Search Strategies for PARDS in Resource Limited Settings

(1)

Supplemental Digital Content

Diagnostic, management, and research considerations for Pediatric Acute Respiratory Distress Syndrome in Resource Limited Settings

Supplemental Table 1: Search Strategies for PARDS in Resource Limited Settings...2

Supplemental Figure 1. Study flow diagram according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol recommendations...10

Supplemental Table 2. Evidence to Decision Framework Table for Recommendation 11.1...11

APPENDIX 1. Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) Group...21

(2)

Supplemental Table 1: Search Strategies for PARDS in Resource Limited Settings PALICC-2 Group 11: Resource-Limited Settings

Initial search 12/8/2020 Updated search 4/11/2022

PubMed:

(("respiratory distress syndrome, adult"[Mesh] OR "acute lung injury"[mesh] OR

"ARDS"[all] OR "respiratory distress syndrome, adult"[all] OR "adult respiratory distress syndrome"[all] OR "adult respiratory distress syndromes"[all] OR "acute respiratory distress syndrome"[all] OR "acute respiratory distress syndromes"[all] OR "shock lung"[all]

OR "shock lungs"[all] OR "acute lung injury"[all] OR "acute lung injuries"[all] OR "acute hypoxemic respiratory failure"[all] OR "acute hypoxemic respiratory failures"[all] OR

"AHRF"[all] OR "idiopathic respiratory distress syndrome"[all] OR "idiopathic respiratory distress syndromes"[all] OR "PARDS"[all] OR "pediatric respiratory distress syndrome"[all]

OR "pediatric respiratory distress syndromes"[all] OR "paediatric respiratory distress syndrome"[all] OR "paediatric respiratory distress syndromes"[all])

AND

("Developing countries"[mesh] OR Oxygen Inhalation Therapy[Mesh:noexp] OR Peritoneal Dialysis[Mesh] OR Patients' Rooms[Mesh] OR "Bubble continuous positive airway pressure"[All] OR "Bubble CPAP"[All] OR "Peripheral inotrope*"[All] OR "peripheral dopamine"[All] OR "peripheral adrenaline"[All] OR "peripheral dobutamine"[All] OR

"peripheral noradrenaline"[All] OR "peripheral vasopressin"[All] OR "peripheral milrinone"[All] OR "Oxygen therap*"[All] OR "o2 therap*"[All] OR "Oxygen inhalation therap*"[All] OR "O2 inhalation therap*"[All] OR "oxygen insufflation"[All] OR "o2 insufflation"[All] OR "oxygen treatment*"[All] OR "o2 treatment*"[All] OR "Peritoneal dialys*"[All] OR "Lack of monitoring"[All] OR "limited monitoring"[All] OR "minimal monitoring"[All] OR "minimally monitored"[All] OR "non monitored"[All] OR "General ward*"[All] OR "Patient room*"[All] OR "Patients room*"[All] OR "Patients' room*"[All] OR

"Patient's room*"[All] OR "LMIC"[All] OR "LMICs"[All] OR "Emerging countr*"[All] OR

"Emerging nation*"[All] OR "low resource*"[All] OR "low income*"[All] OR "middle resource*"[All] OR "middle income*"[All] OR "Lack of resource*"[All] OR "resource limited"[All] OR "limited resource*"[All] OR "limited income*"[All] OR "resource

constrain*"[All] OR "constrained resource*"[All] OR "resource restraint"[All] OR "restrained resource*"[All] OR "restricted resource*"[All] OR "resource poor"[All] OR "third world"[All]

OR "developing world"[All] OR "developing area*"[All] OR "less developed countr*"[All] OR

"least developed countr*"[All] OR "developing countr*"[All] OR "Underdeveloped

countr*"[All] OR "Under Developed countr*"[All] OR "less developed nation*"[All] OR "least developed nation*"[All] OR "developing nation*"[All] OR "Underdeveloped nation*"[All] OR

"Under Developed nation*"[All] OR Bangladesh[Mesh] OR Bhutan[Mesh] OR India[Mesh]

OR Afghanistan[Mesh] OR Iran[Mesh] OR Iraq[Mesh] OR Jordan[Mesh] OR

Lebanon[Mesh] OR Syria[Mesh] OR Turkey[Mesh] OR Yemen[Mesh] OR Nepal[Mesh]

OR Pakistan[Mesh] OR Sri Lanka[Mesh] OR Kazakhstan[Mesh] OR Kyrgyzstan[Mesh] OR Tajikistan[Mesh] OR Turkmenistan[Mesh] OR Uzbekistan[Mesh] OR Russia[Mesh] OR Cambodia[Mesh] OR Indonesia[Mesh] OR Laos[Mesh] OR Malaysia[Mesh] OR

Myanmar[Mesh] OR Philippines[Mesh] OR Thailand[Mesh] OR "Timor-Leste"[Mesh] OR Vietnam[Mesh] OR China[Mesh] OR "Democratic People's Republic of Korea"[Mesh] OR Mongolia[Mesh] OR Cameroon[Mesh] OR "Central African Republic"[Mesh] OR

Chad[Mesh] OR Congo[Mesh] OR "Democratic Republic of the Congo"[Mesh] OR

"Equatorial Guinea"[Mesh] OR Gabon[Mesh] OR "Sao Tome and Principe"[Mesh] OR Burundi[Mesh] OR Djibouti[Mesh] OR Eritrea[Mesh] OR Ethiopia[Mesh] OR Kenya[Mesh]

OR Rwanda[Mesh] OR Somalia[Mesh] OR "South Sudan"[Mesh] OR Sudan[Mesh] OR Tanzania[Mesh] OR Uganda[Mesh] OR Angola[Mesh] OR Botswana[Mesh] OR

(3)

Eswatini[Mesh] OR Lesotho[Mesh] OR Malawi[Mesh] OR Mozambique[Mesh] OR Namibia[Mesh] OR "South Africa"[Mesh] OR Zambia[Mesh] OR Zimbabwe[Mesh] OR Benin[Mesh] OR "Burkina Faso"[Mesh] OR "Cabo Verde"[Mesh] OR "Cote d'Ivoire"[Mesh]

OR Gambia[Mesh] OR Ghana[Mesh] OR Guinea[Mesh] OR "Guinea-Bissau"[Mesh] OR Liberia[Mesh] OR Mali[Mesh] OR Mauritania[Mesh] OR Niger[Mesh] OR Nigeria[Mesh]

