Supplementary Material
Supplementary Table S1. List of 370 proteins used for score function parametrization
PDB code
121p 131l 153l 193l 1aaj 1aak 1abrB 1add 1adeA 1aep 1aliA 1amg 1amp 1aorA 1aozA 1arb
1ars 1ash 1asu 1atlA 1atpE 1ayaA 1bbpA 1bbt2 1bbt3 1bcfA 1bdmB 1bec 1bet 1bglA 1bip
1bnh 1bp2 1briC 1bucA 1bvp1 1bw4 1byb 1cauB 1cbg 1ccr 1celA 1cfb 1chd 1chmA 1cid
1clc 1cmbA 1cnsA 1cpcA 1cpcB 1crl 1csh 1csn 1ctn 1ctt 1cus 1cyg 1daaA 1deaA 1dhr 1dih
1dlc 1dlhA 1dlhB 1dpb 1dppA 1dsbA 1dupA 1dynA 1dyr 1eca 1ede 1eft 1eriA 1esc 1etc
1exh 1fbaA 1fc2D 1fcdA 1fcdC 1fkj 1fnc 1fnf 1fps 1fruA 1gcb 1ghr 1gky 1gln 1gmfA 1gof
1gpb 1gpc 1gph1 1gpr 1gseA 1han 1hbq 1hcd 1hdcA 1hdgO 1hfh 1hgeA 1hjrA 1hlb 1hleA
1hmpA 1hmt 1hmy 1hngA 1hpm 1hslA 1htbA 1htmD 1htp 1hucB 1hvd 1hvm 1hxn 1i1b 1iae
1ikfL 1ilk 1irk 1irl 1iscA 1ivd 1knb 1kptA 1krt 1lba 1lcpA 1lct 1ldm 1lfaA 1lgaA 1lis 1lki
1lpbB 1lpe 1ltsA 1ltsD 1lxa 1mat 1mhcA 1mhlA 1mhlC 1minB 1mioA 1mldA 1mls 1mml
1mmoB 1mmoD 1mmoG 1mnc 1mpp 1mrj 1msaA 1msc 1msfC 1mup 1nal1 1nar 1nbaA
1ncfA 1ndh 1nfp 1nhkL 1nif 1nipA 1omp 1onc 1opr 1ora 1ordA 1osa 1oxa 1oyc 1pbe 1pbn
1pbp 1pbxA 1pdnC 1pfkA 1pgs 1phg 1phr 1pii 1pil 1pkm 1pkp 1plq 1pls 1pne 1pnrA 1poc
1poxA 1ppi 1ppn 1prcC 1prcL 1prcM 1prr 1prtB 1prtD 1psdA 1pspA 1put 1pvc2 1pyaB
1pyp 1qorA 1rcb 1rcf 1rci 1regX 1rfbA 1ribA 1rpa 1rsy 1rtm1 1rtp1 1rvaA 1sacA 1sat 1sbp
1scs 1scuA 1scuB 1sesA 1sltB 1smnA 1snc 1std 1sxcA 1tahA 1tca 1thv 1thx 1tlk 1tml 1tnrA
1tph1 1trb 1trkA 1trrA 1tssA 1ttbA 1tupB 1tys 1udg 1vcaA 1vhh 1vil 1vmoA 1vsgA 1was
1whtA 1whtB 1wsyB 1xnb 1xylA 1xyzA 1yptB 1ytbA 256bA 2abk 2acg 2acq 2ak3B 2alp
2ayh 2azaA 2bbkH 2bltA 2bpa1 2bpa2 2btfA 2cas 2cba 2ccyA 2cdv 2chr 2chsA 2cpl 2ctc
2cwgA 2cyp 2dkb 2dln 2dri 2ebn 2end 2er7E 2fal 2fd2 2gbp 2gdm 2gstA 2hbg 2hhmA 2hmx
2pgd 2phy 2pia 2pnb 2polA 2por 2prd 2rn2 2rslB 2sas 2scpA 2sil 2snv 2stv 2tgi 2tmdA
2tmvP 3aahA 3cd4 3chy 3cla 3est 3gapB 3gly 3grs 3pgk 3pgm 3pmgA 3pte 3rubS 3sdhA
3sicI 3tgl 4blmA 4enl 4fgf 4fxn 4gcr 4rhv1 4rhv3 4sbvA 6taa 7icd 7rsa 8abp 8acn 8atcA
Supplementary Material Table S2. Proteins constituting standard fold library
PDB code
135l 146l 153l 157l 169lA 174lA 176lA 189l 191l 192l 193l 1aab 1aaf 1aak 1aapA 1ab2 1aba
