The main purpose of this proposal is to continue the established high quality doctoral research training in the Department of Biology at IUPUI through the. Given the diverse nature of the discipline of biology, no core classroom courses are required of all students in the program. Students will choose a Research Advisor and form an Advisory Committee during the first year of the Ph.D.
A preliminary written examination in an appropriate subdiscipline within biology will be given at the end of the first year in the Ph.D. The dissertation will be written on an original research topic and submitted as one of the final requirements for the Ph.D. At least three members of the committee (including the research advisor) will be Graduate Faculty members from the Department of Biology.
Deposit of the approved dissertation with the University Graduate School fulfills the requirements for the degree.
Program faculty and administrators a. Program Administration
After the dissertation defense, all deficiencies must be adequately addressed to obtain approval from the Dissertation Research Committee. The candidate will receive the Doctor of Philosophy degree in Integrative Biology from the Indiana University Graduate School. In addition to the full-time faculty, Biology has six active adjunct faculty members (official IUPUI appointments) whose primary appointments are at the IUSM, IUSD, Methodist Research Institute, and Eli Lilly.
We have the libraries on campus at our disposal which were sufficient along with online resources to. Other resources on the technical side are available through core facilities in the School of Natural Sciences and at the IUSM. In addition, the Indiana Clinical and Translational Sciences Institute provides access to core facilities at Purdue University, West Lafayette, Indiana University Bloomington and at the University of Notre Dame.
Other program strengths
PROGRAM RATIONALE 1. Institutional factors
- Student demand
- Transferability
- Access to graduate and professional programs
- Demand and employment factors
- Regional, state and national factors
First position: Post-doc, University of Louisville School of Medicine Current position: Faculty, University of Louisville School of Medicine 1996. Dissertation: Analysis of three biosynthetic ergosterol genes involved in the terminal part of the pathway in Saccharomyces cerevisiae. First Position: Post Doctorate, University of California, Los Angeles Current Position: Faculty, Ohio State University.
First Position: Postdoctoral Fellow, Indiana University School of Medicine Current Position: Senior Regulatory Analyst, i3 Innovus (Indiana). First Position: Postdoctoral, University of Montana/University of Georgia Current Position: Research Assistant Professor, IU School of Medicine 2005 First Position: Postdoctoral, Paracelsus Medical University, Salzburg Current Position: Postdoctoral, Paracelsus Medical University, Salzburg Rachna Sehgal.
First position: Postdoctoral fellow, IU School of Medicine Current position: Postdoctoral fellow, IU School of Medicine 2011.
PROGRAM IMPLEMENTATION AND EVALUATION
The IU schools of medicine and dentistry have research areas in the standard basic sciences with a clear emphasis on the appropriate applied areas of human health. Within the CRBM biology faculty, laboratories work on the regeneration of limbs, liver and spinal cord, induced pluri-potent stem cells (iPS) and the development and repair of the retina. The CRBM is a magnet for graduate interest, as it is one of only a few such centers in the US.
Beyond the uniqueness of CRBM, there are residents of the Indianapolis area with strong interests in graduate education who cannot relocate for marital and other personal reasons. Data about student productivity, awards and placement will be tracked for three to five years afterward. Attracting external awards that provide graduate student support is critical external peer endorsement of the program's effectiveness.
We will closely monitor this parameter and implement mechanisms that have been proven effective nationally, including the mandate of regular meetings of the student with the advisory committee (twice a year).
TABULAR INFORMATION
The role of hormones in growth, development, metabolism, homeostasis and reproduction will be considered. The aim of this course is to gain an understanding of the mechanisms underlying sensory perception at the molecular, cellular and systemic levels. Two important goals of this course are to teach students to effectively use peer-reviewed articles as an important source of information and to make effective and clear presentations.
