SDC 1. Database search terms for the four PICOs
PICO Database Search terms
A1 Pubmed ((((((((NNRTI*[tiab] OR "non-nucleoside reverse transcriptase inhibitor*"[tiab] OR "non-nucleoside reverse-transcriptase inhibitor*"[tiab] OR "non nucleoside reverse transcriptase inhibitor*"[tiab] OR "non- nucleoside reverse-transcriptase inhibitor*"[tiab] OR efavirenz[tiab] OR EFV[tiab] OR etravirine[tiab] OR rilpivirine[tiab] OR nevirapine[tiab] OR NVP[tiab]))) OR (Lopinavir/ritonavir[tiab] OR LPV/RTV[tiab]
OR atazanavir[tiab] OR nelfinavir[tiab] OR NFV[tiab] OR TPV[tiab] OR tipranavir[tiab] OR
fosamprenavir[tiab] OR FPV[tiab] OR ATV[tiab] OR ritonavir[tiab] OR RTV[tiab] OR darunavir[tiab] OR DRV[tiab] OR PI[tiab] OR "protease inhibitor*"[tiab] OR indinavir[tiab] OR IDV[tiab]))) AND
((Child*[tiab] OR infant*[tiab] OR pediatric*[tiab] OR paediatric[tiab]))))) AND (TB[tiab] OR tuberculosis[tiab])
EMBASE (child:ab,ti OR infant:ab,ti OR pediatric:ab,ti OR paediatric:ab,ti) AND (tb:ab,ti OR tuberculosis:ab,ti) AND (('nnrti':ab,ti OR 'non-nucleoside reverse transcriptase inhibitor':ab,ti OR 'non nucleoside reverse transcriptase inhibitor':ab,ti OR 'non-nucleoside reverse-transcriptase inhibitor':ab,ti OR ‘non nucleoside reverse-transcriptase inhibitor’:ab,ti OR 'efavirenz':ab,ti OR 'efv':ab,ti OR 'etravirine':ab,ti OR
'rilpivirine':ab,ti OR 'nevirapine':ab,ti OR 'nvp':ab,ti) OR ('lopinavir/ritonavir':ab,ti OR 'lpv/rtv':ab,ti OR atazanavir:ab,ti OR nelfinavir:ab,ti OR nfv:ab,ti OR tpv:ab,ti OR tipranavir:ab,ti OR fosamprenavir:ab,ti OR fpv:ab,ti OR atv:ab,ti OR ritonavir:ab,ti OR rtv:ab,ti OR darunavir:ab,ti OR drv:ab,ti OR pi*:ab,ti OR 'protease inhibitor':ab,ti OR indinavir:ab,ti OR idv:ab,ti)) AND ([english]/lim OR [french]/lim OR [italian]/lim OR [portuguese]/lim OR [spanish]/lim) AND [1996-2016]/py
A2 Pubmed (((((((PI[tiab] OR "protease inhibitor*"[tiab] OR lopinavir[tiab] OR ritonavir[tiab] OR
lopinavir/ritonavir[tiab] OR LPV[tiab] OR RTV[tiab] OR LPV/RTV[tiab] OR atazanavir[tiab] OR ATV[tiab] OR darunavir[tiab] OR DRV[tiab] OR indinavir[tiab] OR IDV[tiab] OR fosamprenavir[tiab] OR FPV[tiab] OR nelfinavir[tiab] OR NFV[tiab] OR saquinavir[tiab] OR SQV[tiab] OR tipranavir[tiab] OR TPV[tiab]))) OR (NRTI*[tiab] OR "nucleoside reverse transcriptase inhibitor*"[tiab] OR "nucleoside reverse-transcriptase inhibitor*"[tiab] OR "nucleotide reverse transcriptase inhibitor*"[tiab] OR "nucleotide reverse-transcriptase inhibitor*"[tiab] OR zidovudine[tiab] OR AZT[tiab] OR lamivudine[tiab] OR 3TC[tiab] OR stavudine[tiab] OR D4T[tiab] OR tenofovir[tiab] OR TDF[tiab] OR abacavir[tiab] OR ABC[tiab] OR emtricitabine[tiab] OR FTC[tiab] OR didanosine[tiab] OR DDI[tiab]))) AND ((Child*[tiab]
OR infant*[tiab] OR pediatric*[tiab] OR paediatric[tiab])))) AND (TB[tiab] OR tuberculosis[tiab])
EMBASE (child:ab,ti OR infant:ab,ti OR pediatric:ab,ti OR paediatric:ab,ti) AND (tb:ab,ti OR tuberculosis:ab,ti) AND (('nrti':ab,ti OR 'nucleoside reverse transcriptase inhibitor':ab,ti OR 'nucleoside reverse-transcriptase inhibitor':ab,ti OR 'nucleotide reverse transcriptase inhibitor':ab,ti OR 'nucleotide reverse-transcriptase inhibitor':ab,ti OR zidovudine:ab,ti OR AZT:ab,ti OR lamivudine:ab,ti OR 3TC:ab,ti OR stavudine:ab,ti OR D4T:ab,ti OR tenofovir:ab,ti OR TDF:ab,ti OR abacavir:ab,ti OR ABC:ab,ti OR emtricitabine:ab,ti OR FTC:ab,ti OR didanosine:ab,ti OR DDI:ab,ti) OR ('lopinavir/ritonavir':ab,ti OR 'lpv/rtv':ab,ti OR