1abiL 1abmA 1aboA 1abrA 1abrB 1abtA 1acf 1acp 1acyH 1acyL 1adeA 1adn 1adr 1aec 1aep
1aerA 1afb1 1afp 1agi 1agt 1agx 1ahl 1ahsA 1ak2 1akeA 1akp 1aky 1ala 1alc 1ald 1allA
1allB 1alo 1amg 1aml 1amm 1amp 1amy 1ang 1ann 1antI 1anv 1aorA 1aozA 1apa 1apf 1aps
1apxA 1apyA 1apyB 1arb 1arn 1ars 1arv 1ash 1aszA 1ate 1atlA 1atnA 1atpE 1attA 1atx 1aty
1avdA 1axn 1ayaA 1ayl 1babA 1babB 1bafH 1bafL 1bal 1bam 1barA 1bba 1bbdH 1bbdL
1bbhA 1bbjH 1bbjL 1bbpA 1bbt1 1bbt2 1bbt3 1bbt4 1bcfA 1bco 1bdmB 1bdo 1bec 1berA
1bfmA 1bgc 1bgeA 1bgk 1bglA 1bgw 1bhp 1bia 1bip 1bit 1bjmA 1blu 1bmc 1bmfA 1bmfD
1bmfG 1bmg 1bmtA 1bnb 1bncB 1bndA 1bndB 1bnh 1bod 1bovA 1bp2 1bpb 1bplA 1bplB
1bqlH 1bqlL 1brbI 1breA 1briC 1broA 1brsD 1bsrA 1btgA 1btl 1btmA 1btn 1bucA 1bunA
1bunB 1burA 1burT 1bvp1 1bw4 1byb 1c2rA 1c5a 1caa 1cauA 1cauB 1cb1 1cb2A 1cbg
1cbiA 1cbn 1cbs 1cby 1cc5 1ccd 1ccf 1cch 1ccr 1cd8 1cdcA 1cdg 1cdmA 1cdoA 1cdp 1cdtA
1cdwA 1ceaA 1cec 1celA 1cem 1cerO 1cewI 1cfb 1cfh 1cfr 1cglA 1cgmE 1cgo 1cgt 1chc
1chd 1chkA 1chl 1chmA 1chpD 1cid 1cis 1ciu 1ciy 1cjn 1ckaA 1ckiA 1cksB 1clc 1cld 1cleA
1clf 1clh 1clpA 1clxA 1clyH 1clyL 1clzH 1clzL 1cmbA 1cmg 1cmr 1cn1A 1cnpA 1cnsA
1cnv 1coaI 1cod 1colA 1comB 1coo 1cor 1cot 1cov1 1cov2 1cov3 1cov4 1cpcA 1cpcB 1cpo
1cpq 1cpt 1cpy 1cqa 1cqgA 1crb 1cre 1crl 1cry 1csc 1cseE 1cseI 1csh 1cskA 1csmA 1csn
1csp 1csyA 1ctdA 1ctf 1cthA 1ctj 1ctl 1ctm 1ctn 1ctt 1cur 1cus 1cvo 1cxc 1cydA 1cyg 1cyj
1cynA 1cyu 1cyw 1czj 1d66A 1daaA 1dar 1dbbH 1dbbL 1dbqA 1dcoA 1dctA 1ddt 1deaA
1dec 1dehA 1dekA 1dem 1derA 1dfbH 1dfbL 1dfnA 1dhmA 1dhpA 1dhr 1dhx 1dhy 1dik
1din 1div 1dktA 1dkzA 1dlc 1dlhA 1dlhB 1dmc 1dmxA 1dnpA 1doi 1domA 1dot 1doy 1dpe
1dpgA 1drf 1dro 1drs 1drw 1dsbA 1dsn 1dsuA 1dtk 1dtr 1dts 1dtx 1dupA 1dutA 1dvfC
1dvfD 1dvh 1dxiA 1dynA 1dyr 1eaf 1eagA 1eal 1eapA 1eapB 1ebdA 1ebdC 1eca 1eceA
1ehs 1eit 1elpA 1elt 1ema 1emn 1emy 1enh 1enp 1eny 1epaB 1eptA 1eptB 1eptC 1erd 1erg
1eriA 1erp 1erw 1ery 1esc 1esfB 1esl 1etd 1ethA 1etpA 1eur 1exg 1exp 1extA 1ezm 1f3g
1faiH 1far 1fatA 1fbaA 1fbiH 1fbl 1fbr 1fc2C 1fc2D 1fca 1fccC 1fcdA 1fcdC 1fct 1fdn 1fds
1fdx 1fecA 1fgvH 1fgvL 1fha 1fieA 1figH 1figL 1fil 1fim 1finA 1fipA 1fivA 1fjlA 1fjmA
