Supplementary data: The association between HIV, antiretroviral therapy and gestational diabetes: a systematic review and meta-analysis
I. Search strategy
Pubmed Search: 12 October 2015 (#1 AND #2 AND #3) = 290 results
#1
(diabetes[tiab] OR “diabetes mellitus”[tiab] OR “impaired glucose control”[tiab] OR diabetic[tiab] OR “impaired glucose uptake”[tiab] OR “glucose intolerance”[tiab] OR “glucose tolerance”[tiab] OR “oral glucose tolerance”[tiab] OR “impaired glucose tolerance”[tiab] OR “glucose metabolism”[tiab] OR “glucose metabolism disorder”[tiab] OR hyperglycaemia[tiab] OR
hyperglycemia[tiab] OR hyperglycæmia[tiab] OR “glucose plasma”[tiab] OR “plasma glucose”[tiab]
OR “high plasma glucose”[tiab] OR “blood glucose”[tiab] OR “high blood glucose”[tiab] OR “insulin resistance”[tiab] OR “insulin sensitivity”[tiab] OR “glucose tolerance test”[tiab] OR “oral glucose tolerance test”[tiab] OR “OGTT”[tiab] OR “intravenous glucose tolerance”[tiab] OR “glucose day curve”[tiab] OR “Diabetes Mellitus”[Mesh] OR hyperglycemia[Mesh] OR “glucose tolerance test”[Mesh] OR “insulin resistance”[Mesh] OR “Diabetes, Gestational”[Mesh])
#2
(maternal[tiab] OR pregnant[tiab] OR pregnancy[tiab] OR gestational[tiab] OR
gravidarum[tiab] OR gravidity[tiab] OR “pregnancy-induced”[tiab] OR “pregnancy induced”[tiab] OR
“pregnancy related”[tiab] OR “pregnant women”[Mesh])
#3
(HIV[tiab] OR “HIV infection”[tiab] OR AIDS[tiab] OR “Human immunodeficiency virus”[tiab] OR “Acquired immunodeficiency syndrome”[tiab] OR “Acquired immune deficiency syndrome”[tiab] OR “AIDS virus”[tiab] OR “Immunologic Deficiency Syndrome, Acquired”[tiab] OR
“Acquired Immune Deficiency Syndrome”[tiab] OR “Acquired Immune deficiency syndromes”[tiab]
OR “Acquired Immuno Deficiency Syndrome”[tiab] OR “Acquired Immuno-deficiency
Syndrome”[tiab] OR “HTLV- III”[tiab] OR “HTLV-III-LAV Infection”[tiab] OR “human T Cell Lymphotropic Virus Type III”[tiab] OR “Human T-Cell Lymphotropic Virus Type III”[tiab] OR
“Human T Lymphotropic Virus Type III”[tiab] OR “Human T-Lymphotropic Virus Type III”[tiab] OR
“Human T-Cell Leukemia Virus Type III”[tiab] OR “Human T Cell Leukemia Virus Type III”[tiab]
OR “HIV infected”[tiab] OR “HIV infected”[tiab] OR HAART[tiab] OR “Highly Active Anti retroviral Therapy”[tiab] OR “Highly Active Antiretroviral Therapies”[tiab] OR “Highly Active Anti- retroviral Therapy”[tiab] OR “Highly Active Antiretroviral Therapy”[tiab] OR “Highly Active Antiretroviral Therapies”[tiab] OR “Anti retroviral therapy”[tiab] OR “Anti retroviral therapies”[tiab]
OR “Antiretroviral therapy”[tiab] OR “Antiretroviral therapies”[tiab] OR “Anti-retroviral
therapy”[tiab] OR “Anti-retroviral therapies”[tiab] OR “Protease inhibitors”[tiab] OR “Endopeptidase inhibitor”[tiab] OR “Protease antagonists”[tiab] OR Antiprotease[tiab] OR “Peptidase inhibitor”[tiab]
OR “HIV protease inhibitor”[tiab] OR “HIV protease antagonist”[tiab] OR “HIV antiprotease”[tiab]
