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Product Name : Niacinamide
Company Information : Veer-Chemie & Aromatics Private Limited.
A4, Co-operative Industrial Estate,
Balanagar, Hyderabad, 500 037., Telangana, INDIA Phone +91-40-23774064
Emergency Phone No(24 hrs) : +91-40-23774210 Non-Emergency Fax No. : +91-40-23770205
Email : [email protected]
CAS Number : [98-92-0]
Synonyms : Niacinamide
Nicotinamide
3-Pyridine carboxamide Vitamine PP
Characterization : Water soluble B group vitamin
SECTION 2 : COMPOSITION / INFORMATION ON INGREDIENTS Chemical Name : Pyridine-3-carboxylic acid amide
Percentage : ≥ 99%
SECTION 3 : HAZARDS IDENTIFICATION Emergency Overview
Hazard Overview : Irritation to eyes respiratory system & skin
Potential Health Effects : Exposure: Inhalation, Ingestion, Skin contact, Eye contact Target Organs: kidneys, gastrointestinal system
: Acute Effects: May cause eye irritation, May cause skin irritation. May cause respiratory irritation; May cause gastrointestinal effects. Signs and symptoms may include nausea, vomiting, diarrhea, constipation, cramps, and loss of appetite.
: Chronic Effects: May cause liver necrosis (destruction of liver cells)
: Carcinogenicity: not listed by NTP, IARC or OSHA Additional Health Information : Conditions Aggravated: Diabetes, liver conditions and/or
impaired liver function, high blood pressure, gout, ulcers
Page 2 of 6 SECTION 4 : FIRST-AID MEASURES
Eye contact : Rinse immediately with tap water for 10 minutes - open eyelids forcibly.
Consult physician
Skin contact : Remove immediately contaminated clothes, wash affected skin with water and soap - do not use any solvents
Inhalation : Remove the casualty to fresh air and keep him/her calm.
If breathing has stopped, give artificial respiration.
Ingestion : If conscious, induce vomiting to prevent further absorption.
Give oxygen if respiration is shallow. GET MEDICAL ATTENTION. Do not give anything by mouth to an unconscious person
Note to physician : Treat symptomatically SECTION 5 : FIRE-FIGHTING MEASURES
Suitable extinguishing media : Water spray jet, dry powder, foam, carbon dioxide Flash point : 360oF (182oC) Method : Tag open cup.
Specific hazards : Formation of toxic and corrosive combustion gases (nitrogen oxides (NOx)) possible under fire condition
Protection of fire – fighters : Precipitate gases / vapours / mists with water spray Flammability Classification
(OSHA)
: Non-Flammable
Basic Fire Fighting Guidance : Wear self-contained breathing apparatus and protective clothing.
Normal firefighting procedures may be used.
SECTION 6 : ACCIDENTAL RELEASE MEASURES Containment Techniques and
Clean-up Procedures
: Remove all ignition sources. Ventilate the area of spill or leak.
Wear protective equipment during clean-up. Material can then be collected for later disposal. After collection of material, flush area with water. Dispose of the material in accordance with standard practice for disposal of potentially hazardous materials as required by applicable federal, state or local laws.
SECTION 7 : HANDLING AND STORAGE Handling :
Technical measures : Processing in closed systems, if possible superposed by inert gas (e.g. Nitrogen) Local exhaust ventilation necessary.
Take precautionary measures against electrostatic charging Suitable materials : Stainless steel, aluminium, enamel, glass, polyethylene Practices to Minimize Risk : Wear appropriate protective equipment when performing
maintenance on contaminated equipment. Wash hands
thoroughly before eating or smoking after handling this material
Page 3 of 6 Storage :
Storage conditions : Room temperature. Protected from light. Store in a dry place and Ventilated conditions for storage. Keep away from strong acids, strong bases and oxidizing agents. Do not store with poisons.
Packaging materials : Tightly closing; material: glass, aluminum, food-approved plastics
SECTION 8 : EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering Measures : See 7.
Personal protective equipment
Respiratory protection : Respiratory protection is recommended as a precaution to minimize exposure. Effective engineering controls are
considered to be the primary means to control worker exposure.