atazanavir:ab,ti OR nelfinavir:ab,ti OR nfv:ab,ti OR tpv:ab,ti OR tipranavir:ab,ti OR fosamprenavir:ab,ti OR fpv:ab,ti OR atv:ab,ti OR ritonavir:ab,ti OR rtv:ab,ti OR darunavir:ab,ti OR drv:ab,ti OR pi*:ab,ti OR 'protease inhibitor':ab,ti OR indinavir:ab,ti OR idv:ab,ti)) AND ([english]/lim OR [french]/lim OR [italian]/lim OR [portuguese]/lim OR [spanish]/lim) AND [1996-2016]/py
B1 Pubmed (((((((NNRTI*[tiab] OR "non-nucleoside reverse transcriptase inhibitor*"[tiab] OR "non-nucleoside reverse-transcriptase inhibitor*"[tiab] OR "non nucleoside reverse transcriptase inhibitor*"[tiab] OR "non- nucleoside reverse-transcriptase inhibitor*"[tiab] OR efavirenz[tiab] OR EFV[tiab]))) OR (NNRTI*[tiab]
OR "non-nucleoside reverse transcriptase inhibitor*"[tiab] OR "non-nucleoside reverse-transcriptase inhibitor*"[tiab] OR "non nucleoside reverse transcriptase inhibitor*"[tiab] OR "non-nucleoside reverse- transcriptase inhibitor*"[tiab] OR nevirapine[tiab] OR NVP[tiab]))) AND ((Child*[tiab] OR infant*[tiab]
OR pediatric*[tiab] OR paediatric[tiab])))) AND (TB[tiab] OR tuberculosis[tiab])
EMBASE (child:ab,ti OR infant:ab,ti OR pediatric:ab,ti OR paediatric:ab,ti) AND (tb:ab,ti OR tuberculosis:ab,ti) AND ((‘nnrti’:ab,ti OR ‘non nucleoside reverse-transcriptase inhibitor’:ab,ti OR ‘non-nucleoside reverse- transcriptase inhibitor’:ab,ti OR ‘non nucleoside reverse transcriptase inhibitor’:ab,ti OR ‘non-nucleoside reverse transcriptase inhibitor’:ab,ti OR efavirenz:ab,ti OR EFV:ab,ti) OR (‘nnrti’:ab,ti OR ‘non-nucleoside reverse transcriptase inhibitor’:ab,ti OR ‘non-nucleoside reverse-transcriptase inhibitor’:ab,ti OR ‘non nucleoside reverse transcriptase inhibitor’:ab,ti OR ‘non-nucleoside reverse-transcriptase inhibitor’:ab,ti OR nevirapine:ab,ti OR NVP:ab,ti)) AND ([english]/lim OR [french]/lim OR [italian]/lim OR
[portuguese]/lim OR [spanish]/lim) AND [1996-2016]/py
B2 Pubmed (((((NNRTI*[tiab] OR "non-nucleoside reverse transcriptase inhibitor*"[tiab] OR "non-nucleoside reverse- transcriptase inhibitor*"[tiab] OR "non nucleoside reverse transcriptase inhibitor*"[tiab] OR "non- nucleoside reverse-transcriptase inhibitor*"[tiab] OR efavirenz[tiab] OR EFV[tiab])) OR (PI[tiab] OR
"protease inhibitor*"[tiab] OR lopinavir[tiab] OR ritonavir[tiab] OR lopinavir/ritonavir[tiab] OR LPV[tiab]
OR RTV[tiab] OR LPV/RTV[tiab] OR atazanavir[tiab] OR ATV[tiab] OR darunavir[tiab] OR DRV[tiab]
OR indinavir[tiab] OR IDV[tiab] OR fosamprenavir[tiab] OR FPV[tiab] OR nelfinavir[tiab] OR NFV[tiab]
OR saquinavir[tiab] OR SQV[tiab] OR tipranavir[tiab] OR TPV[tiab]))) AND ((Child*[tiab] OR infant*[tiab] OR pediatric*[tiab] OR paediatric[tiab]))) AND ((TB[tiab] OR tuberculosis[tiab]))
EMBASE (child:ab,ti OR infant:ab,ti OR pediatric:ab,ti OR paediatric:ab,ti) AND (tb:ab,ti OR tuberculosis:ab,ti) AND ((‘nnrti’:ab,ti OR ‘non-nucleoside reverse transcriptase inhibitor’:ab,ti OR ‘non-nucleoside reverse- transcriptase inhibitor’:ab,ti OR ‘non nucleoside reverse transcriptase inhibitor’:ab,ti OR ‘non nucleoside reverse-transcriptase inhibitor’:ab,ti OR efavirenz:ab,ti OR EFV:ab,ti) OR ('lopinavir/ritonavir':ab,ti OR 'lpv/rtv':ab,ti OR atazanavir:ab,ti OR nelfinavir:ab,ti OR nfv:ab,ti OR tpv:ab,ti OR tipranavir:ab,ti OR fosamprenavir:ab,ti OR fpv:ab,ti OR atv:ab,ti OR ritonavir:ab,ti OR rtv:ab,ti OR darunavir:ab,ti OR drv:ab,ti OR pi:ab,ti OR 'protease inhibitor':ab,ti OR indinavir:ab,ti OR idv:ab,ti)) AND ([english]/lim OR [french]/lim OR [italian]/lim OR [portuguese]/lim OR [spanish]/lim) AND [1996-2016]/py