OR “Reverse-transcriptase inhibitor”[tiab] OR “Reverse transcriptase inhibitor”[tiab] OR “Antiviral agent”[tiab] OR Antiviral[tiab] OR “Antiviral drug”[tiab] OR “antiviral agent”[tiab] OR “Agent, Anti- Retroviral”[tiab] OR “Anti Retroviral Agent”[tiab] OR “Antiretroviral Agent”[tiab] OR “Fusion Inhibitor, HIV”[tiab] OR “HIV Cell Fusion Inhibitor”[tiab] OR “HIV Entry Inhibitor”[tiab] OR “HIV Integrase Inhibitor”[tiab] OR “HIV Integrase Inhibitors”[tiab] OR “CCR5 Receptor Antagonist”[tiab]
OR Zidovudine[tiab] OR Abacavir[tiab] OR Ziagen[tiab] OR AZT[tiab] OR Retrovir[tiab] OR Didanosine[tiab] OR videx[tiab] OR ddI[tiab] OR Lamivudine[tiab] OR Epivir[tiab] OR Zeffix[tiab]
OR 3TC[tiab] OR Stavudine [tiab] OR Zerit[tiab] OR D4T[tiab] OR Tenofovir[tiab] OR Viread[tiab]
OR Enfuvirtide[tiab] OR Emtricitabine[tiab] OR Emtriva[tiab] OR Atazanavir[tiab] OR
Darunavir[tiab] OR Fosamprenavir[tiab] OR Indinavir[tiab] OR Crixivan[tiab] OR Lopinavir[tiab] OR Saquinavir[tiab] OR Invirase[tiab] OR fortovase[tiab] OR Nelfinavir[tiab] OR Viracept[tiab] OR Norvir[tiab] OR Tipranavir[tiab] OR Dolutegravir[tiab] OR Elvitegravir[tiab] OR Raltegravir[tiab] OR Nevirapine[tiab] OR Viramune[tiab] OR Efavirenz[tiab] OR Stocrin[tiab] OR Maraviroc[tiab] OR Zalcitabine[tiab] OR Amprenavir[tiab] OR Atripla[tiab] OR Combivir[tiab] OR Kivexa[tiab] OR Epzicom[tiab] OR Trizivir[tiab] OR Truvada[tiab] OR Kaletra[tiab] OR Aluvia[tiab] OR Stribild[tiab]
OR Eviplera[tiab] OR Triumeq[tiab] OR Rezolsta[tiab] OR “HIV infections”[Mesh] OR “Acquired immunodeficiency syndrome”[Mesh] OR HIV[Mesh] OR “Antiretroviral Therapy, Highly
Active”[Mesh])
Cochrane Search: 12 October 2015 (#1 AND #2 AND #3) = 14 results
#1
(diabetes:ti,ab OR “diabetes mellitus”:ti,ab OR “impaired glucose control”:ti,ab OR diabetic:ti,ab OR “impaired glucose uptake”:ti,ab OR “glucose intolerance”:ti,ab OR “glucose tolerance”:ti,ab OR “oral glucose tolerance”:ti,ab OR “impaired glucose tolerance”:ti,ab OR “glucose metabolism”:ti,ab OR “glucose metabolism disorder”:ti,ab OR hyperglycaemia:ti,ab OR
hyperglycemia:ti,ab OR hyperglycæmia:ti,ab OR “glucose plasma”:ti,ab OR “plasma glucose”:ti,ab OR “high plasma glucose”:ti,ab OR “blood glucose”:ti,ab OR “high blood glucose”:ti,ab OR “insulin resistance”:ti,ab OR “insulin sensitivity”:ti,ab OR “glucose tolerance test”:ti,ab OR “oral glucose tolerance test”:ti,ab OR “OGTT”:ti,ab OR “intravenous glucose tolerance”:ti,ab OR “glucose day curve”:ti,ab OR [mh “Diabetes Mellitus”] OR [mh hyperglycemia] OR [mh “glucose tolerance test”]
OR [mh “insulin resistance”] OR [mh “Diabetes, Gestational”])
#2
(maternal:ti,ab OR pregnant:ti,ab OR pregnancy:ti,ab OR gestational:ti,ab OR
gravidarum:ti,ab OR gravidity:ti,ab OR “pregnancy-induced”:ti,ab OR “pregnancy induced”:ti,ab OR
“pregnancy related”:ti,ab OR [mh “pregnant women”])
#3
(HIV:ti,ab OR “HIV infection”:ti,ab OR AIDS:ti,ab OR “Human immunodeficiency virus”:ti,ab OR “Acquired immunodeficiency syndrome”:ti,ab OR “Acquired immune deficiency syndrome”:ti,ab OR “AIDS virus”:ti,ab OR “Immunologic Deficiency Syndrome, Acquired”:ti,ab OR
