Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 1 of 10
Appendix 3. Characteristics of Included Randomized Controlled Trials in Perimenopausal and Postmenopausal Women First
Authors, year
Country Intervention s
Control Population HT use before enrollment
Sample size (Exp/
Con)
Age (Exp/
Con)
Frequency Dose (min)
Outcome Instrument
Acupoints Sleep as primary outcome
SD at enrollment
Baccetti, 2014 [46]
Italy EA+ diet +self- massage training
Diet+ self- massage
Post- menopausal women with amenorrhea 12-24 months
No 47/41 45-56 Weekly twice 30 min sessions for 6 weeks
360 logbook GV23, CV22, BL2, LI11, LI4, SP10, SP6, GV20, CV4, CV6, ST37, LR3
No No
Bao, 2014 [45]
U.S.A. MA SA Breast cancer
with antihormone therapy
UK 23/24 63/62 Weekly 20 min sessions for 8 weeks
160 PSQI CV4, CV6,
CV12, LI4, MH6, GB34, ST36, KI4, BL65
No No
Bokmand, 2013 [6]
Denmark MA SA Breast cancer
with antihormone therapy
No 31/29 60/62 Weekly 15-20 min for 5 weeks
75-100 logbook LR3, KI3, SP6, HC6
Yes Yes
Bokmand, 2013 [6]
Denmark MA Usual care Breast cancer with
antihormone therapy
No 31/34 60/62 Weekly 15-20 min for 5 weeks
75-100 logbook LR3, KI3, SP6, HC6
Yes Yes
Borud, 2010 [7]
Norway MA+
self-care
self- care
Post- menopausal women with amenorrhea of average 4.2 years
Yes 134/13
3
53.5/
54.1
10 individual sessions during 12 weeks
UK WHQ No standard
point
No No
Chen, 2009 [21]
China MA+
herbs
Herbs Peri- menopausal women
UK 30/32 48.9/
48.2 (medi an)
Three times a week for 1 month
UK AIS HT7, SP6, BL15, BL23
Yes Yes
Frisk, 2012 [10]
Sweden EA HT Breast cancer
survivors
UK 27/18 54.1/
53.4
30 min twice a week for the first 2 week, and once a week for 10 weeks
420 WHQ Bil: BL15, BL23, BL32 GV20, HE7, PC6, LR3, SP6, SP9
No No
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 2 of 10
Gao, 2014 [22]
China MA hypnotics Peri- menopausal
No 32/32 49.1/
49.5
Daily 20 min for 24 times
480 PSQI EX-B2 Yes Yes
Guo, 2010 [23]
China MA+ BCFT hypnotics Peri- menopausal women
UK 35/30 51.1/
50.8
Daily 30 min for 20days
400 Response rate
GV20, EX-HN1, Anmian, PC6, HT7
Yes Yes
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 3 of 10
Appendix 3. (continued) First
Authors, year
Country Interventio ns
Controls Population HT use before enrollment
Sample size (Exp/
Con)
Age (Exp/
Con)
Frequency Dose (min)
Outcome Instrument
Acupoints Sleep as primary outcome
SD at enrollment
Hachul, 2013 [8]
Brazil MA SA Post-
menopausal womenwith amenorrhea at least 1 year
No 18
(total)
58/59.8 Weekly twice 30 min for 5 weeks
300 PSQI UK Yes No
Hong, 2012 [24]
China MA+
herbs
Herbs Peri- Menopausal Women
No 45/45 49.9/48
.2
15min sessions every other day for 4 months
840 PSQI, estradiol , LH, FSH
Major: Anmian, EX-HN1, HT7, SP6, BL62, KI6 Adjunctive : KI3, PC7
Yes Yes
Hong, 2012 [25]
China MA Herbs Peri-
menopausal women
No 45/45 48.2/49
.9
15min sessions every other day for 4 months
840 PSQI, estradiol , LH, FSH,
Major: Anmian, EX-HN1, HT7, SP6, BL62, KI6 Adjunctive : KI3, PC7
Yes Yes
Hou, 2011 [26]
China EA +herbs Herbs Post- menopausal women with amenorrhea at least 3 months
No 29/30 48.2/49
.6
Weekly three 30 min for 4 weeks
360 KI, estradiol LH, FSH
Major: ST36, SP6, KI3,LR3, LI4, GV20, EX-CA1 Adjunctive:
HT7, PC6, CV6
No No
