Supplemental data
Table S1. ABCB1 genotype frequencies in case (n = 347) and control (n =282) groups.
Variant Genotype Suicide [95% CI], (n) Control [95% CI], (n) Fisher’s exact test, p-value
1236C>T C/C 0.27 [0.23-0.32], (94) 0.30 [0.25-0.35], (84) 0.38
C/T 0.48 [0.43-0.53], (167) 0.50 [0.44-0.56], (141)
T/T 0.25 [0.21-0.30], (86) 0.20 [0.16-0.25], (57)
2677G>T/A G/G 0.23 [0.19-0.28], (80) 0.23 [0.19-0.28], (65) 0.37
G/T 0.47 [0.42-0.53], (164) 0.49 (0.43-0.54], (137)
G/A 0.04 [0.02-0.06], (13) 0.05 (0.03-0.08], (14)
T/A 0.04 [ 0.02-0.07], (14) 0.01 [0.01-0.04], (4)
T/T 0.22 [0.18-0.27], (76) 0.22 [0.18-0.27], (62)
3435C>T C/C 0.15 [0.12-0.19], (53) 0.18 [0.14-0.23], (51) 0.62
C/T 0.50 [0.45-0.55], (173) 0.47 [0.41-0.53], (133)
T/T 0.35 [0.30-0.40], (121) 0.35 [0.29-0.40], (98)
Table S2. The effect of ABCB1 TTT haplotype in suicides of citalopram users.
All suicides All suicides with citalopram or escitalopram prescription Variable and reference category P value OR (95% CI) P value OR (95% CI)
ABCB1, CGC/CGC or CGC/XXX
CGC/TTT 0.928 1.02 (0.67-1.55) 0.868 0.96 (0.62-1.49) TTT/TTT, TTT/XXX 0.397 1.19 (0.80-1.77) 0.427 1.18 (0.78-1.78) Other 0.687 0.87 (0.43-1.75) 0.855 0.94 (0.46-1.91)
Table S3. The effect of ABCB1 TTT haplotype in suicides of male citalopram users.
Males Males with citalopram or escitalopram prescription Variable and reference category P value OR (95% CI) P value OR (95% CI)
ABCB1, CGC/CGC or CGC/XXX
CGC/TTT 0.930 0.97 (0.55-1.74) 0.691 0.89 (0.48- 1.62) TTT/TTT, TTT/XXX 0.232 0.72 (0.42-1.23) 0.222 0.71 (0.40- 1.23) Other 0.301 0.60 (0.23-1.59) 0.343 0.61 (0.22- 1.68)
Table S4. The effect of ABCB1 TTT haplotype in violent suicides of female citalopram users.
Violent females Violent females with citalopram or escitalopram prescription
Variable and reference category P value OR (95% CI) P value OR (95% CI)
ABCB1, CGC/CGC or CGC/XXX
CGC/TTT 0.869 0.93 (0.38-2.25) 0.990 1.01 (0.41- 2.47) TTT/TTT, TTT/XXX 0.205 1.71 (0.74-3.95) 0.193 1.76 (0.75- 4.15) Other 0.875 1.13 (0.26-4.88) 0.793 1.22 (0.28- 5.33)
Table S5. The effect of ABCB1 TTT haplotype in non-violent suicides of male citalopram users.
Non-violent males Non-violent males with citalopram or escitalopram prescription Variable and reference category P value OR (95% CI) P value OR (95% CI)
ABCB1, CGC/CGC or CGC/XXX
CGC/TTT 0.269 0.68 (0.34-1.35) 0.181
0.60 (0.29-1.27) TTT/TTT, TTT/XXX 0.133 0.62 (0.33-1.16) 0.167
0.63 (0.33-1.21) Other 0.183 0.43 (0.13-1.49) 0.170
0.38 (0.10-1.51)
Table S6. The effect of ABCB1 TTT haplotype in violent suicides of male citalopram users.
Violent males Violent males with citalopram or escitalopram prescription Variable and reference category P value OR (95% CI) P value OR (95% CI)
ABCB1, CGC/CGC or CGC/XXX
CGC/TTT 0.307 1.45 (0.71-2.95) 0.307 1.45 (0.71-2.95) TTT/TTT, TTT/XXX 0.714 0.88 (0.44-1.75) 0.714 0.88 (0.44-1.75) Other 0.809 0.86 (0.26-2.83) 0.809 0.86 (0.26-2.83)