OR Senegal[Mesh] OR "Sierra Leone"[Mesh] OR Togo[Mesh] OR Africa[Mesh] OR Cuba[Mesh] OR Dominica[Mesh] OR Dominican Republic[Mesh] OR Grenada[Mesh] OR Haiti[Mesh] OR Jamaica[Mesh] OR "Saint Vincent and the Grenadines"[Mesh] OR Belize[Mesh] OR "Costa Rica"[Mesh] OR "El Salvador"[Mesh] OR Guatemala[Mesh] OR Honduras[Mesh] OR Nicaragua[Mesh] OR Mexico[Mesh] OR Argentina[Mesh] OR Bolivia[Mesh] OR Brazil[Mesh] OR Colombia[Mesh] OR Ecuador[Mesh] OR Guyana[Mesh] OR Paraguay[Mesh] OR Peru[Mesh] OR Venezuela[Mesh] OR Albania[Mesh] OR "Bosnia and Herzegovina"[Mesh] OR "Bulgaria"[Mesh] OR Kosovo[Mesh] OR Moldova[Mesh] OR Montenegro[Mesh] OR "Republic of Belarus"[Mesh] OR "Republic of North Macedonia"[Mesh] OR Russia[Mesh] OR

Serbia[Mesh] OR Ukraine[Mesh] OR Armenia[Mesh] OR Azerbaijan[Mesh] OR "Georgia (Republic)"[Mesh] OR Comoros[Mesh] OR Madagascar[Mesh] OR Fiji[Mesh] OR "Papua New Guinea"[Mesh] OR Vanuatu[Mesh] OR Micronesia[Mesh] OR Samoa[Mesh] OR Tonga[Mesh] OR "Afghan*"[Tw] OR "Burkina*"[Tw] OR "Burund*"[Tw] OR "Chad"[tiab] OR

"Chad"[OT] OR "Chadian"[Tw] OR "Congo*"[Tw] OR "Zaire"[Tw] OR "Eritrea*"[Tw] OR

"Ethiopia*"[Tw] OR ("Guinea*"[Tw] NOT "guinea pig*"[Tw]) OR "Bissau"[Tw] OR

"Haiti*"[Tw] OR "Democratic People’s Republic of Korea"[Tw] OR "North Korea*"[Tw] OR

"Liberia*"[Tw] OR "Madagascar"[Tw] OR "Malagas*"[Tw] OR "Malawi*"[Tw] OR "Mali"[Tw]

OR "Malian*"[Tw] OR "Mozambique"[Tw] OR "mozambican*"[Tw] OR "Niger*"[Tw] OR

"Rwand*"[Tw] OR "Sierra Leone*"[Tw] OR "Somali*"[Tw] OR "Sudan*"[Tw] OR

"Syria*"[Tw] OR "Tajik*"[Tw] OR "Togo*"[Tw] OR "Ugand*"[Tw] OR "Yemen*"[Tw] OR

"Algeria*"[Tw] OR "Angola"[Tw] OR "Banglad*"[Tw] OR "Benin*"[Tw] OR "Bhutan*"[Tw]

OR "Bolivia*"[Tw] OR "Cabo Verde"[Tw] OR "Cape Verde"[Tw] OR "Cambodia*"[Tw] OR

"Cameroon*"[Tw] OR "Comoros"[Tw] OR "Congo*"[Tw] OR "Cote d’Ivoire"[Tw] OR "Ivory Coast"[Tw] OR "Djibouti*"[Tw] OR "Egypt*"[Tw] OR "Salvador*"[tw] OR "Eswatini*"[Tw]

OR "Swaziland*"[Tw] OR "Ghana*"[Tw] OR "Hondur*"[Tw] OR "India*"[Tw] OR

"Kenya*"[Tw] OR "Kiribati*"[Tw] OR "Kyrgy*"[Tw] OR "Laos"[Tw] OR "Laotian*"[Tw] OR

"Lao People's Democratic Republic"[Tw] OR "Lao PDR"[Tw] OR "Lesoth*"[Tw] OR

"Mauritania*"[Tw] OR "Micronesia*"[Tw] OR "Moldov*"[Tw] OR "Mongoli*"[Tw] OR

"Morocc*"[Tw] OR "Myanmar"[Tw] OR "Burma*"[Tw] OR "Nepal*"[Tw] OR "Nicaragu*"[Tw]

OR "Nigeri*"[Tw] OR "Pakistan*"[Tw] OR "Papua*"[Tw] OR "Philippines"[Tw] OR

"Filipino*"[Tw] OR "Sao Tome and Principe"[Tw] OR "Senegal*"[Tw] OR "Solomon Islands"[Tw] OR "Sri Lanka*"[Tw] OR "Sinhalese*"[Tw] OR "Tanzania*"[Tw] OR "Timor- Leste"[Tw] OR "Tunisia*"[Tw] OR "Ukrain*"[Tw] OR "Uzbekistan*"[Tw] OR "Vanuatu"[Tw]

OR "Vietnam*"[Tw] OR "West Bank"[Tw] OR "Gaza*"[Tw] OR "Zambia*"[Tw] OR

"Zimbabw*"[Tw] OR "Albania*"[Tw] OR "Samoa*"[Tw] OR "Argentin*"[Tw] OR

"Armenia*"[Tw] OR "Azerbaijan*"[Tw] OR "Azeri*"[Tw] OR "Belarus*"[Tw] OR

"Belize*"[Tw] OR "Bosnia*"[Tw] OR "Herzegovina*"[Tw] OR "Botswan*"[Tw] OR

"Brazil*"[Tw] OR "Bulgaria*"[Tw] OR "China"[Tw] OR "Chinese*"[Tw] OR "Colombia*"[Tw]

OR "Costa Rica*"[Tw] OR "Cuba*"[Tw] OR "Dominica*"[Tw] OR "Ecuador*"[Tw] OR

"Fiji*"[Tw] OR "Gabon*"[Tw] OR "Georgia*"[Tw] OR "Grenada"[Tw] OR "Guatemal*"[Tw]

OR ("Guyan*"[Tw] NOT "French Guyan*"[Tw]) OR "Indonesia*"[Tw] OR "Iran*"[Tw] OR

"Iraq*"[Tw] OR "Jamaica*"[Tw] OR "Jordan*"[Tw] OR "Kazakh*"[Tw] OR "Kosov*"[Tw] OR

"Leban*"[Tw] OR "Libya*"[Tw] OR "Malaysia*"[Tw] OR "Maldives"[Tw] OR "Marshall Islands"[Tw] OR ("Mexic*"[Tw] NOT "mexican american"[Tw]) OR "Montenegr*"[Tw] OR

"Namibia*"[Tw] OR "North Macedoni*"[Tw] OR "Paragu*"[Tw] OR "Peru*"[Tw] OR

"Russia*"[Tw] OR "Samoa*"[Tw] OR "Serbia*"[Tw] OR "South Africa*"[Tw] OR "St.

