Supplemental Materials and Methods

(1)

Supplemental Materials and Methods

Quantitative analysis was performed on multiple cryosections obtained from at least 5 different pieces of the right and caudate lobes of each animal. Blocks were prepared from the proximal and distal portions of each lobe. A minimum of 5 levels were cut per block to evaluate various planes of the tissue. A section from each level was histochemically stained for DPPIV.

The size of the DPPIV+ colonies was determined by applying the Image J measure algorithm to the DPPIV+ colony outlined using the freehand tool. The total area of the liver section was also measured. The percent repopulation for each section was calculated by dividing the area

occupied by DPPIV+ colonies by the total area of the liver section. The liver sections analyzed for each individual animal were averaged to provide the percent repopulation for that animal.

All sections were analyzed in a blinded fashion.

(2)

Table S1, SDC: Significant genes (FDR<0.05) with a fold-difference greater than or equal to ±3

used for IPA shown in Table 1.

AdH vs LAP+OC.2-

Symbol Entrez Gene Name

5830473C10Rik RIKEN cDNA 5830473C10 gene

A1CF APOBEC1 complementation factor

A2M alpha-2-macroglobulin

AADAC arylacetamide deacetylase

AADAT aminoadipate aminotransferase ABAT 4-aminobutyrate aminotransferase

ABCA1 ATP binding cassette subfamily A member 1 ABCA8 ATP binding cassette subfamily A member 8 ABHD14B abhydrolase domain containing 14B

ABHD15 abhydrolase domain containing 15 ACAA2 acetyl-CoA acyltransferase 2

ACADL acyl-CoA dehydrogenase, long chain

ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 ACAT1 acetyl-CoA acetyltransferase 1

ACER2 alkaline ceramidase 2

ACO1 aconitase 1

ACOT2 acyl-CoA thioesterase 2

ACOX2 acyl-CoA oxidase 2

ACSL1 acyl-CoA synthetase long-chain family member 1 ACSS2 acyl-CoA synthetase short-chain family member 2

ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide

AFM afamin

AGT angiotensinogen

AGTR1 angiotensin II receptor type 1

AGXT2 alanine--glyoxylate aminotransferase 2 AI182371 expressed sequence AI182371

Akr1c14 aldo-keto reductase family 1, member C14 AKR1D1 aldo-keto reductase family 1 member D1 ALAS2 5'-aminolevulinate synthase 2

ALCAM activated leukocyte cell adhesion molecule

ALDH1B1 aldehyde dehydrogenase 1 family member B1

ALDH3A2 aldehyde dehydrogenase 3 family member A2

ALDH6A1 aldehyde dehydrogenase 6 family member A1

ALDH7A1 aldehyde dehydrogenase 7 family member A1

ALDH8A1 aldehyde dehydrogenase 8 family member A1

(3)

ALDH9A1 aldehyde dehydrogenase 9 family member A1 ALDOB aldolase, fructose-bisphosphate B

ALOX5 arachidonate 5-lipoxygenase

ALOX5AP arachidonate 5-lipoxygenase activating protein AMBP alpha-1-microglobulin/bikunin precursor AMDHD1 amidohydrolase domain containing 1 AMPD3 adenosine monophosphate deaminase 3

ANGPTL3 angiopoietin like 3

ANK1 ankyrin 1

ANXA1 annexin A1

AP1S2 adaptor related protein complex 1 sigma 2 subunit

APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein

APOA2 apolipoprotein A2

APOB apolipoprotein B

Apoc1 apolipoprotein C1

APOC2 apolipoprotein C2

APOC4 apolipoprotein C4

APOE apolipoprotein E

APOF apolipoprotein F

APOH apolipoprotein H

APOLD1 apolipoprotein L domain containing 1

APOM apolipoprotein M

Apon apolipoprotein N

APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

AQP3 aquaporin 3 (Gill blood group)

AQP8 aquaporin 8

AQP9 aquaporin 9

ARG1 arginase 1

ARHGAP42 Rho GTPase activating protein 42 ARHGDIB Rho GDP dissociation inhibitor beta AS3MT arsenite methyltransferase

ASGR2 asialoglycoprotein receptor 2

ASNS asparagine synthetase (glutamine-hydrolyzing) ASPDH aspartate dehydrogenase domain containing ATF3 activating transcription factor 3

ATP11B ATPase phospholipid transporting 11B (putative) ATP2B4 ATPase plasma membrane Ca2+ transporting 4 AZGP1 alpha-2-glycoprotein 1, zinc-binding

B3GALT1 beta-1,3-galactosyltransferase 1 B4GALT6 beta-1,4-galactosyltransferase 6

BAAT bile acid-CoA:amino acid N-acyltransferase

(4)

BAIAP2L1 BAI1 associated protein 2 like 1 BBOX1 gamma-butyrobetaine hydroxylase 1

BCL11A B cell CLL/lymphoma 11A

BDH1 3-hydroxybutyrate dehydrogenase, type 1

BGN biglycan

BHLHE40 basic helix-loop-helix family member e40 BHMT betaine--homocysteine S-methyltransferase BHMT2 betaine--homocysteine S-methyltransferase 2

BMP2 bone morphogenetic protein 2

BNIP3 BCL2 interacting protein 3 BNIP3 BCL2 interacting protein 3

BRI3BP BRI3 binding protein

BTD biotinidase

BTK Bruton tyrosine kinase

C14orf1 chromosome 14 open reading frame 1 C1orf210 chromosome 1 open reading frame 210

C1R complement C1r

C2 complement C2

C3 complement C3

C4BPA complement component 4 binding protein alpha C4BPB complement component 4 binding protein beta

C6 complement C6

C8A complement C8 alpha chain

C8B complement C8 beta chain

C8G complement C8 gamma chain

C9 complement C9

CA1 carbonic anhydrase 1

CA12 carbonic anhydrase 12

CA2 carbonic anhydrase 2

CALCRL calcitonin receptor like receptor

Cald1 caldesmon 1

CAMP cathelicidin antimicrobial peptide

Ccl9 chemokine (C-C motif) ligand 9

Ccr2 C-C motif chemokine receptor 2

CD151 CD151 molecule (Raph blood group)

CD177 CD177 molecule

CD37 CD37 molecule

Cd52 CD52 antigen

CD53 CD53 molecule

CD55 CD55 molecule (Cromer blood group)

CD84 CD84 molecule

(5)

CDC25B cell division cycle 25B

CDH2 cadherin 2

CDH5 cadherin 5

CDK6 cyclin dependent kinase 6

CDO1 cysteine dioxygenase type 1

CFH complement factor H

CFI complement factor I

CFL2 cofilin 2

CHI3L1 chitinase 3 like 1

CHPT1 choline phosphotransferase 1 CHST12 carbohydrate sulfotransferase 12

CIDEB cell death-inducing DFFA-like effector b

CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

CLDN1 claudin 1

CLEC12A C-type lectin domain family 12 member A CLEC7A C-type lectin domain family 7 member A

CLU clusterin

CMBL carboxymethylenebutenolidase homolog

CMTM7 CKLF like MARVEL transmembrane domain containing 7 CMTM8 CKLF like MARVEL transmembrane domain containing 8 COBLL1 cordon-bleu WH2 repeat protein like 1

COPZ2 coatomer protein complex subunit zeta 2

CORO1A coronin 1A

CP ceruloplasmin

CPB2 carboxypeptidase B2

CPN1 carboxypeptidase N subunit 1

CPN2 carboxypeptidase N subunit 2

CPOX coproporphyrinogen oxidase

CPS1 carbamoyl-phosphate synthase 1

CPT2 carnitine palmitoyltransferase 2

CREB3L3 cAMP responsive element binding protein 3 like 3

CRP C-reactive protein

CSF3R colony stimulating factor 3 receptor

CST7 cystatin F

CTH cystathionine gamma-lyase

CTSE cathepsin E

CTSG cathepsin G

CXADR coxsackie virus and adenovirus receptor

CXCL10 C-X-C motif chemokine ligand 10

CXCL2 C-X-C motif chemokine ligand 2

(6)

