LAP+OC.2- vs LAP+OC.2+
HIBADH 3-hydroxyisobutyrate HIBADH 3-hydroxyisobutyrate dehydrogenase Hist1h1a histone cluster 1, H1a
1.33 CLDN2,CYP3A4,HP,ORM1
SP1 transcriptio
n regulator
Activated 1.33 ABHD2,ACSL1,ALDH3A2,ANKH,ASS1,CBS/CBSL,CEACAM1,CTH,Cyp2d1/Cyp 2d5,EGFR,ESR1,F7,GDF15,GHR,IGF1,IGFBP4,LCAT,PCK1,SGK1
SLC9A3R1 other 1.33 EGFR,SLC34A2
LRPAP1 other 1.33 LRP1,SERPINA3
SAT1 enzyme 1.33 AMY2A,PRKAA2
SPINT1 other 1.33 CLDN2,IGFBP4
ENPP2 3.36 enzyme 1.33 CIDEA,ENPP2
SPARC -5.651 other 1.31 CIDEC,CYP8B1,GPD1,P2RY2,SLC34A2,TSKU
Creb group Activated 1.31 ARG1,CD14,CIDEC,CPT1A,G6PC,GDA,IGF1,ORM1,PCK1,PRKAA2
BRCA1 transcriptio
n regulator
1.31 CYP3A4,EGFR,ENPP2,ESR1,GDF15,MX1,NFE2L2,PERP
LIF cytokine 1.31 CRP,DCAF11,FBP1,IGF1,LBP,SERPINA3,SOCS2,TMEM176A,TMEM176B
Sphk group 1.30 IL33
PLEKHM1 other 1.30 SQSTM1
SMPD3 enzyme 1.30 IGF1
IGF2BP2 -3.166 translation regulator
1.30 LIMS2
APBB2 other 1.30 LRP1
EIF2A translation regulator
1.30 ATF5
TTC7A other 1.30 EGFR
CYP26B1 enzyme 1.30 ATF5
MEX3C other 1.30 IGF1
ADGRG1 g-protein
coupled receptor
1.30 IGF1
MDC1 other 1.30 CLU
SAMHD1 enzyme 1.30 MX1
ZNF385B other 1.30 PERP
ECI1 enzyme 1.30 CYP4A11
MTSS1 other 1.30 EGFR
FBLIM1 other 1.30 EGFR
GFRA1 transmemb
rane receptor
1.30 ACPP
KLHL40 other 1.30 TP53INP1
CD93 other 1.30 CYP27A1
CASP7 peptidase 1.30 CASP4
DAB2IP other 1.30 CLU
EDF1 transcriptio
n regulator
1.30 NR0B2
ABHD5 enzyme 1.30 PDK4
PCBD1 transcriptio
n regulator
1.30 PAH
PTGIS enzyme 1.30 CYP2E1
ASH2L transcriptio
n regulator
1.30 ESR1
TRPC6 ion
channel
1.30 MX1
HNRNPL other 1.30 CEACAM1
MED24 transcriptio
n regulator
1.30 HTRA1
WASHC1 other 1.30 EGFR
DMPK kinase 1.30 FXYD1
GCKR other 1.30 GCK
GCDH enzyme 1.30 ANG
EPHA4 kinase 1.30 IGF1
CIDEA 5.466 other 1.30 XDH
CDO1 20.552 enzyme 1.30 IGF1
CTTN other 1.30 EGFR
PLCD4 enzyme 1.30 EGFR
NDUFS1 enzyme 1.30 GPX1
NOLC1 transcriptio
n regulator
1.30 ORM1
NBN other 1.30 CLU
MAP3K8 kinase 1.27 ACPP,ARG1,ARRDC3,HP,INHBA,SDR42E1,Urah
ADCYAP1 other 1.20 AMACR,ATRN,ENPP2,GCLM,MREG,ORM1,P2RY2,SERPINA3,SERPINF1,UGT2
B28
CDKN2A transcriptio
n regulator
Activated 0.00 Ccl9,CRP,PSMB9,TOB1,TP53INP1
AdH vs LAP+/-, Upstream Regulators, Downregulated in LAP+/-
Upstream Regulator
Expr Fold Change
Molecule Type
Predicted Activation
State
-log(p value)
Target molecules in dataset
TGFB1 growth
factor