Lucia"[Tw] OR "Saint Lucia"[Tw] OR "St. Vincent and the Grenadines"[Tw] OR "Saint Vincent and the Grenadines"[Tw] OR "Thailand"[Tw] OR "thai"[Tw] OR "Tonga*"[Tw] OR

"Turk*"[Tw] OR "Tuvalu"[Tw] OR "Venezuel*"[Tw] OR "Africa"[Tw] OR ("african"[Tw] NOT

(4)

"african american"[Tw])) AND

english[la]) NOT

("animals"[mh] NOT "humans"[mh]) Searched 12/08/2020, 2301 results Searched 4/11/2022, 845 results

All EBM Reviews:

((Exp respiratory distress syndrome, adult/ OR exp acute lung injury/ OR ("ARDS" OR

"respiratory distress syndrome, adult" OR "adult respiratory distress syndrome" OR "adult respiratory distress syndromes" OR "acute respiratory distress syndrome" OR "acute respiratory distress syndromes" OR "shock lung" OR "shock lungs" OR "acute lung injury"

OR "acute lung injuries" OR "acute hypoxemic respiratory failure" OR "acute hypoxemic respiratory failures" OR "AHRF" OR "idiopathic respiratory distress syndrome" OR

"idiopathic respiratory distress syndromes" OR "PARDS" OR "pediatric respiratory distress syndrome" OR "pediatric respiratory distress syndromes" OR "paediatric respiratory distress syndrome" OR "paediatric respiratory distress syndromes").mp)

AND

(Exp Developing countries/ OR Oxygen Inhalation Therapy/ OR Exp Peritoneal Dialysis/

OR Exp Patients' Rooms/ OR (Bubble continuous positive airway pressure OR Bubble CPAP OR Peripheral inotrope* OR peripheral dopamine OR peripheral adrenaline OR peripheral dobutamine OR peripheral noradrenaline OR peripheral vasopressin OR peripheral milrinone OR Oxygen therap* OR o2 therap* OR Oxygen inhalation therap* OR O2 inhalation therap* OR oxygen insufflation OR o2 insufflation OR oxygen treatment* OR o2 treatment* OR Peritoneal dialys* OR Lack of monitoring OR limited monitoring OR minimal monitoring OR minimally monitored OR non monitored OR General ward* OR Patient room* OR Patients room* OR Patients' room* OR Patient's room* OR LMIC OR LMICs OR Emerging countr* OR Emerging nation* OR low resource* OR low income* OR middle resource* OR middle income* OR Lack of resource* OR resource limited OR limited resource* OR limited income* OR resource constrain* OR constrained resource*

OR resource restraint OR restrained resource* OR restricted resource* OR resource poor OR third world OR developing world OR developing area* OR less developed countr* OR least developed countr* OR developing countr* OR Underdeveloped countr* OR Under Developed countr* OR less developed nation* OR least developed nation* OR developing nation* OR Underdeveloped nation* OR Under Developed nation*).mp OR Exp

Bangladesh/ OR Exp Bhutan/ OR Exp India/ OR Exp Afghanistan/ OR Exp Iran/ OR Exp Iraq/ OR Exp Jordan/ OR Exp Lebanon/ OR Exp Syria/ OR Exp Turkey/ OR Exp Yemen/

OR Exp Nepal/ OR Exp Pakistan/ OR Exp Sri Lanka/ OR Exp Kazakhstan/ OR Exp Kyrgyzstan/ OR Exp Tajikistan/ OR Exp Turkmenistan/ OR Exp Uzbekistan/ OR Exp Russia/ OR Exp Cambodia/ OR Exp Indonesia/ OR Exp Laos/ OR Exp Malaysia/ OR Exp Myanmar/ OR Exp Philippines/ OR Exp Thailand/ OR Exp Timor-Leste/ OR Exp Vietnam/

OR Exp China/ OR Exp Democratic People's Republic of Korea/ OR Exp Mongolia/ OR Exp Cameroon/ OR Exp Central African Republic/ OR Exp Chad/ OR Exp Congo/ OR Exp Democratic Republic of the Congo/ OR Exp Equatorial Guinea/ OR Exp Gabon/ OR Exp

"Sao Tome and Principe"/ OR Exp Burundi/ OR Exp Djibouti/ OR Exp Eritrea/ OR Exp Ethiopia/ OR Exp Kenya/ OR Exp Rwanda/ OR Exp Somalia/ OR Exp South Sudan/ OR Exp Sudan/ OR Exp Tanzania/ OR Exp Uganda/ OR Exp Angola/ OR Exp Botswana/ OR Exp Eswatini/ OR Exp Lesotho/ OR Exp Malawi/ OR Exp Mozambique/ OR Exp Namibia/

OR Exp South Africa/ OR Exp Zambia/ OR Exp Zimbabwe/ OR Exp Benin/ OR Exp Burkina Faso/ OR Exp Cabo Verde/ OR Exp Cote d'Ivoire/ OR Exp Gambia/ OR Exp Ghana/ OR Exp Guinea/ OR Exp Guinea-Bissau/ OR Exp Liberia/ OR Exp Mali/ OR Exp Mauritania/ OR Exp Niger/ OR Exp Nigeria/ OR Exp Senegal/ OR Exp Sierra Leone/ OR Exp Togo/ OR Exp Africa/ OR Exp Cuba/ OR Exp Dominica/ OR Exp Dominican Republic/

OR Exp Grenada/ OR Exp Haiti/ OR Exp Jamaica/ OR Exp "Saint Vincent and the

(5)

Grenadines"/ OR Exp Belize/ OR Exp Costa Rica/ OR Exp El Salvador/ OR Exp

Guatemala/ OR Exp Honduras/ OR Exp Nicaragua/ OR Exp Mexico/ OR Exp Argentina/

OR Exp Bolivia/ OR Exp Brazil/ OR Exp Colombia/ OR Exp Ecuador/ OR Exp Guyana/

OR Exp Paraguay/ OR Exp Peru/ OR Exp Venezuela/ OR Exp Albania/ OR Exp "Bosnia and Herzegovina"/ OR Exp Bulgaria/ OR Exp Kosovo/ OR Exp Moldova/ OR Exp

Montenegro/ OR Exp Republic of Belarus/ OR Exp Republic of North Macedonia/ OR Exp Russia/ OR Exp Serbia/ OR Exp Ukraine/ OR Exp Armenia/ OR Exp Azerbaijan/ OR Exp

