COURSES OF STUDY
52.5. PHARMACOLOGY OF ANTICANCERAND ANTIMICROBIALAGENTS. The relationship between the biology of the mammalian and microbial cell to
the selective action of chemotherapeutic agents will be discussed with emphasis placed on the biological basis of chemotherapy. As fundamental
background the first part of the course will survey the chemistry and biology of nucleic acids and the concept of antimetabolites to nucleic acids. The pharmacology of representative chemotherapeutic agents will then be presented in detail along with consideration of special problems of resistance and toxicity. SPRING. [2.]
Dr. Landon.96 f
VANDERBILT UNIVERSITY
52.6.
PR~JG METABOLISM. Sec~>od a~d Fourth yea~s. The pharmacol?gical impltcatlons of drug metabol1sm wIll be emphasIzed. The enzymatic me- chanisms .of drug biotransf~r~atio~s and ~echniques for their investigationwill
be discussed. PrereqUISIte: BIOchemistry 501. SPRING. Dr. Dint//!.52.7. PSYCHOPHARMACOLOGY.Second and Fourth years. Four separate but related courses will emphasize the neurological, pharmacological, neuro- physiological, neurochemical, and psychological aspects of psychotropic drugs. Besides presenting current theories on the mode of action of psycho- therapeutic drugs, the use of these agents as tools to investigate brain func- tion will also be considered. The significance of available biochemical pharmacological, and behavioral data, with regard to possible psychopatho- logical processes in man, will be critically reviewed. Prerequisite: Anatomy
335.
Individual courses offered include:I. PHARMACOLOGYOF PSYCHOTROPICDRUGS. SPRING.
[2.]
Dr. Sulser.2.. NEUROCHEMICALBASISOF BEHAVIOR. Dr. de Balbian VerJter, Dr. Robi- son, and Dr. Buxbaum. SPRING.
[2.]
(Not offered 1971/72..)3. BEHAVIORAND BEHAVIORALCONTROL TECHNIQUES. FALL. [3] Dr.
Ray. (Not offered 1971/72..)
4.
NEUROPHYSIOLOGY.Dr. Dettbarn and Dr. Buxbaum. (Not offered 1970171.)51.8.
ENDOCRINEPHARMACOLOGY.(32-3-2.)
Second and Fourth year. Em- phasis placed on the mechanism of action of hormones and chemical agents used as substitutes for physiologically occurring hormones. Drugs used to modify action, synthesis, and release of natural hormones will be discussed.Two hours per week. FALL.
[2.]
Dr. Heimberg.530. PHARMACOLOGYOF ANESTHESIA. Fourth year. The objectives of this course are to consider: a) current concepts of general and local anesthetic mechanisms of action in terms of physico-chemical and pharmacologic principles of absorption, distribution, biotransformation, and elimination;
b) toxicologic phenomena such as hepatoxicity of fluorinated agents, nephro- toxicity of methoxyflurane, convulsive activity, malignant hyperthermia, antibiotic-induced paralysis, oxygen toxicity, and other hazards of hyper- baric anesthesia, barbiturates and porphyria, ionic calcium disturbances, etc. Anesthesiology
52.1.
One hour per week. FALL. Dr. Pittinger.56
1. CLERKSIIIP IN CLINICAL PHARMACOLOGY. Fourth year. During the clerkship the students will evaluate patients with general problems in drug therapy, drug toxicity, and drug interactions. In addition, he will partici- pate in the diagnosis and pharmacologic therapy of patients with hyper- tension. He will attend the hypertension clmic and the seminars and rounds of the Clinical Pharmacolo~y Division. (Medicine 571 and Pedi- atrics565).
Full time, six-week unrts. Dr. Niu, Dr. t{filson, Dr. Datu, and Staff.58!.
RESEARCHFELLOWSHIPIN PHARMACOLOGY. Fourth year. The various areas of pharmacology including clinical pharmacology. Full time for twelve or eighteen weeks. FALL& SPRING. Staff.598.
SEMINAR IN NEUROBIOLOGY. (33Ia-33Ib) An interdepartmental seminar involving the Departments of Pharmacology, Psychology, Psy-SCHOOL OF MEDICINE « 97
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chiatry, and Anatomy. The topics covered relate to etiology of mental illness, behavioral psychology, and mechanism of action of drugs which are employed both as psychomimetic a.sents and psychotherapeutic agents.
One hour per week. FALL& SPRING.
LI-I]
Staff.599. SEMINAR IN PHARMACOLOGY. (Boa-Bob) Fourth year. Admission to course by arrangement. One hour per week. FALL&SPRING.
[I-I]
Staff.399. RESEARCH. Experimental and theoretical aspects of the mechanism of action of chemical substances on cell, tissue, and organ function, especially in the following areas: cardiac pharmacology, cancer chemotherapy, anti metabolites as chemotherapeutic agents, metabolic fate of narcotic and tranquilizing drugs, design and synthesis of new molecules as possible chemotherapeutic substances. FALL & SPRING. Hours and credit by ar- rangement. Staff.
