pengaruh daun kemangi terhadap perbaikan gejala skizophrenia

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THE INFLUENCE OF OCIMUM SANCTUM AS AN ADJUVANT THERAPY IN

IMPROVEMENT CLINICAL FEATURES AND COGNITIF FUNCTION OF

SCHIZOPHRENIA PATIENT WHO GET RISPERIDON

Anisa*, Saidah Syamsuddin**

*Participant Of PPDS I Psychiatryc Department Of Medical Faculty UNHAS **Consultant of Psychiatryc Department Of Medical Faculty UNHAS

Abstract

Background : Ocimum sanctum has already known worl wide as traditional herbal medicine. Long time ago people have using Ocimum sanctum to cure diseases. Ocimum sanctum is one of Indonesian tradional medicine. Previous syudy in animal laboratory (rats) showed significant association between Ocimum sanctum (Basil Leaf) and stress. Ocimum sanctum known to have property as an antioxidant, anti inflammation, anti psychotic, neurprotector, etc. Few studies evaluated effect of Ocimum sanctum in Schizophrenia patients.

Methods : In this experimental study we analyzed 2 (two) groups of patients. Each group contains 10 (ten) Schizophrenia patients. One group take Risperidon only and the other group take Risperidon combine with Ocimum sanctum. Each group was given Risperidon 2 mg per day each 12 hour via oral. One group combine with Ocimum sanctum, every patients take 2 pils of Ocimum sanctum leaf per day each 8 hour via oral. All of the procedura was done after meal time. After 2 hours taking Risperidon, we give the patients Ocimum sanctum. Patients were evaluated using PANSS and MOCA-INA score admission and after 14 days of treatment.

Results : PANSS score significantly decreased after 14 days taking Ocimum sanctum compared to control group that take Risperidon only ( p ≥ 0,05 ). MOCA-INA score significantly increased after 14 days taking Ocimum sanctum compared to control group that take Risperidon only ( p ≥ 0,05 ).

Conclusion : By giving Ocimum sanctum as an adjuvant therapy in Schizophrenia patients can help in improvement of clinical features and cognitive function in Schizophrenia patients.

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Risperidon only.

pc sf oc su si hz mn mt jr tr

0 20 40 60 80 100 120 140 160 180 200

pans1 pans2

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Tests of Normality

Kolmogorov-Smirnova _Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

panss1 .208 10 .200* _.919 ₁₀ _.345

panss2 .161 10 .200* _.946 ₁₀ _.622

a. Lilliefors Significance Correction

*. This is a lower bound of the true significance.

Tabel 2. PANSS Score Pair T Test of Control Group.

Paired Samples Test

Paired Differences

t df Sig. (2-tailed)

Mean Std. Deviation

Std. Error Mean

95% Confidence Interval of the Difference

Lower Upper

Pair 1 panss1 - panss2 2.19000E

1 8.60814 2.72213 15.74211 28.05789 8.045 9 .000

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hd ys ly aj sm rn by ik aw am 0

50 100 150 200

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PANSS1 .176 10 .200* _.922 ₁₀ _.374

PANSS2 .254 10 .068 .849 10 .056

Tabel 4. PANSS Score Pair T Test of Eksperimental Group.

Paired Differences

Lower Upper

Pair 1 PANSS1 - PANSS2

6.2200

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Risperidon only.

pc sf oc su si hz mn mt jr tr

0 5 10 15 20 25

moca1 moca2

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moca1 .258 10 .058 .816 10 .022

moca2 .382 10 .000 .774 10 .007

Tabel 6. MOCA-INA Score Pair T Test of Control Group.

Paired Differences

t df Sig. (2-tailed) Mean Std. Deviation

Std. Error Mean

Lower Upper

Pair 1 moca1 - moca2 -3.60000 1.34990 .42687 -4.56566 -2.63434 -8.433 9 .000

Gr.4. MOCA-INA Score of Eksperimental Group, admission and 14 days after treatment with Risperidon and Ocimum Sanctum.

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MOCA1 .293 9 .025 .827 9 .042

MOCA2 .145 9 .200* _.928 ₉ _.464

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Paired Differences

t df

Sig. (2-tailed) Mean

Std. Deviation

Std. Error Mean

Lower Upper

Pair 1 MOCA1 - MOCA2

-7.0000 0