"Georgia (Republic)"/ OR Exp Comoros/ OR Exp Madagascar/ OR Exp Fiji/ OR Exp Papua New Guinea/ OR Exp Vanuatu/ OR Exp Micronesia/ OR Exp Samoa/ OR Exp Tonga/ OR (Afghan* OR Burkina* OR Burund* OR Chad OR Chadian OR Congo* OR Zaire OR Eritrea* OR Ethiopia* OR (Guinea* NOT guinea pig*) OR Bissau OR Haiti* OR Democratic People's Republic of Korea OR North Korea* OR Liberia* OR Madagascar OR Malagas* OR Malawi* OR Mali OR Malian* OR Mozambique OR mozambican* OR Niger* OR Rwand* OR Sierra Leone* OR Somali* OR Sudan* OR Syria* OR Tajik* OR Togo* OR Ugand* OR Yemen* OR Algeria* OR Angola OR Banglad* OR Benin* OR Bhutan* OR Bolivia* OR Cabo Verde OR Cape Verde OR Cambodia* OR Cameroon* OR Comoros OR Congo* OR Cote d'Ivoire OR Ivory Coast OR Djibouti* OR Egypt* OR Salvador* OR Eswatini* OR Swaziland* OR Ghana* OR Hondur* OR India* OR Kenya*

OR Kiribati* OR Kyrgy* OR Laos OR Laotian* OR Lao People's Democratic Republic OR Lao PDR OR Lesoth* OR Mauritania* OR Micronesia* OR Moldov* OR Mongoli* OR Morocc* OR Myanmar OR Burma* OR Nepal* OR Nicaragu* OR Nigeri* OR Pakistan* OR Papua* OR Philippines OR Filipino* OR "Sao Tome and Principe" OR Senegal* OR Solomon Islands OR Sri Lanka* OR Sinhalese* OR Tanzania* OR Timor-Leste OR Tunisia* OR Ukrain* OR Uzbekistan* OR Vanuatu OR Vietnam* OR West Bank OR Gaza*

OR Zambia* OR Zimbabw* OR Albania* OR Samoa* OR Argentin* OR Armenia* OR Azerbaijan* OR Azeri* OR Belarus* OR Belize* OR Bosnia* OR Herzegovina* OR Botswan* OR Brazil* OR Bulgaria* OR China OR Chinese* OR Colombia* OR Costa Rica* OR Cuba* OR Dominica* OR Ecuador* OR Fiji* OR Gabon* OR Georgia* OR Grenada OR Guatemal* OR (Guyan* NOT French Guyan*) OR Indonesia* OR Iran* OR Iraq* OR Jamaica* OR Jordan* OR Kazakh* OR Kosov* OR Leban* OR Libya* OR Malaysia* OR Maldives OR Marshall Islands OR (Mexic* NOT mexican american) OR Montenegr* OR Namibia* OR North Macedoni* OR Paragu* OR Peru* OR Russia* OR Samoa* OR Serbia* OR South Africa* OR St Lucia OR Saint Lucia OR "St. Vincent and the Grenadines" OR "Saint Vincent and the Grenadines" OR Thailand OR thai OR Tonga*

OR Turk* OR Tuvalu OR Venezuel* OR Africa OR (african NOT african american)).tw) AND

English.lg) NOT

(exp animals/ NOT humans/) Searched 12/08/2020, 189 results Searched 4/11/2022, 568 results

Embase:

(("adult respiratory distress syndrome"/ OR Exp "acute lung injury"/ OR ("ARDS" OR

"respiratory distress syndrome, adult" OR "adult respiratory distress syndrome" OR "adult respiratory distress syndromes" OR "acute respiratory distress syndrome" OR "acute respiratory distress syndromes" OR "shock lung" OR "shock lungs" OR "acute lung injury"

OR "acute lung injuries" OR "acute hypoxemic respiratory failure" OR "acute hypoxemic respiratory failures" OR "AHRF" OR "idiopathic respiratory distress syndrome" OR

"idiopathic respiratory distress syndromes" OR "PARDS" OR "pediatric respiratory distress syndrome" OR "pediatric respiratory distress syndromes" OR "paediatric respiratory distress syndrome" OR "paediatric respiratory distress syndromes").ti,ab,kw)

AND

(Developing country/ OR oxygen therapy/ OR Exp Peritoneal Dialysis/ OR (Bubble continuous positive airway pressure OR Bubble CPAP OR Peripheral inotrope* OR

(6)

peripheral dopamine OR peripheral adrenaline OR peripheral dobutamine OR peripheral noradrenaline OR peripheral vasopressin OR peripheral milrinone OR Oxygen therap* OR o2 therap* OR Oxygen inhalation therap* OR O2 inhalation therap* OR oxygen insufflation OR o2 insufflation OR oxygen treatment* OR o2 treatment* OR Peritoneal dialys* OR Lack of monitoring OR limited monitoring OR minimal monitoring OR minimally monitored OR non monitored OR General ward* OR Patient room* OR Patients room* OR Patients' room* OR Patient's room* OR LMIC OR LMICs OR Emerging countr* OR Emerging nation* OR low resource* OR low income* OR middle resource* OR middle income* OR Lack of resource* OR resource limited OR limited resource* OR limited income* OR resource constrain* OR constrained resource* OR resource restraint OR restrained resource* OR restricted resource* OR resource poor OR third world OR developing world OR developing area* OR less developed countr* OR least developed countr* OR

developing countr* OR Underdeveloped countr* OR Under Developed countr* OR less developed nation* OR least developed nation* OR developing nation* OR

Underdeveloped nation* OR Under Developed nation*).ti,ab,kw OR Exp Bangladesh/ OR Exp Bhutan/ OR Exp India/ OR Exp Afghanistan/ OR Exp Iran/ OR Exp Iraq/ OR Exp Jordan/ OR Exp Lebanon/ OR Exp Syria/ OR "Turkey (country)"/ OR Exp Yemen/ OR Exp Nepal/ OR Exp Pakistan/ OR Exp Sri Lanka/ OR Exp Kazakhstan/ OR Exp Kyrgyzstan/

OR Exp Tajikistan/ OR Exp Turkmenistan/ OR Exp Uzbekistan/ OR Exp Russia/ OR Exp Cambodia/ OR Exp Indonesia/ OR Exp Laos/ OR Exp Malaysia/ OR Exp Myanmar/ OR Exp Philippines/ OR Exp Thailand/ OR Exp Timor-Leste/ OR Exp Vietnam/ OR Exp China/

OR Exp Democratic People's Republic of Korea/ OR Exp Mongolia/ OR Exp Cameroon/

OR Exp Central African Republic/ OR Exp Chad/ OR Exp Congo/ OR Exp Democratic Republic of the Congo/ OR Exp Equatorial Guinea/ OR Exp Gabon/ OR Exp "Sao Tome and Principe"/ OR Exp Burundi/ OR Exp Djibouti/ OR Exp Eritrea/ OR Exp Ethiopia/ OR Exp Kenya/ OR Exp Rwanda/ OR Exp Somalia/ OR Exp South Sudan/ OR Exp Sudan/

