v
Abstrak
Pendahuluan : Karsinoma sel skuamosa sinonasal merupakan tumor ganas yang terdapat pada kavum nasi dan sinus paranasal yang ditegakkan berdasarkan hasil pemeriksaan histopatologi. Salah satu gen penekan tumor (tumor suppressor genes) yaitu protein p53 yang berfungsi untuk menghambat siklus sel, apoptosis, diferensiasi, penuaan sel dan menghambat angiogenesis. Tujuan : Untuk mengetahui ekspresi p53 mutanpada karsinoma sel skuamosa sinonasal.
Metode : Penelitian observasional yang dilakukan di RSUP. H. Adam
Malik Medan pada laboratorium Patologi Anatomi dengan pemeriksaan
immunohistokimia pada blok parafin dan data sampel penelitian
sebanyak 30 sampel.
Hasil Penelitian : Penderita karsinoma sel skuamosa sinonasal (SCC) paling banyak ditemukan pada kelompok umur 41-60 tahun (63,3%), laki-laki (63,3%), dan tipe non keratinizing squamous cell carcinoma 21 jaringan (70%), stadium klinis yang terbanyak dijumpai pada stadium IV dengan 11 jaringan (36,7%).
Kesimpulan:
Ekspresi protein p53 mutan yang terbanyak ditemukan
pada tipe
non keratinizaing squamous cell carcinoma.
Tidak terdapat
hubungan yang bermakna antara jenis histopatologi, stadium tumor
terhadap ekspresi protein
p53 mutan
dengan nilai p=0,440
(p>0,05)
.
Kata kunci : karsinoma sel skuamosa sinonasal, protein p53 mutan
Abstract
Introduction :
Squamous cell carcinoma of sinonasal (SCC) is a
malignant tumor in the nasal cavity and paranasal sinuses
that was
established based on the results of histopathologic examination. p53
protein is one of the tumor suppressor genes that plays role in apoptosis,
differentiation, cellular aging, inhibiting the cell cycle and angiogenesis.
Aim:
To determine the expression of p53 mutant in squamous cell
carcinoma of sinonasal
Method : The observational study was done in Anatomic Pathology Laboratory
of H. Adam Malik Medan General Hospital, by examining 30 paraffin blocks with immunohistochemical stainning.
Result : Patients with SCC of the sinonasal was found higher in age of 41-60(63,3%), male (63,3%). Non keratinizing squamous cell carcinoma type was found in 21 samples (70%) and stage IV tumor in 11 sample (36,7%).
Conclusion : The expression of p53 protein mutant were observed mostly in non keratinizing type SCC of the sinonasal. No significant correlation between histopathologic type, tumor stadium and the expression of p53 protein mutant. p value=0,440 (p>0,05).
Keyword : Squamous cell carcinoma of sinonasal, protein p53 mutant
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