CYBB cytochrome b-245 beta chain

CYP17A1 cytochrome P450 family 17 subfamily A member 1 Cyp2c44 cytochrome P450, family 2, subfamily c, polypeptide 44 Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70 Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26 CYP2F1 cytochrome P450 family 2 subfamily F member 1 CYP2J2 cytochrome P450 family 2 subfamily J member 2 Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 CYP4F22 cytochrome P450 family 4 subfamily F member 22 CYP4F8 cytochrome P450 family 4 subfamily F member 8 CYP51A1 cytochrome P450 family 51 subfamily A member 1 CYP7A1 cytochrome P450 family 7 subfamily A member 1 CYR61 cysteine rich angiogenic inducer 61

CYYR1 cysteine and tyrosine rich 1

DBI diazepam binding inhibitor, acyl-CoA binding protein DBT dihydrolipoamide branched chain transacylase E2

DCK deoxycytidine kinase

DCN decorin

Defa10 defensin alpha 10

DGAT2 diacylglycerol O-acyltransferase 2 DHCR24 24-dehydrocholesterol reductase DHRS11 dehydrogenase/reductase 11

DHTKD1 dehydrogenase E1 and transketolase domain containing 1 DLC1 DLC1 Rho GTPase activating protein

DLK1 delta like non-canonical Notch ligand 1 DNASE1L3 deoxyribonuclease 1 like 3

DOCK6 dedicator of cytokinesis 6

Dpt dermatopontin

DPYD dihydropyrimidine dehydrogenase

DPYS dihydropyrimidinase

EBP emopamil binding protein (sterol isomerase) EBPL emopamil binding protein like

ECHDC2 enoyl-CoA hydratase domain containing 2 ECHS1 enoyl-CoA hydratase, short chain 1 EDNRB endothelin receptor type B

EGR1 early growth response 1

ELANE elastase, neutrophil expressed ELOVL2 ELOVL fatty acid elongase 2 ELOVL6 ELOVL fatty acid elongase 6

EMB embigin

(7)

EMCN endomucin

EMP1 epithelial membrane protein 1

ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 EPAS1 endothelial PAS domain protein 1

EPHX1 epoxide hydrolase 1

EPX eosinophil peroxidase

ERMAP erythroblast membrane associated protein (Scianna blood group) ERRFI1 ERBB receptor feedback inhibitor 1

ESRP2 epithelial splicing regulatory protein 2 ETFA electron transfer flavoprotein alpha subunit

Etnk2 ethanolamine kinase 2

F10 coagulation factor X

F11 coagulation factor XI

F11R F11 receptor

F12 coagulation factor XII

F13A1 coagulation factor XIII A chain F13b coagulation factor XIII B chain

F2 coagulation factor II, thrombin

F9 coagulation factor IX

FABP1 fatty acid binding protein 1

FAH fumarylacetoacetate hydrolase

FAM213A family with sequence similarity 213 member A

FAR1 fatty acyl-CoA reductase 1

FAR2 fatty acyl-CoA reductase 2

FBP1 fructose-bisphosphatase 1

FCER1G Fc fragment of IgE receptor Ig FCGR2B Fc fragment of IgG receptor IIb

FCN1 ficolin 1

FDFT1 farnesyl-diphosphate farnesyltransferase 1

FECH ferrochelatase

FERMT2 fermitin family member 2

FERMT3 fermitin family member 3

FETUB fetuin B

FGA fibrinogen alpha chain

FGG fibrinogen gamma chain

FGR FGR protooncogene, Src family tyrosine kinase

FKBP9 FK506 binding protein 9

Flt1 FMS-related tyrosine kinase 1 FMO1 flavin containing monooxygenase 1

FN1 fibronectin 1

(8)

Fn3k fructosamine 3 kinase

FOXO1 forkhead box O1

FTCD formimidoyltransferase cyclodeaminase FURIN furin, paired basic amino acid cleaving enzyme FXYD1 FXYD domain containing ion transport regulator 1 FZD4 frizzled class receptor 4

G6PD glucose-6-phosphate dehydrogenase

GALM galactose mutarotase

GAMT guanidinoacetate N-methyltransferase

GATA1 GATA binding protein 1

GATA4 GATA binding protein 4

GC GC, vitamin D binding protein

GCA grancalcin

GCSH glycine cleavage system protein H

GFI1B growth factor independent 1B transcriptional repressor

GGH gamma-glutamyl hydrolase

GHR growth hormone receptor

GJB1 gap junction protein beta 1

GLDC glycine decarboxylase

GLTPD2 glycolipid transfer protein domain containing 2

GLUD1 glutamate dehydrogenase 1

Gm12253 predicted gene 12253

Gm4758 predicted gene 4758

GMPR guanosine monophosphate reductase Gnmt/LOC100911564 glycine N-methyltransferase

GOT1 glutamic-oxaloacetic transaminase 1

GPAM glycerol-3-phosphate acyltransferase, mitochondrial

GPC3 glypican 3

GPD1 glycerol-3-phosphate dehydrogenase 1

GPM6A glycoprotein M6A

GPR182 G protein-coupled receptor 182

GRB10 growth factor receptor bound protein 10 GRB14 growth factor receptor bound protein 14

GREB1L growth regulation by estrogen in breast cancer 1 like GRHPR glyoxylate and hydroxypyruvate reductase

GSN gelsolin

GSTA3 glutathione S-transferase alpha 3

GSTA5 glutathione S-transferase alpha 5

GSTK1 glutathione S-transferase kappa 1

GSTM2 glutathione S-transferase mu 2

GSTM4 glutathione S-transferase mu 4

(9)

GSTM5 glutathione S-transferase mu 5

GSTT2/GSTT2B glutathione S-transferase theta 2 (gene/pseudogene)

Gulo gulonolactone (L-) oxidase

GYS2 glycogen synthase 2

H19 H19, imprinted maternally expressed transcript (non-protein coding) H19 H19, imprinted maternally expressed transcript (non-protein coding) H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase HAAO 3-hydroxyanthranilate 3,4-dioxygenase

HABP2 hyaluronan binding protein 2

HADH hydroxyacyl-CoA dehydrogenase

Hamp hepcidin antimicrobial peptide

HBG2 hemoglobin subunit gamma 2

HDC histidine decarboxylase

HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 HES1 hes family bHLH transcription factor 1

HGD homogentisate 1,2-dioxygenase

HGFAC HGF activator

HIBADH 3-hydroxyisobutyrate dehydrogenase Hist1h1a histone cluster 1, H1a

Hist1h1b histone cluster 1, H1b

HIST1H2AB histone cluster 1 H2A family member b HIST2H2AB histone cluster 2 H2A family member b HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 HNF4A hepatocyte nuclear factor 4 alpha

HOPX HOP homeobox

HOXA5 homeobox A5

HP haptoglobin

HPD 4-hydroxyphenylpyruvate dioxygenase

HPX hemopexin

Hrg histidine-rich glycoprotein

HSD11B1 hydroxysteroid 11-beta dehydrogenase 1

HSD17B10 hydroxysteroid 17-beta dehydrogenase 10

HSD17B11 hydroxysteroid 17-beta dehydrogenase 11

HSD17B13 hydroxysteroid 17-beta dehydrogenase 13

HSD17B2 hydroxysteroid 17-beta dehydrogenase 2

HSPB8 heat shock protein family B (small) member 8

IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic

IFITM3 interferon induced transmembrane protein 3

Ifitm6 interferon induced transmembrane protein 6

(10)

IGF2 insulin like growth factor 2

IGFBP1 insulin like growth factor binding protein 1 IGFBP2 insulin like growth factor binding protein 2 IGFBP7 insulin like growth factor binding protein 7 IGSF1 immunoglobulin superfamily member 1 IGSF11 immunoglobulin superfamily member 11

Ikzf1 IKAROS family zinc finger 1

IL17RA interleukin 17 receptor A

IL18 interleukin 18

IL1A interleukin 1 alpha

IL6ST interleukin 6 signal transducer

INSIG1 insulin induced gene 1

IRF1 interferon regulatory factor 1 ITGA1 integrin subunit alpha 1 ITGA4 integrin subunit alpha 4

