Supplemental Digital Content 1. Table Results of univariate Cox proportional hazard analysis for prediction of incident microalbuminuria
Variable Coefficient SE Hazard ratio (95% CI) P
Age (per 1 y) 0.024 0.009 1.024 (1.007–1.044) 0.006
Female (vs. Male) 0.201 0.085 1.495 (1.077–2.104) 0.016
Waist circumference (per 1 cm) 0.020 0.009 1.020 (1.003–1.038) 0.025 BMI (per 1 kg/m2) 0.063 0.024 1.065 (1.015–1.116) 0.010 Systolic blood pressure (per 1
mmHg)
0.017 0.004 1.017 (1.009–1.025) <0.001
Diastolic blood pressure (per 1 mmHg)
0.019 0.007 1.019 (1.005–1.033) 0.007
Pulse pressure (per 1 mmHg) 0.023 0.006 1.023 (1.010–1.035) <0.001 LDL cholesterol (per 1 mmol/L) -0.010 0.100 0.989 (0.811–1.199) 0.915 HDL cholesterol (per 1 mmol/L) -0.356 0.196 0.701 (0.475–1.023) 0.066 Log-triglyceride (per 1 log
increase)
1.006 0.371 2.736 (1.310–5.611) 0.007
Log-fasting blood glucose (per 1 log increase)
3.489 0.938 32.742 (4.486–179.005) 0.001
Log-HbA1c (per 1 log increase) 3.817 1.505 45.479 (1.913–699.728) 0.020 Serum creatinine (per 1 μmol/L) -0.014 0.006 0.986 (0.974–0.998) 0.027 Uric acid (per 1 mmol/L) -1.196 1.125 0.302 (0.032–2.655) 0.284 Log-urinary albumin excretion
(per 1 log increase)
4.441 0.324 84.853
(45.182–161.296)
<0.001
Metabolic syndrome 0.294 0.096 1.801 (1.220–2.587) 0.004
Hypertension 0.300 0.079 1.823 (1.338–2.490) <0.001
Diabetes mellitus 0.278 0.128 1.744 (1.017–2.798) 0.044
Current smoker -0.031 0.119 0.940 (0.571–1.465) 0.795
Estimated GFR (per 1 mL·min-1·1.73 m-2)
0.001 0.005 1.001 (0.991–1.012) 0.788 BMI, body-mass index; LDL, low-density lipoprotein; HDL, high-density lipoprotein.
Supplemental Digital Content 2. Table Multivariate Cox proportional hazard analysis including log-urinary albumin excretion as a covariate
Variable Coefficient SE Hazard ratio
(95% CI)
P Coefficient SE Hazard ratio (95% CI)
P
Age (per 1 yr) -0.001 0.010 0.999 (0.980–1.020) 0.932 3.6×10-4 0.010 1.000 (0.982–1.021) 0.971 Female (vs. Male) 0.133 0.087 1.304 (0.932–1.848) 0.123 0.139 0.089 1.321 (0.938–1.885) 0.112 Systolic blood pressure
(per 1 mmHg)
0.004 0.004 1.004 (0.995–1.013) 0.356
Diastolic blood pressure (per 1 mmHg)
0.004 0.007 1.004 (0.990–1.018) 0.595
Log-triglyceride (per 1 log increase)
0.626 0.394 1.870 (0.856–4.009) 0.116 0.635 0.394 1.888 (0.864–4.048) 0.110
Log-fasting blood glucose (per 1 log increase)
1.258 0.919 3.519 (0.495–18.508) 0.196 1.335 0.916 3.799 (0.538–19.834) 0.170
Log-urinary albumin excretion (per 1 log increase)
4.269 0.339 71.440
(36.950–139.494)
<0.001 4.288 0.338 72.847
(37.724–142.042)
0.018
Supplemental Digital Content 3. Table Multivariate analysis for the prediction of log-urinary albumin excretion at end-point with or without log-baseline urinary albumin excretion as a covariate
Model 1 Model 2
Variable Coefficient SE P Coefficient SE P
Age (per 1 yr) 4.9×10-4 7.7×10-4 0.521 -0.001 7.2×10-4 0.041
Female (vs. Male) 0.060 0.008 <0.001 0.034 0.007 <0.001
Systolic blood pressure (per 1 mmHg) 0.002 4.4×10-4 <0.001 6.2×10-4 4.1×10-4 0.130
Log-triglyceride (per 1 log increase) 0.068 0.038 0.075 0.037 0.035 0.300
Log-fasting blood glucose (per 1 log increase) 0.505 0.131 <0.001 0.357 0.122 0.003
Log-urinary albumin excretion (per 1 log increase) 0.559 0.029 <0.001
