green sheet
volume thirteen, number thirty-eight
HUNTINGTON'S DISEASE GENE LOCATED
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november 13, 1983
A
long-sought marker for the inheritance of the mysterious Huntington's Disease has been found through a cooperative effort by the Department of Medical Genetics at the I.U. School of Medicine, Massachusetts General Hospital in Boston, and the Hereditary Disease Foundation of California. The gene which causes the disease has been located on human chromosome number four."Of the 2,500 individuals in Indiana at risk for HD who are living in dread,
this test will allow some of them to know, if they wish, whether they are carrying the disease long before symptoms arise," said Dr. P. Michael Conneally, professor of medical genetics and neurology at I.U.
The work required the three-year collaboration of research teams at Massachusetts General Hospital and the I.U. group. Initial studies were done on volunteers who are part of the National Huntington's Disease Roster located at the I.U.
School of Medicine, under the direction of Dr. Conneally. The DNA analysis was done in the Department of Neurology at Massachusetts General with the blood
typing and final genetic analysis carried out under the direction of Dr. Conneally.
Discovery of the gene is the first step toward early diagnosis, more accurate genetic counseling, prevention and hopefully treatment. This is the first human disease gene to be located on a specific chromosome by new technology which allows direct reading of genes or DNA. Undoubtedly, this new technology will be used in the study of numerous other genetic disorders, according to Dr. Joe Christian, I.U. chairman of medical genetics.
Huntington's Disease is an inherited degenerative disease of the brain, sometimes called Huntington's chorea after the jerky or dance-like movements associated with the disease. Another name is Woody Guthrie's disease, named after the famous folk singer who died from it. While the gene is present throughout life, symptoms appear at an average age of 38 and affected individuals live an average of 19 years after showing the first symptoms. Indiana has twice the national incidence of this disorder beca4se of early migration of affected families from the eastern United States.
The research results will be published Thursday (Nov. 17) in Nature, a leading scientific journal published in Great Britain. Announcement of the discovery made national headlines, and Dr. Conneally flew to Boston for a news conference last Tuesday, returning to Indianapolis for a local news conference on Wednesday.
FIRST BIBLER PROFESSOR NAMED
Dr. Otis R. Bowen was named the first Lester D. Bibler Professor of Family Medicine at the I.U. School of Medicine by the I.U. trustees at a meeting in Richmond on Nov. 4. The popular two-term governor joined the School of Medicine faculty as professor and director of undergraduate family practice education in 1981.
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This is the first endowed professorship in the Department of Family Medicine, according to Dr. A. Alan Fischer, department chairman. It has been named for Dr. Bibler because of his long involvement with general and family practice in Indianapolis. He was graduated from the I.U. School of Medicine in 1925 and, after an internship at Methodist Hospital, began his practice in general medicine in Indianapolis. He has been active in the medical school's alumni association and served the organization as treasurer for many years.
Graduated from the School of Medicine in 1942, Dr. Bowen returned to Bremen (Ind.) in 1946 to establish a general practice after serving in the Army Medical Corps.
Elected to the Indiana House of Representatives from Marshall County in 1957, he served through 1972. During his terms as governor, he actively supported programs to ease physician shortages in rural areas and to broaden the state's medical educition system. He has been a member of the clinical faculty at the medical school since 1976.
At the same meeting, the trustees named John T. Hazer, associate professor of psychology, chairman of the Department of Psychology at the Purdue University School of Science at IUPUI. Hazer has been acting chairman. He joined IUPUI in 1975 and has been involved in teaching undergraduate courses, graduate
industrial psychology courses, and research, consulting and university services.
He was graduated from Miami University at Oxford, Ohio, and received his master's and doctorate from Bowling Green (Ohio) State University.
