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Supplemental Digital Content 3

Table S1. QuantiFERON-TB Gold In-Tube results according to the study group defined by

tuberculin skin testing results shown in Table 1, Supplemental Digital Content.

Group of patients QFN-G-IT results

Positive Negative

No LTBI 0 26

BCG reactors 0 6

LTBI 5 10

Probable active TB 0 2

Previous active TB 1 1

Definitions: No LTBI: Children with TST <5mm; BCG-reactors: BCG-vaccinated children with TST between 5 and 10mm; LTBI: children non-BCG-vaccinated children with TST≥5mm and BCG-vaccinated children with TST ≥10mm; Probable active TB: children with absence of culture confirmation but with abnormal radiography consistent with active TB; Previous active TB:

children with active TB diagnosed in the past, whom active TB chemotherapy was administrated

TST: Tuberculin skin testing; QFN-G-IT: QuantiFERON-TB Gold In Tube; LTBI: Latent

Tuberculosis infection; TB: Tuberculosis; BCG: Mycobacterium bovis bacillus Calmette-Guérin

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