Supplements
Supplement 1. Search terms utilized for each database.
Database Search Terms
PubMed (((((psychotherapy[Title/Abstract] OR "drug therapy"[Title/Abstract] OR psychoeducation[Title/Abstract] OR pharmacotherapy[Title/Abstract] OR "peer support"[Title/Abstract] OR "cognitive behavioral therapy"[Title/Abstract] OR
therapy[Title/Abstract]) OR (("drug therapy" [Subheading] OR "Drug Therapy"[Mesh]) OR ( "Psychotherapy"[Mesh] OR "Psychotherapy, Group"[Mesh] OR "Psychotherapy, Brief"[Mesh] OR "Interpersonal Psychotherapy"[Mesh] OR "Person-Centered
Psychotherapy"[Mesh] OR "Cognitive Behavioral Therapy"[Mesh] OR "Imagery, Psychotherapy"[Mesh] ))) OR ((Therapeutics[MeSH Terms]) OR
(Therapeutics[Title/Abstract]))) OR (("Psychopharmacology"[Mesh]) OR "Drug Therapy"[Mesh]) OR (medication[Title/Abstract] OR "clinical trial"[Title/Abstract] OR
"treatment trial"[Title/Abstract] OR psychopharmacology[Title/Abstract])) AND ((((pregnant[Title/Abstract] OR pregnancy[Title/Abstract] OR breast
feeding[Title/Abstract]) OR ((("Pregnancy"[Mesh]) OR "Pregnant Women"[Mesh]) OR
"Breast Feeding"[Mesh])) OR (Prenatal Exposure Delayed Effects[MeSH Terms])) OR (Maternal Exposure[MeSH Terms]))) AND ((Medical Marijuana OR Marijuana Use OR Cannabidiol OR Cannabinoids OR Cannabaceae[MeSH Terms]) OR
marinol[Title/Abstract] OR marijuana[Title/Abstract] OR marihuana[Title/Abstract] OR Cannabidiol[Title/Abstract] OR cannabi*[Title/Abstract] OR marijuana[Title/Abstract]
OR Cannabaceae[Title/Abstract] OR cannabigerolic[Title/Abstract] OR cannabichromene[Title/Abstract] OR Cannabigerol[Title/Abstract] OR delta-9- THC[Title/Abstract] OR Tetrahyrdocannabinol*[Title/Abstract] OR
Cannabinoid*[Title/Abstract] OR delta(9)-THC[Title/Abstract] OR 9-ene-
Tetrahydrocannabinol[Title/Abstract] OR Δ-9-tetrahydrocannabinol[Title/Abstract] OR delta(9)-Tetrahydrocannabinol[Title/Abstract] OR Tetrahydrocannabinol[Title/Abstract]
OR 9-tetrahydrocannabinol[Title/Abstract] OR delta-9-
tetrahydrocannabinol[Title/Abstract] OR tetra-hydrocannabinol*[Title/Abstract] OR sativ* OR indica[Title/Abstract] OR tetra-hydrocannabinol*[Title/Abstract])
PsycInfo (psychotherapy OR "drug therapy" OR psychoeducation OR pharmacotherapy OR "peer support" OR "cognitive behavioral therapy" OR therapy OR "Psychotherapy, Group" OR
"Psychotherapy, Brief" OR "Interpersonal Psychotherapy" OR "Person-Centered Psychotherapy" OR "Cognitive Behavioral Therapy" OR "Imagery, Psychotherapy" OR Therapeutics OR "Psychopharmacology" OR medication OR "clinical trial" OR
"treatment trial" OR psychopharmacology) AND (pregnant OR pregnancy OR breast feeding OR "Pregnant Women" OR "Breast Feeding" OR Prenatal Exposure Delayed Effects) AND (Medical Marijuana OR Marijuana Use OR Cannabidiol OR Cannabinoids OR Cannabaceae OR marinol OR marijuana OR marihuana OR Cannabidiol OR
cannabi* OR marijuana OR cannabigerolic OR cannabichromene OR Cannabigerol OR Tetrahyrdocannabinol* OR Cannabinoid* OR 9-ene-Tetrahydrocannabinol OR
Tetrahydrocannabinol OR 9-tetrahydrocannabinol OR tetra-hydrocannabinol*OR sativ*
OR indica OR tetra-hydrocannabinol*.)