1fkj 1fkx 1fleI 1fliA 1flp 1flrH 1fmb 1fmcA 1fmd1 1fmd2 1fmd3 1fnc 1fnf 1forH 1forL
1fosE 1fosF 1fps 1fptH 1fptL 1frb 1frd 1fre 1frgH 1frgL 1frpA 1frrA 1frsA 1fruA 1fruB
1frvA 1frvB 1fsc 1fslA 1ftaA 1ftpA 1ftt 1ftz 1fua 1fujA 1fus 1fvcA 1fvcB 1fvl 1fvpA 1fwp
1fxaA 1fxd 1fxiA 1fxrA 1gadO 1gafH 1gafL 1gai 1gal 1garA 1gatA 1gbg 1gbrA 1gca 1gcb
1gclA 1gcmA 1gd1O 1gdhA 1gdoA 1gdy 1gecE 1gen 1gesA 1gfd 1gg2B 1gg2G 1ggaA
1gggA 1ggiH 1ggiL 1ghc 1ghfH 1ghfL 1ghk 1ghlA 1ghr 1ghsA 1ghu 1gia 1gigH 1gks 1gky
1glcG 1gln 1glqA 1gluA 1gnd 1gnhA 1gof 1gox 1gp1A 1gpb 1gpc 1gph1 1gpl 1gpmA 1gpr
1gps 1gpt 1grj 1grx 1gsa 1gseA 1gssA 1gta 1gtmA 1gtpA 1gtqA 1gtrA 1guaA 1guaB 1gur
1gym 1gypA 1hae 1han 1har 1havA 1hbq 1hc4 1hcb 1hce 1hcgA 1hcgB 1hcnA 1hcnB 1hcqA
1hcrA 1hdaA 1hdaB 1hdcA 1hdgO 1hdj 1hdp 1hdr 1hdsA 1hdsB 1hev 1hey 1hfh 1hgeA 1hgu
1hgxA 1hhl 1hic 1hilA 1hilB 1hip 1hitB 1hiwA 1hjrA 1hkt 1hlb 1hlcA 1hleA 1hleB 1hlm
1hlpA 1hlsB 1hma 1hml 1hmpA 1hmt 1hmy 1hna 1hnf 1hnr 1hocA 1hoe 1hom 1hpgA 1hph
1hpi 1hplA 1hpt 1hqaA 1hqi 1hra 1hrc 1hrhA 1hrm 1hrnA 1hroA 1hrzA 1hsaA 1hsbA 1hsbB
1hslA 1hsm 1hstA 1htiA 1htmD 1htp 1htrB 1htrP 1httA 1hucA 1hucB 1hueA 1hulA 1hunA
1hup 1huw 1hvd 1hxn 1hxpA 1hyhA 1hylA 1hyp 1i1b 1iae 1iag 1iaiH 1iaiI 1iaiL 1iaiM 1iba
1ibeA 1ibeB 1ibgH 1ibgL 1ica 1iceA 1iceB 1idm 1ido 1idsA 1ier 1ifc 1ife 1ifj 1igcH 1igcL
1igd 1igfH 1igfL 1igiH 1igl 1igmH 1igmL 1ignA 1igs 1ihfA 1ihfB 1ihvA 1ikfH 1ikfL 1ikm
1ilk 1ilr1 1iml 1indH 1indL 1ino 1inp 1inv 1ioaA 1iow 1irk 1irl 1iro 1iscA 1iso 1isuA 1itg
1ithA 1ivd 1ivlA 1izbB 1japA 1jcv 1jelH 1jelL 1jer 1jhlH 1jhlL 1jpc 1jud 1junA 1kapP 1kaz
1kbaA 1kcw 1kdu 1kelH 1kelL 1kifA 1klcA 1knb 1knt 1knyA 1kpbA 1kptA 1krn 1krt 1kst
1ldm 1ldnA 1ldr 1lea 1led 1lehA 1lenA 1lenB 1lesB 1lfaA 1lfb 1lgcB 1lgr 1lgyA 1lht 1lid
1lip 1lis 1lit 1lki 1lkkA 1lldA 1llp 1lmb3 1lmkA 1lmq 1lmwB 1lnh 1loeA 1loeD 1lopA
1lpbB 1lpe 1lpfA 1lphB 1lpt 1lsi 1lst 1ltdA 1lte 1ltsA 1ltsC 1ltsD 1lucA 1lucB 1lvl 1lwiA
1lxa 1lybA 1lybB 1lylA 1lyp 1lzr 1macA 1mahA 1mai 1mak 1mal 1mamH 1mamL 1masA
1mat 1mbb 1mbe 1mbs 1mcpH 1mcpL 1mcwW 1mdaA 1mdaH 1mdaL 1mdc 1mdyA 1meeA
1mfa 1mfbL 1mgsA 1mhcA 1mhcB 1mhiB 1mhlA 1mhlC 1mifA 1mil 1minA 1minB 1mioA