VOLUNTEERS SOUGHT
Two groups are looking for volunteers for unrelated studies. The first, in
the School of Medicine, needs volunteers ages six through 16 to perform pulmonary function tests. Testing will take place in Riley Hospital, Room 293, under the supervision of a physician. Testing is not painful and will be completed in a single one-half day session. A fee of $20 will be given to those who complete the testing. Call David Wyszomierski, M.D., at ext. 7208.
The Oral Health Research Institute of the School of Dentistry is looking for 20 adult (age 18 and over) volunteers to participate in dental hypersensitivity studies. Purpose is to determine the effectiveness, if any, of a single appli- cation of a toothpaste or rinse in reducing hypersensitivity. Eligible persons must have one hypersensitive tooth and a similar tooth which is not hypersensitive.
The hypersensitivity must be associated with gum recession, erosion, or abrasion and cannot be related to the presence of cavities, large fillings or gum disease.
The teeth become uncomfortable when exposed to hot or cold air, foods or beverages.
Participants will receive all toothpastes and toothbrushes necessary for home use during the study and at the end will receive a modest reimbursement for their time. For more information or to participate call ext. 8822 between 9 a.m. and 4 p.m. and ask for Dr. Jackson.
NATIONAL RESEARCH COUNCIL ANNOUNCES PROGRAMS
Approximately 250 new full-time associateships will be awarded by the National Research Council on a competitive basis in 1984 for research in chemistry, engineering and mathematics, and in the earth, environmental, physical, space and life sciences. Most are open to both recent Ph.D. degree holders and senior investigators. Stipends for the 1984 program year will range from $24,500 a year for recent Ph.D. 'sup to approximately $50,000 a year for senior associates.
Reimbursement is provided for allowable relocation costs and professional travel.
Applications to the National Research Council must be postmarked no later than Jan. 15, 1984. Initial awards will be announced in March and April.
Information on specific research opportunities and federal laboratories, as well as application materials, may be obtained from Associateship Programs, Office of Scientific and Engineering Personnel, JH 608-Dl, National Research Council, 2101 Constitution Avenue, N.W., Washington, D.C. 20418 (202) 334-2760.
REGISTRATION FOR JANUARY TERM BEGINS
Registration for the spring term that opens Jan. 6 will begin Monday with final registration the first week in January. Stephen Richards, associate director of admissions, urges new students to begin the admission procedure as soon as possible. More than 19,000 continuing students are being notified now by mail about the course registration. "If new students wait until December or January to register some classes may be filled," Richards says.
For more information, call the Office of Admissions, ext. 4591.
!NOTICE!
The Green Sheet continues to receive requests to place classified advertisements for the sale of cars, houses, etc. Such items have not been run in the publication for the past year.
NEWS 'N' NOTES FROM HERE 'N' THERE
Evaluation Launched--The campus-wide evaluation of all non-hospital clerical positions will be launched with a meeting at 2:30 p.m. Monday (Nov. 14) in Lecture Hall 100. Notification has been forwarded to deans and appropriate department heads, managers, and supervisors. The Personnel staff will outline the procedure to be used in the process.
Smokeout--The Great American Smokeout, an annual celebration when the American Cancer Society urges smokers to go a full 24 hours without a cigarette will be held Thursday. Smoking has been shown to be responsible for more than 75 percent of all lung cancer, the number one cancer-killer of men. By the end of the '80s, lung cancer is expected to replace breast cancer as the number one cause of cancer death among women.
New Show at Herron--The Herron Gallery of the Herron School of Art has concluded the faculty exhibition and now is showing "Figurative Ceramics - New Directions"
through Dec. 14.
Remember the Book Sale--Still on through Friday is the annual Christmas book sale at the three Indianapolis Campus Bookstores.
Arts Insight Competition--Arts Insight, Indiana's only statewide newsmagazine for the arts, is sponsoring a competition, "Articulating the Arts," to encourage the development of arts writers throughout the state and to foster critical
writing about Indiana visual and performing artists. Feature and review articles will be considered for publication and winners will receive cash awards. Dead- line is Feb. 5. For information contact Ann Stack, president, or Nancy Smith, project director, 925-5689.