OR Exp Tanzania/ OR Exp Uganda/ OR Exp Angola/ OR Exp Botswana/ OR Exp

Eswatini/ OR Exp Lesotho/ OR Exp Malawi/ OR Exp Mozambique/ OR Exp Namibia/ OR Exp South Africa/ OR Exp Zambia/ OR Exp Zimbabwe/ OR Exp Benin/ OR Exp Burkina Faso/ OR Exp Cabo Verde/ OR Exp Cote d'Ivoire/ OR Exp Gambia/ OR Exp Ghana/ OR Exp Guinea/ OR Exp Guinea-Bissau/ OR Exp Liberia/ OR Exp Mali/ OR Exp Mauritania/

OR Exp Niger/ OR Exp Nigeria/ OR Exp Senegal/ OR Exp Sierra Leone/ OR Exp Togo/

OR Exp Africa/ OR Exp Cuba/ OR Exp Dominica/ OR Exp Dominican Republic/ OR Exp Grenada/ OR Exp Haiti/ OR Exp Jamaica/ OR Exp "Saint Vincent and the Grenadines"/

OR Exp Belize/ OR Exp Costa Rica/ OR Exp El Salvador/ OR Exp Guatemala/ OR Exp Honduras/ OR Exp Nicaragua/ OR Exp Mexico/ OR Exp Argentina/ OR Exp Bolivia/ OR Exp Brazil/ OR Exp Colombia/ OR Exp Ecuador/ OR Exp Guyana/ OR Exp Paraguay/ OR Exp Peru/ OR Exp Venezuela/ OR Exp Albania/ OR Exp "Bosnia and Herzegovina"/ OR Exp Bulgaria/ OR Exp Kosovo/ OR Exp Moldova/ OR Exp Montenegro/ OR Exp Republic of Belarus/ OR Exp Republic of North Macedonia/ OR Exp Russia/ OR Exp Serbia/ OR Exp Ukraine/ OR Exp Armenia/ OR Exp Azerbaijan/ OR Exp "Georgia (Republic)"/ OR Exp Comoros/ OR Exp Madagascar/ OR Exp Fiji/ OR Exp Papua New Guinea/ OR Exp Vanuatu/ OR Exp Micronesia/ OR Exp Samoa/ OR Exp Tonga/ OR (Afghan* OR Burkina*

OR Burund* OR Chad OR Chadian OR Congo* OR Zaire OR Eritrea* OR Ethiopia* OR (Guinea* NOT guinea pig*) OR Bissau OR Haiti* OR Democratic People's Republic of Korea OR North Korea* OR Liberia* OR Madagascar OR Malagas* OR Malawi* OR Mali OR Malian* OR Mozambique OR mozambican* OR Niger* OR Rwand* OR Sierra Leone*

OR Somali* OR Sudan* OR Syria* OR Tajik* OR Togo* OR Ugand* OR Yemen* OR Algeria* OR Angola OR Banglad* OR Benin* OR Bhutan* OR Bolivia* OR Cabo Verde OR Cape Verde OR Cambodia* OR Cameroon* OR Comoros OR Congo* OR Cote d'Ivoire OR Ivory Coast OR Djibouti* OR Egypt* OR Salvador* OR Eswatini* OR Swaziland* OR Ghana* OR Hondur* OR India* OR Kenya* OR Kiribati* OR Kyrgy* OR Laos OR Laotian*

OR Lao People's Democratic Republic OR Lao PDR OR Lesoth* OR Mauritania* OR Micronesia* OR Moldov* OR Mongoli* OR Morocc* OR Myanmar OR Burma* OR Nepal*

OR Nicaragu* OR Nigeri* OR Pakistan* OR Papua* OR Philippines OR Filipino* OR "Sao

(7)

Tome and Principe" OR Senegal* OR Solomon Islands OR Sri Lanka* OR Sinhalese* OR Tanzania* OR Timor-Leste OR Tunisia* OR Ukrain* OR Uzbekistan* OR Vanuatu OR Vietnam* OR West Bank OR Gaza* OR Zambia* OR Zimbabw* OR Albania* OR Samoa*

OR Argentin* OR Armenia* OR Azerbaijan* OR Azeri* OR Belarus* OR Belize* OR Bosnia* OR Herzegovina* OR Botswan* OR Brazil* OR Bulgaria* OR China OR Chinese*

OR Colombia* OR Costa Rica* OR Cuba* OR Dominica* OR Ecuador* OR Fiji* OR Gabon* OR Georgia* OR Grenada OR Guatemal* OR (Guyan* NOT French Guyan*) OR Indonesia* OR Iran* OR Iraq* OR Jamaica* OR Jordan* OR Kazakh* OR Kosov* OR Leban* OR Libya* OR Malaysia* OR Maldives OR Marshall Islands OR (Mexic* NOT mexican american) OR Montenegr* OR Namibia* OR North Macedoni* OR Paragu* OR Peru* OR Russia* OR Samoa* OR Serbia* OR South Africa* OR St Lucia OR Saint Lucia OR "St. Vincent and the Grenadines" OR "Saint Vincent and the Grenadines" OR

Thailand OR thai OR Tonga* OR Turk* OR Tuvalu OR Venezuel* OR Africa OR (african NOT african american)).ti,ab,kw)

AND English.lg) NOT

(exp animal/ NOT human/)

Searched 12/08/2020, 4587 results Searched 4/11/2022, 1952 results

Web of Science:

(TS=("ARDS" OR "respiratory distress syndrome, adult" OR "adult respiratory distress syndrome" OR "adult respiratory distress syndromes" OR "acute respiratory distress syndrome" OR "acute respiratory distress syndromes" OR "shock lung" OR "shock lungs"

OR "acute lung injury" OR "acute lung injuries" OR "acute hypoxemic respiratory failure"

OR "acute hypoxemic respiratory failures" OR "AHRF" OR "idiopathic respiratory distress syndrome" OR "idiopathic respiratory distress syndromes" OR "PARDS" OR "pediatric respiratory distress syndrome" OR "pediatric respiratory distress syndromes" OR

"paediatric respiratory distress syndrome" OR "paediatric respiratory distress syndromes"))

AND

(TS=(Bubble continuous positive airway pressure OR Bubble CPAP OR Peripheral inotrope* OR peripheral dopamine OR peripheral adrenaline OR peripheral dobutamine OR peripheral noradrenaline OR peripheral vasopressin OR peripheral milrinone OR Oxygen therap* OR o2 therap* OR Oxygen inhalation therap* OR O2 inhalation therap*