Inhibited 21.18 AFP,ANXA2,BGN,BMP2,C1QB,CAV1,Ccl2,CCNA2,CCND2,CCNE1,CD55,CDH5,CX CL10,CXCL2,CXCL3,DAB2,DCN,EDNRB,F2R,FABP5,FCER1G,FLNA,FOS,FXYD6, GSN,GSTA5,GUCY2C,HMOX1,IGF2,IGFBP2,IGFBP7,IL18,IL1A,LGALS3,LIFR,LPL, LYVE1,MCM2,Mcpt1,MFAP4,MKI67,PCNA,PHGDH,PLAGL1,PLEK2,RAMP2,RASG RP3,RBM3,S100A10,S100A11,SERPINH1,SLC25A4,SLC2A1,SLC4A1,SLC7A5,SOCS 3,SPARC,TGFBR3,TIMP1,TIMP3,Tpm4,TSPAN7,TUBA1A,VCAM1,VIM
SP1 transcriptio
n regulator
Inhibited 17.60 ADAMTS1,ADD3,ALAS2,ANK1,CAV1,Ccl2,CCNA2,CCND2,CD55,CDC25B,CXCL1 0,CXCL3,F2R,FLNA,FOS,HBB,HBG2,HDC,HMOX1,IGF2,IL1A,KLF1,LPL,Mt1,NDR G1,PTN,PTTG1,SLC25A4,SLC2A1,SPARC,SPTB,TGFBR3,TIMP1,UGCG,VIM Vegf group Inhibited 15.32 A2M,ADAMTS1,BMP2,CA2,CALCRL,Ccl2,CDC25B,CDH5,CPA3,CXCL10,EMCN,E
MP1,FLNA,GRB10,HDC,HMOX1,IL18,IL1A,KLF1,LYVE1,MCM2,MKI67,PLK1,PMP 22,SKP2,SOCS3,TIMP1,TPX2,UGCG,VCAM1,VIM
MYC transcriptio n regulator
Inhibited 14.75 ADAMTS1,AFP,ALDOA,Bex3,CAV1,CCNA2,CCND2,CCNE1,CD48,CDC25B,CXCL1 0,EMP1,F2R,FABP5,FLNA,FOS,GPC3,H19,HMOX1,IGF2BP1,LDHB,LUM,MCM6,M KI67,Mt1,NDRG1,PCNA,PLK1,PMP22,PSAT1,PTN,RBBP7,S100A10,SERPINH1,SKP 2,SLC2A1,SLC7A5,SPARC,TAGLN2,TIMP1,TSPAN7,VCAM1,VIM
E2F3 transcriptio
n regulator
Inhibited 14.20 CA12,CCNA2,CCNE1,HIST1H2BG,HIST1H4B,IGF2,KIAA0101,LPL,MCM2,MCM4,M CM6,PCNA,PLK1,PTN,PTTG1,SERPINH1,TIMP3,TPX2
HGF growth
factor
Inhibited 13.54 A2M,ADAMTS1,AFP,BMP2,CALCRL,CAV1,Ccl2,CDC25B,CXCL2,EMP1,FLNA,FOS ,GRB10,HMOX1,LYVE1,MCM2,MKI67,PCNA,PLK1,PMP22,PTTG1,SKP2,SOCS3,TA GLN2,TIMP1,TIMP3,TPX2,VCAM1,VIM
TSC2 other Activated 12.78 A2M,ANXA2,Ccl2,CCND2,CXCL10,FOS,GPNMB,GSN,HMOX1,LGALS3,LOC10036 2769,PLP2,S100A11,SLC2A1,UCP2
IKBKB kinase Inhibited 12.56 AFP,BMP2,Ccl2,CCNA2,CDC25B,CXCL10,CXCL2,CXCL3,DCN,FOS,HMOX1,IGFBP 2,IL1A,LIFR,Mt1,OGN,PLK1,SKP2,SOCS3,TIMP3,VCAM1
FGF2 growth
factor
12.41 AFP,BGN,CAV1,CCND2,DCN,EDNRB,FLNA,FOS,GPNMB,IGF2,IGFBP2,LYVE1,M KI67,PCNA,PTTG1,S100A10,SLC2A1,SOCS3,SPARC,TGFBR3,TIMP1,TIMP3,VCAM 1,VIM
TNF cytokine 11.91 A2M,AQP7,ARHGDIB,BGN,BMP2,CA2,CAV1,Ccl2,CCND2,CD55,CDH5,CPA3,CXC L10,CXCL2,CXCL3,DCN,EDNRB,EGLN3,EMCN,EMP1,FABP5,FCER1G,FOS,GSTP1 ,H19,HDC,HMOX1,HPGDS,IGF2,IGFBP2,IL18,IL1A,LGALS3,LIFR,LPL,LYVE1,Mt1, OGN,PDK3,PHGDH,RNASE1,SLC2A1,SOCS3,SPARC,TIMP1,TIMP3,UCP2,UGCG,V CAM1,VIM
EPO cytokine 11.74 ALAS2,ANK1,CA1,CA2,CCND2,FABP5,FOS,HBB,HBG2,IGF2,IL18,KLF1,LCP1,PCN A,Podxl,RHAG,SKP2,SLC4A1,SOCS3,UCP2,UGCG
IL1B cytokine Inhibited 11.58 A2M,ADAMTS1,BGN,BMP2,Ccl2,CD55,CXCL10,CXCL2,CXCL3,DAB2,DCN,EGLN3 ,FABP5,FOS,H19,HMOX1,HPGDS,IL18,IL1A,LCP1,LIFR,Mcpt1,Mt1,RNASE1,S100A 10,SERPINH1,SLC25A4,SLC2A1,SOCS3,SPARC,TIMP1,TIMP3,UGCG,VCAM1,VIM
JUN transcriptio
n regulator
Inhibited 10.93 A2M,AFP,ANXA2,CAV1,Ccl2,CCNA2,CCND2,CXCL10,CXCL3,FOS,GSTA5,GSTP1, HMOX1,IGFBP2,IGFBP7,IL1A,LGALS3,PLAGL1,S100A10,SOCS3,SPARC,TIMP1,V CAM1,VIM