“Acquired Immune Deficiency Syndrome”:ti,ab OR “Acquired Immune deficiency syndromes”:ti,ab OR “Acquired Immuno Deficiency Syndrome”:ti,ab OR “Acquired Immuno-deficiency
Syndrome”:ti,ab OR “HTLV- III”:ti,ab OR “HTLV-III-LAV Infection”:ti,ab OR “human T Cell Lymphotropic Virus Type III”:ti,ab OR “Human T-Cell Lymphotropic Virus Type III”:ti,ab OR
“Human T Lymphotropic Virus Type III”:ti,ab OR “Human T-Lymphotropic Virus Type III”:ti,ab OR
“Human T-Cell Leukemia Virus Type III”:ti,ab OR “Human T Cell Leukemia Virus Type III”:ti,ab OR
“HIV infected”:ti,ab OR “HIV infected”:ti,ab OR HAART:ti,ab OR “Highly Active Anti retroviral Therapy”:ti,ab OR “Highly Active Antiretroviral Therapies”:ti,ab OR “Highly Active Anti-retroviral Therapy”:ti,ab OR “Highly Active Antiretroviral Therapy”:ti,ab OR “Highly Active Antiretroviral Therapies”:ti,ab OR “Anti retroviral therapy”:ti,ab OR “Anti retroviral therapies”:ti,ab OR
“Antiretroviral therapy”:ti,ab OR “Antiretroviral therapies”:ti,ab OR “Anti-retroviral therapy”:ti,ab OR
“Anti-retroviral therapies”:ti,ab OR “Protease inhibitors”:ti,ab OR “Endopeptidase inhibitor”:ti,ab OR
“Protease antagonists”:ti,ab OR Antiprotease:ti,ab OR “Peptidase inhibitor”:ti,ab OR “HIV protease inhibitor”:ti,ab OR “HIV protease antagonist”:ti,ab OR “HIV antiprotease”:ti,ab OR “Reverse- transcriptase inhibitor”:ti,ab OR “Reverse transcriptase inhibitor”:ti,ab OR “Antiviral agent”:ti,ab OR Antiviral:ti,ab OR “Antiviral drug”:ti,ab OR “antiviral agent”:ti,ab OR “Agent, Anti-Retroviral”:ti,ab OR “Anti Retroviral Agent”:ti,ab OR “Antiretroviral Agent”:ti,ab OR “Fusion Inhibitor, HIV”:ti,ab OR “HIV Cell Fusion Inhibitor”:ti,ab OR “HIV Entry Inhibitor”:ti,ab OR “HIV Integrase
Inhibitor”:ti,ab OR “HIV Integrase Inhibitors”:ti,ab OR “CCR5 Receptor Antagonist”:ti,ab OR Zidovudine:ti,ab OR Abacavir:ti,ab OR Ziagen:ti,ab OR AZT:ti,ab OR Retrovir:ti,ab OR
Didanosine:ti,ab OR videx:ti,ab OR ddI:ti,ab OR Lamivudine:ti,ab OR Epivir:ti,ab OR Zeffix:ti,ab OR 3TC:ti,ab OR Stavudine :ti,ab OR Zerit:ti,ab OR D4T:ti,ab OR Tenofovir:ti,ab OR Viread:ti,ab OR Enfuvirtide:ti,ab OR Emtricitabine:ti,ab OR Emtriva:ti,ab OR Atazanavir:ti,ab OR Darunavir:ti,ab OR Fosamprenavir:ti,ab OR Indinavir:ti,ab OR Crixivan:ti,ab OR Lopinavir:ti,ab OR Saquinavir:ti,ab OR Invirase:ti,ab OR fortovase:ti,ab OR Nelfinavir:ti,ab OR Viracept:ti,ab OR Norvir:ti,ab OR
Tipranavir:ti,ab OR Dolutegravir:ti,ab OR Elvitegravir:ti,ab OR Raltegravir:ti,ab OR Nevirapine:ti,ab OR Viramune:ti,ab OR Efavirenz:ti,ab OR Stocrin:ti,ab OR Maraviroc:ti,ab OR Zalcitabine:ti,ab OR Amprenavir:ti,ab OR Atripla:ti,ab OR Combivir:ti,ab OR Kivexa:ti,ab OR Epzicom:ti,ab OR Trizivir:ti,ab OR Truvada:ti,ab OR Kaletra:ti,ab OR Aluvia:ti,ab OR Stribild:ti,ab OR Eviplera:ti,ab
OR Triumeq:ti,ab OR Rezolsta:ti,ab OR [mh “HIV infections”] OR [mh “Acquired immunodeficiency syndrome”] OR [mh HIV] OR [mh “Antiretroviral Therapy, Highly Active”])
Embase Search: 12 October 2015 (#1 AND #2 AND #3) = 585 results
#1
