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T e I a h d i l a k u k a n p e n e l i t i a n p e m a n t a u a n k a d a r f e n o -b a r -b i t a l s e r u m p a d a 9 p e n d e r i t a e p i l e p s i t i p e g r a n d m a l y a n g telah b e r o b a t r a w a t j a l a n s e l a m a t 2 t a h u n d e n g a n t e r a p i t u n g g a l f e n o b a r b i t a l . T u j u a n d a r i p e n e l i t i a n i n i u n t u k m e n g u k u r k a d a r t u n a k f e n o b a r b i t a l d o s i s e m p i r i k . P e n g a m b i l a n s a m p e l d a r a h d i l a k u k a n p a d a h a r i k e - 7 d a n h a r i k e - 1 0 . C u p l i k a n d a r a h d i a m b i l ! 5 m l d a r i v e n a c u b i t i y a i t u s e s a a t s e b e l u n o b a t d i m i n u m d a n 2 j a m s e s u -d a h o b a t -d i m i n u m . P e n e t a p a n k a -d a r -d i l a k u k a n d e n g a n p r i n -s i p F P I A ( F l u o r e s c e n c e P o l a r i z a t i o n I m m u n o a s s a y ) . D a r i p e n e l i t i a n i n i d i p e r o l e h r e n t a n g d o s i s f e n o b a r b i t a l 0 , 3 -2 , 8 3 n g / k g b b / h a r i d a n r e n t a n g k a d a r t e r a p e t i k f e n o b a r b i -t a l s e r u m 5 , 2 8 - 3 0 , 8 5 U g l m l . T i d a k d i t e m u k a n k a s u s s u b t e r a p e t i k a t a u p u n k a s u s t o k s i s i t a s , d a n t i d a k a d a f l u k t u a s i k a d a r p a d a s e s a a t s e b e l u m o b a t d i m i n u m ( C 2 ) d e n g a n k a d a r 2 j a m s e s u d a h o b a t d i m i n u m ( C 3 ) , t e t a p i d i t e m u k a n I k a s u s f l u k t u a s i k a d a r a n t a r a 2 j a m s e s u d a h o b a t d i m i n u m ( C 1 ) dengan kadar 2 jarn sesudah obat dirninum
( C 3 ) , s e r t a t e r l i h a t h u b u n g a n a n t a r a d o s i s f e n o b a r b i t a l ( m S l k g b b , z h a r i ) d e n g a n k a d a r f e n o b a r b i t a l s e r u m ( p g l n l ) y a n g p e n i n g k a t a n n y a p r o p o r s i o n a l . A d a n y a v a r i a b i f i t a s i n d i v i d u d i t u n j u k k a n d a r i p e r b e d a a n k e p e r l u a n d o s i s d a n h a r g a k l i r e n s .