CCL2 cytokine Inhibited 10.77 Ccl2,CXCL10,CXCL3,EGLN3,FOS,HDC,IL18,IL1A,MKI67,PCNA,TIMP1,VCAM1
KITLG growth
factor
Inhibited 10.48 CA2,Ccl2,CCNA2,CCNE1,EDNRB,FABP5,FOS,HMOX1,IL18,IL1A,KLF1,Podxl,RBBP 7,RHAG,SLC4A1,Tpm4,UCP2,UGCG
TP53 transcriptio
n regulator
10.45 A2M,ADD3,AFP,ANXA2,CAV1,Ccl2,CCNA2,CCND2,CCNE1,CDC25B,F2R,FOS,GS N,GSTP1,H19,HDC,Hist1h1b,HMOX1,IGF2,IGFBP2,IGFBP7,IL1A,KIAA0101,LGALS 3,MCM2,MCM4,MCM6,MKI67,NDRG1,PCNA,PHGDH,PLK1,PPIC,PTTG1,RBBP7,R BM3,SERPINH1,SLC2A1,TAGLN2,TIMP3,Tpm4,TPX2,TUBB,VIM
Alpha catenin group Activated 10.43 ADAMTS1,BGN,CXCL10,CXCL2,IGF2,IGFBP2,IGFBP7,LUM,RHOJ,SOCS3,STEAP2, TIMP1,VCAM1,VIM
HIF1A transcriptio Inhibited 10.26 ADAMTS1,AFP,ALDOA,BGN,BMP2,CAV1,Ccl2,CXCL2,CXCL3,EGLN3,FOS,HIF3A,
n regulator HMOX1,IGF2,IGFBP2,IL1A,LIFR,NDRG1,SLC25A37,SLC2A1,SOCS3,VIM
APP other Inhibited 10.03 ALDOA,CA12,Ccl2,CCND2,CCNE1,CDH5,CXCL10,CXCL2,CXCL3,DCN,DPYSL2,F LNA,FOS,GSTP1,H19,HBG2,HMOX1,IGF2,IGF2BP2,IGFBP2,IL18,IL1A,LDB2,LDHB ,LGALS3,Mt1,OGN,PLK1,RELN,SOCS3,TUBA1A,TUBB,VCAM1
IL6 cytokine Inhibited 10.00 A2M,ADAMTS1,AFP,BGN,BMP2,Ccl2,CCNA2,CCNE1,CD48,CXCL10,CXCL2,CXCL 3,DCN,FOS,HMOX1,IGF2,KIAA0101,LIFR,LPL,MKI67,Mt1,Mt1m/Mt2A,PCNA,PTTG 1,SOCS3,STOM,TIMP1,VCAM1,VIM
ADCYAP1 other 9.99 ADD3,Ccl2,CCNA2,CXCL10,CXCL2,CXCL3,EMB,FOS,GPC3,Hmgb2 (includes others),LUM,MCM2,PLAGL1,S100A10,SLC2A1,SOCS3,SPARC,UCP2
P38 MAPK group Inhibited 9.97 ANK1,BGN,BMP2,CAV1,Ccl2,CCND2,CCNE1,CD55,CXCL10,CXCL3,EDNRB,FLNA ,FOS,HMOX1,IL1A,PCNA,SOCS3,TIMP1,TIMP3,TNNI1,VCAM1
Histone h3 group 9.95 ADD3,AFP,ANK1,CAV1,Ccl2,CCNA2,CCND2,CCNE1,CXCL10,ERMAP,FOS,HOXA5 ,IL1A,MCM2,MCM4,Mt1,PCNA,RELN,SOCS3,SPTA1,STOM,Tpm4
NFKBIA transcriptio
n regulator
Inhibited 9.69 A2M,BMP2,Ccl2,CCNA2,CCND2,CDC25B,CXCL10,CXCL2,CXCL3,DCN,FOS,HMO X1,IGF2,IL1A,LIFR,Mt1,OGN,PCNA,SOCS3,TCEAL9,TIMP1,TIMP3,VCAM1
AGT 4.19 growth
factor
Inhibited 9.52 ADD3,BGN,CAV1,Ccl2,CCND2,CCNE1,CXCL10,CXCL2,CXCL3,DAB2,EDNRB,FOS ,GSTA5,GSTP1,HMOX1,IL18,NDRG1,SLC2A1,SOCS3,TIMP1,UCP2,UGCG,VCAM1 INSR kinase Inhibited 9.40 Ccl2,CCND2,DLK1,FOS,GRB10,H19,IFITM2,IGF2,LCP1,LDB2,MCM2,MCM4,NDN,
NDRG1,OGN,PLAGL1,SLC2A1,SOCS3,TNNI1,UCP2,VCAM1
PPARG ligand-
dependent nuclear receptor
9.38 AQP7,CA2,CAV1,Ccl2,CXCL2,CXCL3,DLK1,EGLN3,ELOVL6,FABP5,HMOX1,IGFB P7,LPL,MKI67,NDRG1,PCNA,PPIC,SLC2A1,SOCS3,TUBB,UCP2,VCAM1,VIM
HRAS enzyme 9.34 A2M,AFP,ANXA2,CAV1,Ccl2,CCNA2,CCND2,CCNE1,CXCL10,CXCL2,F2R,FLNA,F OS,GSN,HDC,HMOX1,IFITM2,IGF2,PCNA,PLK1,PPIC,RBBP7,SPARC,TIMP3,Tpm4, VIM
