Hubungan Antara Usia Dan Jenis Kelamin Terhadap Angka Kejadian Berdasarkan Derajat Keganasan Meningioma Di Instalasi Patologi Anatomi, Rumah Sakit Umum Daerah Dokter Soetomo Periode Tahun 2018

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(1)IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA. DAFTAR ISI. LEMBAR PENGESAHAN ......................................................................................... iii LEMBAR KEPUTUSAN TIM PENGUJI.................. ................................................. iv SURAT PERNYATAAN ORISINILITAS ................. ..................................................v UCAPAN TERIMA KASIH......................................................................................... vi RINGKASAN .......................................................................................................... ...vii DAFTAR ISI ................................................................................................................. xi DAFTAR TABEL ...................................................................................................... xiii DAFTAR GAMBAR .................................................................................................. xiv DAFTAR LAMPIRAN ................................................................................................ xv DAFTAR SINGKATAN ............................................................................................. xv BAB 1 PENDAHULUAN ............................................................................................. 1 1.1. Latar Belakang ................................................................................................ 1. 1.2. Rumusan Masalah ........................................................................................... 3. 1.3. Tujuan Penelitian............................................................................................. 3. 1.3.1. Tujuan Umum .......................................................................................... 3. 1.3.2. Tujuan Khusus ......................................................................................... 3. 1.4. Manfaat Penelitian........................................................................................... 3. 1.4.1. Manfaat Teoritis ....................................................................................... 3. 1.4.2. Manfaat Praktis ........................................................................................ 4. BAB 2 TINJAUAN PUSTAKA .................................................................................... 5 2.1. Anatomi Selaput Meninges ............................................................................. 5. 2.2. Meningioma .................................................................................................... 6. 2.2.1. Pengertian dan Klasifikasi ....................................................................... 6. 2.2.2. Meningioma Jinak : WHO Derajat I ........................................................ 7. 2.2.3. Meningioma Derajat II........................................................................... 10. 2.2.4. Meningioma Derajat III ......................................................................... 11. 2.2.5. Patofisiologi Meningioma ...................................................................... 13. 2.2.6. Makroskopik .......................................................................................... 16. 2.2.7. Diagnosis Penunjang untuk Menentukan Tata Laksana ........................ 16. 2.2.8. Tata Laksana .......................................................................................... 18. 2.2.3. Faktor Risiko.......................................................................................... 19. 2.3. Pengelompokan Usia ..................................................................................... 22. BAB 3 KERANGKA KONSEP PENELITIAN .......................................................... 23 3.1. Kerangka Konsep .......................................................................................... 23. 3.2. Penjelasan Kerangka Konsep ........................................................................ 24 xi. SKRIPSI. HUBUNGAN ANTARA USIA ...... ARLIA AYU DAMAYANTI.

(2) IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA. 3.3. Hipotesis Penelitian ....................................................................................... 24. BAB 4 METODE PENELITIAN ................................................................................ 26 4.1. Jenis dan Rancangan Penelitian .................................................................... 26. 4.1.1. Jenis Penelitian....................................................................................... 26. 4.1.2. Rancangan Penelitian ............................................................................. 26. 4.2. Lokasi dan Waktu Penelitian......................................................................... 26. 4.2.1. Lokasi..................................................................................................... 26. 4.2.2. Waktu Penelitian .................................................................................... 26. 4.3. Populasi, Sampel, dan Teknik Pengambilan Sampel .................................... 26. 4.3.1. Populasi Penelitian ................................................................................. 26. 4.3.2. Sampel Penelitian................................................................................... 27. 4.3.3. Kriteria Penelitian .................................................................................. 27. 4.3.4. Besar Sampel ......................................................................................... 27. 4.3.5. Pengambilan Sampel Penelitian ............................................................. 27. 4.4. Variabel Penelitian dan Definisi Operasional Variabel ................................ 27. 4.4.1. Variabel Penelitian ................................................................................. 27. 4.4.2. Definisi Operasional Variabel................................................................ 28. 4.5. Instrumen Penelitian...................................................................................... 29. 4.6. Cara Kerja Penelitian .................................................................................... 29. 4.6.1. Pengumpulan Data ................................................................................. 29. 4.6.2. Pengolahan Data .................................................................................... 30. 4.6.3. Analisis Data .......................................................................................... 30. 4.7. Kerangka Alur Penelitian Penelitian ............................................................. 31. BAB 5 HASIL PENELITIAN ..................................................................................... 32 5.1. Angka Kejadian Meningioma berdasarkan Usia. .......................................... 34. 5.2. Angka Kejadian Meningioma berdasarkan Jenis Kelamin ........................... 35. 5.3. Angka Kejadian Meningioma berdasarkan Derajat Keganasan.................... 36. 5.4. Angka Kejadian Meningioma berdasarkan Tipe Keganasan Meningioma ... 37. 5.5. Hubungan Usia dan Angka Kejadian berdasarkan Derajat Keganasan Meningioma .................................................................................................. 39. 5.6. Hubungan Jenis Kelamin dan Angka Kejadian berdasarkan Derajat Keganasan Meningioma................................................................................ 41. BAB 6 PEMBAHASAN .............................................................................................. 43 BAB 7 KESIMPULAN DAN SARAN ....................................................................... 48 7.1. Kesimpulan.................................................................................................... 48. 7.2. Saran .............................................................................................................. 48. DAFTAR PUSTAKA .................................................................................................. 49 xii SKRIPSI. HUBUNGAN ANTARA USIA ...... ARLIA AYU DAMAYANTI.

