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Supplemental Digital Content 3. Table.

Diagnostic groups

Varicella at any diagnosis (n=2,526)

Varicella as primary diagnosis (n=1,882)

Varicella as secondary diagnosis (n=644)

Change in length of hospital stay

No. of patients (%) No. of patients (%) No. of patients (%) No. of days (95% CI)

Varicella with complications 741 (29.33) 531 (28.21) 210 (32.61) 2.18 (1.29, 3.06)

Varicella without complications or varicella not

otherwise specified (B019) 1785 (70.67) 1351 (71.79) 425 (65.99) -2.83 (-3.71, -1.95)

B019 as the only diagnosis 972 (38.50) 972 (51.65) 0 -3.37 (-4.68, -2.07)

Complications presumably related to varicella

by organ system 918 (36.34) 517 (27.47) 401 (62.27) 3.08 (2.20, 3.97)

Skin and mucosa 127 (5.03) 51 (2.71) 76 (11.80) 0.65 (-0.95, 2.25)

Circulation 23 (0.91) 14 (0.74) 9 (1.40) 3.00 (-0.63, 6.62)

Neurological 329 (13.02) 227 (12.06) 102 (15.84) 3.24 (2.11, 4.37)

Hematological 24 (0.95) 8 (0.43) 16 (2.48) 4.80 (1.53, 8.06)

Ophthalmological 16 (0.63) 11 (0.58) 5 (0.78) 3.30 (-1.08, 7.68)

Upper respiratory system 109 (4.32) 49 (2.60) 60 (9.32) -2.22 (-4.51, 0.06)

Lower respiratory system 170 (6.73) 83 (4.41) 87 (13.51) 4.36 (3.10, 5.62)

Gastrointestinal system. nutritional complications 10 (0.40) 5 (0.27) 5 (0.78) 6.19 (1.83, 10.56) Secondary infection. not classified other place 67 (2.65) 32 (1.70) 35 (5.43) 10.81 (8.90, 12.72)

Other complications 249 (9.86) 140 (7.44) 109 (16.93) 2.27 (1.14, 3.40)

Immunocompromised conditions 140 (5.54) 71 (3.77) 69 (10.71) 5.32 (3.84, 6.79)

HIV 10 (0.40) 5 (0.27) 5 (0.78) 12.86 (8.90, 16.81)

Cancer 66 (2.61) 30 (1.59) 36 (5.59) 6.24 (4.15, 8.33)

Transplantation 32 (1.27) 21 (1.12) 11 (1.71) 0.66 (-2.37, 3.68)

Immunosupression other 43 (1.70) 17 (0.90) 26 (4.04) 2.29 (-0.41, 4.99)

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Autoimmune conditions 111 (4.39) 56 (2.98) 55 (8.54) 1.12 (-0.75, 3.00)

Hemathologic 8 (0.32) 2 (0.11) 6 (0.93) -2.01 (-8.40, 4.38)

Endocrine 18 (0.71) 4 (0.21) 14 (2.17) 4.69 (0.58, 8.80)

Neurological 1 (0.04) 1 (0.05) 0 20.89 (4.05, 37.73)

Ocular 0 0 0 Na

Respiratory 0 0 0 Na

Gastrointestinal 24 (0.95) 17 (0.90) 7 (1.09) -0.22 (-3.69, 3.25)

Skin 33 (1.31) 15 (0.80) 18 (2.80) -1.18 (-5.88, 3.52)

Connective tissues 29 (1.15) 19 (1.01) 10 (1.55) 0.85 (-2.51, 4.20)

Predisposing conditions 545 (21.58) 299 (15.89) 246 (38.20) 1.90 (0.98, 2.83)

Pulmonary 55 (2.18) 23 (1.22) 32 (4.97) 1.44 (-1.17, 4.05)

Kidney 37 (1.46) 21 (1.12) 16 (2.48) 6.22 (3.47, 8.98)

Pregnancy** 25 (0.99) 13 (0.69) 12 (1.86) -3.39 (-6.57, -0.20)

Chronic liver diseases 4 (0.16) 2 (0.11) 2 (0.31) 25.79 (16.13, 35.45)

Unknown malignancy 1 (0.04) 0 1 (0.16) 10.92 (27.82, 5.99)

Diabetes 30 (1.19) 12 (0.64) 18 (2.80) 3.47 (0.30, 6.63)

Endocrine system diseases 24 (0.95) 17 (0.90) 7 (1.09) -0.03 (-3.16, 3.10)

Diseases of nerve system 46 (1.82) 24 (1.28) 22 (3.42) 6.10 (3.82, 8.38)

Other diseases in the eye 4 (0.16) 3 (0.16) 1 (0.16) -2.77 (-12.51, 6.97)

Diseases of the ear 17 (0.67) 8 (0.43) 9 (1.40) -1.79 (-7.44, 3.86)

Heart. vessel diseases 43 (1.70) 25 (1.33) 18 (2.80) 3.50 (0.78, 6.22)

Respiratory diseases 55 (2.18) 20 (1.06) 35 (5.43) 3.54 (1.05, 6.03)

Gastrointestinal diseases 44 (1.74) 25 (1.33) 19 (2.95) 1.30 (-1.20, 3.80)

Skin diseases 36 (1.43) 16 (0.85) 20 (3.11) 3.93 (-0.44, 8.30)

Arthritis. arthrosis etc. 34 (1.35) 23 (1.22) 11 (1.71) 0.99 (-2.11, 4.09)

Other chronic diseases 64 (2.53) 24 (1.28) 40 (6.21) 2.52 (0.30, 4.73)

Otitis media 0 0 0 Na

Dehydration 187 (7.40) 117 (6.22) 70 (10.87) 0.25 (-1.04, 1.54)

Stroke 0 0 0 Na

** adjusted to women only and age.

Na = Not available

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