FOS -5.28 transcriptio
n regulator
Inhibited 9.29 A2M,CA2,CCNA2,CCNE1,ELOVL6,EMB,FOS,GSTA5,GSTP1,HMOX1,HPGDS,IL1A, LGALS3,LPL,PLAGL1,PTTG1,RBBP7,S100A10,SOCS3,TIMP1,Tpm4,TUBB,UGCG,V CAM1,VIM
Akt group 9.26 A2M,BMP2,Ccl2,CCND2,CXCL10,FOS,HIF3A,HMOX1,IGF2,IGFBP2,LPL,NDRG1,P CNA,PTN,SKP2,SOCS3,VCAM1
Pdgf (complex) complex 9.22 CAV1,Ccl2,CCND2,CXCL3,FOS,HMOX1,MCM6,PCNA,SPARC,TIMP1,TIMP3,VCA M1
CHUK kinase Inhibited 9.18 BMP2,Ccl2,CXCL10,CXCL2,CXCL3,DCN,FOS,HMOX1,IL1A,LIFR,Mt1,OGN,PCNA, PLK1,SOCS3,VCAM1
OSM cytokine 9.16 A2M,ADAMTS1,AFP,ANXA2,AQP7,ATP2B4,CBX3,Ccl2,CCND2,CXCL10,CXCL2,C XCL3,FOS,GPNMB,HMOX1,IL18,LIFR,PCNA,SOCS3,TIMP1,TIMP3,TPX2,TUBA1A, VCAM1
IL4 cytokine Inhibited 8.97 ANXA2,APOLD1,CA2,CBX3,Ccl2,CCND2,CCNE1,CD55,CXCL10,CXCL2,CXCL3,F2
R,FCER1G,FOS,IL18,IL1A,LGALS2,LGALS3,LIFR,NDRG1,PMP22,S100A10,SLC2A1 ,SOCS3,TFEC,TIMP1,TIMP3,VCAM1,VIM
Ins1 other Inhibited 8.94 AQP7,CCNE1,DLK1,ELOVL6,FOS,GSTP1,IGF2,IGFBP2,LDHB,LIFR,LPL,Mt1,PCNA, SLC2A1,SOCS3,SPARC,TIMP1,TIMP3,VIM
NFkB (complex) complex Inhibited 8.86 A2M,ALDH1B1,BMP2,Ccl2,CCND2,CDC25B,CXCL10,CXCL2,CXCL3,EDNRB,FABP 5,FOS,HIF3A,HMOX1,IGFBP2,IL18,IL1A,PLK1,SLC2A1,SLC7A5,SOCS3,TFEC,TIM P1,VCAM1,VIM
CDKN1A kinase Activated 8.77 CCNA2,CCNE1,CDC25B,CPA3,DTL,KIAA0101,LGALS3,MCM2,MCM4,MCM6,MKI 67,PCNA,PHGDH,PLK1,SKP2,TPX2
SMAD3 transcriptio
n regulator
Inhibited 8.77 BGN,BMP2,Ccl2,CCND2,CCNE1,CDH5,CXCL10,CXCL3,FOS,HMOX1,LUM,PCNA,S LC25A4,TIMP1,TIMP3,VIM
Tgf beta group 8.71 BGN,CCND2,CCNE1,CXCL10,CXCL2,DAB2,DCN,FOS,HMOX1,IL1A,SOCS3,SPAR C,TIMP1,TIMP3,VCAM1,VIM
CTNNB1 transcriptio
n regulator
Inhibited 8.69 AFP,BGN,BMP2,CCNA2,CCND2,CCNE1,Cd52,F2R,FCER1G,FOS,HOXA5,IGF2,IGF2 BP1,IGFBP2,LGALS3,LPL,OGN,PCNA,PLK1,PMP22,Podxl,RCN1,TIMP1,TIMP3,UG CG,VCAM1,VIM
IGF1 21.76 growth
factor
Inhibited 8.69 A2M,BGN,BMP2,Ccl2,CCNA2,CCND2,CCNE1,FOS,HBB,HDC,HMOX1,IGF2,IGFBP2 ,IL18,LPL,MKI67,PCNA,SLC2A1,SOCS3,VCAM1,VIM
MYD88 other Inhibited 8.65 Ccl2,CXCL10,CXCL2,CXCL3,EDNRB,FOS,HDC,HMOX1,IL18,IL1A,MCM2,MKI67,S OCS3,TFEC,TIMP1,VCAM1
ESR2 ligand-
dependent nuclear receptor
8.61 ADAMTS1,ANK1,BMP2,CA12,CA2,CAV1,CCNA2,CLEC1B,EMB,FOS,GSTA5,GSTP 1,LPL,MKI67,NDRG1,PSAT1,RELN,SKP2,SLC25A4,SOCS3,TIMP1
MGEA5 enzyme 8.60 C1QB,CALCRL,CAV1,Ccl2,CD48,CD55,DAB2,FLNA,GSN,HPGDS,IGF2,IGFBP7,IL1 8,PRKAR1B,SOCS3,TGFBR3,TIMP1,TIMP3,TUBA1A,VIM
LIF cytokine 8.44 A2M,AFP,BMP2,Ccl2,CCNA2,CCNE1,CDH5,CXCL10,CXCL2,FOS,LIFR,LPL,SOCS3, TIMP1,TSPAN7
PPARA ligand-
dependent nuclear receptor
8.41 ANXA2,AQP7,C1QB,Ccl2,CCNA2,CCNE1,ELOVL6,FABP5,FOS,GSTP1,HMOX1,IGF BP2,LIFR,LPL,Mcpt1,MKI67,PCNA,PLK1,RBP2,UCP2,VCAM1
