• Tidak ada hasil yang ditemukan

PENUTUP

3.1 Kesimpulan

Flavonoid adalah metabolit sekunder dari polifenol, ditemukan secara luas pada tanaman serta makanan dan memiliki berbagai efek bioaktif termasuk anti virus, anti-inflamasi, kardioprotektif, antidiabetes, anti kanker, anti penuaan, antioksidan dan lain-lain. Senyawa flavonoid adalah senyawa polifenol yang mempunyai 15 atom karbon yang tersusun dalam konfigurasi C6-C3-C6, artinya kerangka karbonnya terdiri atas dua gugus C6 (cincin benzena tersubstitusi) disambungkan oleh rantai alifatik tiga karbon. Struktur senyawa flavonoid secara biosintesis berasal dari penggabungan jalur sikimat C6-C3 (cincin A) dan jalur asetat malonat. Adapun klasifikasi dari flavonoid yaitu: true flavonoids (2-phenylbenzopyrans), isoflavonoids (3-benzopyranes) dan neoflavonoids (2-benzopyranes). Penggolongan flavonoid berdasarkan jenis ikatan, yaitu flavonoid o-glikosida, flavonoid c-glikosida, biflavonoid dan flavonoid sulfat.

Setiap tumbuhan umumnya mengandung satu atau lebih senyawa kelompok flavonoid dan memiliki komposisi kandungan flavonoid yang khas. Flavonoid terdapat hampir di semua bagian tumbuhan, seperti daun, akar, kulit tepung sari, nektar, bunga, buah dan biji.

3.2 Saran

Sebaiknya, untuk memahami lebih dalam lagi mengenai karakteristik metabolit sekunder flavonoid, harus membaca lebih banyak literatur serta jurnal- jurnal terbaru terkait materi ini agar mendapatkan wawasan yang lebih luas.

29 DAFTAR PUSTAKA

Agrawal, A.D., 2011, Pharmacological activity of flavonoids: A Review., Int. J.

Pahrmaceut. Sci. Nano., 4(2): 1394–1398.

Akhlaghi, M. dan Foshati, S., 2017, Bioavailability and Metabolism of Flavonoids:

A Review, International Journal of Nutrition Sciences, 2(4): 180-184.

Ameer, K., Shahbaz, H.M., dan Kwon, J.H., 2017, Green Extraction Methods for Polyphenols from Plant Matrices and Their Byproducts: A Review, Comprehensive Review Food Science and Food Safety, 16(2); 1-21.

Awoufack, M.D., Tane, P., dan Morita, H., 2017, Isolation and Structure Characterization of Flavonoids, IntechOpen, London.

Basli, A. Soulet, S. Chaher, N., Mérillon, J.M., Chibane, M., Monti, J.P., dan Richard, T., 2012, Wine polyphenols: Potential agents in neuroprotection, Oxidative Med. Cell. Longev, 1-14.

Batiha G.E., Beshbishy A.M., Ikram M., Mulla Z.S., El-Hack M.E.A.E., Taha A.E., Algammal A.M., dan Elewa Y.H.A., 2020, The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of The Major Natural Polyphenolic Flavonoid: Quercetin. Foods. 9:374.

Brodowska, K.M., 2017, Natural Flavonoids: Classification, Potential Role, and Application of Flavonoid Analogues, Eur. J. Bioological Res, 7(1): 108–

123.

Cassidy A., 2018 Berry anthocyanin intake and cardiovascular health, MolAsp Med, 61(1); 76–82.

Chaves, J.O., Souza, M.C., Silva, L.C., Lachos-Perez, D., Torres-Mayanga, P.C., Machado, A.P.F., Forster-Carneiro, T., Vasques-Espinosa, M., Gonzales- de-Peredo, A.V., dan Barbero, G.F., 2020, Extraction of Flavanoids from Natural Sources Using Modern Techniques, Front. Chem, 8: 1-25.

Chen, L., Cao, H., Huang, Q., Xiao, J., and Teng, H., 2021, Absorption, Metabolism and Bioavailability of Flavonoids: a Review, Critical Reviews in Food Science and Nutrition, 1(1): 1-13.

Ciumărnean L., Milaciu M.V., Runcan O., Vesa S.C., Răchis A.L., Negrean V., Perné M.G., Donca V.I., Alexescu T.G.M., and Para I., 2020, The effects of flavonoids in cardiovascular diseases, Molecules, ;25(1); 1-18.