(diabetes:ab,ti OR ‘diabetes mellitus’:ab,ti OR ‘impaired glucose control’:ab,ti OR diabetic:ab,ti OR ‘impaired glucose uptake’:ab,ti OR ‘glucose intolerance’:ab,ti OR ‘glucose tolerance’:ab,ti OR ‘oral glucose tolerance’:ab,ti OR ‘impaired glucose tolerance’:ab,ti OR ‘glucose metabolism’:ab,ti OR ‘glucose metabolism disorder’:ab,ti OR hyperglycaemia:ab,ti OR
hyperglycemia:ab,ti OR hyperglycæmia:ab,ti OR ‘glucose plasma’:ab,ti OR ‘plasma glucose’:ab,ti OR
‘high plasma glucose’:ab,ti OR ‘blood glucose’:ab,ti OR ‘high blood glucose’:ab,ti OR ‘insulin resistance’:ab,ti OR ‘insulin sensitivity’:ab,ti OR ‘glucose tolerance test’:ab,ti OR ‘oral glucose tolerance test’:ab,ti OR ‘OGTT’:ab,ti OR ‘intravenous glucose tolerance’:ab,ti OR ‘glucose day curve’:ab,ti OR ‘diabetes mellitus’/exp OR ‘hyperglycemia’/exp OR ‘glucose tolerance test’/exp OR
‘insulin resistance’/exp OR ‘pregnancy diabetes mellitus’/exp)
#2
(maternal:ab,ti OR pregnant:ab,ti OR pregnancy:ab,ti OR gestational:ab,ti OR gravidarum:ab,ti OR ‘pregnancy-induced’:ab,ti OR ‘pregnancy induced’:ab,ti OR ‘pregnancy related’:ab,ti OR ‘pregnant woman’/exp)
#3
(HIV:ab,ti OR ‘HIV infection’:ab,ti OR AIDS:ab,ti OR ‘Human immunodeficiency virus’:ab,ti OR ‘Acquired immunodeficiency syndrome’:ab,ti OR ‘Acquired immune deficiency syndrome’:ab,ti OR ‘AIDS virus’:ab,ti OR ‘Immunologic Deficiency Synrome, Acquired’:ab,ti OR
‘Acquired Immune Deficiency Syndrome’:ab,ti OR ‘Acquired Immune deficiency syndromes’:ab,ti OR ‘Acquired Immuno Deficiency Syndrome’:ab,ti OR ‘Acquired Immuno-deficiency Syndrome’:ab,ti OR ‘HTLV- III’:ab,ti OR ‘HTLV-III-LAV Infection’:ab,ti OR ‘human T Cell Lymphotropic Virus Type III’:ab,ti OR ‘Human T-Cell Lymphotropic Virus Type III’:ab,ti OR ‘Human T Lymphotropic Virus Type III’:ab,ti OR ‘Human T-Lymphotropic Virus Type III’:ab,ti OR ‘Human T-Cell Leukemia Virus Type III’:ab,ti OR ‘Human T Cell Leukemia Virus Type III’:ab,ti OR ‘HIV infected’:ab,ti OR
‘HIV infected’:ab,ti OR HAART:ab,ti OR ‘Highly Active Anti retroviral Therapy’:ab,ti OR ‘Highly Active Antiretroviral Therapies’:ab,ti OR ‘Highly Active Anti-retroviral Therapy’:ab,ti OR ‘Highly Active Antiretroviral Therapy’:ab,ti OR ‘Highly Active Antiretroviral Therapies’:ab,ti OR ‘Anti retroviral therapy’:ab,ti OR ‘Anti retroviral therapies’:ab,ti OR ‘Antiretroviral therapy’:ab,ti OR
‘Antiretroviral therapies’:ab,ti OR ‘Anti-retroviral therapy’:ab,ti OR ‘Anti-retroviral therapies’:ab,ti OR ‘Protease inhibitors’:ab,ti OR ‘Endopeptidase inhibitor’:ab,ti OR ‘Protease antagonists’:ab,ti OR Antiprotease:ab,ti OR ‘Peptidase inhibitor’:ab,ti OR ‘HIV protease inhibitor’:ab,ti OR ‘HIV protease antagonist’:ab,ti OR ‘HIV antiprotease’:ab,ti OR ‘Reverse-transcriptase inhibitor’:ab,ti OR ‘Reverse transcriptase inhibitor’:ab,ti OR ‘Antiviral agent’:ab,ti OR Antiviral:ab,ti OR ‘Antiviral drug’:ab,ti OR
‘antiviral agent’:ab,ti OR ‘Agent, Anti-Retroviral’:ab,ti OR ‘Anti Retroviral Agent’:ab,ti OR
‘Antiretroviral Agent’:ab,ti OR ‘Fusion Inhibitor, HIV’:ab,ti OR ‘HIV Cell Fusion Inhibitor’:ab,ti OR
‘HIV Entry Inhibitor’:ab,ti OR ‘HIV Integrase Inhibitor’:ab,ti OR ‘HIV Integrase Inhibitors’:ab,ti OR Zidovudine:ab,ti OR Abacavir:ab,ti OR Ziagen:ab,ti OR AZT:ab,ti OR Retrovir:ab,ti OR
