SUPPLEMENTAL DIGITAL CONTENT
Table S1: Baseline characteristics of the overall cohort, stratified by stent type. All values are percentages unless otherwise stated
Whole cohort Inverse Probability of Treatment Weighted
BMS DES Std Diff BMS DES Std Diff
Number of patients 845 2400 845 2400
Age, years, mean (SD) 59.8
(11.2)
58.5
(10.8) 11.8 58.6
(11.5)
58.8
(10.8) 2.1
Male 67.6 63.0 9.6 63.9 64.2 0.6
Race
White 80.0 80.0 0.1 80.0 80.0 0.0
Black 15.7 15.6 0.3 15.7 15.7 0.1
Asian 2.5 2.8 1.7 2.6 2.7% 0.3
Other 1.8 1.6 1.5 1.7 1.6 0.6
Cause of ESRD
Diabetes 37.9 43.7 11.9 41.8 42.0 0.4
Hypertension 18.2 16.4 4.9 17.6 16.9 1.8
Glomerulonephritis 18.8 17.9 2.4 18.1 18.3 0.7
Other 25.1 22.0 7.2 22.5 22.7 0.5
Time since first ESRD diagnosis, years, median (IQR)
8.9 (5.5- 13.8)
8.7 (5.1-
13.6) 4.3 8.7 (5.5- 13.5)
8.7 (5.1 -
13.7) 1.1
Transplant History
Preemptive kidney transplant 7.1 8.8 6.1 8.3 8.2 0.1
Deceased donor kidney transplant 68.9 68.6 0.6 69.0 68.7 0.7
Prior failed transplant 9.9 10.1 0.5 9.1 10.0 3.0
Time since current transplant, years, median (IQR)
5.5 (2.8- 9.7)
5.4 (2.6-
9.8) 0.03 5.4 (2.7- 9.8)
5.4 (2.6-
9.8) 1.4
Diagnosis at time of index PCI
Multivessel PCI 10.8 14.9 12.4 14.9 13.9 2.6
Stable coronary artery disease 53.5 63.2 19.8 60.7 60.6 0.3
ST elevation MI 22.1 11.9 27.4 14.7 14.7 0.0
Non-ST elevation MI 23.8 24.1 0.7 24.1 24.0 0.2
Unstable Angina 0.6 0.8 2.4 0.5 0.7 2.8
Comorbidities (%)
History of coronary artery bypass
grafting 21.3 21.6 0.7 22.3 21.6 1.6
Prior PCI 11.8 13.8 5.7 12.9 13.1 0.8
Myocardial infarction 55.7 47.8 16 50.6 50.0 1.3
Unstable angina 53.0 60.8 15.7 59.2 58.7 0.9
Heart failure 49.8 49.7 0.2 49.5 49.8 0.6
Hypertension 99.8 99.5 3.8 99.8 99.6 3.5
Atrial fibrillation 23.8 20.5 7.9 21.3 21.3 0.0
Any arrhythmia 26.3 23.4 6.6 26.0 24.2 4.2
Stroke 16.4 16.5 0.1 17.1 16.5 1.7
Valve disease 34.8 34.1 1.4 33.2 34.3 2.4
Peripheral vascular disease 44.5 45.1 1.3 44.0 44.9 1.8
Hyperlipidemia 87.8 88.5 2.1 88.0 88.1 0.1
Gastrointestinal bleeding 23.0 21.5 3.5 21.4 21.9 1.2
Peptic ulcer disease 6.7 6.2 2.2 5.8 6.3 2.1
Cerebrovascular bleed 1.4 1.5 0.7 1.1 1.5 3.6
Liver disease 22.6 20.5 5.1 20.2 21.0 2.0
Lung disease 34.6 33.3 2.8 32.6 33.4 1.9
Tobacco 15.4 13.6 5.0 14.6 14.1 1.3
Dementia 4.4 3.3 5.7 3.4 3.6 1.2
Depression 24.0 25.0 2.3 24.0 25.0 2.3
Cancer 14.1 14.2 0.4 14.1 14.2 0.4
Hypothyroidism 20.6 19.4 3.1 20.6 19.4 3.1
Obesity 20.9 20.4 1.3 20.9 20.4 1.3
Healthcare Utilization
Non-nephrology visits in previous 6 months, median (IQR)
22 (13- 34)
22 (13-
32) 1.8 22 (13-34) 22 (13-32) 1.8 Hospital days in previous 6 months,
median (IQR) 1 (1-6) 1 (1-6) 0.6 1 (1-6) 1 (1-6) 0.6
Nursing home in previous 6 months 3.9 2.8 6.2 3.0 3.1 1.0
Table S2: Results from logistic regression model for receipt of bare metal stent (versus drug-eluting stent) used to generate the propensity score for creation of the matched cohort in patients with a functioning kidney transplant at the time of percutaneous coronary intervention
Estimate
Standa rd Error
Odds ratio
Lower 95%
confide nce limit
Upper 95%
confidenc e limit
p-value
Demographics
Age, per 1 year increase -0.01 <0.01 0.99 0.98 1.00 <0.01
Female sex 0.08 0.05 1.17 0.98 1.40 0.09
Race (vs white)
Asian 0.06 0.21 1.00 0.59 1.68 0.86
Black 0.08 0.13 1.01 0.79 1.28
Other/Unknown -0.21 0.25 0.76 0.41 1.42
Time since ESRD, per 1 year -0.02 0.01 0.98 0.95 1.00 0.08