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HONORS
&
ACCOLADESFifty-one employees representing 820 years of service to the University will be presented Service Recognition Pins by Dr. Glenn W. Irwin Jr., vice president of Indiana University for Indianapolis, at a breakfast Tuesday honoring them for 15 and 20 years of continuous service to the institution.
Employees whose service recognition date is between July and December are honored at the November breakfast and those whose service recognition date was between January and June were honored at a breakfast held in May.
20 Years of Service-- Millicent Burnett, Admitting Room, Riley; Anna Cannon, Admitting - Inpatient; Bill Cassell, Bookstore; Della Green, Ball Residence;
Patricia Griswold, Cerebral Palsy; Marjorie Jassman, Neurosurgery; Vera Johnson, Library, School of Medicine; David Turk, Physical Plant/Electric; Gloria Tyson, Environmental Services; Richard Wallace, Physical Plant/Electric; Barbara Wiggles, Radiology.
15 Years of Service--Thomas Alberding, Printing; John Albright, Othotics; Judith Atkins, Occupational Therapy; Wanda Bragg, Executive Dean/Faculties; Rosa Broaden, Union Building/Food; Earl Bryant, Mail Services; Jack Burks, Building Services;
Mary Chitwood, Radiation Oncology; Ronald Coffin, Biochemistry; Emery Cooley, Physical Plant/Electric; Patricia Copp, Radiology; Jose Esquibel, Building
Services; Gary Feist, Respiratory Therapy; Rose Marie Gaither, Dean-Liberal Arts;
Lydia Gardaer, Medical Nursing; John Gilbert, Parking Services; Edwinna Green, Nursing; Betty Hampton, Materials Management; Judith Hawley, Education; Clara Hazelgrove, Pathology; Rebecca Hensel, Purchasing; Lois Howard, Environmental Services; Vilma Humphrey, University Division; James Jones, Building Services;
Kenneth Julian, Ophthalmology; Norma Laken, Patient Accounts; Myron Lockman, Building Services; Anna Logwood, Hospital Cafeteria; Barbara McQueen, Bursar;
Ann Miller, Purchasing; Louise Montgomery, Surgical Nursing; Dorothy Pock, Dean's Office/Nursing; James Potter, IHETS; Linda Potter, Anesthesiology;
Lela Preston, Hospital Accounting; Sarah Shaw, Environmental Service; Janet Spegal, Purchasing; Carol Sue Sproles, Psychiatry; Joan Stevens, Nursing; Sharon Wilson, Psychiatry.
*News Bureau
Indiana University-Purdue University at Indianapolis
355 Lansing Street Indianapolis, Indiana 46202
(ARCH-791205) ARCHIVES
UNIVERSITY LIBRARY 420 BLAKE STREET
university calendar •
NOVEMBER
14 IUPUI BOOKSTORE BOOKSALE, Campus Bookstore - Cavanaugh Hall, 38th Street Bookstore - Krannert Building, Medical Bookstore - Union Building, through 11-18
NEW STUDENT ACADEMIC ORIENTATION AND COUNSELING, 5:30pm, Lecture Hall, Rooms 101, 102; for information 264-3986
TOPS TESTING, 4-lOpm, Lecture Hall, Room 102; for information 264-2629
BIOCHEMISTRY FACULTY SEMINAR: "Mitochondrial DNA in Aging Eukaryotic Cells", Mary Murray, Graduate Student, 4pm, Medical Science Building, Room 326
THE ALBERT E. STERNE PSYCHIATRY PROGRAM, Larue D. Carter Memorial Hospital Institute of Psychiatric Research, through 11-18
