Steven Singer
6.9 Summary
Immunity to Giardiais complex. Multiple pathways are involved in elimina- tion of the parasite from the GI tract and in prevention of chronic and recurrent infection. These pathways likely exhibit functional redundancy, such that elim- ination of one pathway still allows the immune system to combat the parasite (Figure 6.4). Conversely, antigenic variation within individual parasite strains, as well as genetic variation among parasite strains, can allowGiardiato circum- vent immunological memory responses. Finally, mechanisms involved in para- site elimination may also contribute to symptoms of the disease. Thus, vaccines that promote immune responses might lead to an increase in symptomatic dis- ease, along with a reduced incidence of infection.
REFERENCES FOR FURTHER READING
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Memory responses
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