Huang, 2006 [9]
U.S.A MA SA Post-
menopausal women with amenorrhea at least 6 months
No 12/17 56.9/53
.7
Weekly twice 20 min for the first 2 weeks, and once a week in the remaining 5 weeks
180 PSQI Kd3, SP6, Ren4, UB23 and Adjunctive acupoints according to secondary symptoms including sleep
Yes No
Ji, 2008 [27]
China MA Hypnotics Peri- menopausal women
No 30/30 45-55 Two 30 min session per weekfor 3 months
720 PSQI BL23, HT7,
SP6, Anmian
Yes Yes
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 4 of 10
Ji, 2009 [28]
China MA Hypnotics Peri-
menopausal women
No 24/24 48-55 Two 30 min session per week for 3 months
720 Response rate, estradiol
BL23, HT7, SP6, Anmian
Yes Yes
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 5 of 10
Appendix 3 (continued) First
Authors, year
Country Interventions Controls Population HT use before enrollme nt
Sample size (Exp/
Con)
Age (Exp/
Con)
Frequency Dose (min)
Outcome Instrument
Acupoints Sleep as primary outcome
SD at enrollment
Li, 2000 [31]
China MA
(plum-blosso m needles)
Oryzanol+
vit B1 + herbs
Peri- menopausal women
UK 50/50 49.5/4
8.6
UK UK Response
rate
Major: BL23 Adjunctive:
GV20, BL15, SP6, KI3, BL15, BL20, CV12, ST36, BL18, BL19, GB20, LR3, BL48, BL47, HT7
Yes Yes
Li, 2005 [30]
China Ventro-acup ucnture + placebo (Eurodin)
Eurodin + SA (Ventro-ac upucnture)
Peri- menopausal women
UK 30/15 47.4/4
7.0
30 min sessions once a day in the first 2 days and then once per 3 days for 3 times.
150 Response rate
Major: CV10, CV12, CV6, CV4 Adjunctive : KI17, ST24, Qi Pang, Lower Rheumatic
Yes Yes
Li, 2006 [29]
China MA
(Plum-bloss om needles)
Oryzanol+
vit B1 + herbs
Peri- menopausal women
UK 66/66 48.5/4
7.9
every other day, 2months
UK Response Rate, estradiol, LH, FSH,
Major: BL23 Adjunctive:
GV20, BL15, SP6, KI3, BL15, BL20, CV12, ST36, BL18, BL19, GB20, LR3, BL48, BL47, HT7
Yes No
Lin, 2009 [32]
China MA HT Peri-
menopausal women
No 30/30 50.3/5
0.5
Daily 30 min session for 90 days
2700 Response rate,
estradiol ,L H, FSH,
Major: CV4, SP4, PC6 Adjunctive:
BL15, PC8, HT7, EX-HN1, GB20, LR3, KI1, KI3, CV6,
No No
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 6 of 10
BL20, ST36 Lu, 2014
[33]
China MA Hypnotics Peri-
menopausal women
UK 52/26 49.7/4
9.3
Daily 30min session for 30 days
900 PSQI GV20, HT7,
CV12, SP15, LR14, SP6, LR3, GB20, EX-HN1
Yes Yes
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 7 of 10
Appendix 3 (continued) 603 First
Authors, year
Country Interventions Controls Population HT use before enrollment
Sample size (Exp/
Con)
Age (Exp/
Con)
Frequency Dose (min)
Outcome Instrument
Acupoints Sleep as primary outcome
SD at enrollment
Lu, 2014 [33]
China MA Hypnotics Peri-
menopausal women
UK 52/26 48.2/49
.3
Daily 30min session for 30 days
900 PSQI GV20, GV16,
GV24, Yingtang, GV14
Yes Yes
Ma, 2014 [44]
China EA (50Hz) Hypnotics Peri- menopausal women
UK 45/45 50.0/50
.4
Three 30 min times a week for 4 weeks
360 PSQI Depressive
three needle, the
stabnlizing (Ding Shen Zeng)
Yes Yes
Pi, 2012 [34]
China Auricular Herbs Peri- menopausal women
UK 28/29 48.6/50
.2
Three 3 min presses a day for 8 weeks
504 PSQI CO15, TF4,
AT4
Yes Yes
Qing, 2001 [35]
China Wrist-ankle acupuncture
Oryzanol+
vit B1 + herbs
Peri- menopausal women
UK 32/32 45.2/46