TRPV4 ion
channel
Inhibited Ccl2,CXCL10,CXCL2,FOS,SOCS3,TIMP1,VCAM1
CEBPB transcriptio
n regulator
Inhibited Ccl2,CCNA2,CCND2,CCNE1,CDC25B,CXCL2,CXCL3,DAB2,DCN,EMCN,FOS,HBB, HDC,HIST1H4B,HIST1H4J,PCNA,PLXND1,RBBP7,SOCS3,VIM
CA4 enzyme Activated ANK1,CA1,HEMGN,KEL,RHCE/RHD,SLC4A1,SPTB
SP3 transcriptio
n regulator
ADD3,Ccl2,CDC25B,F2R,FOS,IGF2,IL1A,KLF1,LPL,PTTG1,SERPINH1,SPARC,TGF BR3,TIMP1,VIM
IL1R1 transmemb rane receptor
Ccl2,CXCL10,CXCL2,CXCL3,FOS,IL18,IL1A,LIFR,TIMP1
CDKN2A transcriptio
n regulator
A2M,Ccl2,CCNA2,CCNE1,CDC25B,CXCL10,EHD3,FOS,IL1A,MCM4,MKI67,PCNA, PLAGL1,PLK1,RBBP7,SKP2,VIM
NFE2L2 3.61 transcriptio n regulator
ALAS2,ALDOA,Ccl2,CXCL10,CXCL2,CXCL3,EMCN,GSTA5,GSTP1,HMOX1,IL1A, LPL,Mt1,PSAT1,RAMP2,RBBP7,RELN,SLC2A1,SOCS3,VCAM1
EGF growth
factor
AFP,CAV1,Ccl2,CCND2,CCNE1,DCN,FOS,GSTP1,HMOX1,IGF2,IGFBP2,PCNA,PLA GL1,PTTG1,S100A10,S100A11,SOCS3,SPARC,TIMP1,TIMP3,VCAM1,VIM
DYSF other ANXA2,C1QB,CD48,Cd52,CD55,CXCL10,LCP1,LGALS3,TCEAL9,TIMP1
PI3K (complex) complex Inhibited AQP7,Ccl2,CCND2,CCNE1,CD55,CXCL10,FABP5,FOS,GSTA5,GSTP1,H19,HMOX1,I GF2,IGFBP2,SOCS3,UGCG,VCAM1
IFNG cytokine Inhibited A2M,C1QB,CAV1,Ccl2,CCNA2,CCND2,CD55,CXCL10,CXCL2,CXCL3,EDNRB,EGL N3,F2R,FABP5,FCER1G,FOS,HMOX1,IFITM2,IL18,IL1A,LGALS3,LIFR,LPL,Mt1,PH GDH,PTN,RBBP7,S100A10,SERPINH1,SLC2A1,SLC7A5,SOCS3,TGFBR3,TIMP1,TI MP3,VCAM1
Immunoglobulin complex ALAS2,Ccl2,CCND2,CCNE1,CXCL10,CXCL2,CXCL3,DPYSL2,FCER1G,FOS,HMOX 1,IL1A,SLC25A37,TIMP1,VCAM1
PDGF BB complex Inhibited ADD3,Ccl2,CCNE1,CXCL2,DAB2,DCN,EDNRB,FLNA,FOS,H19,HMOX1,IGF2,LGA LS3,Mt1,PCNA,SOCS3,TIMP1,VCAM1
CD38 enzyme Inhibited ALDOA,ANXA2,CCND2,CCNE1,EGLN3,LGALS3,NDRG1,PSAT1,SLC2A1,SLC7A5, SOCS3,VCAM1,VIM
TICAM1 other Inhibited Ccl2,CXCL10,CXCL2,CXCL3,EDNRB,IL18,IL1A,MCM2,MKI67,SOCS3,TFEC,VCAM 1
LCN2 transporter Inhibited BMP2,Ccl2,CXCL10,CXCL2,CXCL3,HMOX1,IL1A,TAGLN2,VIM
HIPK2 kinase ALAS2,ANK1,CCND2,KLF1,LGALS3,SLC25A37,SLC4A1,SPTB,VIM
Ap1 complex CCNA2,FOS,GSTA5,GSTP1,HBB,HMOX1,IL1A,LPL,NDRG1,SPARC,TIMP1,VCAM1
LDL complex Inhibited BMP2,Ccl2,CDH5,CXCL10,CXCL2,EDNRB,EMB,FOS,HMOX1,IGFBP2,IL1A,MKI67, SOCS3,TGFBR3,VCAM1
IL5 cytokine Inhibited A2M,ALDOA,ANXA2,CCND2,CCNE1,CD55,EGLN3,LUM,NDRG1,PMP22,PSAT1,R BM3,SLC2A1,SLC7A5,SNTB1,VIM
CSF2 cytokine Inhibited Ccl2,CCNA2,CXCL10,CXCL2,F2R,FOS,HDC,IL1A,KLF1,LCP1,MCM6,MKI67,PHGD H,PLK1,PMP22,RBM3,SKA3,SNTB1,SOCS3,TPX2
PTPRJ 3.13 phosphatas
e
Inhibited CCNA2,CXCL2,CXCL3,FOS,HDC,IL18,IL1A,PLAGL1
