SEVERE SEPSIS: IMPACT OF TIME OF ASSESSMENT AND RELATIONSHIP WITH OUTCOME-R1
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small vessels (PPV)
Spearman’s Rho p value
Mean arterial pressure 0.009 0.89
Cardiac index 0.132 0.06
CVP -0.105 0.100
pH 0.192 0.002
SvO2 0.238 <0.001
Hemoglobin 0.115 0.07
Lactate -0.088 0.16
DO2 0.188 0.007
VO2 0.052 0.45
O2ER -0.211 0.001
Age -0.013 0.85
APACHE II score 0.003 0.96
SOFA score -0.085 0.19
Intensity of vasopressor support
-0.171 0.006
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proportion of perfused small vessels (PPV) and mean arterial pressure (MAP).
Spearman’s rho 0.009 p=0.89
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proportion of perfused small vessels (PPV) and oxygen delivery (DO2).
Spearman’s rho 0.188, p=0.007
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proportion of perfused small vessels (PPV) and venous O2 saturation (SvO2).
Spearman’s rho 0.238, p<0.001
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proportion of perfused small vessels (PPV) and lactate levels. Spearman’s rho -0.088, p=0.16
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proportion of perfused small vessels (PPV) and arterial pH. Spearman’s rho 0.192, p=0.002
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proportion of perfused small vessels (PPV) and vasopressor load. Spearman’s rho -0.171, p=0.006
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predicting ICU outcome.
Area [95% CI] P value
Systemic variables
Mean arterial pressure 0.576 [0.505 - 0.647] 0.038
Cardiac output 0.588[0.510 – 0.666] 0.029
CVP 0.585[0.514 – 0.657] 0.021
SvO2 0.616[0.543 – 0.689] 0.002
DO2 0.631[0.554 – 0.707] 0.001
O2ER 0.596[0.522 – 0.670] 0.012
pH 0.594[0.524 – 0.664] 0.010
Lactate 0.612[0.542 – 0.681] 0.002
Hemoglobin 0.582[0.512 – 0.653] 0.025
Therapeutic variables Intensity of vasopressor support
0.576[0.505 -0.647] 0.038
Hydrocortisone 0.500[0.362-0.638] 1.00
Meeting SSC criteria 0.504[0.427 – 0.580] 0.92
Severity scores
APACHE II score 0.578[0.504 – 0.651] 0.040
SOFA score 0.638[0.567 – 0.709] <0.001
Microcirculatory variables
Vessel density tot 0.614 [0.545 - 0.683] 0.002
Vessel density perf tot 0.699 [0.635 - 0.764] <0.001
Vessel density small 0.624 [0.555 - 0.693] 0.001
Vessel density perf small 0.742 [0.681 - 0.803] <0.001
Proportion perf all % 0.743 [0.684 - 803] <0.001
Proportion perf large % 0.504 [0.432 - 0.575] 0.92
Proportion perf small % 0.818 [0.766 - 0.871] <0.001
MFI 0.609[0.529 - 0.689] 0.012
Heterogeneity PPV 0.619[0.497 – 0.741] 0.06
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perfused small vessels (PPV) at early and late stages of sepsis. AUROC curves were similar in early (0.877 [0.829 – 0.924] and later 0.744 [0.602 – 0.885] phases but the cut-off defined using Youden’s index was lower in early (PPV 56%) than in late (PPV 75%) phase.
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according to achievement of resuscitative goals. Patients were characterized as achieving Surviving Sepsis Campaign (SSC) guidelines for resuscitation (mean arterial pressure > 65 mmHg, SvO2 or ScvO2 above 65 or 70%, CVP between 8-12 mmHg) (26) or not. P = 0.52
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quartiles of proportion of perfused small vessels. Patients were separated in quartiles of proportion of perfused small vessels. Each quartile counts 51 patients. The left axis is used to report the numbers of ICU survivors (blue rectangles) and non survivors (red rectangles). The right axis is used to report ICU survival rate. Chi square p<0.001.
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inclusion in the trial. Generalized Linear Model for effect of time p<0.001.
Post hoc test (with Bonferroni correction): a 2007: p= 0.004 vs ≤2000, b 2008: p= 0.021 vs
≤2000, c 2009: p<0.001 vs ≤2000, p=0.005 vs 2001, p=0.001 vs 2002, p=0.049 vs 2003
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