HIF CONCENTRATION AND HEART MUSCLE HISTOPATHOLOGY

(1)

(2)

Ba c k ground

P

Physic a l exe rc ise is :



re gula r physic a l a c t ivit y pe rfor m e d in

c e r t a in pe riod of t im e a nd int e nsit y



a im s t o m a int a in t he body a lw a ys in good

c ondit ion of he a lt h a nd fit ne ss



re c om m e nde d for preve nt ive , c urat ive ,

(3)

(4)

•2 5 -3 0 % Ae robic physic a l a c t ivit ie s

•7 0 -7 5 % Ana e robic physic a l a c t ivit ie s

Sprint run c ha sing a ba ll a nd hit t ing ba ll

w it h full pow e r a re a na e robic physic a l

(5)

I f t he re is im pa ire d

he a r t func t ion a nd t he

(6)

Sudde n de a t h in a t hle t e s

fre que nt ly oc c urs during t he

c om pe t it ion

I t is a ssum e d t ha t pe rfor m ing high

int e nsit y ex e rc ise w it hout t a k ing re st

da ys for t he upc om ing c om pe t it ion ha s

gre a t im pa c t in c a rdia c m uscle da m a ge

a nd sudde n de a t h during t he

(7)

Sudde n de a t h

if t he he a r t suc c e ssfully a da pt s

_{w it h suc h c ondit ion so t ha t it m a y}

c om pe nsa t e t he loa d t a ke n during

physic a l ex e rc ise .

T he re fore , t he c a rdio-prot e c t ive

e ffe c t ex e r t e d by t he physic a l

ex e rc ise c a n be a c hieve d

N e e d t o unde rst a nd t he

m e c ha nism of c a rdia c

a da pt a t ion w he n w e

pe rfor m physic a l

(8)

(9)

Ba se d on t he a bove m e nt ione d ex pla na t ion, a

st udy should be pe rfor m e d, in orde r t o

re c ognize t he m e c ha nism of m ole c ula r

a da pt a t ion in c a rdia c m uscle during physic a l

ex e rc ise w it h a loa ding of a e robic a nd

a na e robic physic a l a c t ivit ie s.

(10)

M at e ria l a nd M e t hods

Anim a l m ode l a nd inst rum e nt

Anim a l T re a dm ill _{for ra t}

• m a le Wist a r ra t s

(11)

(12)

(13)

(14)

(15)

(16)

Pa ra m e t e r on hypox ia

Kontrol 1 Hari 3 Hari 7 Hari 10 Hari

(17)

Gambar 4.3. Gambaran Hist opat ologi Ot ot Jant ung Kelompok Aerobik

Ket : A : Kont rol (Normal), B : 1 Hari (Normal) C : 3Hari (Hipert rofi + iskemik)

D : 7 Hari (Iskemik) E : 10 Hari (Infark):H ipe r t ropi :I ske m ik :I nfa rk

Gambar 4.4. Gambaran Hist opat ologi Ot ot Jant ung Kelompok Anaerobik

A

B

C

D

E

A

B

C

D

E

(18)

Groups Wit hout Tre a t m e nt

1 da y 3 da ys 7 da ys 1 0 da ys

Sc ore Sc ore Sc ore Sc ore Sc ore

H I S I N H I S I N H I S I N H I S I N H I S I N

% % % % % % % % % %

Cont rol - -

-ΔAerobik - - - + 1 0 - + 1 0 - - 1 0 1 0

Ana e robik - - - + 2 0 - + 2 0 - - 4 0 1 0

(19)

(20)