IKBKG kinase Inhibited BMP2,Ccl2,CXCL2,CXCL3,DCN,FOS,IL1A,LIFR,Mt1,OGN,SOCS3
ERBB2 kinase Inhibited ANXA2,CCNA2,CCND2,CCNE1,CXCL10,CXCL3,EMP1,F2R,FOS,H19,IGF2,IL1A,LG ALS3,LUM,MKI67,NDRG1,PCNA,SKP2,SLC2A1,SPARC,TCEAL9,TIMP3,TUBA1A, VIM
SMAD7 transcriptio n regulator
BGN,BMP2,Ccl2,CCNA2,CCNE1,CXCL10,DCN,HMOX1,PCNA,TIMP1,TIMP3
SRC kinase CA2,CAV1,CCND2,CCNE1,CXCL10,F2R,FOS,HMOX1,PLK1,VCAM1,VIM
DICER1 enzyme AFP,CCND2,FOS,H19,IGF2,IGF2BP1,IGF2BP2,KLF1,LCP1,PMP22,SOCS3,SPARC,VI M
TNFSF11 cytokine Inhibited CA2,CAV1,Ccl2,CCNE1,CXCL3,DAB2,FOS,GRB10,HMOX1,IL1A,LDB2,PLK1,SLC2 A1,SOCS3,VCAM1
IL10 cytokine BMP2,Ccl2,CCND2,CD55,CXCL10,CXCL2,CXCL3,DCN,FCER1G,FOS,HMOX1,IL18,
IL1A,PHGDH,SOCS3,TIMP1,VCAM1
PTGER2 g-protein
coupled receptor
CCNA2,CFP,HDC,HIST1H2AB,IL1A,MKI67,PLK1,TIMP1,TIMP3,TPX2
KCNK9 ion
channel
A2M,CA1,HEMGN,KEL,RHAG,RHCE/RHD,SPTA1
AR ligand-
dependent nuclear receptor
CAV1,CCNA2,CDC25B,EDNRB,EHD3,EMB,FABP5,GPR182,GSN,GSTP1,IGF2,MCM 2,MCM4,NDRG1,PLK1,SKP2,STEAP2,TPX2,VIM
IL1 group Inhibited ADAMTS1,BMP2,Ccl2,CD55,CXCL10,CXCL3,DCN,FOS,H19,HMOX1,SLC2A1,SOCS 3,SPARC,TIMP1,UGCG,VCAM1
ERK group Inhibited BGN,CAV1,Ccl2,CCNE1,CXCL10,CXCL2,DPYSL2,FOS,HMOX1,NDRG1,SLC2A1,TI MP1,TUBA1A,UGCG
GATA1 transcriptio
n regulator
ALAS2,ANK1,CA1,CA2,CCND2,CPA3,HBB,HBG2,KLF1,Podxl,SLC4A1,SPTA1,SPT B
SMARCB1 transcriptio
n regulator
A2M,ADD3,CCNA2,CCNE1,FOS,GSN,IGFBP2,MCM2,MCM4,PTN,SKP2,SPARC
LEP growth
factor
Inhibited AQP7,CAV1,Ccl2,CCNA2,CXCL10,DLK1,ELOVL6,FOS,IGFBP2,LIFR,LPL,PCNA,SO CS3,SPARC,TIMP1,TIMP3,UCP2,VCAM1,VIM
IL1A -4.49 cytokine Inhibited ADAMTS1,CA2,Ccl2,CXCL10,CXCL2,CXCL3,FOS,HDC,HMOX1,IL18,IL1A,SPARC, VCAM1
ADIPOQ other BMP2,CXCL10,CXCL3,DLK1,FOS,HMOX1,LPL,PCNA,TIMP1,UCP2,VCAM1
RELA transcriptio
n regulator
Inhibited A2M,AFP,ARHGDIB,BMP2,CAV1,Ccl2,CXCL10,CXCL2,CXCL3,FOS,HMOX1,IGFB P2,IL1A,LUM,PLK1,VCAM1,VIM
ERK1/2 group Inhibited BMP2,CAV1,Ccl2,CCND2,CXCL10,CXCL3,EMCN,FOS,H19,IL1A,PCNA,PTN,SOCS3 ,TIMP1,VCAM1
MTPN transcriptio
n regulator
Inhibited Ccl2,CCNA2,CCND2,FOS,Mt1,S100A10,SPARC,TUBA1A,VCAM1
CSF1R kinase Inhibited CCND2,CCNE1,FOS,IL1A,PCNA,VCAM1
CSF1 cytokine Inhibited Ccl2,CCND2,CCNE1,CXCL2,CXCL3,F2R,FCER1G,FOS,IL18,IL1A,PCNA,VCAM1
ESR1 6.61 ligand- dependent
nuclear receptor
Inhibited ADD3,BMP2,CA2,CAV1,CCNA2,CCNE1,CD55,CLEC1B,CXCL3,DAB2,FLNA,FOS,F XYD6,GSN,GSTA5,H19,HPGDS,IFITM2,IGF2,IGFBP2,IL1A,KLF1,KLHL13,KNL1,LP L,MKI67,PCNA,PSAT1,PTTG1,SGO2,SKP2,SLC25A4,SLC7A5,VIM
Histone h4 group CCNE1,CXCL10,CXCL3,FOS,GSTP1,IL1A,MCM4,Mt1,PCNA,SOCS3,VCAM1
SOX4 transcriptio
n regulator
