FACULTY OF MEDICINE
F. HISTORY OF BIOCHEMISTRY
30. The historical significance of the suffix "-ese" for enzymes catalyzing synthetic processes - M. A. Marginson.
PUBLISHED WORK Book
1. AUGUSTEYN, R.C, ROGERS. K. M. and COLLIN, H. B. - The Eye, Vol. I . 1979.
Annual Research Reviews, Scries ed. D. F. Horrobin, Eden Press, Montreal (1979).
Chapter of Book
2. MITCHELL, A. and RODWELL, A. W. - Nutrition, Growth and Reproduction, in The Mycoplasmas, eds. M. F. Barile and S. Razin, Academic Press, New York, 7: 103-139 (1979).
Articles
3. AUGUSTEYN, R. C. - On the Possible Role of Glutathione in Maintaining Human Lens Protein Sulphydryls. Exp. Eve Res.. 25:665-671 (1979).
4. BALDWIN, G. S. and DAVIDSON, B. E. - Amino Acid Sequences of Soluble Tryptic Peptides of Chorismate Mutase/Prephenate Dehydratase from Escherichia coli K12.
Biochim. Biophvs. Acta. 579:483-486 (1979).
5. BROOME, M. C, HILLIER, A. J. and JAGO, G. R. - The Walsh and Cogan Method for Estimating Diacetyl as applied in Metabolic Studies with Starter Bacteria. Aust. J. Dairv Technol.. 34:70-71 (1979).
6. BROOME, M. C, THOMAS, M. P., HILLIER, A. J., HORWOOD, J. F. and JAGO, G. R. - The Effect of Linoleic Acid on the Growth and Metabolism of Streptococcus lactis.
Aust. J. Dairy Technol. 34:163-168 (1979).
7. BYRT, P. and GRANT, B. R. - Some Conditions Governing Zoospore Production in Axenic Cultures of Phytophthora cinnamomi Rands. Aust. J. Bol.. 27:103-115 (1979).
8. CROSSLEY, L. C , JAGO, G. R. and DAVIDSON, B. E. - Partial Sequence Data for the L-(+)-Lactate Dehydrogenase from Streptococcus cremoris US3 including the Amino Acid Sequences around thc Single Cysteine Residue and at the N-Terminus. Biochim. Biophvs.
Ada. 557:342-355(1979).
9. DREHER, T. W.. HAWTHORNE, D. B. and GRANT, B. R. - Comparison of Open- Column and High-Pcrformance Gel Permeation Chromatography in the Separation and Molecular-Weight Estimation of Polysaccharides. J. Chromatography, 174: 443-446 (1979).
10. EDWARDS, K., NAGASHIMA, M., DRYBURGH, H., WYKES, A. and SCHREIBER, G. - Secretion of Proteins from Liver Cells is Suppressed by the Proteinase Inhibitor N-a- tosyl-L-lysyl Chloromethanc, but not by Tunicamycin, an Inhibitor of Glycosylation.
FEBSLetters. 700:269-272 (1979).
11. EDWARDS, K., URBAN, J. and SCHREIBER, G. - Relationship between Protein Synthesis and Secretion in Liver Cells and the State of the Adenine Nucleotide System.
Aust. J. Biol. Sci., 32:299-307 (1979).
12. FELLOWS, F. C. I. and HIRD, F.J. R. - Nitrogen Metabolism and Excretion in the Freshwater Crayfish Cherax destructor. Comp. Biochem. Physiol, 6473:235-238 (1979).
13. FINCH, L. R.. CHRISTOPHERSON, R. I. and JONES, M. E. - A Simple Centrifuge Column for Desalting Protein Solutions. Anal. Biochem.. 100:184-187 (1979).
14. HAIGH, E. A., THULBORN, K. R. and SAWYER, W. H. - Comparison of Fluorescence Energy Transfer and Quenching Methods to Establish the Position and Orientation of Components within the Transverse Plane of the Lipid Bilayer. Application to the Gramicidin A-Bilayer Interaction. Biochemislrv, 75:3525-3532 (1979).
15. HAWTHORNE, D. B., SAWYER, W. H. and GRANT, B. R. - The Structure ofthe Low Molecular-Weight Glucans Isolated from the Siphonous Green Alga Caulerpa simpliciuscula. Carbohydrate Res.. 77:157-167 (1979).
