3. Wanfang Data knowledge service platform (WanFang Data)

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Supplementary Figure S1. The sensitivity analysis results of the time of mechanical ventilation. (TIFF)

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Supplementary Figure S2. The sensitivity analysis results of time of length of ICU stay.

(TIFF)

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Supplementary Figure S3. The sensitivity analysis results of PCT level. (TIFF)

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Supplementary Figure S4. The sensitivity analysis results of APACKEII score. (TIFF)

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Supplementary Figure S5. The sensitivity analysis results of TNF-α level. (TIFF)

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Supplementary Figure S6. The sensitivity analysis results of IL-6 level. (TIFF)

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Supplementary Table 1. Search Terms

Data base Retrieval strategy

1. CNKI (Search in All Fields)

(Thematic = Xuebijing) and (Thematic = Wusitading) and (Thematic

= Nongduzheng or Thematic = Ganranxingxiuke or Thematic = Nongduxingxiuke) (Exact match)

2. The VIP information resource integration service platform (VIP) (Search in All Fields)

(Title or keywords = “Nongduzheng” or “Ganranxingxiuke” or

“Nongduxingxiuke”) and (Title or keywords = “Xuebijing”) and (Title or keywords = “Wusitading”)

3. Wanfang Data knowledge service platform (WanFang Data)

Title or keywords: (“Nongduzheng” + “Ganranxingxiuke” +

“Nongduxingxiuke”) * Title or keywords: (“Xuebijing”) * Title or keywords: (“Wusitading”) * Date: -2017

4. China Biology Medicine disc (SinoMed)

#6 #3 and #4 and #5

#5 #2 or #1

#4 “Wusitading” [Title/Abstract]

#3 “Xuebijing” [Title/Abstract]

#2 “Nongduzheng” or “Ganranxingxiuke” or

“Nongduxingxiuke” [Title/Abstract]

#1 "Nongduzheng"[Mesh]

5. Pubmed

#6 Add Search ((Xuebijing[Title/Abstract]) AND Ulinastatin[Title/Abstract]) AND (("Sepsis"[Mesh]) OR ((((((((((((((Sepsis[Title/Abstract]) OR Severe

Sepsis[Title/Abstract]) OR Sepsis, Severe[Title/Abstract]) OR Pyemia[Title/Abstract]) OR Pyemias[Title/Abstract]) OR Pyohemia[Title/Abstract]) OR Pyohemias[Title/Abstract]) OR Pyaemia[Title/Abstract]) OR Pyaemias[Title/Abstract]) OR Septicemia[Title/Abstract]) OR Septicemias[Title/Abstract]) OR

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Poisoning, Blood[Title/Abstract]) OR Blood

Poisoning[Title/Abstract]) OR (Blood Poisonings[Title/Abstract]

OR Poisonings, Blood[Title/Abstract])))

#5 Add Search ("Sepsis"[Mesh]) OR

((((((((((((((Sepsis[Title/Abstract]) OR Severe

Sepsis[Title/Abstract]) OR Sepsis, Severe[Title/Abstract]) OR Pyemia[Title/Abstract]) OR Pyemias[Title/Abstract]) OR Pyohemia[Title/Abstract]) OR Pyohemias[Title/Abstract]) OR Pyaemia[Title/Abstract]) OR Pyaemias[Title/Abstract]) OR Septicemia[Title/Abstract]) OR Septicemias[Title/Abstract]) OR Poisoning, Blood[Title/Abstract]) OR Blood

OR Poisonings, Blood[Title/Abstract]))

#4 Add Search Ulinastatin[Title/Abstract]

#3 Add Search Xuebijing[Title/Abstract]

#2 Add Search (((((((((((((Sepsis[Title/Abstract]) OR Severe Sepsis[Title/Abstract]) OR Sepsis, Severe[Title/Abstract]) OR Pyemia[Title/Abstract]) OR Pyemias[Title/Abstract]) OR Pyohemia[Title/Abstract]) OR Pyohemias[Title/Abstract]) OR Pyaemia[Title/Abstract]) OR Pyaemias[Title/Abstract]) OR Septicemia[Title/Abstract]) OR Septicemias[Title/Abstract]) OR Poisoning, Blood[Title/Abstract]) OR Blood

OR Poisonings, Blood[Title/Abstract])

#1 Add Search "Sepsis"[Mesh]

6. Cochrane library

#1 MeSH descriptor: [Sepsis] explode all trees

#2 Sepsis:ti,ab,kw or Pyemias:ti,ab,kw or Pyohemia:ti,ab,kw or Pyohemias:ti,ab,kw or Pyaemia:ti,ab,kw (Word variations have been searched)

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#3 Pyaemias:ti,ab,kw or Septicemia:ti,ab,kw or

Septicemias:ti,ab,kw or Poisoning, Blood:ti,ab,kw or Blood Poisoning:ti,ab,kw (Word variations have been searched)

#4 Blood Poisonings:ti,ab,kw or Poisonings, Blood:ti,ab,kw (Word variations have been searched)

#5 Xuebijing:ti,ab,kw (Word variations have been searched)

#6 Ulinastatin:ti,ab,kw (Word variations have been searched)

#7 #1 or #2 or #3 or #4

#8 #5 and #6 and #7

7. Embase

#1 'sepsis':ab,ti OR 'pyemias':ab,ti OR 'pyohemia':ab,ti OR 'pyohemias':ab,ti OR 'pyaemia':ab,ti OR 'pyaemias':ab,ti OR 'septicemia':ab,ti OR 'septicemias':ab,ti OR 'poisoning, blood':ab,ti OR 'blood poisoning':ab,ti OR 'blood poisonings':ab,ti OR 'poisonings, blood':ab,ti

#2 'xuebijing':ab,ti

#3 'ulinastatin':ab,ti

#4 #1 AND #2 AND #3

8. Web of science

#1 ((((((((((((((theme: (Sepsis) OR theme: (Severe Sepsis)) OR theme:

(Sepsis, Severe)) OR theme: (premia)) OR theme: (pyemia)) OR theme: (pyohemie)) OR theme: (pyohemia)) OR theme:

(praemia)) OR theme: (pyaemia)) OR theme: (Septicemia)) OR theme: (septicemia)) OR theme: (Poisoning, Blood)) OR theme:

(Blood Poisoning)) OR theme: (Blood Poisonings)) OR theme:

(Poisonings, Blood))

#2 theme: (xuejiping)

#3 theme: (Ulinastatin)

#4 #1 AND #12 AND #3