NEW EMPLOYEE ORIENTATION, 2pm, Fesler Hall, Hurty Hall C; for information Barbara Jones 264-8931 SPRING SEMESTER CONTINUING STUDENT ANO NEW STUDENT REGISTRATION BEGINS
15 PERSONNEL TRAINING ANO DEVELOPMENT PROGRAM: "University Retirement Pl ans-PERF", 10-Noon, Nursing Building, Room 221; for information Barbara Jones 264-8931
CHEER GUILD EXECUTIVE COUNCIL, GENERAL MEMBERSHIP MEETING, lOam, Cheer Guild Conference Room
STUDENT POLITICAL SCIENCE ASSOCIATION ROUNDTABLE DISCUSSION: "The 1980 Reagan Coal it ion", James Riggs, 4pm, Cavanaugh Hall, Room 439; for information R. Fredland 264-3855
PERSONNEL SEMINAR: "University Retirement Plans: PERF, 10-Noon, Nursing Building, Room 221; for information Barbara Jones 264-8931
JOB SEARCH WORKSHOP, llam, Krannert Science Building, Room B65; for information Mary Jane Koch 264-2554 PERSONAL PRODUCTIVITY/TIME MANAGEMENT WORKSHOP, 9am-4pm, Business/SPEA Building, Room 4095, through
11-17; for information Peggy Zike 264-3418 SCHOOL OF MEDICINE CLASSES ENO
16 BIOCHEMISTRY SEMINAR: "The Protein Phospahtases: Their Properties and Role in Cellular Regulation", Tom Ingebritsen, Department of Pharmacology, School of Medicine, University of Colorado, Denver, 1:30pm, Medical Science Building, Room 326
PHYSIOLOGY SEMINAR: "The Ins and Outs of Bruch Border Membrane Ves i c 1 es", Stephen A. Kempson, Assist ant Professor, Department of Physiology and Biophysics, 4pm, Medical Science Building, Room 205; for information Ann Hollingsworth 264-7772
CHEMISTRY SEMINAR: "Molecular Structure and Dynamics of Interfaces as Revealed by Surface Enhanced Optical Spectroscopy"i Richard P. Van Ouyne, Northwestern University; for information M. Zeldin 923-1321
TOPS TESTING, 4- Opm, Lecture Hall, Room 102; for information 264-2629 17 HERRON OPEN HOUSE, 9-Noon and l-4pm, Herron Auditorium
PERSONNEL TRAINING ANO DEVELOPMENT PROGRAM: "Purchasing Procedures", 9:30-llam, Nursing Building, Room 232;
for information Barbara Jones 264-8931
PEDIATRIC ANO ADULT HEMATOLOGY CONFERENCE: Case Presentations, 3-5pm, Clinical Building, Room 377; for information Robert Baehner 264-8784
PATHOLOGY SEMINAR: "Psycho-social Profile From the Physical Features of Injury", John Pless, University Hospital, Room N436, Noon-lpm; for information Linda Bailey 264-8577
INTRODUCTION TO CLERICAL PROCEDURES: Personnel Action Form (PAF), Brown-Bag Lunch, Union Building, 11:45-12:30pm; for information Roxanne Phillips 264-4537
IUPUI MEN'S BASKETBALL, Oakland City, 7:30pm, there; for information 264-3529
FACULTY FORUM: "Trend Away From Main-Line Churches", Frank Nordby, Evening Administration, Noon-1, Cavanaugh Hall, Room 537; for information 264-2585
18 IHSAA GIRLS SWIMMING AND DIVING CHAMPIONSHIPS, Natatorium, through 11-19; for information 264-3517 BIOLOGY SEMINAR: "Some Aspects of Photosynthesis", Robert Perlstein, Noon, Krannert Science Building,
Room 357; for information Dr. Kathryn Wilson 923-1321 ext. 257
