiments. NeuroImage, 20, 1865–1871.
Neumann, K., Euler, H. A., von Gudenberg, A. W., Giraud, A. -L., Lanfermann, H., Gall, V., &
Preibisch, C. (2003). The nature and treatment of stuttering as revealed by fMRI a within- and between-group comparison. Journal of Fluency Disorders, 28, 281–409.
Neumann, K., Preibisch, C., Euler, H. A., von Gudenberg, A. W., Lanfermann, H., Gall, V., &
Giraud, A. L. (2005). Cortical plasticity associated with stuttering therapy. Journal of Fluency Disorders, 30, 23–39.
Novitski, N., Alho, K., Korzyukov, O., Carlson, S., Martinkauppi, S., Escera, C., Rinne, T., Aronen, H. J., & Naatanen, R. (2001). Effects of acoustic gradient noise from functional magnetic reso-nance imaging on auditory processing as reflected by event-related brain potentials. NeuroImage, 14, 244–251.
Novitski, N., Anourova, I., Martinkauppi, S., Aronen, H. J., Naatanen, R., & Carlson, S. (2003).
Effects of noise from functional magnetic resonance imaging on auditory event-related potentials in working memory task. NeuroImage, 20, 1320–1328.
Obrist, W. D., Thompson, H. K., Jr., King, C. H., & Wang, H. S. (1967). Determination of regional cerebral blood flow by inhalation of 133-Xenon. Circulation Research, 20, 124–135.
Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., & Ugurbil, K.
(1992). Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proceedings of the National Academy of Sciences, USA, 89, 5951–5955.
Owen, W. J., Borowsky, R., & Sarty, G. E. (2004). fMRI of two measures of phonological pro-cessing in visual word recognition: Ecological validity matters. Brain and Language, 90, 40–46.
Palmer, E. D., Rosen, H. J., Ojemann, J. G., Buckner, R. L., Kelley, W. M., & Petersen, S. E.
(2001). An event-related fMRI study of overt and overt word stem completion. NeuroImage, 14, 182–193.
Peck, K. K., Moore, A. B., Crosson, B. A., Gaiefsky, M., Gopinath, K. S., White, K., & Briggs, R.
W. (2004). Functional magnetic resonance imaging before and after aphasia therapy: Shifts in he-modynamic time to peak during an overt language task. Stroke, 35, 554–559.
Phelps, E. A., Hyder, F., Blamire, A. M., & Shulman, R. G. (1997). fMRI of the prefrontal cortex during overt verbal fluency. NeuroReport, 8, 561–565.
Poncelet, B. P., Wedeen, V. J., Weisskoff, R. M., & Cohen, M. S. (1992). Brain parenchyma mo-tion: Measurement with cine echo-planar MR imaging. Radiology, 185, 645–651.
Preibisch, C., Neumann, K., Raab, P., Euler, H. A., von Gudenberg, A. W., Lanfermann, H., &
Giraud, A. L. (2003a). Evidence for compensation for stuttering by the right frontal operculum.
NeuroImage, 20, 1356–1364.
Preibisch, C., Raab, P., Neumann, K., Euler, H. A., von Gudenberg, A. W., Gall, V., Lanfermann, H., & Zanella, F. (2003b). Event-related fMRI for the suppression of speech-associated artifacts in stuttering. NeuroImage, 19, 1076–1084.
Price, C. J., Wise, R. J., & Frackowiak, R. S. (1996a). Demonstrating the implicit processing of visually presented words and pseudowords. Cerebral Cortex, 6, 62–70.
Price, C. J., Wise, R. J. S., Warburton, E. A., Moore, C. J., Howard, D., Patterson, K., Frackowiak, R. S., & Friston, K. J. (1996b). Hearing and saying: The functional neuro-anatomy of auditory word processing. Brain, 119, 919–931.
Raichle, M. E., Martin, W. R., Herscovitch, P., Mintun, M. A., & Markham, J. (1983). Brain blood flow measured with intravenous H215O. II. Implementation and validation. Journal of Nuclear Medicine, 24, 790–798.
Ravicz, M. E., & Melcher, J. R. (2001). Isolating the auditory system from acoustic noise during functional magnetic resonance imaging: Examination of noise conduction through the ear canal, head, and body. The Journal of the Acoustical Society of America, 109, 216–231.