This course focuses on cellular and molecular concepts of bone and cartilage and applications in bioengineering. Genetic defects in the immune system, immune complex diseases, immune-mediated hypersensitivity reactions and autoimmune diseases will be discussed. Each year, this course rotates between topics such as plant biochemistry, plant genetics, plant physiology, plant molecular genetics, plant omics and plant development.
This course will introduce students to epigenetic phenomena in various organisms, from yeast to humans, and explore the basic molecular biology that governs this level of gene regulation.
Curriculum Vitae
C-terminal polybasic domain of rac mediates isoform-specific regulation of
Characterization of the ERG26 gene from Saccharomyces cerevisiae encoding the C-3 steroid dehydrogenase (C-4 decarboxylase), involved in sterol biosynthesis. Characterization of the ERG27 gene from Saccharomyces cerevisiae encoding the 3-keto-reductase involved in demethylation of C-4 sterols. Isolation, characterization and regulation of the Candida albicans ERG27 gene encoding the sterol-3-keto-reductase.
Cloning and sequencing of the Candida albicans C-4 gene for sterol methyl oxidase (ERG25) and expression of ERG25 conditional lethal mutations in Saccharomyces cerevisiae. Isolation, characterization and regulation of the Candida albicans ERG27 gene encoding sterol 3-keto reductase. Isolation, characterization and regulation of the Candida albicans ERG27 gene encoding sterol 3-keto reductase.
Nan Jia, Cloning and Characterization of the ERG27 and ERG24 geners in the Yeast Candida albicans, August 2001. Saccharomyces cerevisiae and the Cloning and Characterization of the C-4 Sterol Methyloxidase Gene (ERG25) from Candida albicans, August 2000.
COURSE ASSIGNMENTS
University of Chicago, University Pre-doctoral Fellowship one of 4 awarded to the Division of Biological Sciences and the Pritzker School of Medicine). Living material experimental developmental biology course consisting of laboratories at the tissue, cellular and subcellular level written by Dr. Includes reading of primary research articles Experiments added and changed as needed. Munck) O'Hara, Purdue University Program, "The role of ependymal cells in the remodeling of injured axolotl spinal cord", Degree: December, 1992.
S STUDENTS GRADUATED
- Li J, Sato M, Jerome C, Turner CH, Fan Z, Burr DB 2005 Microdamage accumulation in the monkey vertebra does not occur when bone turnover is
- Li J, Burr DB, Turner CH 2002 Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by
- Li J, Mori S, Kaji Y, Kawanishi J, Akiyama T, Norimatsu H 2000 Concentration of bisphosphonate (Incadronate) in callus area and its effects on fracture healing in rats
- Kaji Y, Mori S, Mashiba T, Kawasaki K, Li J, Norimatsu H, Nonaka K 1996 Evaluation of bone mineral densities by DXA and pQCT after short term
Li J, Turner CH 2007 Role of L-Type Voltage-gated Calcium Channel Cav1.3 in Bone Mechanotransduction. Li J, Mori S, Kaji Y, Kawanishi J, Akiyama T, Norimatsu H 2000 Concentration of bisphosphonate (Incadronate) in the callus area and its effects on fracture healing in rats. Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Norimatsu H 1999 Effects of bisphosphonate (YM175) on fracture healing of long bones in rats.
Kaji Y, Mori S, Kawasaki K, Li J, Li C, Kawanishi J, Akiyama T, Norimatsu H 1998 Dagiti panagbalbaliw kadagiti osteoclast kalpasan ti maymaysa a panagipauneg ti incadronate disodium. Li C, Mori S, Li J, Kaji Y, Akiyama T, Kawanishi J, Norimatsu H 1999 Dagiti napaut nga epekto ti incadronate disodium (YM-175) iti pannakaagas ti pannakaburak ti femur ti rata. Ueno K, Akeda M, Mori S, Kaji Y, Li J, Kawanishi J, Akiyama T, Li C, Norimatsu H 1999 Konsentrasion ti incadronate disodium iti tibia ti rata kalpasan ti a.
