Studies in Cancer Chemotherapy

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The r o l e of rnetals i n b i o l o g i c a l processes h a s been discussed with particular emphasis on the importance af

c h e l a t i o n . Furs t 23 has suggested t h a t many anticancer drugs

may owe their activity to t h e i r c h e l a t i n g properties. A number of new amidoximcs and hydroxyamidines have been made from the app~opriate i n i d o y l chloride and a hydroxylarine. The s p e c t r a l and chelating properties of t h e s e cornpo-ads are discussed.

A l l the compounds have Seen submitted t o the antic=cer screening p r o g r m n e of t h e National Cancer Institute. The r e s u l t s available so f a r are presented and indicate that the compounds are t o x i c but inactive a g a i n s t experimental turnours.

Sodium s u l p h i d e reduces clrphenyl-:nitro-cinnamonitrile ( 1 06) to 2-amino-3-phenylquinolin~ -oxide (-1 07) in good yield.

Extension of the reduction to other

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o-nitrocinnamonitriles gives poor results. The spectral properties, configurations and conformations of the o-nitrocinnamonitriles are d i s c u s s e d . The

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2-aminoquinoline-~xide group is shown to form solid metal

complexes. That from 2-amino-3-phenylquinolinel -oxide ( I 07) with n i c k e l has been prepared. Antitwnour screening results are

presented for s e v e r a l 2-aminoquinoline derivatives. None of these compounds appears to be active.

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