Ravicz, M. E., Melcher, J. R., & Kiang, N. Y. (2000). Acoustic noise during functional magnetic resonance imaging. The Journal of the Acoustical Society of America, 108, 1683–1696.
Riecker, A., Ackermann, H., Wildgruber, D., Dogil, G., & Grodd, W. (2000). Opposite hemispheric lateralization effects during speaking and singing at motor cortex, insula and cerebellum.
NeuroReport, 11, 1997–2000.
Rosen, H. J., Ojemann, J. G., Ollinger, J. M., & Petersen, S. E. (2000). Comparison of brain acti-vation during word retrieval done silently and aloud using fMRI. Brain and Cognition, 42, 201–217.
Roy, C. S. C. (1890). On the regulation of the blood supply of the brain. The Journal of Physiology, 11, 85–108.
Rumsey, J. M., Horwitz, B., Donohue, B. C., Nace, K., Maisog, J. M., & Andreason, P. (1997).
Phonological and orthographic components of word recognition. A PET-rCBF study. Brain, 120, 739–759.
Shulman, G. L., Corbetta, M., Buckner, R. L., Raichle, M. E., Fiez, J. A., Miezin, F. M., & Petersen, S. E. (1997). Top-down modulation of early sensory cortex. Cerebral Cortex, 7, 193–206.
Shuster, L. I., & Lemieux, S. K. (2005). An fMRI investigation of covertly and overtly produced mono- and multisyllabic words. Brain and Language, 93, 20–31.
Slifer, K., Cataldo, M. F., Cataldo, M. D., Llorente, A. M., & Gerson, A. C. (1993). Behavior analy-sis of motion control for pediatric neuroimaging. Journal of Applied Behavioral Analyanaly-sis, 26, 469–470.
Small, S. L., Noll, D. C., Perfetti, C. A., Hlustik, P., Wellington, R., & Schneider, W. (1996).
Localizing the lexicon for reading aloud: Replication of a PET study using fMRI. NeuroReport, 7, 961–965.
Talairach, J., & Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain (M. Rayport, Trans.). New York: Thieme Medical Publishers, Inc.
Talavage, T. M., & Edmister, W. B. (2004). Nonlinearity of fMRI responses in human auditory cortex. Human Brain Mapping, 22, 216–228.
Talavage, T. M., Edmister, W. B., Ledden, P. J., & Weisskoff, R. M. (1999). Quantitative assess-ment of auditory cortex responses induced by imager acoustic noise. Human Brain Mapping, 7, 79–88.
Turkeltaub, P. E., Eden, G. F., Jones, K. M., & Zeffiro, T. A. (2002). Meta-analysis of the functional neuroanatomy of single-word reading: Method and validation. NeuroImage, 16, 765–780.
Viswanath, N. S., Karmonik, C., King, D., Rosenfield, D. B., & Mawad, M. (2003). Functional magnetic resonance imaging (fMRI) of a stutterer’s brain during overt speech. Journal of Neuroimaging, 13, 280–281.
Woods, R. P., Grafton, S. T., Holmes, C. J., Cherry, S. R., & Mazziotta, J. C. (1998a). Automated image registration: I. General methods and intrasubject, intramodality validation. Journal of Computer Assisted Tomography, 22, 139–152.
Woods, R. P., Grafton, S. T., Watson, J. D., Sicotte, N. L., & Mazziotta, J. C. (1998b). Automated image registration: II. Intersubject validation of linear and nonlinear models. Journal of Computer Assisted Tomography, 22, 153–165.
Yang, S., Ross, T. J., Zhang, Y., Stein, E. A., & Yang, Y. (2005). Head motion suppression using real-time feedback of motion information and its effects on task performance in fMRI.
NeuroImage, 27, 153–162.
Yetkin, F. Z., Hammeke, T. A., Swanson, S. J., Morris, G. L., Mueller, W. M., McAuliffe, T. L.,
& Haughton, V. M. (1995). A comparison of functional MR activation patterns during silent and audible language tasks. American Journal of Neuroradiology, 16, 1087–1092.