Cases
Admissions 28d-59m
Admissions during enrolment hours
Screened
Eligible with severe/
very severe pneumonia
Enrolled
8927 admissions
7588 (85%) admissions
3687 (49%) with cough and/or difficult breathing
1925 (52%) cases
920 (48%) cases:
• 465 (51%) HIV unexposed
• 298 (32%) HIV-exposed, -uninfected
• 115 (13%) HIV-infected
• 42 (5%) HIV exposure unknown
1762 (48%) excluded:
• 1124 no severe pneumonia
• 327 not from catchment area
• 285 recent hospitalization
• 26 recent PERCH case
1005 (52%) excluded:
• 361 reason not specified
• 319 refused consent
• 120 no legal guardian
• 111 inadequate follow-up time
• 59 met quota for day’s enrolments
• 18 screening error
• 17 other Exclusions
Exclusions
HIV-infected Controls
HIV Clinic attendees 28d-59m during enrolment hours
Eligible for enrolment
Enrolled
Analyzed
853 attendees
728 (85%) HIV- infected controls
134 (18%) HIV- infected controls
136 HIV-infected controls
125 (15%) excluded:
• 100 not from catchment area
• 18 recent PERCH case
• 4 recent hospitalization
594 (82%) excluded:
• 478 reason not specified
• 63 refused consent
• 30 screening error
• 12 no legal guardian
• 11 other Exclusions
Exclusions
2 HIV-infected community controlsa Inclusions
Supplemental Digital Content 2. Case and HIV-infected Control Enrolments in PERCH – South African Site
aHIV-infected community controls reflect controls enrolled into the PERCH study from the community who were HIV-infected. For analysis purposes, the two HIV-infected community controls were combined with the controls enrolled from HIV clinics to form the full set of HIV-infected controls.