NEW STUDENT ACADEMIC ORIENTATION AND COUNSELING, lpm, Lecture Hall, Room 101, 102; for information 264-3986 UNIVERSITY THEATRE PRODUCTION: "The Runner Stumbles", 8pm, Mary Cable Building Theatre, also 11-19; for
information Della Pacheco 264-2094
IU VS SOUTHERN ILLINOIS: Swimming and Diving, Natatorium, 7pm; for information 264-2725
19 SIX SATURDAYS IN SCIENCE, 9am-Noon, Krannert Building; for information Dean Pat Boaz 923-1321 ext. 317 21 SPRING SEMESTER CONTINUING STUDENT AND NEW STUDENT REGISTRATION BEGINS
TOPS TESTING, 4-lOpm, Lecture Hall, Room 102; for information 264-2629
- - - u n i v e r s i t y calendar, Administration Building, Room
136.Phone:
264-210122 LAST DAY TO WITHDRAW WITH GRADE OF W OR F
BIOCHEMISTRY SEMINAR: "An Investigation of Interaction between Enzymes by Chromatography Immunobilization and Energy Transfer", John Harrison, Professor of Biochemistry, University of North Carolina at Chapel Hill, 4-5pm, Medical Science Building, Room 326
NURSING COLLOQUIUM: "Patient Care Research Colloquium", 8-4:15, Nursing Building; for information Cindy McCune 264-3519
IUPUI MEN'S BASKETBALL, Anderson, 7:30pm, here; for information ·264-3529
23 CHEMISTRY SEMINAR: "Organometallic Chemistry: Certain Lithium Reagents", Basil Wakefield, University of Salford, United Kingdom; for information M. Zeldin 923-1321
THANKSGIVING RECESS, no classes, through 11-27 28 CLASSES RESUME
SCHOOL OF MEDICINE CLASSES BEGIN
NEW EMPLOYEE ORIENTATION, 9am, Fesler Hall, Hurty Hall C; for information Barbara Jones 264-8931 BIOCHEMISTRY SEMINAR: "Modulation of Gene Expression in Salivary Glands\ Don Carlson, Professor of
Biochemistry, Purdue University, 4pm, Medical Science Building, Room 3L6 TOPS TESTING, 4-lOpm, Lecture Hall, Room 102; for information 264-2629 IUPUI MEN'S BASKETBALL, Franklin, 7:30pm, there, for information 264-3529
30 INDIANA UNIVERSITY TAX PRACTITIONER INSTITUTES: "Individual Federal Income Tax Returns, Adam's Mark Hotel, 2544 Executive Drive, Indianapolis, through 12-1; for information Eileen Walters 812/335-5323
CHEMISTRY SEMINAR: "Conformation of Confined Polymer Chains", E. F. Casassa, Carnegie-Mellon; for information M. Zeldin 923-1321
NEW STUDENT ACADEMIC ORIENTATION AND COUNSELING, 5:30pm, Lecture hall, Rooms 101 and 102; for information
264-3986 .
PHYSIOLOGY SEMINAR: "The Relationship between Lynph and Interstitial Fluids", Dr. Julius J. Friedman, 4pm, Medical Science Building, Room 205; for information Ann Hollingsworth 264-1772
IUPUI MEN'S BASKETBALL, Indiana Central, 7:30pm, there; for information 264-3529
DECEMBER
PATHOLOGY SEMINAR: "Human Megakaryocytopoiesis", Ronald Hoffman, Noon-lpm, University Hospital, Room N436; for information Linda Bailey 264-8577
IUPUI FACULTY COUNCIL, 3:30pm, Law School, Room 116; for information Bernice Chumley 264-2215
2 BIOLOGY SEMINAR: "Affinity Labeling of the Phenothiazine Site on Calmodulin", Or. Harry Jarrett, Noon, Krannert Building, Room 357; for information Dr. Kathryn Wilson 923-1321 ext. 257
TOPS TESTING, 10-4pm, Lecture Hall, Room 101; for information 264-2629 IU BOARD OF TRUSTEES MEETING, IUPUI campus; for information R.E. Burton