ITGAM integrin subunit alpha M

ITGB2 integrin subunit beta 2

ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 ITIH3 inter-alpha-trypsin inhibitor heavy chain 3

ITIH4 inter-alpha-trypsin inhibitor heavy chain family member 4 JUNB JunB protooncogene, AP-1 transcription factor subunit KCNN4 potassium calcium-activated channel subfamily N member 4 KEL Kell blood group, metallo-endopeptidase

KIAA0101 KIAA0101

KIAA1161 KIAA1161

KIAA1462 KIAA1462

KLF1 Kruppel like factor 1

KLF12 Kruppel like factor 12

KLKB1 kallikrein B1

KMO kynurenine 3-monooxygenase

Kng1/Kng1l1 kininogen 1 Kng1/Kng1l1 kininogen 1

KRT8 keratin 8

KYNU kynureninase

LAP3 leucine aminopeptidase 3

LAPTM4B lysosomal protein transmembrane 4 beta

LAPTM5 lysosomal protein transmembrane 5

LBP lipopolysaccharide binding protein

LCAT lecithin-cholesterol acyltransferase

(11)

LCN12 lipocalin 12

LCP1 lymphocyte cytosolic protein 1 LCP2 lymphocyte cytosolic protein 2

LDB2 LIM domain binding 2

LDHC lactate dehydrogenase C

LGALS2 galectin 2

LGALS3BP galectin 3 binding protein

LGALS9B galectin 9B

LGR4 leucine rich repeat containing G protein-coupled receptor 4 LIFR leukemia inhibitory factor receptor alpha

LIFR leukemia inhibitory factor receptor alpha LIMA1 LIM domain and actin binding 1

LIPC lipase C, hepatic type

LMAN1 lectin, mannose binding 1

LOC690020 similar to killer cell lectin-like receptor, subfamily A, member 17 LPAR6 lysophosphatidic acid receptor 6

LPL lipoprotein lipase

LRRC58 leucine rich repeat containing 58 LSP1 lymphocyte-specific protein 1

LTA4H leukotriene A4 hydrolase

LUM lumican

Ly6a (includes others) lymphocyte antigen 6 complex, locus A Ly6a (includes others) lymphocyte antigen 6 complex, locus A Ly6a (includes others) lymphocyte antigen 6 complex, locus A

LYVE1 lymphatic vessel endothelial hyaluronan receptor 1

LYZ lysozyme

MAF MAF bZIP transcription factor

MAGED1 MAGE family member D1

MAL2 mal, T cell differentiation protein 2 (gene/pseudogene)

MAOB monoamine oxidase B

Masp1 mannan-binding lectin serine peptidase 1 MASP2 mannan binding lectin serine peptidase 2 MAT1A methionine adenosyltransferase 1A Mbl1 mannose-binding lectin (protein A) 1

MBL2 mannose binding lectin 2

MBNL1 muscleblind like splicing regulator 1

MCC mutated in colorectal cancers

Mcpt8 (includes others) mast cell protease 8

(12)

MFAP4 microfibrillar associated protein 4

mir-154 microRNA 494

MMP8 matrix metallopeptidase 8

MORC4 MORC family CW-type zinc finger 4

Mpo myeloperoxidase

MS4A3 membrane spanning 4-domains A3

MST1 macrophage stimulating 1

MTTP microsomal triglyceride transfer protein

MYO1B myosin IB

MYO1F myosin IF

NCKAP1L NCK associated protein 1 like

NDRG2 NDRG family member 2

NFE2 nuclear factor, erythroid 2

NFIA nuclear factor I A

NFIB nuclear factor I B

Ngp neutrophilic granule protein

NID1 nidogen 1

NIPAL1 NIPA like domain containing 1 NIPSNAP1 nipsnap homolog 1 (C. elegans)

NIT2 nitrilase family member 2

NKG7 natural killer cell granule protein 7

NQO2 NAD(P)H quinone dehydrogenase 2

NR1H4 nuclear receptor subfamily 1 group H member 4 NR5A2 nuclear receptor subfamily 5 group A member 2 NREP neuronal regeneration related protein

NSDHL NAD(P) dependent steroid dehydrogenase-like NUPR1 nuclear protein 1, transcriptional regulator

OGN osteoglycin

OIT3 oncoprotein induced transcript 3

OLFM4 olfactomedin 4

OLFML3 olfactomedin like 3

OLR1 oxidized low density lipoprotein receptor 1

OTC ornithine carbamoyltransferase

PAH phenylalanine hydroxylase

PARVA parvin alpha

PC pyruvate carboxylase

PCBD1 pterin-4 alpha-carbinolamine dehydratase 1

PCSK9 proprotein convertase subtilisin/kexin type 9

PDIA5 protein disulfide isomerase family A member 5

PDK3 pyruvate dehydrogenase kinase 3

(13)

PDK4 pyruvate dehydrogenase kinase 4

PECR peroxisomal trans-2-enoyl-CoA reductase

PERP PERP, TP53 apoptosis effector

PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PGLYRP1 peptidoglycan recognition protein 1

PGM1 phosphoglucomutase 1

PGRMC1 progesterone receptor membrane component 1 PGRMC1 progesterone receptor membrane component 1

PHYH phytanoyl-CoA 2-hydroxylase

PHYHD1 phytanoyl-CoA dioxygenase domain containing 1 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q PIP5K1B phosphatidylinositol-4-phosphate 5-kinase type 1 beta Pkhd1 polycystic kidney and hepatic disease 1

PLA2G12B phospholipase A2 group XIIB PLA2G2A phospholipase A2 group IIA

PLAC8 placenta specific 8

PLAGL1 PLAG1 like zinc finger 1

PLEK pleckstrin

PLG plasminogen

PLK2 polo like kinase 2

PLOD1 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

PLXND1 plexin D1

PMP22 peripheral myelin protein 22

PON1 paraoxonase 1

PON3 paraoxonase 3

PPARA peroxisome proliferator activated receptor alpha PPARGC1A PPARG coactivator 1 alpha

Ppbp pro-platelet basic protein

PPIC peptidylprolyl isomerase C

PRG2 proteoglycan 2, pro eosinophil major basic protein PRG3 proteoglycan 3, pro eosinophil major basic protein 2

PRKD3 protein kinase D3

PROC protein C, inactivator of coagulation factors Va and VIIIa

PROS1 protein S (alpha)

PROX1 prospero homeobox 1

PRTFDC1 phosphoribosyl transferase domain containing 1

PRTN3 proteinase 3

PSAT1 phosphoserine aminotransferase 1

PTPRC protein tyrosine phosphatase, receptor type C

Pzp pregnancy zone protein

QPRT quinolinate phosphoribosyltransferase

(14)

RAB27A RAB27A, member RAS oncogene family

RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

RAMP2 receptor activity modifying protein 2 RASGRP2 RAS guanyl releasing protein 2 RASGRP3 RAS guanyl releasing protein 3 RatNP-3b (includes others) defensin RatNP-3 precursor RatNP-3b (includes others) defensin RatNP-3 precursor RBM12 RNA binding motif protein 12 RBM47 RNA binding motif protein 47

RBP2 retinol binding protein 2

RBP4 retinol binding protein 4

REEP6 receptor accessory protein 6

RELN reelin

Retnlg resistin like gamma

RGD1564614 similar to complement factor H-related protein

RGD1566401 similar to GTL2, imprinted maternally expressed untranslated

RGN regucalcin

RGS18 regulator of G-protein signaling 18

RHAG Rh-associated glycoprotein

RHCE/RHD Rh blood group D antigen

RHOJ ras homolog family member J

RNASE1 ribonuclease A family member 1, pancreatic Rnase2 (includes others) ribonuclease A family member 2

Rnase2 (includes others) ribonuclease A family member 2 Rnase2 (includes others) ribonuclease A family member 2 Rnase2 (includes others) ribonuclease A family member 2 Rnase2 (includes others) ribonuclease A family member 2 RNASE4 ribonuclease A family member 4