16. HILLIER, A. J., JERICHO. R. E., GREEN S. M. and JAGO, G. R. - Properties and Function of Fumarate Reductase (NADH) in Streptococcus lactis. Aust. .1. Rial. Sri., 32:
625-635(1979).
17. HURRELL, J. G. R., LEACH, S. J., MART1NELLI, R. A., INGLIS, A. S., RUB1RA, M. R., HAGEMAN, T. C. and SCHERAGA, H. A. - Amino Acid Sequences of Portions ofthe czand/JChains of Bovine Fibrinogen. Arch. Biochem. Biophys., 792:27-32 (1979).
18. LEACH, S. J., MAXFIELD, F. R., STIMSON, E. R., POWERS, S. P. and SCHERAGA, H. A. - Infrared Spectra of the /V-Acetyl-/v"-Methylamides of Glycine, L-Alanine, and L-Leucinc in Dilute Solutions of Chloroform and Carbon Tetrachloride. Biopolymers, 18:
2507-2521(1979).
19. LEACH, S. J., MINASIAN. E., DESLAURIERS, R., MAXFIELD, F. R., McQUIE, J. R., MEINWALD, Y. C, NEMETHY, G., POTTLE, M. S., RAE. I. D., SCHERAGA, H. A., STIMSON, E. R. and VAN NISPEN, J. W. -Cyclized Dipeptide Model for a/J-Bend. Proc.
Natl. Acad Sci. USA. 76:2512-2514(1979).
20. McKENZIE, G. H., CH'NG, A. L. and GAYLER, K. R. - Glutamine Synthetase/
Glutamine:er-Ketoglutarate Aminotransferase in Chloroplasts from the Marine Alga Caulerpa simpliciuscula. Plant Physiol.. 63:578-582(1979).
21. MITCHELL, A. and FINCH, L. R. - Enzymes of Pyrimidine Metabolism in Mycoplasma mycoides subsp. mycoides. J. Bacteriol. 137:1073-1080(1979).
22. REYNOLDS, E. C, FINCH, L. R. and HARRIS, A. W. - Deoxyribonucleoside Triphos- phate Pools and Differential Thymidine Sensitivities of Cultured Mouse Lymphoma and Myeloma Cells. Biochim. Biophys. Acta. 561:110-123 (1979).
23. REYNOLDS, E. C, FINCH, L. R. and HARRIS, A. W. - Effect of Thymidine on the Sensitivity of Cultured Mouse Tumor Cells to 1-/9-D-Arabinofuranosylcytosine. Cancer Res.. 39:538-541 (1979).
24. SAWYER. W. H., CALVERT, P. D. and NICHOL, L. W. - Binding Equations for Interacting Systems Comprising Multivalent Acceptor and Bivalent Ligand: Application to Antigen-Antibody Systems. / theor. Biol. 50:233-247(1979).
25. SCHREIBER, G., DRYBURGH, H., MILLERSHIP, A., MATSUDA, Y., PHILLIPS. J., EDWARDS, K., MAGGS, J. and INGLIS, A. - The Synthesis and Secretion of Rat Transferrin. / Biol. Chem.. 254:12013-12019 (1979).
26. SMITH, M. M. and GAYLER, K. R. - Free Amino Acids in the Marine Green Alga Caulerpa simpliciuscula. Bot. Marina, 22:361 -365 (1979).
27. THOMAS, M. P., BROOME, M. C, HILLIER, A. J. and JAGO, G. R. - A Comparative Study ofthe Formation of Acetate from Pyruvate in Group N Streptococci. Aust. J. Dairv Technol. 34:91-\Q\ (1979).
28. THULBORN, K. R., MINASIAN, E. and LEACH, S. J. -Leghaemoglobin from Trifolium subterraneum. Purification and Characterization. Biochim. Biophvs. Acta, 578: 476-48 3 (1979).
29. THULBORN, K. R., SAWYER, W. H., JOHNS, S. R. and WILLING, R. 1. - "C NMR Studies on Fluorescent Probes: l 3C Chemical Shifts and Longitudinal Relaxation Times of n-Hydroxy-Fatty («=2,6,9,12) Acids and /i-(9-Anthroyloxy)-Stcaric (n=6,12) Acids. Chem.
Phys. Lipids, 24:11 -16 (1979).
