Supplemental Table
Summary of main results Adjusted main results of sensitivity analysis
by excluding patients with cerebrovascular diseases
Severe Sepsis
p value
Severe Sepsis
p value
<65 y.o.
(n = 28) ≥65 y.o.
(n = 45) <65 y.o.
(n=27) ≥65 y.o.
(n=33)
Age, y (mean) 37.3 77.6 <0.001 Age, y (mean) 37.3 78.1 <0.001 Male, n (%) 20 (71) 31 (69) 0.97 Male, n (%) 20 (74) 22 (67) 0.74 Septic shock, n (%) 8 (29) 20 (44) 0.27 Septic shock, n (%) 8 (30) 16 (48) 0.22
SOFA score (mean) 7.8 7.8 0.87 SOFA score (mean) 7.8 8.4 0.98
Three-month survival, n (%) 25 (89) 27 (60) 0.008 Three-month survival, n (%) 25 (93) 20 (61) 0.006
CD4+ T cells, (/μL) 423 196 0.03 CD4+ T cells, (/μL) 423 229 0.05
CD8+ T cells, (/μL) 320 145 0.07 CD8+ T cells, (/μL) 320 139 0.05
%CD28+ in CD4+ T cells, (%) 94.8 84.5 0.01 %CD28+ in CD4+ T cells, (%) 94.8 86.8 0.04 %CD28+ in CD8+ T cells, (%) 52.1 30.9 0.01 %CD28+ in CD8+ T cells, (%) 52.1 32 0.003 %PD-1+ in CD4+ T cells, (%) 8.1 12.6 0.01 %PD-1+ in CD4+ T cells, (%) 8.1 14.7 0.008 %PD-1+ in CD8+ T cells, (%) 7.7 13.8 0.08 %PD-1+ in CD8+ T cells, (%) 7.7 14.3 0.04