RND3 Rho family GTPase 3

RNF125 ring finger protein 125 Rrbp1 ribosome binding protein 1

RRM2 ribonucleotide reductase regulatory subunit M2 RRM2 ribonucleotide reductase regulatory subunit M2 Rtp3 receptor transporter protein 3

RUNX1 runt related transcription factor 1 S100A11 S100 calcium binding protein A11 S100A8 S100 calcium binding protein A8 S100A9 S100 calcium binding protein A9 SCCPDH saccharopine dehydrogenase (putative)

SDC2 syndecan 2

(15)

SDC4 syndecan 4

SEC16B SEC16 homolog B, endoplasmic reticulum export factor Sectm1b secreted and transmembrane 1B

SELENBP1 selenium binding protein 1

SELL selectin L

SEMA4G semaphorin 4G

SERPINA10 serpin family A member 10 SERPINA3 serpin family A member 3 SERPINA4 serpin family A member 4 SERPINA6 serpin family A member 6 SERPINB1 serpin family B member 1 SERPINB10 serpin family B member 10 SERPINC1 serpin family C member 1 SERPIND1 serpin family D member 1 SERPINF1 serpin family F member 1 SERPINF2 serpin family F member 2 SERPING1 serpin family G member 1 SERPINH1 serpin family H member 1

SLA Src-like-adaptor

SLC10A1 solute carrier family 10 member 1 SLC16A12 solute carrier family 16 member 12 SLC16A4 solute carrier family 16 member 4 SLC17A3 solute carrier family 17 member 3 SLC22A18 solute carrier family 22 member 18 SLC22A8 solute carrier family 22 member 8 SLC25A23 solute carrier family 25 member 23 SLC25A37 solute carrier family 25 member 37 SLC27A2 solute carrier family 27 member 2 SLC2A2 solute carrier family 2 member 2 SLC2A3 solute carrier family 2 member 3 SLC36A2 solute carrier family 36 member 2 SLC38A1 solute carrier family 38 member 1 SLC38A3 solute carrier family 38 member 3 SLC38A4 solute carrier family 38 member 4 SLC38A5 solute carrier family 38 member 5 SLC39A5 solute carrier family 39 member 5

SLC4A1 solute carrier family 4 member 1 (Diego blood group) SLC6A13 solute carrier family 6 member 13

SLC7A2 solute carrier family 7 member 2

SLCO2A1 solute carrier organic anion transporter family member 2A1

SMOC1 SPARC related modular calcium binding 1

(16)

SOCS3 suppressor of cytokine signaling 3 SORBS2 sorbin and SH3 domain containing 2 SPARC secreted protein acidic and cysteine rich SPINT1 serine peptidase inhibitor, Kunitz type 1

SPN sialophorin

SPP2 secreted phosphoprotein 2

SPTA1 spectrin alpha, erythrocytic 1 SPTB spectrin beta, erythrocytic

SQLE squalene epoxidase

Srgn serglycin

SRR serine racemase

ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 ST6GAL1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1

ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

STAB2 stabilin 2

STARD10 StAR related lipid transfer domain containing 10 Stfa2/Stfa2l1 stefin A2

Stfa2/Stfa2l1 stefin A2

Stfa3 stefin A3

STOM stomatin

SUCLG2 succinate-CoA ligase GDP-forming beta subunit

Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1

TCN2 transcobalamin 2

TFRC transferrin receptor

THRB thyroid hormone receptor beta

Timd2 T cell immunoglobulin and mucin domain containing 2 TIMP1 TIMP metallopeptidase inhibitor 1

TJP1 tight junction protein 1

TLR3 toll like receptor 3

TM4SF4 transmembrane 4 L 6 family member 4 TM6SF1 transmembrane 6 superfamily member 1 TMEM150A transmembrane protein 150A

TMEM2 transmembrane protein 2

TMEM205 transmembrane protein 205

TMEM37 transmembrane protein 37

TMEM47 transmembrane protein 47

TMEM53 transmembrane protein 53

TMEM97 transmembrane protein 97

TMPRSS6 transmembrane protease, serine 6 TNFRSF14 TNF receptor superfamily member 14

TNFSF13 tumor necrosis factor superfamily member 13

(17)

TNNI1 troponin I1, slow skeletal type

TSPAN12 tetraspanin 12

TSPAN31 tetraspanin 31

TSPAN7 tetraspanin 7

TST thiosulfate sulfurtransferase

Tsx testis specific X-linked gene

TTPA alpha tocopherol transfer protein

TTR transthyretin

TUBA4A tubulin alpha 4a

TUBB6 tubulin beta 6 class V

UCP2 uncoupling protein 2

UGP2 UDP-glucose pyrophosphorylase 2

UGT2B11 UDP glucuronosyltransferase family 2 member B11

Uox urate oxidase

UPB1 beta-ureidopropionase 1

UROS uroporphyrinogen III synthase

VAT1 vesicle amine transport 1

VCAM1 vascular cell adhesion molecule 1

VKORC1 vitamin K epoxide reductase complex subunit 1

VNN1 vanin 1

VTN vitronectin

XK X-linked Kx blood group

XPNPEP2 X-prolyl aminopeptidase 2

YES1 YES protooncogene 1, Src family tyrosine kinase

ZADH2 zinc binding alcohol dehydrogenase domain containing 2 ZDHHC15 zinc finger DHHC-type containing 15

ZDHHC9 zinc finger DHHC-type containing 9

ZFP36 ZFP36 ring finger protein

ZFP36L1 ZFP36 ring finger protein like 1

ZNF189 zinc finger protein 189

(18)

AdH vs LAP+OC.2+

Symbol Entrez Gene Name

1300017J02Rik RIKEN cDNA 1300017J02 gene 5830473C10Rik RIKEN cDNA 5830473C10 gene

A1CF APOBEC1 complementation factor

A2M alpha-2-macroglobulin

AADAC arylacetamide deacetylase

AADAT aminoadipate aminotransferase AASS aminoadipate-semialdehyde synthase ABAT 4-aminobutyrate aminotransferase

ABCA1 ATP binding cassette subfamily A member 1

Abca8a ATP-binding cassette, subfamily A (ABC1), member 8a ABCA9 ATP binding cassette subfamily A member 9

ABCB10 ATP binding cassette subfamily B member 10 ABCC6 ATP binding cassette subfamily C member 6 ABCD3 ATP binding cassette subfamily D member 3 ABCG1 ATP binding cassette subfamily G member 1

Abcg3 ATP-binding cassette, subfamily G (WHITE), member 3 Abcg3l2 ATP-binding cassette, subfamily G (WHITE), member 3-like 2 ABHD1 abhydrolase domain containing 1

ABHD14B abhydrolase domain containing 14B ABHD2 abhydrolase domain containing 2 ABHD6 abhydrolase domain containing 6

ABTB2 ankyrin repeat and BTB domain containing 2 ACAA2 acetyl-CoA acyltransferase 2

ACACB acetyl-CoA carboxylase beta

ACADL acyl-CoA dehydrogenase, long chain

ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain ACADSB acyl-CoA dehydrogenase, short/branched chain ACADVL acyl-CoA dehydrogenase, very long chain

ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 ACAT1 acetyl-CoA acetyltransferase 1

ACBD5 acyl-CoA binding domain containing 5

ACMSD aminocarboxymuconate semialdehyde decarboxylase Acnat1/Acnat2 acyl-coenzyme A amino acid N-acyltransferase 1 Acnat1/Acnat2 acyl-coenzyme A amino acid N-acyltransferase 1

ACO1 aconitase 1

ACOT12 acyl-CoA thioesterase 12

ACOT2 acyl-CoA thioesterase 2

ACOX1 acyl-CoA oxidase 1

ACOX2 acyl-CoA oxidase 2

(19)

ACOX3 acyl-CoA oxidase 3, pristanoyl ACP2 acid phosphatase 2, lysosomal

ACPP acid phosphatase, prostate

ACSF2 acyl-CoA synthetase family member 2

ACSL1 acyl-CoA synthetase long-chain family member 1 ACSS2 acyl-CoA synthetase short-chain family member 2

