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PDF Fragment-based screening and discovery of small ... - Vanderbilt University

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Figure 1-1. The cancer immunity cycle.
Figure 1-2. Co-inhibitory and co-stimulatory receptors that regulate T cell function.
Figure 1-3. Immune-related toxicities in patients treated with antibody immune checkpoint blockade single agent and combination therapy
Figure 2-1. TIGIT inhibits the Cancer Immunity Cycle at several steps.
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TIGIT negatively regulates several steps in the cancer immunity cycle Reexamination of fragment binding to TIGIT WT TIM-3 structure and function Co-crystal structures of fragment hits bound to TIM-3 Concluding Remarks

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