Supplementary Table 2. Flowchart of the systematic literature search conducted on June 6
th2018 and study selection
1 Number of studies identified through database
searching n=2166
Number of additional studies identified through other sources including contact with researchers
n=0
Identfcaton
a Reason for exclusion n=29 n=1 pediatric cohort
n=14 no CTNNB1 mutation type data available n=3 no full text available
n=1 conference abstract n=6 no recurrence data described n=1 no DTF as a main subject n=3 review, no original article
b Number of eligible studies for which IPD were not sought (give reasons) n=8 n=8 overlapping databases (defined as using a cohort from the same institute(s))
c Number participants for whom no data were provided n=385 patients
n=270 corresponding authors not willing to participate
n=115 unknown reasons, possible exclusion by the corresponding authors due to our inclusion criteria
d Number of studies for which IPD were not provided n=3 corresponding authors not willing to participate
e Number participants excluded n=350 Colombo et al.23 (n=179)
Total excluded patients: n=68 Total included patients: n=111 n=32 intra-abdominal DTF
n=29 other treatment than surgery alone n=7 age <18 years
Mussi et al.41 (n=25) Total excluded patients: n=8 Total included patients: n=17 n=1 other treatment than surgery alone n=4 wait and see only
n=1 R2 resection n=2 recurrent tumors
van Broekhoven et al.22 (n=101) Total excluded patients; n=54 Total included patients: n=47 n=40 adjuvant radiotherapy
n=4 other treatment than surgery alone n=6 age <18 years
n=1 other mutation n=3 intra-abdominal DTF Mullen et al.20 (n=115) Total excluded patients; n=52 Total included patients: n=63 n=8 pre-/ post-operative radiotherapy n=2 pre-/ post-operative photon therapy n=13 intra-abdominal DTF
n=10 systemic treatment n=2 second gross resection n=1 other mutation n=6 age <18 years n=10 recurrent tumors
Nishida et al.42 (n=11) Total excluded patients: n=8 Total included patients: n=3
n=8, other treatment than surgery alone Salas et al.49 (n=89)
Total excluded patients n=50 Total included patients: n=39 n=1 other mutation
n=14 age <18 years n=1 recurrence unknown n=31 recurrent tumors n=3 unknown tumor status Kim et al.43 (n=159)
Total excluded patients: n=110 Total included patients: n=49 n=20 other treatment than surgery alone n=10 age <18 years
n=6 other mutation n=15 intra-abdominal DTF n= 1 unknown tumor status n=18 recurrent tumors
n=40 other diagnosis (Dupuytren’s contracture, plantar fibromatosis)
