High Level of Aldose Reductase as the Risk Factor for Diabetic Retinopathy in Type-2 Diabetes Mellitus Patients in Bali.

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High

Level of Aldose Reductase

_as

the Risk

Factor

for

Diabetic

Retinopathy

in

Type-2 Diabetes

Mellitus

patients

in

Bali

D. M. _{Wihandanir; I}

K.

_{Suastika2, N. A. Bagiadar,}

S G.

MatF

,io,__*.'^TgT:of Biochemisty, Faculty of Medicine, Udayana University Bali, -L)rv$lon

o f _{Endocrinolo gy and Metabo lism, Deparmenf}

o f Internal n

r"ai"#,

Faculty of Medicine, Udayana _{University Bali,}

tEiilanan

Institute

foi

_{Molecular Biology, Jl. Diponegoro 69, Jakarta 10430,}

Indonesia.

E-mail : dmwihandini@yahoo.co.id

Abstract

!{etic

Retinopathy

(DR) is

_{the most common complication}

in

_{Diabetes Mellitus}

(ptvt)

9n0 the major cause

of

blindness

in

productiv"-ut"

-"o--.rnity.

Evidences show that

the

occurrence

of

DR is

_affected

by

_genetic "and _environment

factors.

Aldose reductase

(ALR2)

is

a

rate-rimiting

enzfi"

in

the polyol

_{pathway. The} activity

ALR2 is

_{significantly higher}

withii

_diabetic

pu,i*,

with

RD

than those

without RD' The risk to have _{microvasculair complications witnin}

tlpe-l

_{DM patients}

with high activity of

1t^V

ilJ

times higher than tlrose whohave normal activity

of

ALR2

(Reddy et al., _{2008). The increasing prevalence}

of RD

_{is correlated}

with the

increased level of

ALf2-,

m{nlv

among type-2

DM

patients with duration of disease

l."tt

JIT

l0

years

(oishi

et al., io02). r-troaims of this rtoJy

*ur

to elucidate whether the high level

of

_{aldose reductase was}

risk

_factor

for

_{dia'betic retinopathy}

@Rtl"

Wpe-2 diabetes mellitus

(T2DM)

patients

in

Bali.

case-control

design.,,,ur'ffi.6

employing

35

_cases

of

_{diabetiC retinopathy}

and

35

_controls

without

diabetic retinopathy' ELISA method was used to measure aldose reductase _{level. The level}

of

aldose reductase were

_analysed using

x2

and

otrr", aut"

*ere

analysed using t_

independent and

Mann-whitney. ThJresult

of

_{the study showed that}

high level

of

ALR2 was found more in _{RD patients than non_RD patients (p=0,002), an}

indication frat high level of ALR2 is a risk factor for RD (OR:3,S4; _p=OlOOZl.

It

_{was concluded} trat _{high level of ALR2 was the risk factor}

forlio

"-;"g'de;'-zotutpatients

in Bali.

Ke5'wo rds : Aldo se reductase, _{diabetic retinopathy, tryp e-2 diab}

etes mellitus

Book ofAbstract

Gtn ICBB, 18

-

19 _{September 2015}

Bali - INDONESIA

:'- E

r-L;T