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Supplemental Digital Content 4. Characteristics of excluded studies

Study Reason for exclusion

Guldiken 2011 Study population: overlapping cohort with included study Dagkiran 2020 Study population: unclear if the study population consisted of a

minimum of 10 adult cases

Jethanamest 2014 Study population: unclear if the study population consisted of a minimum of 10 adult cases

Lavinsky-Wolff 2012 Study population: unclear if the study population consisted of a minimum of 10 adult cases

Pamuk 2018 Study population: unclear if the study population consisted of a minimum of 10 adult cases

Sweeney 2015 Study population: unclear if the study population consisted of a minimum of 10 adult cases

Ulug 2009 Study population: unclear if the study population consisted of a minimum of 10 adult cases

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