1mioB 1mirA 1mjc 1mkaA 1mla 1mlbB 1mldA 1mls 1mmc 1mml 1mmoB 1mmoD 1mmoG
1mmq 1mngA 1mnp 1mntA 1mof 1molA 1mpp 1mrb 1mreH 1mrg 1mrj 1msc 1msfC 1mspA
1mtrA 1mtx 1mucA 1mup 1mut 1mxa 1mygA 1mykA 1mylB 1myt 1mzm 1nal1 1nar 1nbaA
1nbvH 1ncbH 1ncbL 1nciA 1ncm 1ncs 1ncx 1ndaA 1ndh 1nea 1ner 1nfkA 1nfp 1ngqH
1nhkL 1nhp 1nif 1nin 1nipA 1nldH 1nldL 1nmbH 1nmbL 1nnc 1nnt 1noa 1nor 1noyA 1npc
1npk 1npoA 1nrb 1nscA 1nsnH 1nsnL 1nsqA 1ntn 1ntr 1ntx 1nueA 1oacA 1oaw 1obpA 1obr
1occA 1occB 1occC 1occD 1occE 1occF 1occG 1occH 1occI 1occJ 1occK 1occL 1occM
1ocp 1octC 1ofv 1olhA 1oma 1omp 1onc 1opbA 1opgH 1opgL 1orc 1ordA 1oroB 1ortA 1osa
1otfA 1otgA 1outA 1outB 1ovaA 1oxa 1oxy 1oyc 1paa 1pafA 1pamA 1paz 1pba 1pbe 1pbgA
1pbk 1pbn 1pbxA 1pbxB 1pca 1pce 1pch 1pco 1pcrH 1pcrL 1pcrM 1pczA 1pda 1pdc 1pdgA
1pdnC 1pdo 1pdz 1pea 1peh 1pex 1pfiA 1pfkA 1pfnA 1pfsA 1pft 1pfxC 1pgb 1pgs 1phg
1phk 1pho 1php 1phr 1pht 1pi2 1pig 1pii 1pkm 1pkn 1pkp 1pkyA 1pla 1plc 1plfB 1plgH
1plgL 1plj 1plk 1plq 1pls 1pma1 1pmaA 1pmc 1pmlA 1pmpA 1pmy 1pne 1pnh 1pnkA
1pnkB 1poa 1poc 1pod 1pog 1poh 1pot 1poxA 1pp2L 1ppa 1ppfE 1pplE 1ppo 1ppt 1prcC
1prcH 1prcL 1prcM 1preA 1prhA 1prn 1proA 1prr 1prtA 1prtB 1prtC 1prtD 1prtF 1prv
1psdA 1psf 1pshA 1psj 1psm 1psoE 1pta 1ptf 1ptq 1ptvA 1ptx 1puc 1pueE 1put 1pvaA 1pvc1
1pvc2 1pvc3 1pvc4 1pvdA 1pvuA 1pxtB 1pyaA 1pyaB 1pyc 1pyiA 1pytA 1pytC 1pytD
1qasA 1qba 1qorA 1qpaA 1qpg 1qrdA 1quk 1qwfA 1r1a1 1r1a2 1r1a3 1r69 1ra9 1rap 1rblA
1rgeA 1rgs 1rhgA 1rhpA 1ribA 1rie 1ril 1rinA 1rinB 1rip 1ris 1rlr 1rmfH 1rmfL 1rnl 1rodA
1ron 1roo 1rou 1rpa 1rpo 1rrgA 1rro 1rsy 1rtc 1rtfB 1rtnA 1rtp1 1rtu 1rvaA 1rvv1 1sacA 1sap
1sat 1sba 1sbp 1schA 1scmB 1sco 1scs 1sctA 1sctB 1scuA 1scuB 1scy 1sebD 1semA 1sesA
1sfe 1sftA 1sgpE 1sgpI 1sgt 1shaA 1shfA 1shp 1sis 1slfB 1slm 1sltB 1sluA 1sluB 1sly 1smd
1smeA 1smnA 1smpI 1smrA 1smvA 1snc 1sosA 1spbP 1spf 1sphA 1spiA 1sra 1srdA 1srsA
1sso 1std 1ste 1stfI 1stmA 1stu 1sup 1sva1 1svb 1svn 1svpA 1svr 1sxcA 1sxl 1sxm 1symA
1tabI 1tafA 1tafB 1tag 1tahA 1tam 1taq 1tbrJ 1tbrR 1tca 1tcoA 1tcoB 1tcp 1tcwA 1tcxA
1tehA 1ten 1tetH 1tetL 1tfd 1tfe 1tfi 1tfpA 1tfr 1tfs 1tgj 1tgsI 1tgxA 1thg 1thjA 1thm 1thtA