.2
12-24 hours for 5 times per week for 2 weeks
7200- 14400
Response rate
Upper 1&2 on the palm side(Yin) of the wrist
Yes No
Si, 2013 [36]
China MA+
Auricular
Hypnotics Peri- menopausal women
UK 38/34 49.7/49
.4
MA: daily 30 min sessions for 4 weeks Auricular:
daily press 3-5 times, and 30 min before sleep per night for 4 weeks
UK (1680)
Response rate
KI3, SP6, GV20, EX-HN1, HT7, BL62, KI6 Auricular:
CO15, TF4, CO18, CO12, CO10, AH6a
Yes Yes
Sun, 2013 [37]
China MA Herbs Peri
menopausal women
No 30/30 52.6/52
.5
Daily 30 min for 8 weeks
1680 PSQI Major:
EXCA1, CV3, CV4, CV6, TE17, GB20 Adjunctive:
Yes Yes
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 8 of 10
GV24, GV20, PC6, HT7, SP6, KI3, LR3, GB20
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 9 of 10
Appendix 3 Cont First
Authors, year
Country Interventions Controls Population HT use before enrollment
Sample size (Exp/
Con)
Age (Exp/
Con)
Frequency Dose (min)
Outcome Instrument
Acupoints Sleep as primary outcome
SD at enrollment
Yang, 2013 [38]
China Acupoint sticking therapy
Placebo acupoint sticking therapy
Peri- menopausal women
UK 30/30 50.2/49
.7
6-12 hrs per time, each other day, for 20 times
7200- 14400
Response rate estradiol , LH, FSH,
CV8, CV6, ST36
Yes No
Yao, 2004 [39]
China Scalp acupuncture
Herbs Peri- menopausal women
UK 40/40 50.4/48
.6
Daily 60 min for 20 days
1200 Response rate
MS1, MS8 Yes Yes
Yu, 2011 [40]
China MA Herbs Peri-
menopausal women
UK 72/72 53.2 Daily 30
min session for 20 days
600 Response rate
Major: GV20, SP6, BL13, BL15, BL17, BL18, BL20, BL23, HT7 Adjunctive : BL15, BL20, ST36, SP9, SP6, BL19, GB20, LI4, LR3, CV12, ST40
Yes Yes
Zhao, 2010 [41]
China MA Herbs Peri-
menopausal women
No 30/15 44.7/44
.1
45 min per session for 8 weeks
UK Response rate
UK Yes No
Zhao, 2010
[41] China MA +herbs Herbs Peri-
menopausal women
No 30/15 47.0/44
.1
45 min per session for 8 weeks
UK Response rate
UK Yes No
Zhao, 2012 [42]
China MA HT Peri-
menopausal women
No 30/30 50.2/49
.7
Weekly three 15 min session for 8 weeksnn
360 KI, estradiol , LH, FSH,
Major: SP4, KI12, CV4, CV12, GV20, GV4, GB41, GB28 Adjunctive : KI3, BL23, ST36, SP6, LR3, PC6
No No
Chiu HY, Hsieh YJ, Tsai PS. Acupuncture to reduce sleep disturbances in perimenopausal and postmenopausal women: a meta-analysis. Obstet Gynecol 2016;127.
The authors provided this information as a supplement to their article.
© Copyright 2016 American College of Obstetricians and Gynecologists. Page 10 of 10
Abbreviation: SD= sleep disturbances. MA= manual acupuncture. UK= unknown. NR= not reported. TCMA= Traditional Chinese medicine acupuncture. SA= sham
acupuncture. HT= hormone therapy. KI = Kupperman’s Index. PSQI = Pittsburgh Sleep Quality Index. WHQ = Women's Health Questionnaire. AIS = Athens Insomnia Scale.
KI = Kupperman’s Index. PSQI = Pittsburgh Sleep Quality Index. MA = Manual acupuncture. EA = Electroacupuncture. FSH = follicle-stimulating hormone. LH = luteinizing hormone. BCFT = brain circulation function therapy
Zhu, 2011 [43]
China MA Hypnotics Peri-
menopausal women
UK 30/30 50/51 Treatment duration was 30days
UK Response rate
Major:
Yintang, GV20, EX-HN1, HT7 PC6, anmian Adjunctive:BL 20, BL18, GB44, CV12, LR2, ST40, BL19
Yes Yes
