eTable 3. Enrollment results for randomized controlled trials (trials are listed based on date of publication from earliest to latest)

eTable 3. Enrollment results for randomized controlled trials (trials are listed based on date of publication from earliest to latest)

Author, Year of Publication (Reference)

Start Date of Enrollment (month/year)

Study Group

Total Number of

Patients

Mean Age (years)

±SD

Sex # Patients with a Pulmonary or Non- Pulmonary Risk Factor for ALI or ARDS

# Males (%)

# Female

(%) Pulmonary Non-Pulmonary

Gainnier et al, 2004 9/00 Treatment 28 60±18 21 (75) 7 (25) 23 5

Control 28 62±15 20 (71) 8 (29) 22 6

Wheeler et al, 2006 6/00 PA Catheter 513 50±16 277 (54) 236 (46) 323^b 195^b

No PA Catheter 487 50±15 258 (53) 229 (47) 297 190

Tsangaris et al, 2007 2001^a Treatment 8 42±17 NA NA NA NA

Control 8 44±16 NA NA NA NA

Meade et al, 2008 8/00 Treatment 475 55±17 282 (59) 193 (41) 372^b 325^b

Control 508 57±17 307 (60) 201 (40) 425^b 353^b

Mercat et al, 2008 9/02 Treatment 385 60±16 260 (68) 125 (32) 270 115

Control 382 60±15 256 (67) 126 (33) 286 96

Fernandez et al, 2008 9/03 Treatment 21 54±18 12 (57) 9 (43) 13 8

Control 19 55±15 13 (68) 6 (32) 13 6

Talmor et al, 2008 5/04 Treatment 30 55±16 19 (63) 11 (37) 7 23

Control 31 51±23 17 (55) 14 (45) 5 26

Liu et al, 2008 1/05 Treatment 37 52±16 21 (57) 16 (43) 28 9

Control 38 52±19 26 (68) 12 (32) 28 10

Kesecioglu et al, 2009 1/03 Treatment 208 57±16 131 (63) 77 (37) 86 122

Control 210 57±16 138 (66) 72 (44) 79 131

Taccone et al, 2009 2/04 Treatment 168

60±16^c 244 (71)^c 98 (29)^c 224^b,c 102^b,c

Control 174

Huh et al, 2009 7/04 Treatment 30 55±20 18 (60) 12 (40) 19 11

Control 27 62±11 17 (63) 10 (37) 18 9

Xi et al, 2010 3/03 Treatment 55 62±16 38 (69) 17 (31) 25 30

Control 55 66±15 40 (73) 15 (27) 21 34

Papazian et al, 2010 3/06 Treatment 177 58±16 NA NA 142 35

Control 162 58±15 NA NA 123 39

Stapleton et al, 2011 2006^a Treatment 40 49±17 24 (60) 16 (40) 23^b 41^b

Control 48 51±17 33 (69) 15 (31) 18^b 48^b

Mentzelopoulos et al, 2011

2006^b HFO

15 54±20 12 (80) 3 (20) 12 3

HFO-TGI Control

Craig et al, 2011 9/06 Treatment 30 53±17 22 (73) 8 (27) 17 13

Control 30 53±20 22 (73) 8 (27) 17 13

Matthay et al, 2011 8/07 Treatment 152 52±16 85 (56) 67 (44) 96^b 58^b

Control 130 51±16 72 (55) 58 (45) 74^b 57^b

Mentzelopoulos et al, 2012

7/06 Treatment 61 51±18 46 (75) 15 (25) 54 7

Control 64 53±17 47 (73) 17 (27) 48 16

Gao Smith et al, 2012 12/06 Treatment 162 56±17 102 (62) 60 (38) 103 58

Control 164 54±17 110 (67) 54 (33) 105 59

Rice et al, 2012 1/08 Treatment 508 52±17 267 (53) 241 (47) 95 48

Control 492 52±16 243 (49) 249 (51) 93 36

Ferguson et al, 2013 7/07 Treatment 275 55±16 167 (61) 108 (39) NA NA

Control 273 54±16 153 (56) 120 (44) NA NA

Young et al, 2013 12/07 Treatment 398 55±19 256 (64) 142 (36) 302 96

Control 397 56±16 239 (60) 158 (40) 304 93

aPatients may have had more than one risk factor for ALI or ARDS; ^bStart month of enrollment not reported; ^cData not provided for individual study groups; NA - not available;

PA - pulmonary artery; HFO – high frequency oscillation; TGI – tracheal gas insufflation