Cinhal pregnant women OR pregnant woman OR pregnancy OR pregnant OR expecting mother OR breast feeding OR Prenatal Exposure Delayed Effects OR Maternal Exposure AND Medical Marijuana OR Marijuana Use OR Cannabidiol OR Cannabinoids OR
Cannabaceae OR marinol OR marijuana OR marihuana OR cannabi* OR marijuana OR cannabigerolic OR cannabichromene OR Cannabigerol OR delta-9-THC OR
Tetrahyrdocannabinol*OR Cannabinoid* OR delta(9)-THC OR 9-ene-
Tetrahydrocannabinol OR delta(9)-Tetrahydrocannabinol OR Tetrahydrocannabinol OR
9-tetrahydrocannabinol OR delta-9-tetrahydrocannabinol OR tetra-hydrocannabinol* OR sativ* OR indica OR tetra-hydrocannabinol* AND psychotherapy OR drug therapy OR psychoeducation OR pharmacotherapy OR peer support OR cognitive behavioral therapy OR therapy OR Psychotherapy, Group OR Psychotherapy, Brief OR Interpersonal Psychotherapy OR Person-Centered Psychotherapy OR Cognitive Behavioral Therapy OR Imagery, Psychotherapy OR Therapeutics OR Psychopharmacology OR medication OR clinical trial OR treatment trial
Web of Science
TS=(Medical Marijuana OR Marijuana Use OR Cannabidiol OR Cannabinoids OR Cann abaceae OR marinol OR marijuana OR marihuana OR Cannabidiol OR cannabi* OR ma rijuana OR Cannabaceae OR cannabigerolic OR cannabichromene OR Cannabigerol OR delta-9-THC OR Tetrahyrdocannabinol* OR Cannabinoid* OR delta(9)-THC OR 9-ene- Tetrahydrocannabinol OR Δ-9-tetrahydrocannabinol OR delta(9)-Tetrahydrocannabinol OR Tetrahydrocannabinol OR 9-tetrahydrocannabinol OR delta-9-tetrahydrocannabinol OR tetra-hydrocannabinol* OR sativ* OR indica OR tetra-hydrocannabinol*)
AND
(pregnant OR pregnancy OR breast feeding OR "Pregnant Women" OR "Breast Feeding
" OR Prenatal Exposure Delayed Effects OR Maternal Exposure) AND
psychotherapy OR "drug therapy" OR psychoeducation OR pharmacotherapy OR "peer s upport" OR "cognitive behavioral therapy" OR therapy OR "Psychotherapy, Group"OR "
Psychotherapy, Brief" OR "Interpersonal Psychotherapy" OR "Person-Centered Psychot herapy" OR "Cognitive Behavioral Therapy" OR "Imagery, Psychotherapy" OR Therape utics OR "Psychopharmacology" OR medication OR "clinical trial" OR "treatment trial"
OR psychopharmacology) Scopus ( psychotherapy OR "drug
therapy" OR psychoeducation OR pharmacotherapy OR "peer
support" OR "cognitive behavioral therapy" OR therapy OR "Psychotherapy, Group" OR "Psychotherapy, Brief" OR "Interpersonal Psychotherapy" OR "Person- Centered Psychotherapy" OR "Cognitive Behavioral Therapy" OR "Imagery,
Psychotherapy" OR therapeutics OR "Psychopharmacology" OR medication OR "cl inical trial" OR "treatment
trial" OR psychopharmacology ) AND ( pregnant OR pregnancy OR breast AND feeding OR "Pregnant Women" OR "Breast Feeding" OR prenatal AND exposure AND delayed AND effects OR maternal
AND exposure ) AND ( medical AND marijuana OR marijuana
AND use OR cannabidiol OR cannabinoids OR cannabaceae OR marinol OR mari juana OR marihuana OR cannabidiol OR cannabi OR marijuana OR cannabaceae OR cannabigerolic OR cannabichromene OR cannabigerol OR tetrahyrdocannabinol OR cannabinoid OR 9-ene-tetrahydrocannabinol OR tetrahydrocannabinol OR 9- tetrahydrocannabinol OR sativ OR indica OR tetra-hydrocannabinol ) AND ( LIMI T-TO ( DOCTYPE , "ar" ) OR LIMIT-TO ( DOCTYPE , "re" ) ) AND ( LIMIT-TO ( SRCTYPE , "j" ) )
Cochrane Marijuana pregnant
Supplement 2. Downs and Black scoring for included studies.