OR oxygen insufflation OR o2 insufflation OR oxygen treatment* OR o2 treatment* OR Peritoneal dialys* OR Lack of monitoring OR limited monitoring OR minimal monitoring OR minimally monitored OR non monitored OR General ward* OR Patient room* OR Patients room* OR Patients' room* OR Patient's room* OR LMIC OR LMICs OR Emerging countr* OR Emerging nation* OR low resource* OR low income* OR middle resource* OR middle income* OR Lack of resource* OR resource limited OR limited resource* OR limited income* OR resource constrain* OR constrained resource* OR resource restraint OR restrained resource* OR restricted resource* OR resource poor OR third world OR developing world OR developing area* OR less developed countr* OR least developed countr* OR developing countr* OR Underdeveloped countr* OR Under Developed countr*

OR less developed nation* OR least developed nation* OR developing nation* OR Underdeveloped nation* OR Under Developed nation* OR Afghan* OR Burkina* OR Burund* OR Chad OR Chadian OR Congo* OR Zaire OR Eritrea* OR Ethiopia* OR (Guinea* NOT guinea pig*) OR Bissau OR Haiti* OR Democratic People's Republic of Korea OR North Korea* OR Liberia* OR Madagascar OR Malagas* OR Malawi* OR Mali OR Malian* OR Mozambique OR mozambican* OR Niger* OR Rwand* OR Sierra Leone*

OR Somali* OR Sudan* OR Syria* OR Tajik* OR Togo* OR Ugand* OR Yemen* OR Algeria* OR Angola OR Banglad* OR Benin* OR Bhutan* OR Bolivia* OR Cabo Verde OR Cape Verde OR Cambodia* OR Cameroon* OR Comoros OR Congo* OR Cote d'Ivoire

(8)

OR Ivory Coast OR Djibouti* OR Egypt* OR Salvador* OR Eswatini* OR Swaziland* OR Ghana* OR Hondur* OR India* OR Kenya* OR Kiribati* OR Kyrgy* OR Laos OR Laotian*

OR Lao People's Democratic Republic OR Lao PDR OR Lesoth* OR Mauritania* OR Micronesia* OR Moldov* OR Mongoli* OR Morocc* OR Myanmar OR Burma* OR Nepal*

OR Nicaragu* OR Nigeri* OR Pakistan* OR Papua* OR Philippines OR Filipino* OR "Sao Tome and Principe" OR Senegal* OR Solomon Islands OR Sri Lanka* OR Sinhalese* OR Tanzania* OR Timor-Leste OR Tunisia* OR Ukrain* OR Uzbekistan* OR Vanuatu OR Vietnam* OR West Bank OR Gaza* OR Zambia* OR Zimbabw* OR Albania* OR Samoa*

OR Argentin* OR Armenia* OR Azerbaijan* OR Azeri* OR Belarus* OR Belize* OR Bosnia* OR Herzegovina* OR Botswan* OR Brazil* OR Bulgaria* OR China OR Chinese*

OR Colombia* OR Costa Rica* OR Cuba* OR Dominica* OR Ecuador* OR Fiji* OR Gabon* OR Georgia* OR Grenada OR Guatemal* OR (Guyan* NOT French Guyan*) OR Indonesia* OR Iran* OR Iraq* OR Jamaica* OR Jordan* OR Kazakh* OR Kosov* OR Leban* OR Libya* OR Malaysia* OR Maldives OR Marshall Islands OR (Mexic* NOT mexican american) OR Montenegr* OR Namibia* OR North Macedoni* OR Paragu* OR Peru* OR Russia* OR Samoa* OR Serbia* OR South Africa* OR St Lucia OR Saint Lucia OR "St. Vincent and the Grenadines" OR "Saint Vincent and the Grenadines" OR

Thailand OR thai OR Tonga* OR Turk* OR Tuvalu OR Venezuel* OR Africa OR (african NOT african american))

AND

English in post-search filters

Scopus:

(TITLE-ABS-KEY({ARDS} OR {respiratory distress syndrome, adult} OR {adult respiratory distress syndrome} OR {adult respiratory distress syndromes} OR {acute respiratory distress syndrome} OR {acute respiratory distress syndromes} OR {shock lung} OR {shock lungs} OR {acute lung injury} OR {acute lung injuries} OR {acute hypoxemic respiratory failure} OR {acute hypoxemic respiratory failures} OR {AHRF} OR {idiopathic respiratory distress syndrome} OR {idiopathic respiratory distress syndromes} OR {PARDS} OR {pediatric respiratory distress syndrome} OR {pediatric respiratory distress syndromes} OR {paediatric respiratory distress syndrome} OR {paediatric respiratory distress syndromes}))

AND

(TITLE-ABS-KEY({Bubble continuous positive airway pressure} OR {Bubble CPAP} OR {Peripheral inotrope*} OR {peripheral dopamine} OR {peripheral adrenaline} OR

{peripheral dobutamine} OR {peripheral noradrenaline} OR {peripheral vasopressin} OR {peripheral milrinone} OR {Oxygen therap*} OR {o2 therap*} OR {Oxygen inhalation therap*} OR {O2 inhalation therap*} OR {oxygen insufflation} OR {o2 insufflation} OR {oxygen treatment*} OR {o2 treatment*} OR {Peritoneal dialys*} OR {Lack of monitoring}

OR {limited monitoring} OR {minimal monitoring} OR {minimally monitored} OR {non monitored} OR {General ward*} OR {Patient room*} OR {Patients room*} OR {Patients' room*} OR {Patient's room*} OR {LMIC} OR {LMICs} OR {Emerging countr*} OR {Emerging nation*} OR {low resource*} OR {low income*} OR {middle resource*} OR {middle income*} OR {Lack of resource*} OR {resource limited} OR {limited resource*} OR {limited income*} OR {resource constrain*} OR {constrained resource*} OR {resource restraint} OR {restrained resource*} OR {restricted resource*} OR {resource poor} OR {third world} OR {developing world} OR {developing area*} OR {less developed countr*}

OR {least developed countr*} OR {developing countr*} OR {Underdeveloped countr*} OR {Under Developed countr*} OR {less developed nation*} OR {least developed nation*} OR {developing nation*} OR {Underdeveloped nation*} OR {Under Developed nation*} OR {Afghan*} OR {Burkina*} OR {Burund*} OR {Chad} OR {Chadian} OR {Congo*} OR {Zaire}

OR {Eritrea*} OR {Ethiopia*} OR ({Guinea*} NOT {guinea pig*}) OR {Bissau} OR {Haiti*}

OR {Democratic People's Republic of Korea} OR {North Korea*} OR {Liberia*} OR

(9)

{Madagascar} OR {Malagas*} OR {Malawi*} OR {Mali} OR {Malian*} OR {Mozambique}

OR {mozambican*} OR {Niger*} OR {Rwand*} OR {Sierra Leone*} OR {Somali*} OR {Sudan*} OR {Syria*} OR {Tajik*} OR {Togo*} OR {Ugand*} OR {Yemen*} OR {Algeria*}

