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DEGENERASI
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Sifat degenerasi :
• Ringan (reversibel)
• Berat (irreversibel) Nekrosis
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Degenerasi Infiltrasi
Adanya jejas pada sel Perubahan metabolisme
Adanya perubahan metabolisme Jejas pada sel
Degenerasi & infiltrasi
Dapat terjadi gangguan yang bersifat biokimia/ biomolekuler
DEGENERASI
Sering disertai
pengendapan zat-zat : Lemak Amiloid
Lipoid (zat yang menyerupai lemak)
Degenerasi : D. Albumin D. Hidropik (D.vakuoler)
D. Hyalin
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DEGENERASI HIDROPIK
(Degenerasi vakuoler)Edema intraseluler menonjol (> deg. bengkak keruh)
Kerusakan tampak lebih berat
Sediaan :
Kuretage cavum uteri ( abortus imminens) perdarahan hebat
Hasil Kuretage (makroskopis):
Gelembung jernih Ø bervariasi
Diagnosa : Mola hidatidosa
Macroscopis (Hydatidiform Mole)
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5 Complete mole. All villi are markedly swollen.
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Normal Villi
The 1sttrimester (7-8 weeks)(20X)
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7 Complete mole showing large villi with stromal edema & marked
8 ! " # $ %
& '
! " # % $ " "
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9 )
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ACUTE INFLAMATION
GROSS :
REDNESS (RUBOR)
HEAT (CALOR)
SWELLING (TUMOR)
PAIN (DOLOR)
LOSS OF FUNCTION (FUNCTIO LAESA)
ACUTE INFLAMATION
MICROSCOPIC :
Hyperaemia
Exudation
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Hyperaemia
Micro-vascular changes
(Lewis’s Triple Response) :
• Flush
Dull red line (capilar dilatation)
• Flare
Bright red (artery dilatation)
• Wheal
Protein fluid interstitial (wheal) Fluid dilution of toxin
Protein :
- Globulin antibodies
- Fibrin to limit spread bacterial Wound healing
12 -Chemical Mediator
Endothelial Damage
Permeabilitas
Exudation (Mechanism)
Protein Passage :
PMN & MN
Pass (amoeboid)
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Fig. 11.127.Outer aspect of appendix involved by acute inflammation. A thick purulent coating is seen together with marked hyperemia of the serosa.
Hyperemia
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Acute appendicitis with massive inflammatory infiltrate, extensive ulceration,
and hemorrhage. An island of heavily inflamed residual mucosa is seen in the center.
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15 WOUND HEALING
COMPLICATIONS : - CONTRACTURE - GRANULATION - KELOID
- FIBROSIS REGENERATION
SPECIAL SITUATION.
HEALING
PRIMARY HEALING : - CLEAN EXISED WOUND
- GOOD POSITION (PALNED SURG.INCIS) IMMEDIATELY: - BLOOD CLOT
2-3 HOURS : - INFLAMATION (+) - MILD HYPERAEMIA - FEW POLYMORPHS
16 2-3 DAYS : - MACROPHAGE
REMO-VING CLOT - FIBROBLASTIC 10-14 DAYS : - SCAB LOOSE
- EPITHELIAL COVERING. - FIROUS UNION
WOUND HEALING
WEEKS : - SCAR TISSUE SLIGHLY HYPERAEMIA
- GOOD FIBROUS UNION MONTHS – YEAR:
- DEVASCULARISATION - COLLAGEN(-) ENZYME - SCAR MINIMAL.
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17 LOSS OF TISSUE >>
NECROSIS (+) INFECTION (+)
EARLY : BLOOD & FIBRIN CLOT (+) ACUTE INFL. CELLS (+)
FEW DAYS : - EPITH.PROLIFERATION - NEW CAPILARY
- MACROPHAGE - PMN, FIBROBLAST
SECONDARY HEALING
1 WEEK : - SURFACE DEBRIS (-) - FIBROBLASTS >> - EPITH.PROLIF’TION - CAPILARY >>
- GRANULATION
18 2 WEEKS : - EPITH.COVERING COMPL
- TRANSVERS COLLAGEN - DECREASED CAPILARY - FEW CELLS
MONTH : - FULL EPITH.COVERING - SURFACE DEPRETION (< ) - THICK COLLAGEN SCAR - VASCULAR ( < )