Didanosine:ab,ti OR videx:ab,ti OR ddI:ab,ti OR Lamivudine:ab,ti OR Epivir:ab,ti OR Zeffix:ab,ti OR 3TC:ab,ti OR Stavudine:ab,ti OR Zerit:ab,ti OR D4T:ab,ti OR Tenofovir:ab,ti OR
Tenofovirdisoproxil:ab,ti OR Viread:ab,ti OR Enfuvirtide:ab,ti OR Emtricitabine:ab,ti OR
Emtriva:ab,ti OR Atazanavir:ab,ti OR Darunavir:ab,ti OR Fosamprenavir:ab,ti OR Indinavir:ab,ti OR Crixivan:ab,ti OR Lopinavir:ab,ti OR Saquinavir:ab,ti OR Invirase:ab,ti OR fortovase:ab,ti OR Nelfinavir:ab,ti OR Viracept:ab,ti OR Ritanovir:ab,ti OR Norvir:ab,ti OR Tipranavir:ab,ti OR Dolutegravir:ab,ti OR Elvitegravir:ab,ti OR Raltegravir:ab,ti OR Nevirapine:ab,ti OR Viramune:ab,ti OR Efavirenz:ab,ti OR Stocrin:ab,ti OR Rilviparine:ab,ti OR Maraviroc:ab,ti OR Zalcitabine:ab,ti OR Amprenavir:ab,ti OR Atripla:ab,ti OR Combivir:ab,ti OR Kivexa:ab,ti OR Epzicom:ab,ti OR
Trizivir:ab,ti OR Truvada:ab,ti OR Kaletra:ab,ti OR Aluvia:ab,ti OR Stribild:ab,ti OR Eviplera:ab,ti OR Triumeq:ab,ti OR Rezolsta:ab,ti OR ‘acquired immune deficiency syndrome’/exp OR ‘human immunodeficiency virus’/exp OR ‘AIDS patient’/exp OR ‘highly active antiretroviral therapy’/exp)
Global Health Library Search: 5 October 2015 (#1 AND #2 AND #3) = 286 results
#1
(diabetes OR "diabetes mellitus" OR "impaired glucose control" OR diabetic OR "impaired glucose uptake" OR "glucose intolerance" OR "glucose tolerance" OR "oral glucose tolerance" OR
"impaired glucose tolerance" OR "glucose metabolism" OR "glucose metabolism disorder" OR hyperglycaemia OR hyperglycemia OR "glucose plasma" OR "plasma glucose" OR "high plasma glucose" OR "blood glucose" OR "high blood glucose" OR "insulin resistance" OR "insulin sensitivity"
OR "glucose tolerance test" OR "oral glucose tolerance test" OR OGTT OR "intravenous glucose tolerance" OR "glucose day curve")
#2
(maternal OR pregnant OR pregnancy OR gestational OR gravidarum OR gravidity OR
"pregnancy-induced" OR "pregnancy induced" OR "pregnancy related")
#3
(HIV OR "HIV infection" OR AIDS OR "Human immunodeficiency virus" OR "Acquired immunodeficiency syndrome" OR "Acquired immune deficiency syndrome" OR "AIDS virus" OR
"Immunologic Deficiency Syndrome, Acquired" OR "Acquired Immune Deficiency Syndrome" OR
"Acquired Immune deficiency syndromes" OR "Acquired Immuno Deficiency Syndrome" OR
"Acquired Immuno-deficiency Syndrome" OR "HTLV- III" OR "HTLV-III-LAV Infection" OR
"human T Cell Lymphotropic Virus Type III" OR "Human T-Cell Lymphotropic Virus Type III" OR
"Human T Lymphotropic Virus Type III" OR "Human T-Lymphotropic Virus Type III" OR "Human T-Cell Leukemia Virus Type III" OR "Human T Cell Leukemia Virus Type III" OR "HIV infected"
OR "HIV-infected" OR HAART OR "Highly Active Anti retroviral Therapy" OR "Highly Active Antiretroviral Therapies" OR "Highly Active Anti-retroviral Therapy" OR "Highly Active
Antiretroviral Therapy" OR "Highly Active Antiretroviral Therapies" OR "Anti retroviral therapy" OR