ALDH1B1,EMB,EMP1,FCER1G,FOS,Ifitm1,IGF2,Mt1,PPIC,Tpm4,TUBA1A,VIM ACOX1 4.66 enzyme Activated ACER2,ADAMTS1,ANXA2,GSTP1,IGFBP2,LGALS3,LPL,RBM3,TAGLN2,UCP2,UG
CG
TLR4 transmemb
rane receptor
Inhibited BMP2,Ccl2,CCND2,CXCL10,CXCL2,CXCL3,DAB2,DLK1,HDC,HMOX1,IL18,IL1A,P LAGL1,SOCS3,UGCG,VCAM1
SMAD4 transcriptio
n regulator
AFP,BGN,BMP2,Ccl2,CCND2,CCNE1,CDH5,FOS,HMOX1,SLC25A4,TIMP1,TIMP3,V IM
IL6R transmemb
rane receptor
A2M,CXCL10,CXCL2,CXCL3,IGF2,SOCS3,TIMP1,VCAM1
GATA2 transcriptio
n regulator
ALAS2,CDH5,CPA3,EMCN,HDC,HEMGN,KEL,KLF1,Mcpt1,RHAG,RHCE/RHD,SKP 2,SLC4A1,VCAM1
RBL1 transcriptio
n regulator
Activated CCNA2,CCNE1,FOS,MCM2,MCM6,PCNA,PLK1,SKP2
KIT transmemb
rane receptor
Ccl2,CCND2,CPA3,CXCL3,HDC,HMOX1,LGALS3,SOCS3,SPTA1
VEGFA growth
factor
Inhibited ADAMTS1,CAV1,Ccl2,CCNE1,CD55,CDH5,CXCL10,FOS,GRB10,HMOX1,PCNA,RA SGRP3,SPARC,VCAM1
NOD2 other Inhibited BMP2,CXCL10,CXCL2,CXCL3,IL18,IL1A,RASGRP3,SOCS3
IL11 cytokine A2M,ANXA2,DLK1,FOS,SOCS3,TIMP1,VCAM1
NR3C1 ligand-
dependent nuclear receptor
A2M,BMP2,CAV1,Ccl2,CXCL10,CXCL2,CXCL3,DPP7,EMP1,F2R,FCER1G,FOS,GST P1,IL18,IL1A,Mt1,Mt1m/Mt2A,PLAGL1,PRKAR1B,STOM,TIMP3,UGCG,VCAM1
PPARD ligand-
dependent nuclear receptor
AQP7,C1QB,Ccl2,CCND2,CCNE1,GSTA5,IGFBP2,LDHB,LPL,Mcpt1,PCNA,UCP2
STAT1 transcriptio
n regulator
Inhibited A2M,ALAS2,Ccl2,CCND2,CCNE1,CXCL10,CXCL3,EGLN3,FCER1G,FOS,IFITM2,PT N,S100A10,SOCS3
SNAI1 transcriptio CCND2,CCNE1,CD55,CDC25B,CDH5,FLNA,FOS,GSN,SPARC
n regulator
BTK kinase CCND2,CCNE1,CXCL10,CXCL3,EMP1,FABP5,HMOX1,IL18,IL1A
FGFR2 kinase Inhibited AFP,CA2,CCND2,DAB2,GRB10,IGF2,IL1A,LGALS2,TFEC,VCAM1 KLF1 -4.05 transcriptio
n regulator
ALAS2,CD55,HBB,HBG2,SERPINH1,SPTB
PRL cytokine Inhibited A2M,ANXA2,CAV1,CXCL10,DCN,FOS,GPNMB,IGF2,LYVE1,PCNA,SOCS3,SPARC, TIMP1,VIM
VHL transcriptio
n regulator
CA12,CAV1,DAB2,EGLN3,HMOX1,PCNA,SKP2,SLC2A1,SPARC,VIM
PTEN phosphatas
e
CA12,CA2,Ccl2,CCNE1,CDH5,CXCL10,CXCL2,FOS,IGF2,IGFBP2,LGALS3,MKI67,N DRG1,PLK1,PTN,SKP2,SOCS3,VCAM1
CYP1B1 enzyme Inhibited CBX3,CCNE1,HMOX1,IGFBP2,MCM4,Mt1,SKP2
FAS transmemb
rane receptor
ANXA2,BGN,Ccl2,CD48,CXCL10,CXCL2,CXCL3,FOS,GPNMB,IL18,IL1A,LGALS3, LUM,TAGLN2,UGCG,VCAM1
STAT3 transcriptio
n regulator
Inhibited A2M,ALAS2,CCND2,CCNE1,CDH5,CXCL10,CXCL2,CXCL3,FCER1G,FOS,HMOX1,I FITM2,Mt1,NDRG1,PTN,SLC2A1,SOCS3,TIMP1,VIM
APOE transporter BGN,CAV1,Ccl2,CCND2,CXCL3,F2R,FOS,HMOX1,IL1A,LPL,SOCS3,TIMP1,VCAM 1
MITF transcriptio
n regulator
Inhibited APOLD1,CDC25B,EDNRB,FOS,GPNMB,HPGDS,LGALS3,MCM2,MCM4,MCM6,PL K1,TMCC2,TPX2