OR {Angola} OR {Banglad*} OR {Benin*} OR {Bhutan*} OR {Bolivia*} OR {Cabo Verde}

OR {Cape Verde} OR {Cambodia*} OR {Cameroon*} OR {Comoros} OR {Congo*} OR {Cote d'Ivoire} OR {Ivory Coast} OR {Djibouti*} OR {Egypt*} OR {Salvador*} OR {Eswatini*} OR {Swaziland*} OR {Ghana*} OR {Hondur*} OR {India*} OR {Kenya*} OR {Kiribati*} OR {Kyrgy*} OR {Laos} OR {Laotian*} OR {Lao People's Democratic Republic}

OR {Lao PDR} OR {Lesoth*} OR {Mauritania*} OR {Micronesia*} OR {Moldov*} OR {Mongoli*} OR {Morocc*} OR {Myanmar} OR {Burma*} OR {Nepal*} OR {Nicaragu*} OR {Nigeri*} OR {Pakistan*} OR {Papua*} OR {Philippines} OR {Filipino*} OR {Sao Tome and Principe} OR {Senegal*} OR {Solomon Islands} OR {Sri Lanka*} OR {Sinhalese*} OR {Tanzania*} OR {Timor-Leste} OR {Tunisia*} OR {Ukrain*} OR {Uzbekistan*} OR

{Vanuatu} OR {Vietnam*} OR {West Bank} OR {Gaza*} OR {Zambia*} OR {Zimbabw*} OR {Albania*} OR {Samoa*} OR {Argentin*} OR {Armenia*} OR {Azerbaijan*} OR {Azeri*} OR {Belarus*} OR {Belize*} OR {Bosnia*} OR {Herzegovina*} OR {Botswan*} OR {Brazil*} OR {Bulgaria*} OR {China} OR {Chinese*} OR {Colombia*} OR {Costa Rica*} OR {Cuba*} OR {Dominica*} OR {Ecuador*} OR {Fiji*} OR {Gabon*} OR {Georgia*} OR {Grenada} OR {Guatemal*} OR ({Guyan*} NOT {French Guyan*}) OR {Indonesia*} OR {Iran*} OR {Iraq*}

OR {Jamaica*} OR {Jordan*} OR {Kazakh*} OR {Kosov*} OR {Leban*} OR {Libya*} OR {Malaysia*} OR {Maldives} OR {Marshall Islands} OR ({Mexic*} NOT {mexican american}) OR {Montenegr*} OR {Namibia*} OR {North Macedoni*} OR {Paragu*} OR {Peru*} OR {Russia*} OR {Samoa*} OR {Serbia*} OR {South Africa*} OR {St Lucia} OR {Saint Lucia}

OR {St. Vincent and the Grenadines} OR {Saint Vincent and the Grenadines} OR

{Thailand} OR {thai} OR {Tonga*} OR {Turk*} OR {Tuvalu} OR {Venezuel*} OR {Africa} OR ({african} NOT {african american}))

AND

English in post-search filters

(10)

Supplemental Figure 1. Study flow diagram according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol

recommendations.

(11)

Supplemental Table 2. Evidence to Decision Framework Table for Recommendation 11.1 Recommendation

11.1. Healthcare providers working in RLS should be mindful of precipitating factors for PARDS (e.g., dengue, malaria, measles, scrub typhus) and concurrent comorbidities [e.g., human immunodeficiency virus (HIV), malnutrition, chronic anemia] that are not commonly encountered in high-income countries. (Ungraded good practice statement).

Desirable Effects

How substantial are the desirable anticipated effects?

JUDGEMENT MAIN ARGUMENTS ADDITIONAL

CONSIDERATIONS Large There are numerous publications that common

diseases in RLS can lead to PARDS: Bhattacharya 2019, Machakanur 2019, Pothapregada 2016

(Dengue); Kimura 2014 (Malaria); Han 2016, Li 2015 (Measles); Nallasamy 2020, Wangrangsimakul 2020, KumarBhat 2014 (scrub typus); Das 2011, Kendirli 2012 (H1N1); Kawachi 2009 (H5N1); Xiao 2019 (Sepsis); Rabie 2017, Kitchin 2012 (HIV)

(12)

Undesirable Effects

How substantial are the undesirable anticipated effects?

CONSIDERATIONS Trivial There are no undesirable effects on considering these

common precipitating factors in RLS for diagnosis of PARDS.

Balance of Effects

Does the Balance between desirable and undesirable effects favor the recommendation?

CONSIDERATIONS Favors the

intervention

Knowing the precipitating factors of PARDS and comorbidities in RLS will help in starting specific treatment for these diseases.

Implementation

Is the recommendation feasible to implement?

CONSIDERATIONS Yes It is feasible to include these factors as precipitating

factors for PARDS in sites where these diseases and comorbidities are common.

Additional relevant areas (i.e. values, resources, equity, subgroup considerations) (Ok to leave blank if N/A)

(13)

11.2. In RLS where all the criteria for PARDS cannot be fulfilled, the term "Possible PARDS"

should be used when the patient has history and physical examination findings consistent with known precipitating factors and clinical features of PARDS. (Ungraded definition recommendation).

Remarks: In these settings, the use of oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2) or oxygen saturation index (OSI) (as per PALICC PARDS guidelines) is appropriate and may be preferred over arterial partial pressure of oxygen (PaO2)/FiO2 or oxygenation index (OI).

Remarks: Imaging is recommended to diagnose possible PARDS and can include

ultrasound or chest radiograph demonstrating parenchymal disease; however, there is no absolute need for imaging criteria to diagnose "Possible PARDS" if timing, oxygenation and risk factor criteria are present.

Desirable Effects

CONSIDERATIONS Moderate There are no studies examining how good applying

“partial” definitions is for the diagnosis of PARDS (eg:

validity of PALICC’s definition without CXR/imaging).

We did not mandate alternative point of care imaging to be used in this definition because it may not be uniformly available in all resource-limited settings (eg:

(14)

lung ultrasound).

Many studies that examined common precipitating causes of PARDS (e.g. severe pneumonia) lack classification or description of PARDS in their cohort.

Applying a modified definition would allow better description and understanding of this condition in resource limited settings.

Duyu 2020 (severe LRTI; definition of ARDS not described); Graham 2019 (RCT of pulse oximetry – patients with severe respiratory distress but PARDS not described); Chisti 2015 (RCT in severe pneumonia but no PARDS mentioned); Das 2011 (H1N1 but ARDS not defined)

Undesirable Effects

CONSIDERATIONS Don't know There may be an overdiagnosis of Possible PARDS

using the proposed definition, that has yet to be

validated in resource limited settings. Future validation studies are required.

