Specificity (%)
Sensitivity (%)
100 80 60 40 20 0
020406080100
qPELOD2 AUC: 78.9 (95% CI 75.3−82.4) Sensitivity: 62.4, Specificity: 82.3
PPV: 21, NPV: 96.7
PRISM3 AUC: 87.2 (95% CI 83.9−90.5) PIM2 AUC: 85.7 (95% CI 82.8−88.7)
Age: < 1mo [Complete data n=1901]
Specificity (%)
Sensitivity (%)
100 80 60 40 20 0
020406080100
qPELOD2 AUC: 74.9 (95% CI 72.5−77.3) Sensitivity: 52.5, Specificity: 87.2
PPV: 14.3, NPV: 97.8
PRISM3 AUC: 84.4 (95% CI 82.2−86.7) PIM2 AUC: 84.9 (95% CI 83.2−86.7)
Age: 1−11 mo [Complete data n=11098]
Specificity (%)
Sensitivity (%)
100 80 60 40 20 0
020406080100
qPELOD2 AUC: 71.2 (95% CI 67.1−75.3) Sensitivity: 50.9, Specificity: 85.5
PPV: 9.8, NPV: 98.2
PRISM3 AUC: 85.1 (95% CI 81.8−88.3) PIM2 AUC: 82.8 (95% CI 79.5−86.2)
Age: 12−23 mo [Complete data n=5728]
Specificity (%)
Sensitivity (%)
100 80 60 40 20 0
020406080100
qPELOD2 AUC: 72.4 (95% CI 69.4−75.5) Sensitivity: 47, Specificity: 88.2
PPV: 13.3, NPV: 97.8
PRISM3 AUC: 86 (95% CI 83.5−88.5) PIM2 AUC: 82.6 (95% CI 80.1−85.1)
Age: 24−59 mo [Complete data n=7791]
Specificity (%)
Sensitivity (%)
100 80 60 40 20 0
020406080100
qPELOD2 AUC: 71.6 (95% CI 68.9−74.3) Sensitivity: 41.4, Specificity: 89.5
PPV: 14.7, NPV: 97.2
PRISM3 AUC: 86.2 (95% CI 84.2−88.3) PIM2 AUC: 78.7 (95% CI 76.2−81.1)
Age: 60−143 mo [Complete data n=8629]
Specificity (%)
Sensitivity (%)
100 80 60 40 20 0
020406080100
qPELOD2 AUC: 67.8 (95% CI 65−70.5) Sensitivity: 54.9, Specificity: 75.4
PPV: 12.2, NPV: 96.4
PRISM3 AUC: 81.4 (95% CI 79.1−83.7) PIM2 AUC: 75.1 (95% CI 72.5−77.7)
Age: >=144 mo [Complete data n=7049]
Supplemental Figure 1: Receiver operating characteristics curves and area under the curve
(AUC) for mortality prediction, stratified by age group, based on the quick Pediatric Logistic Organ Dysfunction-2 score (qPELOD2), the pediatric risk of mortality III (PRISM3) risk score and the pediatric index of mortality 2 (PIM2) risk score. The shaded areas indicate the 95%
confidence intervals for sensitivity of the AUC. Positive and negative predictive values (PPV and NPV respectively), as well as sensitivity and specificity of the qPELOD2 score are shown in the top left corner of each subplot.
