https://links.lww.com/MD/D74

(1)

Table S1 Rate of fracture according to age

Characteristics Total participants

No fracture (n, %) Fracture (n, %) Age (years old)

50-54 27,423 (99.9) 32 (0.1)

55-59 21,862 (99.8) 38 (0.2)

60-64 19,891 (99.6) 89 (0.5)

65-69 19,634 (99.2) 166 (0.8)

70-74 16,906 (98.8) 204 (1.2)

75-79 10,696 (98.0) 214 (2.0)

80-84 5,726 (97.1) 169 (2.9)

85+ 2,877 (98.0) 58 (2.0)

Table S2 Crude hazard ratios (95% confidence interval) of each variable for hip fracture

Characteristics Hazard ratio 95% CI P-value

Depression 1.46 1.27-1.68 <0.001*

Age group 1.57 1.51-1.63 <0.001*

Sex 1.18 1.00-1.38 0.047*

Income 0.98 0.96-1.00 0.107

Region of residence 0.89 0.78-1.01 0.072

Hypertension 1.29 1.09-1.52 0.003*

Diabetes 1.35 1.18-1.54 <0.001*

Dyslipidemia 0.70 0.61-0.81 <0.001*

Ischemic heart disease 1.03 0.86-1.23 0.765

Stroke 1.62 1.42-1.85 <0.001*

Osteoporosis 2.10 1.83-2.42 <0.001*

*Cox-proportional hazard regression model, Significance at P < 0.05

Table S3 The relative hazard ratios between young men and old men subgroups.

Young men Old men

HR 1.23 1.40

*log HR 0.20701 (E1) 0.33647 (E2)

95% CI for HR 0.66 to 2.27 1.01 to 1.94

(2)

*95% CI for log HR -0.41551 to 0.81977 0.00995 to 0.64710

Width of CI 1.23528 0.63715

SE [=width/(2*1.96)] 0.31512 0.16253

Difference between log hazard ratios

d (=E1-E2) -0.12946

SE (d) √(0.31512²+0.16253²) = 0.35456 CI (d) -0.12946 ± 1.96*0.35456 =

-0.82439 to 0.56547

Test of interaction Z = -0.12946/0.35456 = -0.36512 (P =0.72) Ratio of hazard ratio

Relative hazard ratio (RHR)

exp (-0.12946) = 0.88

CI (RHR) 0.44 to 1.76

*Natural logarithms of values on preceding row.

HR, hazard ratio; CI, confidence interval; SE, standard error

Table S4 The relative hazard ratios between young men and old men subgroups.