30. THULBORN, K. R., TILLEY, L. M., SAWYER, W. H. and TRELOAR, F. E. - The Use of «-(9-Anthroyloxy) Fatty Acids to Determine Fluidity and Polarity Gradients in Phospholipid Bilayers. Biochim. Biophvs. Acta, 558:166-178 (1979).
31. TILLEY, L., THULBORN, K. R. and'SAWYER, W. H. - An Assessment ofthe Fluidity Gradient of the Lipid Bilayer as Determined by a Set of n-(9-Anthroy!oxy) Fatty Acids («=2,6,9,12,16)./ Biol. Chem. 254:2592-2594 (1979).
32. URBAN, J., CHAN, D. and SCHREIBER, G. - A Rat Serum Glycoprotein whose Synthesis Rate Increases Greatly during Inflammation. J. Biol. Chem., 254: 10565-10568 (1979).
THESES PASSED FOR HIGHER DEGREES Doctor of Science
1. MARTIN, T. J. - Collected Papers in Biochemical Endocrinology.
Doctor of Philosophy
2. PATERSON, Y. J. - The Effect of Side Chain Complexity on the Dimensions of Poly- peptide Chains.
BIOCHEMISTRY 131 3. THULBORN, K. R. - n-(9-Anthroyloxy) Fatly Acids as Fluorescent Probes for
Biomembranes.
4. WRIGHT, S. W. - Properties of Chloroplasts Isolatedfrom Siphonous Green Algae.
Master of Science
5. CHANDRASENA, S. I.- The Functional Significance of Aspartate Aminotransferase.
6. DAVY, R. M. - The Effect of Altered Haem Liganding and other Modifications on the Properties of Cytochrome c.
7. MITCHELL, J. - Equilibration ofnP into the Nucleotides ofMouse-L Cells.
8. STONE, F. H. - Hydroxyurea Sensitivity of Three Types of Murine Tumour Cells.
9. VERONI, M. C. - The Synthesis and Evaluation of Relaxin Related Peptides.
THESES IN PROGRESS PhD Theses in Progress
BYRT, P. N. - Biochemical Investigations in Phytophthora cinnamomi.
CHELLADURAI, M. - Intermediate Forms of Secretory Proteins.
CH'NG, A. L. - Assimilation of Nitrogenous Compounds by Marine Benthic Algae.
DAVIES, W. D. - Biochemical Studies on some Escherichia coli Genes Responsible for the Biosynthesis of Aromatic Amino Acids.
DAVULURI'SIVAPRASAD - Amino Acid Metabolism in Relation to End-Products of Nitrogen Metabolism.
DREHER, T. W. - Studies on the Wound Response of the Coenocylic Green Alga Caulerpa simpliciuscula.
EAST. I. J. - Immunogenicily and A ntigenicity of Globin Proteins.
EVANS, D. J. - Studies on the Synthesis and Tertiary Structure of Peptides and their Relationship to Protein Folding.
HAIGH, E. A. - Fluorescence Studies of Protein-Lipid Interactions in Biomembranes.
HAWTHORNE, D. B. - Studies on ihe Structure and Function of Polysaccharides from the Green Alga Caulerpa simpliciuscula.
HICK.EY, M. W. - Aspects of the Carbohydrate and Amino Acid Metabolism of Lactobacilli.
HUDSON, G. S. - Comparative Studies of Chorismate Mutase-Prephenate Dehydratase and Chorismate Mutase-Prephenate Dehydrogenase ofE. coli K12.
NAGASHIMA, M. - Studies on the Svnthesis and Secretion of Glycoproteins.
RADFORD, 1. R. - Effect of Cytotoxic Drugs on DNA Synthesis. '
SMALL, D. H. - Synthesis of Myelin Basic Protein in relation to Multiple Sclerosis Serum Factors.
SYKES, G. E. - Regulation of Development of Seed Proteins.
MSc Theses in Progress
COVENTRY, M.J - Aspects of Carbohydrate Metabolism in Lactic Acid Streptococci.
HILL, J. S. - 77i£> Molecular Basis of Hereditary Spherocytosis.
SUBSTANTIAL GRANTS RECEIVED Grants have been received as follows:
ARGC: Structure and Function of Enzymes involved in the Synthesis of Phenylalanine and Tyrosine in E. coli.