Cortez, R.; luna-Vital, DA; Margulis, D.; Mejia, EG Pigmen alami: Metode stabilisasi antosianin untuk aplikasi makanan. Kompr. Pdt. Ilmu Pangan.

Makanan Saf.2017,16, 180–198.

30 D'Amelia V., Aversano R., Chiaiese P., and Carputo D., 2018, the antioxidant properties of Plant Flavonoids: Their exploitation by molecular plant breeding, Phytochem,17(1); 611–625.

Dias, M.C., Pinto, D.C.G.A., dan Silva, A.M.S, 2021, Plant Flavonoids: Chemical Characteristics and Biological Activity, Molecules, 26(5377): 1-16.

Dwyer, J.T., dan Peterson, J., 2013, Tea and flavonoids: Where we are, where to go next, Am. J. Clin. Nutr. 98(6): 1611S–1618S.

Ginwala R., Bhavsar R., Chigbu D.G.I., Jain P., and Khan Z.K., 2019, Potential Role Of Flavonoids In Treating Chronic Inflammatory Diseases With A Special Focus On The Anti-Inflammatory Activity Of Apigenin. Antioxidants 8(35); 1-30.

Gonzales, G.B., Smagghe, G., Grootaert, C., Zotti, M., Raes, K., and Camp, J.V., 2015, Flavonoid Interactions During Digestion, Absorption, Distribution and Metabolism: A Sequential Structure–Activity/Property Relationship- Based Approach in The Study of Bioavailability and Bioactivity, Drug Metabolism Reviews, 1(1): 1-16.

Górniak I., Bartoszewski R., and Króliczewski J., 2019, Comprehensive review of antimicrobial activities of plant flavonoids, Phytochem Rev, 18(1); 241–

272.

Harborne J.B. dan Baxter H., 1999, The Handbook of Natural Flavonoids. Volume 1 John Wiley & Sons; Chichester, UK.

Harborne, J.B., Mabry, T.J., dan Mabry, H., 2013, The Flavonoids, Springer, Berlin.

Hathway DE. 1992. The Condensed Tannins. In Wood Extractives (Hillis W. E).

Academic Press. New York.

Hollman, P.C.H., 2004, Absorption, Bioavailability, and Metabolism of Flavonoids, Pharmaceutical Biology, 42(1): 74-83.

Huvaere, K., dan Skibsted, L.H., 2015 Flavonoids protecting food and beverages against light, J. Sci. Food Agric., 95(1): 20–35.

Khoo, H.E., Azlan, A., Tang, S.T., dan Lim, S.M., 2017, Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits, Food Nutr. Res., 61(1): 1-22.

Ku, Y., Ng, M., Cheng, S., Lo, A.W., Xiao, Z., Shin, T., Chung, G., dan Lam, H., 2020, Understanding the Composition, Biosynthesis, Accumulation and Transport of Flavonoids in Crops for the Promotion of Crops as Healthy

31 Sources of Flavonoids for Human Consumption, Journal MDPI, 12(1717):

2-23.

Kumar S., and Pandey A.K., 2013, Chemistry and biological activities of flavonoids: An Overview. Sci. World J. 2013(1); 1-17.

Matthies, A., Clavel, T., dan Gütschow, M., 2008, Conversion of Daidzein and Genistein by an Anaerobic Bacterium Newly Isolated from The Mouse Intestine, Appl Envrion Microbiol, 74(1): 4847–4852.

Martins, S., Mussatto, S.I., Martinez-Avila, G., Montanez-Saenz, J., Aguilar, C.N., dan Teixeira, J.A., 2011, Bioactibe Phenolic Compounds: Production and Extraction by Solid-State Fermentation, Biotechnology Adv, 29(3): 365- 373.

Oliveira M.R.D., Nabavi S.F., Daglia M., Rastrelli L., and Nabavi S.M., 2016, Epigallocatechin gallate and mitochondria-A story of life and death. Pharmacol Res, 104(1); 70–85.

Panche, A.N., Diwan, A.D., dan Chandra, S.R., 2016, Flavonoid: An Overview, Journal of Nutritional Science, 5(47): 1-15.