1thv 1thx 1tib 1tie 1tif 1tig 1tih 1tiiA 1tiiC 1tiiD 1tin 1tis 1tiu 1tiv 1tle 1tlk 1tme1 1tme2
1tme3 1tmf1 1tmf2 1tmf3 1tmf4 1tmhA 1tml 1tnfA 1tnm 1tnrA 1tnt 1tof 1ton 1tpg 1tph1
1tplA 1trb 1treA 1trkA 1trnA 1trrA 1try 1tsp 1tssA 1tsy 1ttbA 1tud 1tupB 1tvt 1tvxA 1tys
1ubdC 1ubi 1ubsA 1ubsB 1ucyE 1ucyH 1udiI 1ukd 1ukz 1ula 1umuA 1unaA 1utg 1vcaA
1vcc 1vcpA 1vfaA 1vfaB 1vgeH 1vgeL 1vhh 1vhiA 1vhp 1vhrA 1vid 1vih 1vil 1vin 1vjw
1vmoA 1vnb 1vnc 1vnd 1vokA 1volA 1vom 1vpt 1vrtA 1vsd 1vsgA 1vtmP 1wad 1wapA
1was 1wba 1wbc 1wdcA 1wdcC 1wfbA 1wgtA 1whi 1whtA 1whtB 1wiu 1wkt 1wtlA 1wtuA
1xad 1xbl 1xel 1ximA 1xnb 1xnd 1xsm 1xsoA 1xtcA 1xtcC 1xtcD 1xvaA 1xxaA 1xyaA 1xyn
1xypA 1xyzA 1yal 1yat 1ycc 1yeb 1ygpA 1yhaA 1yna 1ypcI 1yppA 1yrnA 1yrnB 1ytbA 1ytc
1ytfB 1ytfC 1ytfD 1ytw 1yua 1yuhA 1yuhB 1zaaC 1zaq 1zer 1zfd 1zfo 1znbA 1zqaA 1zymA
205l 256bA 2aaa 2aaiB 2abd 2abk 2abxA 2ace 2acg 2achA 2achB 2acq 2act 2admA 2afgA
2afnA 2ak3A 2alp 2alr 2apr 2asi 2asr 2atcB 2ayh 2azaA 2azuA 2bb2 2bbi 2bbkH 2bbvC 2bds
2bgu 2bi6H 2bltA 2bopA 2bpa1 2bpa2 2bpa3 2btfA 2bus 2cae 2cas 2cba 2cbh 2ccyA 2cdv
2cdx 2cgrH 2cgrL 2chr 2clrA 2cmd 2cnd 2cpl 2crd 2cro 2crt 2cstA 2ctc 2cts 2ctx 2cwgA
2cy3 2cyp 2cyr 2dkb 2dldA 2dnjA 2dri 2drpA 2ebn 2ech 2end 2eng 2eql 2er7E 2erl 2fal
2fb4H 2fb4L 2fbjH 2fbjL 2fcr 2fd2 2fgwH 2fx2 2fxb 2gbp 2gcr 2gdm 2gfbA 2gfbB 2gmfA
2hpqP 2hsp 2hts 2hvm 2ifo 2ihl 2imn 2kaiA 2kaiB 2kauA 2kauB 2kauC 2kmb1 2lbp 2ldx
2lhb 2liv 2madL 2mcg1 2mcm 2mev1 2mev2 2mev3 2mev4 2mhr 2mhu 2mm1 2mnr 2mrb
2mtaC 2nacA 2ohxA 2olbA 2omf 2ora 2pal 2pcdA 2pcdM 2pec 2pelA 2pf1 2pgd 2pghA
2pghB 2phiA 2phlA 2phy 2pia 2pii 2pldA 2plh 2plt 2plv1 2plv2 2plv3 2plv4 2pnb 2polA
2por 2prd 2prf 2prk 2pspA 2ptl 2ran 2reb 2rhe 2rhn1 2rhn2 2rhn3 2rmcA 2rmu1 2rslB 2rspA
2sam 2sas 2sblB 2scpA 2sfa 2sga 2sh1 2sil 2sn3 2spcA 2stv 2tbvA 2tct 2tgi 2tmdA 2tmvP
2trxA 2uce 2vaaA 2ztaA 3adk 3b5c 3bcl 3blm 3c2c 3cd4 3chy 3ci2 3cla 3cms 3cox 3dfr 3ebx
3ecaA 3egf 3est 3gctA 3gf1 3grs 3hfmH 3hhrA 3hhrC 3ladA 3mddA 3ovo 3pga1 3pgm
3pmgA 3psg 3pte 3rp2A 3rubL 3rubS 3sdhA 3sdpA 3sicI 3tgl 451c 4aahA 4aahB 4blmA
4cpaI 4enl 4fgf 4fxc 4fxn 4gpd1 4htcI 4icb 4kbpA 4mdhA 4mt2 4pfk 4ptp 4rhv2 4rhv3 4rhv4