(3) IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA. DAFTAR TABEL. Tabel 2.1 Tipe meningioma berdasarkan klasifikasi dari WHO.................................... 7 Tabel 2.2 Mutasi gen pada meningioma ...................................................................... 14 Tabel 4.1 Definisi Operasional dan Skala Pengukuran Variabel................................. 28 Tabel 5.1 Data pasien meningioma bulan Januari 2018 – Desember 2018 di Instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya ........................................ 32 Tabel 5.2 Data pasien menignioma pada bulan Januari 2018 – Desember 2018 di Instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya berdasarkan usia ..................................................................................................................... 34 Tabel 5.3 Data pasien menignioma pada bulan Januari 2018 – Desember 2018 di Instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya berdasarkan jenis kelamin ........................................................................................................ 36 Tabel 5.4 Data pasien menignioma pada bulan Januari 2018 – Desember 2018 di Instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya berdasarkan derajat keganasan ....................................................................................... 37 Tabel 5.5 Data pasien menignioma pada bulan Januari 2018 – Desember 2018 di Instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya berdasarkan tipe keganasan meningioma .............................................................................. 38 Tabel 5.6 Hubungan antara Usia dan Angka Kejadian berdasarkan Derajat Keganasan Meningioma Periode Tahun 2018 .............................................................. 40 Tabel 5.7 Hubungan antara Jenis Kelamin dan Angka Kejadian berdasarkan Derajat Keganasan Meningioma Periode Tahun 2018 ........................................... 41. xiii SKRIPSI. HUBUNGAN ANTARA USIA ...... ARLIA AYU DAMAYANTI.

(4) IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA. DAFTAR GAMBAR. Figur 2.1 Anatomi Selaput Meningens. ......................................................................... 6 Figur 2.2 Variasi histologi meningioma WHO derajat I.............................................. 10 Figur 2.3 Variasi histologi meningioma WHO derajat II ............................................ 11 Figur 2.4 Variasi histologi meningioma WHO derajat III ........................................... 13 Figur 2.5 Hasil imaging CT kasus meningioma. ......................................................... 17 Figur 3.1 Kerangka Konseptual Penelitian .................................................................. 23 Figur 5.1 Diagram Meningioma Berdasarkan Kelompok Usia ................................... 35 Figur 5.2 Diagram Meningioma Berdasarkan Jenis Kelamin...................................... 36 Figur 5.3 Diagram Meningioma Berdasarkan Derajat Keganasan .............................. 37 Figur 5.4 Diagram Meningioma Berdasarkan Tipe Keganasan Meningioma ............. 39. xiv SKRIPSI. HUBUNGAN ANTARA USIA ...... ARLIA AYU DAMAYANTI.

(5) IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA. DAFTAR LAMPIRAN. Lampiran 1 JADWAL PENELITIAN ......................................................................... 52 Lampiran 2 RINCIAN BIAYA PENELITIAN ........................................................... 53 Lampiran 3 PERMOHONAN IJIN PENELITIAN ..................................................... 54 Lampiran 4 SERTIFIKAT ETIK RSUD DR SOETOMO .......................................... 55 Lampiran 5 HASIL STATISTIK ................................................................................. 56. xv SKRIPSI. HUBUNGAN ANTARA USIA ...... ARLIA AYU DAMAYANTI.

(6) IR - PERPUSTAKAAN UNIVERSITAS AIRLANGGA. DAFTAR SINGKATAN AIDS. : Acquired Immune Deficiency Syndrome. CD4. : Cluster of Differentiation 4. CNS. : Central Nervous Systems. DNA. : Deoxyribonucleic Acid. ICP. : Intracranial Pressure. LPD. : Lembar Pengumpulan Data. MRA. : Magnetic Resonance Angiography. MRI. : Magnetic Resonance Imaging. NF 2. : Neurofibromin 2. hCG. : Human Chorionic Gonadotropin. PRL. : Prolactin. FSH. : Follicle Stimulating Hormone. LH. : Luteinizing Hormone. xvi SKRIPSI. HUBUNGAN ANTARA USIA ...... ARLIA AYU DAMAYANTI.

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