Physiology
CHARLES RAWLINSON PARK, M.D., Professor of Physiology and Chairman of the Department
JOHN H. EXTON, M.B., Ch.B., Ph.D., Professor of Physiology,' Investigator, Howard Hughes Medical Institute
H. C. MENG, M.D., Ph.D., Profmor of Physiology JANE H. PARK, Ph.D., Profmor of Physiology
ROBERTL.POST, M.D., Professor of Physiology
EARL W. SUTHERLAND, JR., M.D., Professor of Physiology,' Career Investigator, American Heart Association
OSCAR B. CROFFORD, JR., M.D., Associate Professor of Physiology,' Investigator, Howard Hughes Medical Institute
JOEL G. HARDMAN, Ph.D., Associate Professor of Physiology TETSURO KONO, Ph.D., Associate Professor of Physiology DAVID M. REGEN, Ph.D., Associate Professor of Physiology
GEORGE ALAN ROBISON, Ph.D., Associate Professor of Physiology,' Investigator, Howard Hughes Medical Institute
EDWARD
J.
BATTERSBY, M.D., Assistant Professor of PhysiologyIAN M. BURR, M.D., Assistant Professor of Physiology/ Investigator, Howard Hughes Medical Institute
R. J. Ho, Ph.D., Assistant Profmor of Physiology
L.
WILLIAM McLAIN, JR., M.D., Assistant Professor of Physiology ANTHONYR.
MEANS, Ph.D., Assistant Professor of Physiology PHILIP W. FELTS, M.D., Instrllctor in PhysiologyROGER JOHNSON, Ph.D., Instructor in Physiology
FRANCOISE BASTIDE, Ph.D., Research Associate in Physiology THOMAS CLAUS, Ph.D., Research Associate in Physiology CSABA HEGYVARY, M.D., Research Associate in Physiology
STEPHEN B. LEWIS, M.D., Research Associate in Physiology
MICHIHIKO OGUCHI, M.D., Ph.D., Research Associate in Physiology 98 " VANDERBILT UNIVERSITY
SIMONPELKIS, Ph.D., Research Associate in Physiology/ Visiting Investigator, Howard Hughes Medical Institute
GUENTERSCHULTZ,M.D., Research Associate in Physiology THOMASSODERLlNG,Ph.D., Research Associate in Physiology GOTAROTODA, M.D., Research Associate in Physiology
~The Department of Physiology offers courses leading to the Ph.D.
degree. Courses described below which are numbered in the 300 series are offered primarily for that program but are open to medical students by special arrangement.
501. PHYSIOLOGY. (32.1) This course consists of lectures, conferences, and laboratory work, designed to cover the essentials in physiology for first year medical students. It or its equivalent is also required of all graduate students majoring in physiology. SPRING. [8] Dr.
C.
Park.52.1.
TOPICSIN GENERAL PHYSIOLOGY. First year. The course will start with the basic cellular processes of accumulation, membrane transport, bioelectric potentials, contraction, and secretion from the point of view of elementary applied physical chemistry. The discussion will extend to the operation of these processes in the function of erythrocytes, nerves, sensory receptors, muscles, glands, and excretory organs. When ap- plicable the mechanism of the hormonal control of these cells will be in- cluded. One hour per week. SPRING. Dr. Post.52.2..
LECTURESON RESEARCHPROGRESSIN MOLECULARBIOLOGY. (350a-35ob) Second and Fourth years. A course co-sponsored by the Departments of Microbiology, Physiology, and Molecular Biology, in which members of these and other departments present their own research activities in relation to current problems in their field. First semester: biophysical aspects will be stressed, including the application of modern physicochemical techniques to studies of macromolecules and enzyme action. Second semes- ter: physiological aspects will be stressed, including the molecular basis of the function of specialized tissues, and the mechanisms for metabolic control of gene action and multi-enzyme systems. (Microbiology 52.2.) First and second semesters may be taken independently. Two hours per week.FALL& SPRING. [2.-2.]
581.RESEARCHFELLOWSHIPIN PHYSIOLOGY. Fourth year. Opportunities will
be
available in the fields of membrane transport and intermediary metabolism and in the hormonal control of these processes. Full time for twelve or eighteen weeks. Dr.C.
Park.582..
ADVANCED PHYSIOLOGY. (32.3) Second and Fourth years. This course deals with special topics in physiology and consists of laboratory work and conferences. Prerequisite: 501 or equivalent. Hours and credit by arrangement. FALL&SPRING. Dr.C.
Park and Staff.32.2..
PHYSIOLOGICALTECHNIQUESAND PREPARATIONS.A
course designed for advanced students. Hours and credit by arrangement. Dr.C.
Park.399.
RESEARCH. Staff.SCHOOL OF MEDICINE f 99
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Preventive Medicine & Public Health
ROBERT W. QUINN, M.D., C.M.,
Profeuor of Preventive and Social Medicine and Chairman of the Department of Preventive Medicine and Public HealthRICHARD O. CANNON, M.D.,
Profeuor of HosPital AdministrationALVIN E. KELLER, M.D.,
Clinical Profeuor of Preventive Medicine and Public Health, EmeritusLEWIS B. LEFKOWITZ,JR., M.D.,
Associate Profeuor of Preventive MedicineLEsUE A. FALK, M.D., D.Phil.,
Auociate Clinical Professor of Preventive Medi-cme