Respiratory protection should not substitute for feasible engineering controls.
In case of open handling or accidental release :
Particle mask or respiratory with independent air supply Hand protection : Protective gloves
Eye protection : Safety glasses
SECTION 9 : PHYSICAL AND CHEMICAL PROPERTIES
Color : Practically white
Form : Crystalline powder/Granular
Odor : Almost odourless, with bitter taste
Molecular mass : 122.13 g/mol Empirical formula : C6H6N2O
Solubility : 10’000 mg/l, diethyl ether 16’000 mg/l, n-octanol 77’000 mg/l, ethanol absolute 100’000 mg/l, glycerine 660’000 mg/l, ethanol 96 % 691’000 mg/l, water (20 °C)
Partition coefficient : log Pow -0.38 (octanol/water 20 °C) (Shake Flask Method, OECD No. 107) pH value : 6.0 to 7.5 (5% aqueous solution) Melting temperature : 128 to 131 oC
Boiling temperature : 157 oC @0.0005 mm Hg Minimum ignition energy : 10 - 20 mj
Page 4 of 6 SECTION 10 : STABILITY AND REACTIVITY
Stability : Stable at ambient conditions.
Conditions to avoid : Light Humidity
Materials to avoid : Acids, bases (hydrolysis) and oxidizing agents.
Hazardous Decomposition : Cyanide and nitrogen oxides may be released during thermal decomposition.
Note : Drying operations at the lowest temperature possible SECTION 11 : TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects Acute toxicity
LD50 Oral - rat - 3500 mg/kg
Skin corrosion/irritation no data available
Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity no data available
Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure no data available
Aspiration hazard no data available Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Additional Information RTECS: QS3675000
Page 5 of 6 SECTION 12 : ECOLOGICAL INFORMATION
Ready biodegradability : Readily biodegradable 96 %, 28 days
(Modified OECD Screening Test, OECD No. 301 E Ecotoxicity : barely toxic for fish (guppy)
LC50 (96 h) > 1000 mg/l
Barely toxic for planktonic crustaceans (Daphnia magna) EC50 (48 h) > 1000 mg/l
Barely toxic for microorganisms (Vorticella campanula) NOEC 3500 mg/l
Barely toxic for algae (green algae) EbC50 (72 h) > 1000 mg/l
Air pollution : observe local/national regulations SECTION 13 : DISPOSAL CONSIDERATIONS
Waste from residues : Incinerate in qualified installation with flue gas scrubbing Observe local/national regulations regarding waste disposal RCRA waste : Not regulated under RCRA
SECTION 14 : TRANSPORT INFORMATION
DOT / IATA Proper Shipping Name : Chemicals, N.o.s, [Niacinamide], Not regulated as per IATA
IMDG Proper shipping Name : Chemicals, N.o.s, [Niacinamide], Not regulated as per IATA
SECTION 15 : REGULATORY INFORMATION OSHA Hazards : Irritant (eye)
WHMIS Classification : Class D, Division 2, Subdivision B : Irritant
Chemical Inventory Status: TSCA : Yes EINECS : 202-713-4 Canada : DSL Japan : 5-736 Korea : KE-29935 Australia : Yes China : Yes Philippines: Yes Switzerland: G-8524 SARA 313 : Not listed
Reportable Quantities : Not applicable State Regulations : Not applicable
Other Regulatory Listings: Regulated as dietary supplement under FDA.
Page 6 of 6 SECTION 16 : OTHER INFORMATION
Use : Pharmaceutical active substance in vitamin preparations Food, Feed additive & Cosmetic Application.
Biological activity : 1 N.E. (Niacin Equivalent) corresponds to 1 mg Niacin (as either Nicotinic acid or Nicotinamide) or 60 mg dietary tryptophan.
Precautionary Statement :
Please note that the information contained herein is furnished without warranty of any kind. Users should consider these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use and disposal of these materials and the safety and health of employees and customers
Revision No : 1.07 Revision & Issue Date : 01.10.2019 Next review due date:30.09.2022
END MSDS