Time since current kidney transplant, years 0.02 0.01 1.02 0.99 1.05 0.11
Preemptive transplant 0.22 0.16 1.24 0.90 1.71 0.19
Deceased donor kidney transplant (versus
living) 0.02 0.09 1.02 0.85 1.22 0.84
History of prior failed kidney transplant 0.17 0.19 1.19 0.83 1.70 0.36 Cause of end-stage renal disease (vs
other/unknown)
Diabetes 0.02 0.08 1.12 0.88 1.43 0.63
Hypertension 0.06 0.08 1.17 0.91 1.51
Glomerulonephritis 0.01 0.09 1.11 0.86 1.45
Non-nephrology outpatient visits, per 1 visit
increase 0.002 <0.01 1.00 1.00 1.01 0.41
Hospital days in 6m prior, per 1 day increase -0.003 <0.01 1.00 0.99 1.01 0.50
Any nursing home stay -0.22 0.25 0.81 0.49 1.32 0.39
Multivessel intervention 0.37 0.13 1.45 1.13 1.87 0.00
Index Presentation (vs unstable angina)
Stable coronary artery disease 0.09 0.15 0.90 0.32 2.51 <0.01
ST-elevation myocardial infarction -0.51 0.16 0.50 0.18 1.40 Non-ST elevation myocardial infarction 0.22 0.15 1.03 0.38 2.81 Cardiovascular Comorbidities
Coronary artery bypass grafting history -0.10 0.11 0.91 0.73 1.12 0.35 Percutaneous coronary intervention history 0.15 0.13 1.16 0.91 1.49 0.24
Myocardial infarction 0.02 0.13 1.02 0.79 1.33 0.87
Angina 0.18 0.09 1.19 1.00 1.42 0.05
Heart failure 0.03 0.09 1.03 0.86 1.23 0.76
Hypertension -0.67 0.78 0.51 0.11 2.38 0.39
Atrial fibrillation -0.10 0.11 0.91 0.74 1.12 0.37
Other arrhythmia -0.04 0.10 0.96 0.79 1.17 0.67
Stroke/Transient ischemic attack 0.05 0.13 1.05 0.82 1.35 0.68
Valvular disease 0.01 0.09 1.01 0.84 1.22 0.92
Peripheral arterial disease 0.01 0.09 1.01 0.85 1.21 0.89
Cerebrovascular disease -0.001 0.13 1.00 0.78 1.28 0.99
Other comorbid conditions
Diabetes mellitus 0.09 0.11 1.10 0.88 1.36 0.41
Peptic ulcer disease -0.03 0.17 0.97 0.69 1.36 0.85
Intracranial hemorrhage 0.12 0.35 1.12 0.57 2.23 0.74
Liver disease -0.12 0.10 0.88 0.72 1.08 0.23
Chronic lung disease -0.06 0.09 0.95 0.79 1.14 0.55
Smoking history -0.11 0.12 0.90 0.70 1.14 0.37
Dementia -0.22 0.22 0.80 0.52 1.24 0.32
Depression 0.11 0.10 1.12 0.91 1.37 0.27
Cancer -0.11 0.12 0.90 0.71 1.14 0.37
Hypothyroid 0.14 0.11 1.15 0.93 1.43 0.21
Obesity 0.01 0.11 1.01 0.82 1.25 0.90
Census Region (vs West South Central)
East North Central -0.26 0.09 0.89 0.66 1.19 <0.01
West North Central 0.03 0.13 1.18 0.82 1.69
East South Central 0.16 0.15 1.34 0.90 2.00
Mid Atlantic 0.07 0.11 1.23 0.89 1.69
Mountain -0.09 0.16 1.05 0.70 1.57
Northeast -0.21 0.18 0.93 0.60 1.45
Pacific 0.47 0.14 1.85 1.28 2.67
South Atlantic -0.02 0.10 1.13 0.84 1.53
Table S3: Unadjusted inverse probability of treatment weighted event rates
1-year 2-year 3-year Complete f/u
BMS DES BMS DES BMS DES BMS DES
Outcom e
N Events
Events / 100 person-
years N Events
Events / 100 person -years
N Events
Events / 100 person -years
N Events
Events / 100 person -years
N Events
Events / 100 person -years
N Events
Events / 100 person -years
N Events
Events / 100 person -years
N Events
Events / 100 person -years
Death 95 11.9 218 9.6 160 10.5 376 8.6 227 10.3 510 8.1 373 11.8 903 9.8
Death or
MI 149 20.2 385 18.2 232 17.8 607 16.3 301 17.6 767 15.6 436 18.3 1142 16.6
Death,
MI or RR 236 34.5 640 33.0 342 29.3 897 26.9 423 28.3 1072 25.0 532 27.1 1392 24.0
Bleed 62 8.3 136 6.4 83 6.4 211 5.5 99 5.8 255 5.1 127 5.3 339 4.8
Supplemental Figure: Kaplan-Meier curves and associated hazard ratios comparing drug-eluting stents