ACY3 aminoacylase 3

ADD2 adducin 2

ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide ADHFE1 alcohol dehydrogenase, iron containing 1

ADI1 acireductone dioxygenase 1

ADK adenosine kinase

ADRA1B adrenoceptor alpha 1B

ADRA2B adrenoceptor alpha 2B

AFM afamin

AFP alpha fetoprotein

AGMAT agmatinase

AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2

AGT angiotensinogen

AGTR1 angiotensin II receptor type 1 AGXT alanine-glyoxylate aminotransferase AGXT2 alanine--glyoxylate aminotransferase 2

AHCY adenosylhomocysteinase

AHR aryl hydrocarbon receptor

AI182371 expressed sequence AI182371

AIM1 absent in melanoma 1

AKR1C1/AKR1C2 aldo-keto reductase family 1 member C2 Akr1c12/Akr1c13 aldo-keto reductase family 1, member C13 Akr1c13 aldo-keto reductase family 1, member C13 Akr1c14 aldo-keto reductase family 1, member C14 AKR1C4 aldo-keto reductase family 1 member C4 AKR1D1 aldo-keto reductase family 1 member D1 AKR7A2 aldo-keto reductase family 7 member A2 AKR7A3 aldo-keto reductase family 7 member A3 ALAS2 5'-aminolevulinate synthase 2

ALCAM activated leukocyte cell adhesion molecule

ALDH18A1 aldehyde dehydrogenase 18 family member A1

ALDH1A1 aldehyde dehydrogenase 1 family member A1

ALDH1L2 aldehyde dehydrogenase 1 family member L2

ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)

(20)

ALDH3A2 aldehyde dehydrogenase 3 family member A2 ALDH5A1 aldehyde dehydrogenase 5 family member A1 ALDH6A1 aldehyde dehydrogenase 6 family member A1 ALDH7A1 aldehyde dehydrogenase 7 family member A1 ALDH8A1 aldehyde dehydrogenase 8 family member A1 ALDH9A1 aldehyde dehydrogenase 9 family member A1 ALDOA aldolase, fructose-bisphosphate A

ALDOB aldolase, fructose-bisphosphate B

ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase

ALOX5 arachidonate 5-lipoxygenase

ALOX5AP arachidonate 5-lipoxygenase activating protein

AMACR alpha-methylacyl-CoA racemase

AMBP alpha-1-microglobulin/bikunin precursor AMDHD1 amidohydrolase domain containing 1 AMPD3 adenosine monophosphate deaminase 3 AMY2A amylase, alpha 2A (pancreatic)

ANG angiogenin

ANGPTL3 angiopoietin like 3

ANGPTL4 angiopoietin like 4

ANGPTL6 angiopoietin like 6

ANK1 ankyrin 1

Anp32b acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E ANPEP alanyl aminopeptidase, membrane

ANXA1 annexin A1

ANXA2 annexin A2

AOX1 aldehyde oxidase 1

Aox3 aldehyde oxidase 3

Aox4 aldehyde oxidase 4

AP1S2 adaptor related protein complex 1 sigma 2 subunit

APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein

APCS amyloid P component, serum

APOA2 apolipoprotein A2

APOA5 apolipoprotein A5

APOB apolipoprotein B

Apoc1 apolipoprotein C1

APOC2 apolipoprotein C2

APOC4 apolipoprotein C4

APOE apolipoprotein E

APOF apolipoprotein F

APOH apolipoprotein H

(21)

Apol9a/Apol9b apolipoprotein L 9b

APOM apolipoprotein M

Apon apolipoprotein N

AQP3 aquaporin 3 (Gill blood group)

AQP8 aquaporin 8

AR androgen receptor

ARG1 arginase 1

ARHGAP29 Rho GTPase activating protein 29 ARHGAP42 Rho GTPase activating protein 42 ARHGAP5 Rho GTPase activating protein 5 ARHGDIB Rho GDP dissociation inhibitor beta ARL1 ADP ribosylation factor like GTPase 1

ARNTL aryl hydrocarbon receptor nuclear translocator like

ARRB1 arrestin beta 1

ARRB2 arrestin beta 2

ARRDC3 arrestin domain containing 3

ART4 ADP-ribosyltransferase 4 (Dombrock blood group) AS3MT arsenite methyltransferase

ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ASF1B antisilencing function 1B histone chaperone

ASGR1 asialoglycoprotein receptor 1 ASGR2 asialoglycoprotein receptor 2

ASL argininosuccinate lyase

ASNS asparagine synthetase (glutamine-hydrolyzing) ASPDH aspartate dehydrogenase domain containing ASPM abnormal spindle microtubule assembly

ASS1 argininosuccinate synthase 1

ATAD2 ATPase family, AAA domain containing 2 ATAD5 ATPase family, AAA domain containing 5 ATF5 activating transcription factor 5

ATL3 atlastin GTPase 3

ATP1B1 ATPase Na+/K+ transporting subunit beta 1 ATP1B2 ATPase Na+/K+ transporting subunit beta 2 ATP2B4 ATPase plasma membrane Ca2+ transporting 4

Atp6ap1l ATPase, H+ transporting, lysosomal accessory protein 1-like ATP8A1 ATPase phospholipid transporting 8A1

ATPIF1 ATPase inhibitory factor 1

ATRN attractin

AU041133 expressed sequence AU041133

AUH AU RNA binding methylglutaconyl-CoA hydratase

AURKB aurora kinase B

(22)

AVPR1A arginine vasopressin receptor 1A AZGP1 alpha-2-glycoprotein 1, zinc-binding

B2M beta-2-microglobulin

B3GALT1 beta-1,3-galactosyltransferase 1 B4GALT6 beta-1,4-galactosyltransferase 6

BAAT bile acid-CoA:amino acid N-acyltransferase BAIAP2L1 BAI1 associated protein 2 like 1

BARD1 BRCA1 associated RING domain 1

BBOX1 gamma-butyrobetaine hydroxylase 1 BCAR1 BCAR1, Cas family scaffolding protein BCAS2 breast carcinoma amplified sequence 2

BCHE butyrylcholinesterase

BCKDHB branched chain keto acid dehydrogenase E1 subunit beta

BCL11A B cell CLL/lymphoma 11A

BDH1 3-hydroxybutyrate dehydrogenase, type 1

BEX4 brain expressed X-linked 4

BHLHE40 basic helix-loop-helix family member e40 BHMT betaine--homocysteine S-methyltransferase BHMT2 betaine--homocysteine S-methyltransferase 2

BMP1 bone morphogenetic protein 1

BPHL biphenyl hydrolase like

BRI3BP BRI3 binding protein

Bst2 bone marrow stromal cell antigen 2

BTD biotinidase

BTK Bruton tyrosine kinase

BUB1 BUB1 mitotic checkpoint serine/threonine kinase BUB1B BUB1 mitotic checkpoint serine/threonine kinase B BZW2 basic leucine zipper and W2 domains 2

C10orf10 chromosome 10 open reading frame 10 C10orf35 chromosome 10 open reading frame 35 C11orf52 chromosome 11 open reading frame 52 C11orf54 chromosome 11 open reading frame 54 C11orf71 chromosome 11 open reading frame 71 C11orf86 chromosome 11 open reading frame 86 C19orf12 chromosome 19 open reading frame 12 C19orf38 chromosome 19 open reading frame 38 C1orf115 chromosome 1 open reading frame 115 C1orf21 chromosome 1 open reading frame 21 C1orf210 chromosome 1 open reading frame 210

C1R complement C1r

C1RL complement C1r subcomponent like

(23)

C1S complement C1s

C2 complement C2

C20orf194 chromosome 20 open reading frame 194 C2orf72 chromosome 2 open reading frame 72

C3 complement C3

C4BPA complement component 4 binding protein alpha C4BPB complement component 4 binding protein beta

C6 complement C6

C6orf120 chromosome 6 open reading frame 120 C6orf89 chromosome 6 open reading frame 89 C7orf31 chromosome 7 open reading frame 31

