Supplementary Table 1 - Univariate Cox proportional hazards results for progression free survival (PFS) and overall survival (OS) and for all patients and for anaplastic astrocytoma. Dashes represent analyses unable to be performed due to non-convergence. Abbreviations: AA = anaplastic astrocytoma; AO = anaplastic oligodendroglioma; AOA = anaplastic oligoastrocytoma; GTR = gross total resection; HR = hazard ratio; KPS = Karnofsky performance status;
STR = subtotal resection TMZ = temozolomide.
All patients (n=71)
PFS HR 95% CI p-value OS HR 95% CI p-value
Age 1.04 1.01-1.07 0.003 1.05 1.02-1.08 <0.001
Sex 2.51 1.16-5.42 0.02 1.56 0.76-3.2 0.23
Race 0.78 0.11-5.73 0.81 0.73 0.1-5.4 0.76
KPS >70 0.25 0.13-0.5 <0.001 0.25 0.13-0.49 <0.001
AO/AOA histology (vs. AA) 0.3 0.13-0.68 0.004 0.52 0.25-1.08 0.08
Adjuvant TMZ 1.65 0.72-3.8 0.24 1.43 0.64-3.18 0.38
Headache 1.14 0.57-2.27 0.71 0.89 0.43-1.82 0.74
Seizure 0.49 0.24-0.97 0.04 0.46 0.22-0.93 0.03
Enhancement 1.41 0.61-3.27 0.43 1.54 0.66-3.57 0.32
1p/19q co-deletion 0.51 0.1-2.63 0.42 0.48 0.09-2.5 0.38
Concurrent TMZ 0.72 0.37-1.4 0.33 0.66 0.34-1.3 0.23
STR/GTR (vs. biopsy) 0.24 0.12-0.48 <0.001 0.22 0.11-0.44 <0.001 AA (n=42)
Age 1.04 1.01-1.07 0.003 1.04 1.01-1.07 0.006
Sex 1.5 0.63-3.54 0.36 1.38 0.55-3.48 0.50
Race 1.25 0.17-9.32 0.83 1.19 0.16-8.92 0.86
KPS >70 0.27 0.12-0.57 0.001 0.29 0.13-0.65 0.003
Adjuvant TMZ 0.99 0.34-2.87 0.99 0.84 0.29-2.48 0.76
Headache 1.32 0.61-2.88 0.48 1.15 0.49-2.7 0.74
Seizure 0.32 0.13-0.75 0.01 0.45 0.19-1.06 0.07
Enhancement 1.99 0.79-5.02 0.15 2.16 0.79-5.91 0.13
Concurrent TMZ 0.76 0.36-1.63 0.48 0.67 0.3-1.49 0.32
STR/GTR (vs. biopsy) 0.31 0.15-0.67 0.003 0.21 0.09-0.49 <0.001
AO/AOA (n=29)
Age 1.07 1-1.15 0.05 1.09 1.03-1.16 0.002
Sex 4.37 0.8-23.78 0.09 1.59 0.44-5.67 0.48
Race - - - -
KPS >70 0.33 0.06-1.8 0.20 0.24 0.07-0.83 0.02
Adjuvant TMZ 1.2 0.26-5.55 0.81 1.69 0.46-6.17 0.42
Headache 1.14 0.25-5.14 0.86 0.61 0.16-2.36 0.47
Seizure 1.07 0.24-4.81 0.93 0.44 0.11-1.73 0.24
Enhancement 1.09 0.13-9.11 0.94 1.04 0.22-4.9 0.96
1p/19q co-deletion 0.45 0.08-2.56 0.37 0.48 0.09-2.64 0.40
Concurrent TMZ 0.31 0.06-1.62 0.17 0.61 0.17-2.21 0.45
STR/GTR (vs. biopsy) 0.29 0.05-1.58 0.15 0.37 0.07-1.8 0.22