"Anti retroviral therapies" OR "Antiretroviral therapy" OR "Antiretroviral therapies" OR "Anti- retroviral therapy" OR "Anti-retroviral therapies" OR "Protease inhibitors" OR "Endopeptidase inhibitor" OR "Protease antagonists" OR Antiprotease OR "Peptidase inhibitor" OR "HIV protease inhibitor" OR "HIV protease antagonist" OR "HIV antiprotease" OR "Reverse-transcriptase inhibitor"
OR "Reverse transcriptase inhibitor" OR "Antiviral agent" OR Antiviral OR "Antiviral drug" OR
"antiviral agent" OR "Agent, Anti-Retroviral" OR "Anti Retroviral Agent" OR "Antiretroviral Agent"
OR "Fusion Inhibitor, HIV" OR "HIV Cell Fusion Inhibitor" OR "HIV Entry Inhibitor" OR "HIV Integrase Inhibitor" OR "HIV Integrase Inhibitors" OR "CCR5 Receptor Antagonist")
POPline Search: 12 October 2015
(#1 AND #2 AND #3 OR keywords) = 93 results
#1
(diabetes OR "diabetes mellitus" OR "impaired glucose control" OR diabetic OR "impaired glucose uptake" OR "glucose intolerance" OR "glucose tolerance" OR "oral glucose tolerance" OR
"impaired glucose tolerance" OR "glucose metabolism" OR "glucose metabolism disorder" OR hyperglycaemia OR hyperglycemia OR "glucose plasma" OR "plasma glucose" OR "high plasma glucose" OR "blood glucose" OR "high blood glucose" OR "insulin resistance" OR "insulin sensitivity"
OR "glucose tolerance test" OR "oral glucose tolerance test" OR OGTT OR "intravenous glucose tolerance" OR "glucose day curve")
#2
(maternal OR pregnant OR pregnancy OR gestational OR gravidarum OR gravidity OR
"pregnancyinduced" OR "pregnancy induced" OR "pregnancy related")
#3
(HIV OR "HIV infection" OR AIDS OR "Human immunodeficiency virus" OR "Acquired immunodeficiency syndrome" OR "Acquired immune deficiency syndrome" OR "AIDS virus" OR
"Immunologic Deficiency Syndrome, Acquired" OR "Acquired Immune Deficiency Syndrome" OR
"Acquired Immune deficiency syndromes" OR "Acquired Immuno Deficiency Syndrome" OR
"Acquired Immunodeficiency Syndrome" OR "HTLV III" OR "HTLVIIILAV Infection" OR "human T Cell Lymphotropic Virus Type III" OR "Human TCell Lymphotropic Virus Type III" OR "Human T Lymphotropic Virus Type III" OR "Human TLymphotropic Virus Type III" OR "Human TCell Leukemia Virus Type III" OR "Human T Cell Leukemia Virus Type III" OR "HIV infected" OR
"HIVinfected" OR HAART OR "Highly Active Anti retroviral Therapy" OR "Highly Active Antiretroviral Therapies" OR "Highly Active Antiretroviral Therapy" OR "Highly Active
Antiretroviral Therapy" OR "Highly Active Antiretroviral Therapies" OR "Anti retroviral therapy" OR
"Anti retroviral therapies" OR "Antiretroviral therapy" OR "Antiretroviral therapies" OR
"Antiretroviral therapy" OR "Antiretroviral therapies" OR "Protease inhibitors" OR "Endopeptidase inhibitor" OR "Protease antagonists" OR Antiprotease OR "Peptidase inhibitor" OR "HIV protease inhibitor" OR "HIV protease antagonist" OR "HIV antiprotease" OR "Reversetranscriptase inhibitor"
OR "Reverse transcriptase inhibitor" OR "Antiviral agent" OR Antiviral OR "Antiviral drug" OR
"antiviral agent" OR "Agent, AntiRetroviral" OR "Anti Retroviral Agent" OR "Antiretroviral Agent"