C8A complement C8 alpha chain

C8B complement C8 beta chain

C8G complement C8 gamma chain

C9 complement C9

C9orf135 chromosome 9 open reading frame 135

CA1 carbonic anhydrase 1

CA14 carbonic anhydrase 14

CA2 carbonic anhydrase 2

CA3 carbonic anhydrase 3

CA8 carbonic anhydrase 8

CABP2 calcium binding protein 2

Cald1 caldesmon 1

CAMP cathelicidin antimicrobial peptide

Casp12 caspase 12

CAT catalase

CBL Cbl protooncogene

CBLN3 cerebellin 3 precursor

CBR4 carbonyl reductase 4

CBS/CBSL cystathionine-beta-synthase

CBX3 chromobox 3

CCDC82 coiled-coil domain containing 82

Ccl2 chemokine (C-C motif) ligand 2

CCL3L3 C-C motif chemokine ligand 3 like 3

Ccl9 chemokine (C-C motif) ligand 9

CCNA2 cyclin A2

CCNB1 cyclin B1

CCNB2 cyclin B2

(24)

CCND1 cyclin D1

CCND2 cyclin D2

CCNE1 cyclin E1

CCNE2 cyclin E2

CCNF cyclin F

Ccr2 C-C motif chemokine receptor 2

CD151 CD151 molecule (Raph blood group)

CD164 CD164 molecule

CD177 CD177 molecule

CD2AP CD2 associated protein

CD302 CD302 molecule

CD36 CD36 molecule

CD37 CD37 molecule

CD44 CD44 molecule (Indian blood group)

CD48 CD48 molecule

Cd52 CD52 antigen

CD53 CD53 molecule

CD55 CD55 molecule (Cromer blood group)

CD63 CD63 molecule

CD81 CD81 molecule

CD84 CD84 molecule

CDC25A cell division cycle 25A CDC25B cell division cycle 25B

CDC6 cell division cycle 6

CDCA2 cell division cycle associated 2 CDCA3 cell division cycle associated 3 CDCA5 cell division cycle associated 5 CDCA7 cell division cycle associated 7

CDH17 cadherin 17

CDH2 cadherin 2

CDK1 cyclin dependent kinase 1

CDK6 cyclin dependent kinase 6

Cdkn3 cyclin-dependent kinase inhibitor 3

CDO1 cysteine dioxygenase type 1

CDR2 cerebellar degeneration related protein 2

CDT1 chromatin licensing and DNA replication factor 1

CEACAM1 carcinoembryonic antigen related cell adhesion molecule 1 CEBPA CCAAT/enhancer binding protein alpha

CEBPB CCAAT/enhancer binding protein beta

CENPA centromere protein A

CENPE centromere protein E

(25)

CENPF centromere protein F

CENPI centromere protein I

CENPK centromere protein K

CENPN centromere protein N

CENPT centromere protein T

CENPV centromere protein V

CEP76 centrosomal protein 76

CEPT1 choline/ethanolamine phosphotransferase 1

Ces1f carboxylesterase 1F

Ces2c (includes others) carboxylesterase 2C

CFH complement factor H

CFI complement factor I

CFL2 cofilin 2

CFP complement factor properdin

CGRRF1 cell growth regulator with ring finger domain 1

CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10

CHDH choline dehydrogenase

CHI3L1 chitinase 3 like 1

CHIC1 cysteine rich hydrophobic domain 1

CHKA choline kinase alpha

Chn2 chimerin 2

CHPT1 choline phosphotransferase 1 CHST11 carbohydrate sulfotransferase 11 CHST12 carbohydrate sulfotransferase 12

CIDEA cell death-inducing DFFA-like effector a CIDEB cell death-inducing DFFA-like effector b CIDEC cell death inducing DFFA like effector c CIT citron rho-interacting serine/threonine kinase

CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4

CLDN2 claudin 2

CLDN3 claudin 3

CLEC12A C-type lectin domain family 12 member A CLEC7A C-type lectin domain family 7 member A CLIC1 chloride intracellular channel 1

CLMN calmin

CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant CLOCK clock circadian regulator

CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit

CLSPN claspin

CLU clusterin

(26)

Cmah cytidine monophospho-N-acetylneuraminic acid hydroxylase CMBL carboxymethylenebutenolidase homolog

CMTM6 CKLF like MARVEL transmembrane domain containing 6 CMTM7 CKLF like MARVEL transmembrane domain containing 7 CMTM8 CKLF like MARVEL transmembrane domain containing 8 COBLL1 cordon-bleu WH2 repeat protein like 1

COMT catechol-O-methyltransferase

CORO1A coronin 1A

CP ceruloplasmin

CPA1 carboxypeptidase A1

CPB2 carboxypeptidase B2

CPN1 carboxypeptidase N subunit 1

CPN2 carboxypeptidase N subunit 2

CPOX coproporphyrinogen oxidase

CPPED1 calcineurin like phosphoesterase domain containing 1

CPS1 carbamoyl-phosphate synthase 1

CPT1A carnitine palmitoyltransferase 1A CPT2 carnitine palmitoyltransferase 2

CREB3L3 cAMP responsive element binding protein 3 like 3 CREG1 cellular repressor of E1A stimulated genes 1

CREM cAMP responsive element modulator

Crip2 cysteine rich protein 2

CRLS1 cardiolipin synthase 1

CROT carnitine O-octanoyltransferase

CRP C-reactive protein

CRYZ crystallin zeta

CSAD cysteine sulfinic acid decarboxylase CSF3R colony stimulating factor 3 receptor

CST7 cystatin F

CTBS chitobiase

CTH cystathionine gamma-lyase

Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha

CTRB2 chymotrypsinogen B2

CTSC cathepsin C

CTSE cathepsin E

CTSG cathepsin G

CTSH cathepsin H

CXADR coxsackie virus and adenovirus receptor

CXCL11 C-X-C motif chemokine ligand 11

CXCL12 C-X-C motif chemokine ligand 12

(27)

Cxcl9 chemokine (C-X-C motif) ligand 9

CYB5A cytochrome b5 type A

CYB5B cytochrome b5 type B

CYBB cytochrome b-245 beta chain

Cyfip2 cytoplasmic FMR1 interacting protein 2

CYP17A1 cytochrome P450 family 17 subfamily A member 1

CYP1A2 cytochrome P450 family 1 subfamily A member 2

CYP27A1 cytochrome P450 family 27 subfamily A member 1

Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1

Cyp2a12/Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 12

Cyp2b13/Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9

CYP2B6 cytochrome P450 family 2 subfamily B member 6

Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12

Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13

Cyp2c44 cytochrome P450, family 2, subfamily c, polypeptide 44

Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70

CYP2C8 cytochrome P450 family 2 subfamily C member 8

CYP2C9 cytochrome P450 family 2 subfamily C member 9

Cyp2d1/Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 1

Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22

Cyp2d26 cytochrome P450, family 2, subfamily d, polypeptide 26

CYP2D6 cytochrome P450 family 2 subfamily D member 6

CYP2E1 cytochrome P450 family 2 subfamily E member 1

CYP2F1 cytochrome P450 family 2 subfamily F member 1

CYP2J2 cytochrome P450 family 2 subfamily J member 2

Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9

Cyp2t4 cytochrome P450, family 2, subfamily t, polypeptide 4

CYP39A1 cytochrome P450 family 39 subfamily A member 1

Cyp3a25 (includes others) cytochrome P450, family 3, subfamily a, polypeptide 25

CYP3A4 cytochrome P450 family 3 subfamily A member 4

CYP3A7 cytochrome P450 family 3 subfamily A member 7

Cyp3a73 cytochrome P450, family 3, subfamily a, polypeptide 73

CYP4A11 cytochrome P450 family 4 subfamily A member 11

Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14

CYP4F12 cytochrome P450 family 4 subfamily F member 12

(28)

CYP4F22 cytochrome P450 family 4 subfamily F member 22 CYP4F3 cytochrome P450 family 4 subfamily F member 3 CYP4F8 cytochrome P450 family 4 subfamily F member 8 CYP51A1 cytochrome P450 family 51 subfamily A member 1 CYP7A1 cytochrome P450 family 7 subfamily A member 1 CYP8B1 cytochrome P450 family 8 subfamily B member 1 CYR61 cysteine rich angiogenic inducer 61