Wernette, 2018
Forray, 2015
Barlow, 2015
Yonkers, 2012
Whicher, 2012
Eisen, 2000
Corse, 1998
Palinkas,
Is the hypothesis/aim/objective
of the study clearly described? 1 1 1 1 1 1 0
Are the main outcomes to be measured clearly described in the Introduction or Methods section?
1 1 1 1 1 1 1
Are the characteristics of the patients included in the study
clearly described? 1 1 1 1 1 1 1
Are the interventions of
interest clearly described? 1 0 1 1 1 1 1
Are the distributions of principal confounders in each group of subjects to be compared clearly described?
1 1 1 1 0 0 0
Are the main findings of the
study clearly described? 1 1 1 1 1 1 1
Does the study provide estimates of the random variability in the data for the main outcomes?
1 1 1 1 1 0 1
Have all important adverse events that may be a consequence of the
intervention been reported?
1 1 1 1 1 1 1
Have the characteristics of patients lost to follow-up been
described? 1 1 1 1 0 0 0
Have actual probability values been reported(e.g. 0.035 rather than <0.05) for the main outcomes except where the probability value is less than 0.001?
1 1 1 1 1 0 1
Were the subjects asked to
participate in the study 1 0 1 0 0 1 1
representative of the entire population from which they were recruited?
Were those subjects who were prepared to participate representative of the entire population from which they were recruited?
0 0 0 0 0 0 1
Were the staff, places, and facilities where the
patients were treated, representative of the treatment the majority of patients receive?
1 1 1 1 1 1 1
Was an attempt made to blind study subjects to the
intervention they have received ?
0 0 0 0 0 0 1
Was an attempt made to blind those measuring the main
outcomes of the intervention? 0 0 1 1 0 0 0
If any of the results of the study were based on “data dredging”, was this made clear?
1 1 1 1 1 0 1
In trials and cohort studies, do the analyses
adjust for divergent lengths of follow-up of patients, or in case-control studies, is the time period between the intervention and outcome the same for cases and controls?
1 1 0 1 1 1 0
Were the statistical tests used to assess the main outcomes
appropriate? 1 1 1 1 1 1 1
Was compliance with the intervention/s reliable (Where there was noncompliance with the allocated treatment or where there was
contamination of one group, the question should be answered no)
1 0 1 1 1 1 0
Were the main outcome measures used accurate (valid
and reliable)? 0 1 1 1 1 1 0
Were the patients in different intervention groups (trials and cohort studies) or were the cases and controls (case- control studies) recruited from the same population? The question should be answered unable to determine for cohort and case control studies where there is no information concerning the source of patients included in the study
1 0 1 1 1 1 0
Were study subjects in different intervention groups (trials and cohort studies) or were the cases and controls (case- control studies) recruited over the same period of time?
For a study which does not specify the time period over which patients were recruited, the question should be answered as unable to determine.
1 0 1 1 1 1 1
Were study subjects randomized to intervention groups? Studies which state that subjects were randomized should be answered yes except where method of
randomization would not ensure random allocation. For example alternate allocation would score no because it is predictable
1 0 1 1 0 0 0
Was the randomized intervention assignment concealed from both patients and health care staff until recruitment was complete and irrevocable? All non-
randomized studies should be answered no. If assignment was concealed from patients but not from staff, it should be answered no
0 0 0 1 0 0 0
Was there adequate
adjustment for confounding in the analyses from which the main findings were drawn?
0 0 1 0 0 0 0
Were losses of patients to follow-up taken into account?
If the numbers of patients lost to follow-up are not reported, the question should be answered as unable to determine. If the proportion lost to follow-up was too small to affect the main findings, the question should be answered yes.
1 1 1 1 0 1 0
Did the study have sufficient power to detect a clinically important effect where the probability value for a
difference being due to chance is less than 5%?
1 1 1 1 1 1 1
Total Score 22 16 23 24 17 16 14