Panja, P., 2017, Green Extraction Methods of Food Polyphenols from Vegetable Materials, Curr. Opin. Food Sci., 23: 173-182.

Pourakbari R., Taher S.M., Mosayyebi B., Ayoubi-Joshaghani M.H., Ahmadi H., and Aghebati-Maleki L., 2020, Implications for glycosylated compounds and their anti-cancer effects. Int. J. Biol. Macromol, 163(1); 1323–1332.

Redondo-Blanco, S. Fernández, J., López-Ibáñez, S., Miguélez, E.M., Villar, C.J., dan Lombó, F., 2020, Plant phytochemicals in food preservation: Antifungal bioactivity: A review, J. Food Prot., 83(1): 163–171.

Rintelen, K.V., Arida, E., Hauser, C., 2017, A Review of Bioversity-Related Issues and Challenges in Megadiversi Indonesia and Other Southeast Asian Countries, Research Ideals and Outcomes, 3(20860): 1-16.

Rodríguez-García C., Sánchez-Quesada C., and Gaforio J.J., 2019, Dietary flavonoids as cancer chemopreventive agents: An updated review of human studies. Antioxidants. 8(137); 1-23.

Rosello-Soto, E., Barba, F.J., Lorenzo, J.M., Munekata, P.E.S., Gomez, B., dan Molto, J.C., 2019, Phenolic Profile of Oils Obtained from Horchata Byproducts Assisted by Supercritical-CO2 and its Relationship with Antioxidant and Lipid Oxidation Parameters: Triple TOF-LC-MS-MS Characterization, Food Chem, 274: 865-871.

32 Singh M., Kaur M., dan Silakari O., 2014 Flavones: An Important Scaffold for

Medicinal Chemistry. Eur. J. Med. Chem. 84:206–239.

Soquetta, M.B., Tonato, D., Quadros, M.M., Boeira, C.P., Cichoski, A.J., Terra, L.M., dan Kuhn, R.C., 2019, Ultrasound Extraction of Bioactive Compounds from Citrus reticulata Peel Using Electrolyzed Water, Journal Food Prosecc Preserv, 43(12): 1-9.

Stobiecki, M., dan Kachlicki, P., 2006, Isolation and Identification of Flavonoids, Springer, USA.

Tzanova, M., Atanasov, V., Yaneva, Z., Ivanova, D., dan Dinev, T., 2020, Selectivity of Current Extraction Techniques for Flavanoids from Plant Materials, Processes, 8(10): 1-30.

Vitale, DC; Piazza, C.; Melili, B.; Drago, F.; Salomone, S. Isoflavones: Aktivitas estrogenik, efek biologis dan bioavailabilitas. Eur. J. Metabolisme Obat.

Farmakokinet.2013,38, 15–25.

Vukics, V., dan Guttman, A., 2010, Structural Characterization of Flavonoid Glycosides by Multi-stage Mass Spectrometry, Mass Spectrom Rev., 29(1):

1-16.

Wong, E. Isoflavonoid. DiFlavonoid; Harborne, JB, Mabry, TJ, Mabry, H., Eds.;

Pegas: Boston, MA, AS, 1975.

Wu W., Li R., Li X., He J., Jiang S., Liu S., and Yang J., 2015, Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry, Viruses, 8(6); 1-18.

Xu X., Zhou X.D., and Wu C.D., 2012, Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes, Arch. Oral Biol, 57(1); 678–683.

Yan, Y., Kohli, A., dan Koffas, M.A.G., 2005, Biosynthesis of Natural Flavanones in Saccharomyces cerevisiae, Applied and Enviromental Microbiology , 9(71): 5610-5613.

Zaidun N.H., Thent Z.C., and Latiff A.A., 2018,, Combating oxidative stress disorders with citrus flavonoid: Naringenin. Life Sci. 208(1);111–122.

De Luna, S.L.; Ramírez-Garza, R.E.; Saldívar, S.O.S. Environmentally friendly methods for flavonoid extraction from plant

material: Impact of their operating conditions on yield and antioxidant properties.

Sci. World J. 2020, 2020, 6792069.

Ferdinando, M.D.; Brunetti, C.; Fini, A.; Tattini, M. Flavonoids as antioxidants in plants under abiotic stresses. In Abiotic StressResponses in Plants:

Dokumen terkait