4sbvA 4sgbI 4tgf 4ts1A 4xiaA 4xis 4znf 5cytR 5hir 5ldh 5p21 5p2pA 5pal 5rubA 5rxn 5timA
5znf 6fabH 6fabL 6insE 6rxn 6taa 7aatA 7apiA 7apiB 7fabH 7fabL 7pcy 7pti 7rsa 7timA 7znf
8abp 8acn 8atcA 8atcB 8catA 8dfr 8fabA 8fabB 8i1b 8pti 8rucI 8rxnA 8tlnE 9ldtA 9pap 9pcy
Supplementary Table S3. Fold library taken from Rost et al27
PDB code
153l 180lA 1aab 1aac 1aaf 1aak 1aapA 1aba 1aboA 1abrB 1aca 1acf 1ack 1acp 1add 1adeA
1adn 1aep 1afp 1agg 1agt 1alkA 1amg 1amj 1aml 1amp 1aorA 1aozA 1apnA 1aps 1arb 1arv
1ash 1aszB 1atb 1atlA 1aty 1axn 1azcA 1babA 1bam 1bba 1bbhA 1bbl 1bbo 1bbpA 1bbt1
1bbt2 1bbt3 1bbt4 1bcfA 1bco 1bcsA 1bct 1bec 1bfg 1bfmA 1bgc 1bglA 1bi6H 1bia 1bip
1blsA 1bmdA 1bmtA 1bmv1 1bmv2 1bnb 1bncA 1bndA 1bnh 1bovA 1bpb 1brd 1brhA 1brlA
1brsD 1btl 1btmA 1btn 1bunA 1bunB 1bvp1 1bw4 1byb 1bzm 1c5a 1cbg 1cbn 1cc5 1ccf
1cd8 1cdcA 1cdg 1cdkA 1cds 1cdtA 1ceaA 1celA 1ceo 1cewI 1cfb 1cfh 1cgmE 1chc 1chd
1chmA 1cid 1ciqA 1clb 1clc 1cld 1cmbA 1cnsA 1cnv 1colA 1coo 1cov4 1cpcA 1cpcB 1cpt
1csbA 1csbB 1cseI 1csh 1csmA 1csn 1ctdA 1ctf 1ctm 1ctn 1ctt 1cus 1cwpA 1cyj 1cyx 1d66A
1daaA 1dbs 1dchA 1dctA 1ddt 1deaA 1dec 1dhr 1dhx 1dih 1dik 1dlc 1dmaA 1dmc 1dpgA
1dppA 1dsbA 1dtr 1dupA 1dvh 1dynA 1dyr 1eaf 1eciA 1ecl 1ecmA 1ede 1eft 1egpA 1ehs
1eit 1enh 1eny 1epaA 1erd 1eriA 1esc 1esl 1etb1 1etd 1exg 1fbaA 1fbl 1fbr 1fc1A 1fc2C 1fca
1fcdA 1fcdC 1fct 1fipA 1fkj 1flp 1fnf 1fosE 1fosF 1fps 1frn 1frpA 1frrA 1frsA 1ftt 1fvl 1fxd
1gal 1garA 1gatA 1gca 1gcb 1gcmA 1gdhA 1gdtA 1gfc 1ggtA 1ghr 1gky 1glcG 1gln 1gmpA
1gne 1gof 1gp1A 1gpb 1gpc 1gph4 1gpmA 1gpr 1gpt 1griA 1grj 1grx 1gtqA 1gtrA 1gypA
1han 1haoH 1hbq 1hce 1hcgB 1hcnA 1hcnB 1hcrA 1hdcA 1hfh 1hgeA 1hgeB 1hjrA 1hlb
1hleB 1hma 1hmpB 1hnf 1hnr 1hny 1hoe 1hph 1hpi 1hplA 1hpm 1hpt 1hrf 1hrv4 1hryA
1hsbA 1hsbB 1hstA 1htmB 1htp 1htrP 1hueA 1hulA 1humA 1hurA 1huw 1hviA 1hxn 1hyhA
1hyp 1iae 1ica 1iceA 1iceB 1ifc 1ifi 1ifm 1igd 1ilk 1imbA 1ino 1inp 1irk 1iro 1irp 1isuA 1itg
1ithB 1klnA 1knb 1kptA 1krs 1kst 1ktx 1lab 1latA 1lba 1lccA 1lcf 1lcpA 1ldl 1ldm 1ldr 1lea
1lesA 1lfaA 1lfb 1lgr 1lin 1lip 1lis 1lki 1lkkA 1lla 1lmb3 1lpbA 1lpe 1lpt 1lst 1ltdA 1ltsA
1ltsC 1ltsD 1lvl 1lxa 1lylA 1lyp 1lzr 1mal 1mat 1mbc 1mdc 1mdyA 1mfa 1mhlA 1mhlC