DAG1 dystroglycan 1

DAO D-amino acid oxidase

DBF4 DBF4 zinc finger

DBI diazepam binding inhibitor, acyl-CoA binding protein DBT dihydrolipoamide branched chain transacylase E2 DCAF11 DDB1 and CUL4 associated factor 11

DCK deoxycytidine kinase

DCLRE1B DNA cross-link repair 1B

DCTD dCMP deaminase

DDC dopa decarboxylase

DDT D-dopachrome tautomerase

Ddx58 DEXD/H-box helicase 58

DECR2 2,4-dienoyl-CoA reductase 2, peroxisomal

Defa10 defensin alpha 10

DEPDC1 DEP domain containing 1

DEPDC7 DEP domain containing 7

DEXI Dexi homolog

DGAT2 diacylglycerol O-acyltransferase 2 DHCR24 24-dehydrocholesterol reductase DHCR7 7-dehydrocholesterol reductase

DHRS11 dehydrogenase/reductase 11

DHRS3 dehydrogenase/reductase 3

DHRS4 dehydrogenase/reductase 4

DHTKD1 dehydrogenase E1 and transketolase domain containing 1 DIAPH3 diaphanous related formin 3

DIO1 iodothyronine deiodinase 1

DLC1 DLC1 Rho GTPase activating protein

DLGAP5 DLG associated protein 5

DLK1 delta like non-canonical Notch ligand 1

DMGDH dimethylglycine dehydrogenase

DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3

DNMT1 DNA methyltransferase 1

(29)

DOCK6 dedicator of cytokinesis 6

DONSON downstream neighbor of SON

DPEP2 dipeptidase 2

DPP4 dipeptidyl peptidase 4

Dpt dermatopontin

DPY19L3 dpy-19 like 3 (C. elegans)

DPYD dihydropyrimidine dehydrogenase

DPYS dihydropyrimidinase

DRAM2 DNA damage regulated autophagy modulator 2

DSC2 desmocollin 2

DSG2 desmoglein 2

DSP desmoplakin

DTL denticleless E3 ubiquitin protein ligase homolog DUSP6 dual specificity phosphatase 6

DUT deoxyuridine triphosphatase

DYNLT1 dynein light chain Tctex-type 1 DYNLT3 dynein light chain Tctex-type 3

E2F8 E2F transcription factor 8

EBP emopamil binding protein (sterol isomerase)

EBPL emopamil binding protein like

ECH1 enoyl-CoA hydratase 1

ECHDC2 enoyl-CoA hydratase domain containing 2 ECHS1 enoyl-CoA hydratase, short chain 1 ECT2 epithelial cell transforming 2

EDEM1 ER degradation enhancing alpha-mannosidase like protein 1

EFNA1 ephrin A1

EFNA5 ephrin A5

EGFR epidermal growth factor receptor EGLN3 egl-9 family hypoxia inducible factor 3

EHD3 EH domain containing 3

EHD4 EH domain containing 4

EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase EI24 EI24, autophagy associated transmembrane protein

EIF3D eukaryotic translation initiation factor 3 subunit D ELANE elastase, neutrophil expressed

ELOVL2 ELOVL fatty acid elongase 2 ELOVL5 ELOVL fatty acid elongase 5

EMB embigin

EML5 echinoderm microtubule associated protein like 5

ENPEP glutamyl aminopeptidase

ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1

(30)

ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 EPAS1 endothelial PAS domain protein 1

EPHA2 EPH receptor A2

EPHX1 epoxide hydrolase 1

EPX eosinophil peroxidase

ERBB3 erb-b2 receptor tyrosine kinase 3 ERLEC1 endoplasmic reticulum lectin 1

ERMAP erythroblast membrane associated protein (Scianna blood group) ERRFI1 ERBB receptor feedback inhibitor 1

ESR1 estrogen receptor 1

ESRP2 epithelial splicing regulatory protein 2 ETFA electron transfer flavoprotein alpha subunit ETFB electron transfer flavoprotein beta subunit ETFDH electron transfer flavoprotein dehydrogenase

ETHE1 ETHE1, persulfide dioxygenase

Etnk2 ethanolamine kinase 2

EVI2A ecotropic viral integration site 2A

EXO1 exonuclease 1

EXTL1 exostosin like glycosyltransferase 1

EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit

F10 coagulation factor X

F11 coagulation factor XI

F11R F11 receptor

F12 coagulation factor XII

F13A1 coagulation factor XIII A chain F13b coagulation factor XIII B chain

F2 coagulation factor II, thrombin

F2R coagulation factor II thrombin receptor

F5 coagulation factor V

F7 coagulation factor VII

F9 coagulation factor IX

FAAH fatty acid amide hydrolase

FABP1 fatty acid binding protein 1 FABP7 fatty acid binding protein 7

FADS1 fatty acid desaturase 1

FADS2 fatty acid desaturase 2

(31)

FADS6 fatty acid desaturase 6

FAH fumarylacetoacetate hydrolase

FAM105A family with sequence similarity 105 member A FAM111A family with sequence similarity 111 member A FAM117A family with sequence similarity 117 member A FAM126A family with sequence similarity 126 member A FAM134B family with sequence similarity 134 member B Fam169b family with sequence similarity 169, member B FAM188A family with sequence similarity 188 member A FAM213A family with sequence similarity 213 member A FAM3A family with sequence similarity 3 member A FAM49B family with sequence similarity 49 member B FAM84B family with sequence similarity 84 member B FAM8A1 family with sequence similarity 8 member A1 FANCD2 Fanconi anemia complementation group D2

FAR1 fatty acyl-CoA reductase 1

FAR2 fatty acyl-CoA reductase 2

FARP2 FERM, ARH/RhoGEF and pleckstrin domain protein 2

FBP1 fructose-bisphosphatase 1

FBXO5 F-box protein 5

FBXO8 F-box protein 8

FCER1G Fc fragment of IgE receptor Ig FCGR1A Fc fragment of IgG receptor Ia FCGR2B Fc fragment of IgG receptor IIb

FCHSD2 FCH and double SH3 domains 2

FCN1 ficolin 1

FDFT1 farnesyl-diphosphate farnesyltransferase 1

FERMT2 fermitin family member 2

FERMT3 fermitin family member 3

FETUB fetuin B

FGA fibrinogen alpha chain

FGF21 fibroblast growth factor 21 FGFR2 fibroblast growth factor receptor 2

FGG fibrinogen gamma chain

FGGY FGGY carbohydrate kinase domain containing

FGL1 fibrinogen like 1

FHDC1 FH2 domain containing 1

FITM2 fat storage inducing transmembrane protein 2

FKBP8 FK506 binding protein 8

FLI1 Fli-1 protooncogene, ETS transcription factor

FLNA filamin A

(32)

Fmnl1 formin-like 1

FMO1 flavin containing monooxygenase 1 FMO3 flavin containing monooxygenase 3 FMO5 flavin containing monooxygenase 5

FN1 fibronectin 1

Fn3k fructosamine 3 kinase

FOXA1 forkhead box A1

Foxn3 forkhead box N3

FOXO1 forkhead box O1

FTCD formimidoyltransferase cyclodeaminase FURIN furin, paired basic amino acid cleaving enzyme

FUT2 fucosyltransferase 2

FXYD1 FXYD domain containing ion transport regulator 1 FXYD5 FXYD domain containing ion transport regulator 5

FYB FYN binding protein

FZD4 frizzled class receptor 4

FZD8 frizzled class receptor 8

G6PC glucose-6-phosphatase catalytic subunit G6PC3 glucose-6-phosphatase catalytic subunit 3 GABARAPL1 GABA type A receptor associated protein like 1 GADD45G growth arrest and DNA damage inducible gamma