OR "Fusion Inhibitor, HIV" OR "HIV Cell Fusion Inhibitor" OR "HIV Entry Inhibitor" OR "HIV Integrase Inhibitor" OR "HIV Integrase Inhibitors" OR "CCR5 Receptor Antagonist")
Keywords: Pregnant Women,Pregnancy AND Diabetes,Glucose Tolerance Test,Glucose Metabolism Effects AND HIV,HIV Infections,Antiretroviral Drugs,Antiretroviral Therapy = 3
African Journal Online Search: 11 October 2015 (#1 AND #2) = 70 references
#1
(maternal OR pregnant OR pregnancy OR gestational OR gravidarum OR gravidity OR
"pregnancy related" OR "pregancy induced")
#2
(HIV OR AIDS OR "HIV infection" OR "HIV infected" OR "antiretroviral therapy" OR
"protease inhibitor")
II. Data collection form
Figure S1: standardized data collection sheet
III. Risk of bias
Figure S2: Bias evaluation per study.
IV. Diagnostic criteria Diagnostic Criteria GDMa
Plasma glucose levels GDM diagnosis if Fasting (mg/dl)
1-hour (mg/dl)
2-hour (mg/dl)
3-hour (mg/dl) 2-hour OGTTb IADPSGc
criteria25
≥1 abnormal value >92 >180 >153
3-hour OGTT Carpenter and Coustan criteria20,24,30
≥2 abnormal value >95 >180 >155 >140
3-hour OGTT National Diabetes Data Group criteria21,22,29,32
≥2 abnormal value >105 >190 >165 >145
Fasting plasma criteria35 >95
Oral serum glucose35 >200
1-hour loading test34 >200mg/dl
International Classification of Diseases codes26
ICD-9 code 648.8
Diagnostic Criteria GId
3-hour OGTT Carpenter and Coustan critera30
1 abnormal value >95 >180 >155 >140
Fasting plasma glucose18 >95
2-hour post-meal plasma glucose18
>120
50 gram 1-hour
OGTT20,21,24,32 >140 or
>130
Random blood glucose33 >140
Homeostasis model for insulin resistance28
[(fasting glucose x fasting insulin)/405]
Area under the glycemia curve19
calculated using plasma glucose levels after 75g glucose intake 4x during pregnancy
Table S1: Overview of Diagnostic Criteria and Definitions
aGDM = gestational diabetes mellitus; bOGTT= oral glucose tolerance test; cIADPSG = International Association of Diabetes and Pregnancy Study Group; dGI= glucose intolerance
V. Meta-analysis results IV.i HIV and gestational diabetes
Figure S3. Subgroup analysis based on % of participants on cART therapy, with <100% ranging from 86% to 15%.
IV.ii Protease inhibitors and gestational diabetes
Figure S4: Subgroup analysis by duration of ART use based on percent of participants on ART before pregnancy, with Marti 2007 being the only study with >50% participants on ART before pregnancy.
Figure S5: Subgroup analysis of severity of HIV based on median CD4 count of more than 450cell/uL or unspecified. The only study with a CD4 of <450 cell/uL was Lorenzi 1998, which likewise did not find a significant association.
Figure S6: Subgroup analysis by age of participants, with median maternal age above or below 30 years
Figure S7: Subgroup analysis of studies reporting ethnicity, consistently with majority of African American participants
IV.iii Protease inhibitors and glucose intolerance
Figure S8: Meta-analysis of cohort studies comparing glucose intolerance (GI) in PI-exposed and PI- unexposed population.