1mhtA 1minA 1minB 1mjc 1mla 1mlbA 1mml 1mmoC 1mmoD 1mmoG 1mntB 1molA 1mrj
1mrt 1msaA 1mseC 1mup 1mut 1mylA 1mypA 1nal1 1nar 1nbaA 1ncfA 1nciA 1ndh 1neq
1orb 1ordA 1otfA 1otgA 1ovaD 1oxa 1oyc 1pba 1pbe 1pbn 1pbp 1pda 1pdc 1pdgA 1pdnC
1pea 1pfiA 1pgs 1php 1phr 1pht 1pii 1pil 1pkp 1pkyA 1plc 1plq 1pls 1pmc 1pne 1pnh 1pnkA
1pnkB 1pnrA 1poc 1pov1 1poxA 1ppbL 1ppt 1prcC 1prcH 1prcM 1prs 1prtA 1prtC 1prtD
1prtF 1pru 1psdB 1pse 1psm 1pspA 1pta 1ptf 1pth 1ptq 1ptx 1puc 1put 1pvc2 1pvc3 1pvdA
1pvuA 1pxtA 1pyaA 1pyaB 1pyiA 1pyp 1qorA 1r1a1 1r69 1rblM 1rcb 1rcf 1rci 1rec 1regX
1ret 1rfbA 1ribA 1rip 1ris 1rpa 1rpo 1rro 1rsy 1rthA 1rtm1 1rvaA 1sacA 1sat 1sbp 1scmA
1scmB 1scuA 1scuB 1se2 1sesA 1sh1 1shg 1sis 1sltA 1smnA 1smpI 1snc 1spbP 1spf 1sra
1sriA 1sso 1std 1stfI 1stu 1stwA 1svr 1tabI 1tag 1tahA 1tca 1tcp 1ten 1tfi 1thg 1thl 1thm
1thtA 1thv 1thx 1tie 1tif 1tig 1tiv 1tlfA 1tlk 1tmf4 1tml 1tnrA 1tnt 1top 1tplA 1tpm 1trb
1trkA 1trw 1tsp 1tssA 1tupA 1tvs 1tvt 1tys 1ubi 1ubsA 1ubsB 1udh 1udiI 1urnA 1utg 1vcaA
1vcc 1vhh 1vih 1vil 1vmoA 1vqb 1vsd 1vsgA 1wapA 1wfbA 1whtB 1xaa 1xis 1xnb 1xra
1xsoA 1xxaA 1xyzA 1ycc 1yrnA 1yrnB 1ysc 1ytbA 1yts 1yua 1zaaC 1zaq 256bA 2aaa 2abk
2achB 2acq 2admA 2ak3A 2ayh 2bbkH 2bbkL 2bbvA 2bds 2bgu 2bopA 2bpa1 2bpa2 2bpa3
2btfA 2cae 2cas 2cbh 2ccyA 2chr 2chsA 2cmd 2cpl 2cro 2ctc 2cyp 2cyr 2dgcA 2dkb 2dldA
2dln 2dri 2drpA 2ebn 2ech 2end 2erl 2fal 2fxb 2gdm 2glt 2gmfA 2gsq 2hbg 2hft 2hmx 2hnq
2hntE 2hpdA 2hts 2i1b 2ifo 2kauA 2kauB 2kauC 2ligA 2liv 2ltnB 2mcm 2mev1 2mev4 2mhr
2mnr 2mrb 2mtaC 2nadA 2ohxA 2olbA 2omf 2pcdA 2pdd 2pde 2pec 2pgd 2phlA 2phy 2pia
2pna 2polA 2por 2psg 2ptl 2reb 2rn2 2rspA 2sas 2sblB 2scpB 2sga 2sil 2snv 2spcA 2stv
2tbvA 2tct 2tgi 2tmdA 2ts1 2yhx 3bcl 3cd4 3chy 3cla 3cox 3cpp 3dfr 3dni 3ebx 3ecaA 3egf
3gapB 3gly 3grs 3hhrB 3icd 3ifm 3il8 3inkC 3mdeA 3mdsA 3ovo 3pfk 3pgm 3pmgA 3pte
3sdhA 3sicI 3tgf 3tgl 3wrp 451c 4aahA 4aahB 4at1A 4cpaI 4enl 4fxn 4gcr 4htcI 4mt2 4sbvB
Supplementary Table S4. Probes sequences used with Rost et al27test set
protein chain
153l 1alkA 1amj 1bct 1bip 1bpb 1c5a 1cdcA 1cgmE 1chmA 1cmbA 1cpcA 1cpt 1csmA 1ctt
1dlc 1dvh 1eaf 1eriA 1fkj 1frpA 1frsA 1fxd 1gcb 1gfc 1gpr 1gtqA 1hfh 1hgeA 1hryA 1iceA
