CHIE KOJIMA
4.8 Conclusion
Dendrimers are unique and well-defined materials. Their molecular weight and chemical composition are theoretically defined, and the characterization of newly synthesized compounds is relatively easy. It is worthwhile to develop functional nanoparticles based on dendritic polymers. Dendrimers are particularly useful for systematic synthesis and the investigation of functional macromolecules. The design of functional dendritic nanoparticles is important for the next generation of DDSs,i.e. stimuli-responsive DDSs. This chapter summarizes the various functional dendritic polymers that can be prepared incorporating temperature-, photo-, pH-, redox- and enzyme-sensitive moieties for drug delivery. Improvement of functional dendritic polymers is required to make them more effective in vivo. From a practical point of view, a disadvantage of dendrimers is their high cost. Hyperbranched polymers are a useful alternative to dendrimers, because they are simple to synthesize and have a similar globular structure. Temperature-sensitive and pH-sensitive hyperbranched polymers have been reported by several groups.12,126–131It is expected that in the future, dendritic and hyperbranched polymers will expand to develop potential novel drug carriers.
Acknowledgements
I thank Ms. Noriko Tano for her help with figure preparation and reference arrangement.
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