GALM galactose mutarotase

GAMT guanidinoacetate N-methyltransferase

GAS2 growth arrest specific 2

GAS6 growth arrest specific 6

GATA1 GATA binding protein 1

GBE1 1,4-alpha-glucan branching enzyme 1

GC GC, vitamin D binding protein

GCA grancalcin

GCDH glutaryl-CoA dehydrogenase

GCGR glucagon receptor

GCK glucokinase

GCSH glycine cleavage system protein H GDF15 growth differentiation factor 15

GFI1B growth factor independent 1B transcriptional repressor

GFRA1 GDNF family receptor alpha 1

GGCT gamma-glutamylcyclotransferase

GGCX gamma-glutamyl carboxylase

GHR growth hormone receptor

GJB1 gap junction protein beta 1

(33)

Gk glycerol kinase

GLDC glycine decarboxylase

GLIPR1 GLI pathogenesis related 1 GLIPR2 GLI pathogenesis related 2

GLS glutaminase

GLS2 glutaminase 2

GLTP glycolipid transfer protein

GLTPD2 glycolipid transfer protein domain containing 2

GLUD1 glutamate dehydrogenase 1

GLYAT glycine-N-acyltransferase

Gm12253 predicted gene 12253

Gm4756 predicted gene 4756

Gm4758 predicted gene 4758

GMFG glia maturation factor gamma

GMPR guanosine monophosphate reductase GNAI2 G protein subunit alpha i2

GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gnmt/LOC100911564 glycine N-methyltransferase

GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 GNS glucosamine (N-acetyl)-6-sulfatase

GOT1 glutamic-oxaloacetic transaminase 1 GP1BA glycoprotein Ib platelet alpha subunit GP1BB glycoprotein Ib platelet beta subunit GP1BB glycoprotein Ib platelet beta subunit

GPAM glycerol-3-phosphate acyltransferase, mitochondrial

GPC3 glypican 3

GPC4 glypican 4

GPD1 glycerol-3-phosphate dehydrogenase 1

GPHN gephyrin

GPLD1 glycosylphosphatidylinositol specific phospholipase D1

GPNMB glycoprotein nmb

GPR4 G protein-coupled receptor 4

GPRC5C G protein-coupled receptor class C group 5 member C GPRC5C G protein-coupled receptor class C group 5 member C

GPT glutamic--pyruvic transaminase

GPT2 glutamic--pyruvic transaminase 2

GRAMD1C GRAM domain containing 1C

GRAP2 GRB2-related adaptor protein 2

GRB10 growth factor receptor bound protein 10 GRB14 growth factor receptor bound protein 14

GREB1L growth regulation by estrogen in breast cancer 1 like

(34)

GRHPR glyoxylate and hydroxypyruvate reductase

GSN gelsolin

GSTA1 glutathione S-transferase alpha 1 GSTA1 glutathione S-transferase alpha 1 GSTA3 glutathione S-transferase alpha 3 GSTK1 glutathione S-transferase kappa 1 GSTM1 glutathione S-transferase mu 1 GSTM2 glutathione S-transferase mu 2 Gstm3 glutathione S-transferase, mu 3 GSTM4 glutathione S-transferase mu 4 GSTM5 glutathione S-transferase mu 5 Gstp3 glutathione S-transferase pi 3 Gstt1 glutathione S-transferase, theta 1

GSTT2/GSTT2B glutathione S-transferase theta 2 (gene/pseudogene) Gstt3 glutathione S-transferase, theta 3

Gucy1b2 guanylate cyclase 1, soluble, beta 2

Gulo gulonolactone (L-) oxidase

GYG1 glycogenin 1

GYS2 glycogen synthase 2

H19 H19, imprinted maternally expressed transcript (non-protein coding) H19 H19, imprinted maternally expressed transcript (non-protein coding)

H2AFX H2A histone family member X

H2AFZ H2A histone family member Z

H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase HAAO 3-hydroxyanthranilate 3,4-dioxygenase

HABP2 hyaluronan binding protein 2

HACL1 2-hydroxyacyl-CoA lyase 1

HADH hydroxyacyl-CoA dehydrogenase

HAGH hydroxyacylglutathione hydrolase

HAL histidine ammonia-lyase

Hamp hepcidin antimicrobial peptide

HAO1 hydroxyacid oxidase 1

HAO2 hydroxyacid oxidase 2

HAT1 histone acetyltransferase 1

HBB hemoglobin subunit beta

HBE1 hemoglobin subunit epsilon 1

HBG2 hemoglobin subunit gamma 2

Hbq1 hemoglobin, theta 1

HDC histidine decarboxylase

(35)

HDHD3 haloacid dehalogenase like hydrolase domain containing 3

HEATR5A HEAT repeat containing 5A

HEMGN hemogen

HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 HES1 hes family bHLH transcription factor 1

HEXA hexosaminidase subunit alpha

HFE hemochromatosis

HFE2 hemochromatosis type 2 (juvenile)

HGD homogentisate 1,2-dioxygenase

HGFAC HGF activator

HHEX hematopoietically expressed homeobox HIBADH 3-hydroxyisobutyrate dehydrogenase HIBCH 3-hydroxyisobutyryl-CoA hydrolase HIF3A hypoxia inducible factor 3 alpha subunit HINT2 histidine triad nucleotide binding protein 2 Hist1h1a histone cluster 1, H1a

Hist1h1b histone cluster 1, H1b

HIST1H2AB histone cluster 1 H2A family member b HIST1H2AC histone cluster 1 H2A family member c HIST1H2AH histone cluster 1 H2A family member h Hist1h2bb histone cluster 1, H2bb

HIST1H2BD histone cluster 1 H2B family member d HIST1H2BG histone cluster 1 H2B family member g HIST1H2BI histone cluster 1 H2B family member i Hist1h2bl histone cluster 1, H2bl

Hist1h2bl histone cluster 1, H2bl

HIST1H3G histone cluster 1 H3 family member g HIST1H3G histone cluster 1 H3 family member g HIST1H3G histone cluster 1 H3 family member g HIST1H4B histone cluster 1 H4 family member b HIST1H4J histone cluster 1 H4 family member j HIST1H4J histone cluster 1 H4 family member j HIST1H4J histone cluster 1 H4 family member j HIST1H4J histone cluster 1 H4 family member j HIST2H2AB histone cluster 2 H2A family member b HIST2H2AB histone cluster 2 H2A family member b HIST2H2AB histone cluster 2 H2A family member b Hist2h2bb histone cluster 2, H2bb

HJURP Holliday junction recognition protein

HLA-E major histocompatibility complex, class I, E

(36)

HMBS hydroxymethylbilane synthase Hmgb2 (includes others) high mobility group box 2 Hmgb2 (includes others) high mobility group box 2 Hmgb2 (includes others) high mobility group box 2 Hmgb2 (includes others) high mobility group box 2

HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 Hmgn2 (includes others) high mobility group nucleosomal binding domain 2 Hmgn2 (includes others) high mobility group nucleosomal binding domain 2 HMMR hyaluronan mediated motility receptor

HNF4A hepatocyte nuclear factor 4 alpha HNF4G hepatocyte nuclear factor 4 gamma

HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1

HOPX HOP homeobox

HP haptoglobin

HPD 4-hydroxyphenylpyruvate dioxygenase

HPN hepsin

HPX hemopexin

Hrg histidine-rich glycoprotein

HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 HSD17B11 hydroxysteroid 17-beta dehydrogenase 11 HSD17B13 hydroxysteroid 17-beta dehydrogenase 13 HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 HSD17B4 hydroxysteroid 17-beta dehydrogenase 4 Hsd17b6/LOC100362350 hydroxysteroid (17-beta) dehydrogenase 6 Hsd17b6/LOC100362350 hydroxysteroid (17-beta) dehydrogenase 6

Hsd3b4 (includes others) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 HSF2 heat shock transcription factor 2

HSPA13 heat shock protein family A (Hsp70) member 13 HSPB8 heat shock protein family B (small) member 8

HTRA1 HtrA serine peptidase 1

HYAL1 hyaluronoglucosaminidase 1

IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog ICOSLG/LOC102723996 inducible T cell costimulator ligand

ID2 inhibitor of DNA binding 2, HLH protein

IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic

IFFO2 intermediate filament family orphan 2