KRAS enzyme ALDOA,BGN,CAV1,CXCL10,FOS,GPC3,GSN,IFITM2,IGF2,IGF2BP2,IGFBP2,ITM2A
,PLAGL1,SPARC,STOM,VIM RARRES2 15.87 transmemb
rane receptor
Ccl2,CCNA2,CCND2,CD55,CXCL2
PRKCA kinase ARHGDIB,CAV1,CCNE1,CD55,CXCL2,CXCL3,FOS,LPL,VCAM1
ANK1 -3.02 other ANK1,RHAG,RHCE/RHD
CTGF growth
factor
ADAMTS1,AFP,DCN,EGLN3,IGF2,RAMP2,SPARC,TIMP1,TIMP3
AKT1 kinase Inhibited BMP2,CCND2,CCNE1,CXCL10,FABP5,FOS,GSTA5,HMOX1,IGF2,SLC2A1,TGFBR3, TIMP1,VIM
HMOX1 -3.04 enzyme Activated Ccl2,CXCL10,CXCL2,CXCL3,FOS,HMOX1,RELN,SPARC,VCAM1
IGF2 -69.40 growth
factor
BMP2,Ccl2,H19,IFITM2,IGF2,IGFBP2,MCM2,MCM4,NDRG1,OGN,SOCS3
TGFA growth
factor
CXCL10,CXCL2,FOS,GSTP1,PLAGL1,PTTG1,S100A10,VIM
MIF cytokine Inhibited Ccl2,CXCL2,CXCL3,F2R,FOS,RAMP2,TIMP1,VCAM1
BET group ALAS2,HMOX1,KLF1,SLC4A1
C8 complex Ccl2,CXCL2,CXCL3,VCAM1
C9 10.95 other Ccl2,CXCL2,CXCL3,VCAM1
C7 other Ccl2,CXCL2,CXCL3,VCAM1
C3 peptidase Ccl2,CD55,CXCL10,CXCL2,CXCL3,IL1A,UCP2
INSIG1 other CXCL10,CXCL2,CXCL3,DLK1,ELOVL6,FABP5,LPL,STEAP2,UCP2
AMPK complex BMP2,Ccl2,CCND2,CXCL10,HMOX1,LDHB,SLC2A1,UCP2,VIM
WNT5A cytokine ARHGDIB,CXCL2,DAB2,FLNA,IL1A,LCP1,SOCS3,SPARC,VIM
F2R -6.85 g-protein
coupled receptor
Inhibited Ccl2,CD55,CXCL3,F2R,FOS,HMOX1,VCAM1
FAM3B cytokine CAV1,DCN,PTN,RNASE1,SPARC
ERBB3 kinase BGN,CCND2,HMOX1,IGF2,PLK1,SOCS3,SPARC,TIMP3
TAC1 other Inhibited Ccl2,CXCL10,CXCL3,FOS,HDC,HMOX1,IL1A,LDB2
SOCS1 other Activated A2M,Ccl2,CCNE1,CXCL10,CXCL2,FCER1G,FOS,SOCS3,VCAM1
E2F1 transcriptio
n regulator
CA2,CAV1,CCNA2,CCND2,CCNE1,CDC25B,FOS,H19,HIST1H2AB,KIAA0101,MCM 2,MCM4,MCM6,PCNA,PSAT1,VCAM1,VIM
YY1 transcriptio
n regulator
CBX3,CCNA2,FOS,GPC3,HMOX1,MCM4,MCM6,MKI67,PCNA,PLAGL1,PLK1,SLC2 5A4,TNNI1
F2 peptidase Inhibited ALDH1B1,CCNA2,CCND2,CD55,CXCL3,EDNRB,F2R,FOS,HMOX1,RHOJ,SKP2,TA GLN2,VCAM1
RASSF1 other CAV1,CCNA2,CCND2,DAB2,EMP1,FOS,GSN,LDB2
Shc group CCND2,CCNE1,FOS,LPL
S100A8 other A2M,ADAMTS1,C1QB,Ccl2,CXCL10,CXCL2,CXCL3,H19,HMOX1,IL1A,VCAM1
KLF2 transcriptio
n regulator
Ccl2,CD55,CXCL2,HBB,HBG2,IGF2,NDRG1,SLC2A1,TIMP1,VCAM1
E2F4 transcriptio
n regulator
CCNA2,CCNE1,HIST1H2AB,KIAA0101,MCM4,MCM6,MKI67,PCNA,PLK1,PSAT1,P TTG1,TPX2
KLF6 transcriptio
n regulator
Ccl2,CXCL2,DLK1,IL1A,MKI67,PCNA,SERPINH1
IL10RA transmemb
rane receptor
ADD3,BMP2,CA2,DCN,EDNRB,FABP5,IL1A,LUM,OGN,PMP22,SLC2A1,SOCS3,SP ARC,TFEC
JAK2 kinase Inhibited ACER2,Ccl2,CCND2,CXCL10,FOS,Ifitm1,NDN,SOCS3,SPTB
MET kinase Inhibited CCND2,DAB2,FOS,HDC,HMOX1,IL18,PLK1,SOCS3
BDNF growth
factor
ANXA2,BMP2,CCND2,ELOVL6,FLNA,FOS,PCNA,PRKAR1B,RELN,S100A10,SERPI NH1,SPARC,TUBA1A,VIM