Kim and Na et al 1 / 3 Table e-1. Comparison of MMSE subdomains among CAA patients with and without cSS and the AD group

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Kim and Na et al 1 / 3

Table e-1. Comparison of MMSE subdomains among CAA patients with and without cSS and the AD group

CAA

AD group p-value cSS(-) group cSS(+) group

MMSE total score 23.6±4.5 22.9±2.9 22.3±4.3 0.221

MMSE subdomain scores

Attention subdomain 2.9±2.0 3.6±1.6 3.5±1.8 0.680

Language subdomain 7.5±0.7 7.3±1.0 7.3±0.9 0.421

Visuospatial subdomain 0.7±0.5 0.8±0.4 0.8±0.4 0.666

Memory subdomain 12.6±2.5^a,c 11.2±2.0^b 10.6±2.5^b 0.007

A four group one-way analysis of covariance (ANCOVA) followed by a LSD post-hoc test was performed using age, sex, and education years as covariates. Continuous variables are expressed as the mean ± standard deviation.

The CN group showed significant differences compared to all other groups.

a Significant difference (p < 0.05) between the CAA with cSS group and the other groups.

b Significant difference (p < 0.05) between the CAA without cSS group and the other groups.

c Significant difference (p < 0.05) between the AD group and the other groups.

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Kim and Na et al 2 / 3

Table e-2. Comparison of hippocampal volume among the four groups

CAA

AD group CN group p-value cSS(-) group cSS(+) group

Left hippocampal

volume, mm³ 3096.7±592.7^a,c 2742.9±659.7^b 2862.1±388.7^b 3655.0±458.6 <0.001 Right hippocampal

volume, mm³ 3201.9±572.1^c 2885.2±651.3 2939.0±608.2^b 3736.5±550.4 <0.001 A four group one-way analysis of covariance (ANCOVA) followed by a LSD post-hoc test was used. Age, sex, education years, and ICV were used as covariates. Continuous variables are expressed as the mean ± standard deviation.

The CN group showed significant differences compared to all other groups.

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Kim and Na et al 3 / 3

Table e-3. Comparison of lobar cortical thickness among the four groups

CAA

AD group CN group p-value cSS(-) group cSS(+) group

Left frontal lobe, mm 2.48±0.10 2.45±0.14^d 2.50±0.09 2.55±0.09â 0.038ê Left parietal lobe, mm 2.28±0.09 2.24±0.18^d 2.23±0.11^d 2.34±0.09â,c 0.004ê Left temporal lobe, mm 2.60±0.12 2.52±0.18^d 2.58±0.17^d 2.74±0.12â,c <0.001ê Left occipital lobe, mm 1.92±0.09 1.91±0.11 1.90±0.10 1.93±0.09 0.424 Right frontal lobe, mm 2.45±0.09^d 2.46±0.14^d 2.48±0.10^d 2.54±0.09â,b,c 0.035ê Right parietal lobe, mm 2.29±0.08 2.24±0.17^d 2.24±0.12^d 2.34±0.09â,c 0.006ê Right temporal lobe, mm 2.68±0.10â 2.56±0.19^b,d 2.61±0.15^d 2.77±0.11â,c <0.001ê Right occipital lobe, mm 1.94±0.08 1.94±0.14 1.93±0.10 1.96±0.09 0.623 A four group one-way analysis of covariance (ANCOVA) followed by a LSD post hoc test was used. Age, sex, education years, and ICV were used as covariates. Continuous variables are expressed as the mean ± standard deviation.

d Significant difference (p < 0.05) between the CN group and the other groups.

e Significant p-values (p < 0.05).