1irk 1knb 1lccA 1lea 1lis 1ltdA 1ltsA 1lxa 1mdyA 1mjc 1mla 1msaA 1orb 1otgA 1pba 1pbn
1plq 1pls 1pnkB 1prs 1pvuA 1pyp 1rblM 1rfbA 1snc 1sra 1sso 1svr 1thv 1tie 1ubi 1ubsB
1udh 1vsgA 1wapA 1whtB 1xnb 1xxaA 2cyp 2end 2gsq 2phy 2pna 2psg 2rn2 2snv 2ts1 3bcl
Supplementary Table S6. Library of 320 protein folds used with Fischer et al27Error: Reference source
not found test set
Protein chain
1aak 1abtA 1acp 1acx 1add 1ads 1ald 1alkA 1aozA 1apa 1aps 1atnA 1atr 1avhA 1bbrE 1bet
1bgeB 1bgsE 1bib 1bmv1 1bmv2 1bnh 1bovA 1brd 1bst 1btc 1c5a 1cauA 1cde 1chmA 1cid
1cmbA 1cobA 1colA 1cpcA 1csc 1cseE 1cseI 1ctf 1ctm 1dhr 1dsbA 1ede 1ego 1f3g 1fbpA
1fc1A 1fha 1fiaA 1fkf 1fnb 1fxd 1gal 1gatA 1gd1O 1gdhA 1gf1 1gky 1glaG 1gmpA 1gof
1gox 1gp1A 1gpb 1hbg 1hc6 1hdp 1hfh 1hgeA 1hgeB 1hmy 1hoe 1hplA 1hslA 1hstA 1hucB
1huw 1hyp 1i1b 1ifc 1imbA 1ipd 1irk 1lap 1lba 1le2 1lfb 1lfi 1lis 1lmb3 1ltsA 1lz1 1mat
1mba 1mbc 1mcoH 1mec4 1minB 1mioC 1molA 1msbA 1mypA 1mypC 1nar 1ndk 1nipB
1nsbA 1omp 1osa 1ovaA 1paz 1pda 1pdgB 1pgx 1phh 1pi2 1pii 1pkp 1poc 1poh 1poxA
1prcC 1prcH 1prcL 1pspA 1ptsA 1pyaA 1pyaB 1pyp 1r69 1rbp 1rcb 1rec 1rfbA 1rhd 1ribA
1rnh 1rpa 1rprA 1rveA 1sacA 1sbp 1scmA 1scmB 1scmC 1shaA 1sltA 1snc 1sryA 1sto 1tahA
1tap 1tbpA 1tca 1ten 1tfd 1tie 1tml 1tnfA 1top 1tpkA 1tplA 1trb 1trkA 1ubq 1ula 1utg 1vmoA
1vqb 1vsgA 1wsyA 1wsyB 1ycc 1zaaC 256bA 2aaiB 2abk 2abxA 2ace 2afnA 2apr 2ayh
2azaA 2baa 2bb2 2bbkH 2bbmA 2bopA 2bpa1 2bpa2 2btfP 2ca2 2cas 2ccyA 2cna 2cpkE 2cpl
2cpp 2cy3 2cyp 2dnjA 2end 2er7E 2fb4H 2fb4L 2fxb 2gbp 2gcr 2glsA 2glt 2gmfA 2gstA
2hhmA 2hipA 2hpdA 2il8B 2lbp 2liv 2madL 2mev3 2mhr 2mnr 2ms2A 2msbB 2mtaC 2omf
2pabA 2pcy 2pgd 2pia 2pkaA 2plv1 2plv2 2plv4 2polA 2por 2ptl 2reb 2rhe 2rslA 2sarA
2scpA 2sicI 2sim 2sn3 2spcA 2stv 2taa 2tbvA 2tgi 2tmdA 2tmvP 2trxA 2ts1 2tscA 2wrpR
2yhx 3adk 3b5c 3bcl 3blm 3cd4 3chy 3cox 3ebx 3ecaA 3gapA 3gly 3grs 3hhrB 3hlaA 3hlaB
3icd 3lzm 3pgk 3pgm 3pmgA 3rubS 3sc2A 3sc2B 3sdpA 3sgbE 3tgl 451c 4aahA 4bp2 4cla
4cpv 4dfrA 4enl 4fgf 4fxn 4htcI 4mdhA 4mt2 4pfk 4ptp 4xiaA 5cpa 5hvpA 5p21 5rubA 6ldh
6tmnE 6xia 7aatA 7apiA 7rsa 7timA 8acn 8adh 8atcA 8atcB 8catA 8fabA 8fabB 9abp 9pap