ARGC: Amino Acid Biosynthesis during Photosynthesis of Marine Algae.
ARGC: Thc Role of 1, 3 /iGlucans in Wound Healing.
ARGC: The Redox Properties of Leghaemoglobin-Ligand Complexes: a Probe of Hacm-Pockct Structure.
ARGC: Evolutionary Aspects of Biochemistry.
ARGC: The Structure and Evolution of Primitive Haemoglobins.
ARGC: Protein-Lipid Interactions in Natural and Model Membranes.
Australian Wool Corporation: Peptide Models for Beta Structures in Keratins.
NH&MRC: Synthesis and Secretion of Protein by the Liver.
NH&MRC: Oxidation during Senile Nuclear Cataract Formation.
NH&MRC: Diagnostic, Biosynthetic and Molecular Studies on Haemoglobinopathies (with Dept. of Haematology. Queen Victoria Hospital).
Naiionai institutes of Heailh: The Mechanism of Senile Cataract Formation.
Utah Foundation: Studies on Eucalypt Die-back Disease.
In addition, 12 smaller grants were received from the following donors:
Anti-Cancer Council of Victoria; Australian Research Grants Committee; Medical Research Committee, University of Melbourne; Research and Graduate Studies Committee, University of Melbourne; Rowden White Estate.
COMMUNITY HEALTH
RESEARCH TOPICS IN PROGRESS 1. Melbourne Stroke Register- D. G. Christie.
2. A trial ofa support service to stroke survivors - D . G. Christie.
3. Occupational aspects of the health of workers in the Australian Petroleum Industry - A feasibility study-D. G. Christie, J. Harper.
4. Epidemiological study of occupationally related skin disease in the rubber and cement industries-D. Dunt.
5. Care ofthe dying patient: an evaluation of hospice care - D. Dunt.
6. Common beliefs about health and medical care among selected ethnic groups- D. Dunt.
PUBLISHED WORK Chapter of Book
1. CHRISTIE, D. G. - Chapter 7 'Physical Health', in The Health and Social Survey ofthe North-West Region of Melbourne, ed. J. Krupinski, The Institute of Mental Health Research, Mental Health Division, Victoria, Special publication No. 7 (1979).
Articles
2. CHRISTIE, D. G. and GARDNER, A. - Radiologic heart volume and subsequent mortality. Acta Radiologica. 20:65-69 (1979).
3. LAWRENCE, L. and CHRISTIE, D. G. - Quality of life after stroke: a 3 year follow-up.
Age and Ageing. 8:167-172 (1979).
4. CHRISTIE, D. G. - Screening for hypertension: some practical problems. J. Rov. Coll.
Gen. Pract.. 29:597-601 (1979).
5. CHRISTIE, D. G.- Improved survival from stroke: an effect of anti-hypertensive therapy.
Med. J. Aust., 2:391 -393 (1979).
6. CHRISTIE, D. G. - Before and After Studies: a cautionary tale. Brit. Med. J.. 2: 1629 (1979).
7. CHRISTIE, D. G. - Prevention of cardiovascular disease: could we be wrong? Med. J.
Aust.. 2:408 (editorial)(1979).
8. WEBSTER, R. W. - Undergraduate teaching in primary medical care. Aust. Pam. Phvs., SO): 808-813 (1979).
9. GREEN, S., KAUFERT, J. M.. DUNT, D. and others - The collection of information on the use of services among the elderly - a comparison between respondent recall and record audit. Soc. Sci. & Med. I3A:231 (1979).
10. KAUFERT, J. M, GREEN, S., DUNT, D. and others-Assessing functional status among elderly patients: a comparison of questionnaire and service provider ratings. Medical Care.
XVII(8):%01(\919).
11. OPIT, L. J. and DUNT, D. - The need for CT. head scanning in a defined population.
Community Health Studies. HI: 181 (1979).
12. TURNLEY, B., DUNT, D., PARKER, M. L. and others - Child care in temporary maternal absence - A cross cultural survey, in L. Roudopulos, ed., Aspects of Social Services Delivery to Immigrants. Clearing House in Migrants Issues. Melbourne (1979).
SUBSTANTIAL GRANTS RECEIVED Grants have been received as follows:
NH&MRC: Melbourne Stroke Register.
Australian Institute of Petroleum: Occupational Aspects of Health of Workers in the Australian Petroleum Industry.