Li J, Mori S, Kaji Y, Kawanishi J, Li C, Akiyama T, Norimatsu H 1999 Effects of Bisphosphonate on Early Fracture Healing Callus Formation in Rats. Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Akiyama T, Li C, Norimatsu H 1999 Long bone fracture healing under bisphosphonate (YM175) treatment in rats. Kawanishi J, Mori S, Li J, Kaji Y, Akiyama T, Norimatsu H 1998 Factors influencing calcaneus bone mineral density in dialysis patients.
Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Akiyama T, Norimatsu H 1997 Effects of bisphosphonate on rat femoral fracture healing. Kaji Y, Mori S, Kawasaki K, Mashiba T, Li J, Norimatsu H 1997 Single administration of incadronate disodium increases the number of osteoclasts in vivo in mice. Mori S, Li J, Kaji Y, Mashiba T, Kawasaki K, Kawanishi J, Norimatsu H 1997 Effect of incadronate disodium on rat femoral fracture healing.
Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Norimatsu H 1997 Effect of YM-175 on fracture healing in rats: Evaluation by histomorphometric analysis. Kaji Y, Mori S, Kawasaki K, Mashiba T, Li J, Kawanishi J, Norimatsu H 1997 Time course changes in osteoclasts after a single administration of incadronate disodium in rats. Komatsubara S, Mori S, Mashiba T, Otsuka I, Taki M, Kawanishi J, Kaji Y, Li J, Norimatsu H 1996 Prevention of Osteopenia in Neurectomized Sciatic Rats by Preadministration of Incadronate Disodium.
Kawanishi J, Mori S, Mashiba T, Kaji Y, Li J, Norimatsu H 1996 Risk factors related to compressive vertebral fractures in adults.
Professors who had a remarkable and positive influence
Exceptional professors (Top 3) who had a remarkable and positive influence Level 3: Professors who especially influenced the whole course of a student’s life and
I gained my teaching interests and ideas from my experience as a student in China and Japan, and as a researcher in Japan and the United States. As an international student in Japan, I had studied and worked in the fields of Biomedical Engineering and Molecular Biology. Since 2006, I have created two new courses, an undergraduate-level course in the Department of Biomedical Engineering, IUPUI School of Engineering, and a graduate-level course in the.
Because both of these two courses are related to my research interests in bone cell biology and regeneration, I really enjoy teaching these subjects. The course BME352 “Cell/Tissue Behavior and Properties” (3 credits) introduces undergraduate students to the biological principles of cell/tissue behavior and properties. This course is intended to provide basic molecular and cellular mechanisms related to skeletal biology and disorders to graduate students in Biology, Anthropology, and Biomedical Engineering at Indiana University and Purdue and IUPUI, undergraduates in Basic Sciences at the IU School of Medicine and Dentistry, and clinical fellows in Orthopedic Surgery, Rheumatology and Endocrinology.
Mentoring individual students in research in the laboratory is another part of my teaching responsibility. I supervised 22 undergraduate biology students and 2 undergraduate biomedical engineering students, 6 non-thesis graduate students, 4 master's candidates (3 in biology and 1 in biomedical engineering) and 1 Ph.D. candidates. I try very hard to attract students to my lab and help them gain research experience.
In the future, I would like to write a textbook that contains all the materials for each subject, 3) to attract more motivated students to participate in research programs in mine. Currently, our research focuses on the role of Stat3 in bone metabolism and fracture repair, because patients with Stat3 mutations have osteoporosis and pathologic fractures. Ten million people in the US suffer from osteoporosis, a disease of reduced bone mass and debilitating fractures.
Study of the role of Stat3 in bone formation will provide new insight into the molecular mechanisms underlying the anabolic response of bone. Furthermore, because Stat3 is also involved in cancer and cancer metastasis, understanding the role of Stat3 in bone metabolism may help prevent and treat bone cancer metastasis.