Balance of Effects

CONSIDERATIONS Probably

favors the intervention

The potential desirable effect of increased recognition of PARDS in resource limited settings outweighs the

“negative effect” of overdiagnosis.

Implementation

CONSIDERATION S

Probably yes This definition should be feasible to apply in most resource-limited countries; the term Possible PARDS

“should be considered in settings where imaging criterion for PARDS cannot be satisfied.

Additional relevant areas (i.e. values, resources, equity, subgroup considerations) (Ok to leave blank if N/A)

(15)

11.5 All hospitals in RLS should implement locally adapted protocols for starting,

maintenance, and weaning of MV and for extubation of patients with PARDS. (Ungraded policy statement).

Desirable Effects

CONSIDERATIONS Large Each resource-limited setting has their own unique

logistical setup, administrative arrangement and challenges. The key is to ensure that each site consider its own resources and barriers in planning mechanical ventilation support of children with PARDS.

Having a protocol will also help standardize practice across a wide range of provider skill sets.

Undesirable Effects

CONSIDERATIONS

(16)

Trivial Locally adapted protocols should have minimal side effects. However, there needs to be a system for assessment of these protocols and refinement, if necessary.

Balance of Effects

Having a locally adapted protocolized care is advantageous to ensure consistency of care to be applied to all patients.

Implementation

CONSIDERATIONS Varies The feasibility to develop and implement protocolized

care would likely vary amongst different contexts (geographical, socio-economic, cultural etc).

11.6 All members of the multidisciplinary team involved in the care of a patient with PARDS must be provided with regular MV training and education. (Ungraded policy statement, 100%

agreement).

Desirable Effects

CONSIDERATIONS Large Ensuring adequate education and maintenance of the

skills and knowledge for mechanical ventilation, which is the cornerstone of management of PARDS patients, is critical. All sites that support PARDS patients should ensure that there is regular and ongoing education and training provided to all staff caring for these patients, in order to ensure compliance with best evidence-based practice.

Undesirable Effects

(17)

JUDGEMENT MAIN ARGUMENTS ADDITIONAL CONSIDERATIONS Trivial Minimal side effects from regular education/training

session.

Balance of Effects

Training and education are critical for safe MV practice. Resource-limited settings to ensure the essential and basic knowledge are provided for those caring for patients who required MV.

Implementation

CONSIDERATIONS Varies Different sites will have different challenges and

barriers to implementing regular teaching/education of staff caring for PARDS who require mechanical ventilation.

(18)

11.7. While using pulmonary and non-pulmonary ancillary therapies in RLS, current overall evidence (as provided by PALICC-2) as well as availability and costs of these therapies locally, should be taken into consideration. (Ungraded policy statement)

Desirable Effects

CONSIDERATIONS Varies Different pulmonary and non-pulmonary ancillary

therapies have different desirable effects. We will align with the benefits as per PALLIC-2 guidelines.

Undesirable Effects

CONSIDERATIONS Varies Different pulmonary and non-pulmonary ancillary

therapies have different side effects. We will align with the benefits as per PALLIC2 guidelines.

(19)

Balance of Effects

CONSIDERATIONS Varies The balance of benefit to harms/burden may be

different in RLS than in high-resource settings.

Implementation

CONSIDERATIONS Varies The availability and cost of such therapies are likely to

be different across RLS sites. We will need to

consider the overall risk:benefit ratio, availability, and cost of such therapies before providing them to the patients in these settings.

11.10. For long term outcomes of PARDS patients in RLS, alignment with PALICC-2 recommendations should be kept wherever possible and according to available resources.

(Ungraded policy statement).

Desirable Effects

CONSIDERATIONS Large Over time, as we expect mortality from PARDS to

improve in RLS, it is important to start planning for long-term follow-up of survivors of PARDS patients.

Undesirable Effects

CONSIDERATIONS Trivial Potential side effect of costs involved in providing long

term follow-up of PARDS patients.

Balance of Effects

(20)

JUDGEMENT MAIN ARGUMENTS ADDITIONAL CONSIDERATIONS Don’t know The potential impact of long-term follow-up in

resource-limited settings remain unknown. Future studies are required to provide preliminary data in this important area in clinical outcomes of PARDS

patients.

Implementation

CONSIDERATIONS Varies Any documentation of long-term follow-up of PARDS

patients in RLS will be useful. Within each setting, there will be unique challenges in ensuring follow-up care.

(21)

APPENDIX 1. Second Pediatric Acute Lung Injury Consensus Conference (PALICC- 2) Group

Co-Chairs – Guillaume Emeriaud, Yolanda M López-Fernández, Robinder G Khemani Methodologists: Narayan Prabhu Iyer, Melania Bembea, Steven Kwasi Korang, Katherine M. Steffen

Experts

Section 1 (Definition, Incidence and Epidemiology) Nadir Yehya, Lincoln Smith, Neal J.

Thomas, Jerry J. Zimmerman, Simon J. Erickson, Steven L. Shein

Section 2 (Pathobiology, Severity, and Risk Stratification) Jocelyn R. Grunwell, Mary K.

Dahmer, Anil Sapru, Michael W. Quasney, Heidi R Flori.

Section 3 (Ventilatory Support) Analia Fernandez, Vicent Modesto i Alapont, Peter Rimensberger, Ira Cheifetz.

Section 4 (Pulmonary Specific Ancillary Treatment) Courtney Rowan, Adrienne G. Randolph, Martin Kneyber.

Section 5 (Non pulmonary treatment) Stacey Valentine, Sapna Kudchadkar, Shan Ward, Vinay Nadkarni, Martha A.Q. Curley.

Section 6 (Monitoring) Anoopindar Bhalla, Florent Baudin, Muneyuki Takeuchi, Pablo Cruces.

Section 7 (Noninvasive support) Christopher L Carroll, Natalie Napolitano, Marti Pons- Odena, Sandrine Essouri.

Section 8 (Extracorporeal Support) Jérome Rambaud, Ryan Barbaro, Duncan Macrae, Heidi Dalton.

Section 9 (Morbidity and Long-Term Outcomes) Elizabeth Killien, Aline Maddux, Sze Man Tse, Scott Watson.

Section 10 (Clinical Informatics and Data Science) L. Nelson Sanchez-Pinto, Michaël Sauthier, Prakadeshwari Rajapreyar, Philippe Jouvet, Christopher Newth.

Section 11 (Resource-Limited Settings) Brenda Morrow, Asya Agulnik, Werther Brunow de Carvalho, Mohamod Chisti, Jan Hau Lee.

Librarians: Katie Lobner, Lynn Kysh, Alix Pincivy, Philippe Dodin