133
GERONTOLOGY AND GERIATRIC MEDICINE
NATIONAL RESEARCH INSTITUTE OF GERONTOLOGY AND GERIATRIC MEDICINE, MOUNT ROYAL HOSPITAL
RESEARCH TOPICS IN PROGRESS
1. Accidents lo Patients and Staff in Mount Royal Hospital - D. M. Prinsley.
2. Unwanted Effects of Medication - D. M. Prinsley and L. Mashford (Dept. of Pharma- cology, St. Vincent's Hospital).
3. Disturbed Behaviour among the Elderly - D. M. Prinsley and H. Bower (Consultant Psychiatrist, Mount Royal Hospital).
4. Patterns of Entry into Institutional Care among the Aged: (a) A Study of "Waiting Lists" for Nursing Homes: (b) Analysis of backgrounds of patients newly admitted to nursing homes, investigating prior living arrangements, assessment and alternative modes of care - A.
Howe.
5. Paget's Disease of Bone in the Elderly-D. M. Prinsley.
6. A Comparative Trial of Dihydroergotamine and Indomethacin in the Treatment of Postural Hypotension-J. J. Hammond.
7. A Prospective Evaluation of the Level of Blood Pressure in the Immediate Post-Stroke Period-J. J. Hammond.
8. A Study ofthe Effectiveness ofa New Anti-arthritic drug for use among the Elderly - D. M.
Prinsley.
9. Studies of Nutrition and Vitamin Status of Elderly Institutionalised Patients - D. M.
Prinsley and D. Flint (Section of Human Nutrition, Deakin University).
PUBLISHED WORK Chapter in Book
1. PRINSLEY, D. M. - Geriatrics in Community Health, in cd. R. Walpole, Community Health in Australia. Penguin Books. Australia: 107-116(1979).
Articles
2. BRACKENRIDGE, C. J. - Statistical Study of Sarcoma Complicating Paget's Disease of Bone in Three Countries, Brit. J. of Cancer. 40: 107-200(1979).
3. BRACKENRIDGE, C. J. - Relation of Occupational Stress to the Age of Onset of Huntington's Disease, Acta Neurologica Scandinavia. 60:272-276 (1979).
4. HOWE, A. L. - Family support for the Aged: Some evidence and interpretation, Aust. J. of Social Issues. 14:259-273 (1979).
5. PRINSLEY, D. M. and CAMERON, K. P. - Old People Living Alone - Is Organised Observation Necessary? A ust.J. of Social Issues. 14:297-300 (1979).
6. PRINSLEY, D. M. and CAMERON, K. P. - Management of Urinary Incontinence. A New Absorbent Bed Sheet, Med. J. of Australia. 1:578-579 (1979).
7. PRINSLEY, D. M. - Prevention of Accidents in the Elderly Aged Group, Safelv Institute of Australia Inc.. 2(1): 5-7 (1979).
8. PRINSLEY, D. M. - Research Needs and Research Activities in Geriatrics in Australia, in eds. J. A. Donald, A. V. Everitt and P. J. Wheeler, Ageing in Australia. Australian Association of Gerontology: 65-67(1979).
Report
9. PRINSLEY, D. M., KIDD, B., HOWE, A. L. and CAMERON, K. P. - The Experience of Retirement Migration to Phillip Island and Its Impact on the Community, Occasional Paper in Gerontology. (National Research Institute of Gerontology and Geriatric Medicine) /(October, 1979)63'pp.
GERONTOLOGY A N D GERIATRIC MEDICINE 135 SUBSTANTIAL GRANTS RECEIVED
Grants have been received as follows:
* Nicholas Research Laboratories: Trial ofa new incontinence pad.
* University of Melbourne Medical Research Committee and Mental Health Research Fund:
Study of disturbed behaviour amongst the elderly.
ARGC: Study of retirement migration to Phillip Island.
Ramaciotti Foundation: Evaluation of an experimental street visitor scheme.
U.S. Vitamins (Australia) Pty Ltd: Study of Paget's Disease of bone in the elderly.
Merck, Sharp and Dohme Pty Ltd: Evaluation of the effectiveness of a new anti-arthritic drug.
* These grants were made in 1978 but work carried on through 1979.
MEDICAL BIOLOGY
THh WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH RESEARCH TOPICS IN PROGRESS