Supplementary Table 1. List of FHIT-regulated genes

(1)

Supplementary Table 1. List of FHIT-regulated genes

Probe Set ID

Fold Change

Gene

Symbol Gene Name

38479_at -1,51 ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 36572_r_at -1,51 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1

34890_at 1,25 ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A

35831_at -1,57 ATP9A ATPase, Class II, type 9A

36142_at -1,55 ATXN1 ataxin 1

33266_at -1,34 AURKB aurora kinase B

846_s_at 1,51 BAK1 BCL2-antagonist/killer 1

1801_at -1,61 BARD1 BRCA1 associated RING domain 1

41724_at -1,53 BCAP31 B-cell receptor-associated protein 31

38010_at 1,38 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3

32655_s_at -1,41 BRD8 bromodomain containing 8

36634_at 1,34 BTG2 BTG family, member 2

41081_at -1,84 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 35699_at -1,86 BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 38437_at -1,27 CASC3 cancer susceptibility candidate 3

487_g_at 1,47 CASP9 caspase 9, apoptosis-related cysteine peptidase

40349_at -1,35 CBR4 carbonyl reductase 4

40697_at -1,66 CCNA2 cyclin A2

34736_at -1,62 CCNB1 cyclin B1

32263_at -1,52 CCNB2 cyclin B2

35907_at -1,48 CCNF cyclin F

33324_s_at -1,71 CDC2 cell division cycle 2, G1 to S and G2 to M 38414_at -1,61 CDC20 cell division cycle 20 homolog (S. cerevisiae) 1536_at -2,09 CDC6 cell division cycle 6 homolog (S. cerevisiae) 2031_s_at 1,48 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)

1599_at -1,34 CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)

527_at -2,91 CENPA centromere protein A

37302_at -1,74 CENPF centromere protein F, 350/400ka (mitosin) 39692_at -1,24 CREB3L2 cAMP responsive element binding protein 3-like 2

32067_at 1,50 CREM cAMP responsive element modulator

32962_at 1,35 CTH cystathionase (cystathionine gamma-lyase)

35025_at -1,78 CXCL5 chemokine (C-X-C motif) ligand 5

36616_at -1,46 DAZAP2 DAZ associated protein 2

39420_at 1,70 DDIT3 DNA-damage-inducible transcript 3

37913_at -2,19 DHFR dihydrofolate reductase

37231_at -1,67 DLG7 discs, large homolog 7 (Drosophila) 1044_s_at 1,26 E2F5 E2F transcription factor 5, p130-binding 40887_g_at 1,29 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 39542_at -1,45 ENC1 ectodermal-neural cortex (with BTB-like domain) 38375_at -1,35 ESD esterase D/formylglutathione hydrolase

38158_at -2,05 ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)

37156_at -1,60 ETV1 ets variant gene 1

32617_at -2,19 FANCI Fanconi anemia, complementation group I 41583_at -1,29 FEN1 flap structure-specific endonuclease 1 1992_at 295,32 FHIT fragile histidine triad gene

34715_at -1,70 FOXM1 forkhead box M1

35083_at 1,23 FTL ferritin, light polypeptide

HUMGAPDH/M33197_3_at 1,26 GAPDH glyceraldehyde-3-phosphate dehydrogenase

36582_g_at 1,32 GARS glycyl-tRNA synthetase

1890_at 1,93 GDF15 growth differentiation factor 15

39677_at -2,65 GINS1 GINS complex subunit 1 (Psf1 homolog) 32531_at 2,18 GJA1 gap junction protein, alpha 1, 43kDa

319_g_at -1,43 H1FX H1 histone family, member X

39046_at -1,48 H2AFV H2A histone family, member V

35435_s_at -1,49 HADH hydroxyacyl-Coenzyme A dehydrogenase 39969_at -1,44 HIST1H4C histone cluster 1, H4c

38065_at -1,93 HMGB2 high-mobility group box 2

(2)

41231_f_at -1,35 HMGN2 high-mobility group nucleosomal binding domain 2 36863_at -1,32 HMMR hyaluronan-mediated motility receptor (RHAMM) 33817_at -1,95 HNRPA3 heterogeneous nuclear ribonucleoprotein A3

33986_r_at 1,34 HSP90AB1 Heat shock protein 90kDa alpha (cytosolic), class B member 1

36925_at 1,75 HSPA2 heat shock 70kDa protein 2

37679_at 1,46 IFRD1 interferon-related developmental regulator 1

31832_at -2,00 KIAA0286 KIAA0286 protein

40517_at -1,28 KIAA0372 KIAA0372

31936_s_at -2,24 KIAA0430 KIAA0430

41651_at -1,41 KIAA1033 KIAA1033

40726_at -2,64 KIF11 kinesin family member 11

34563_at -1,34 KIF14 kinesin family member 14

36837_at -2,50 KIF2C kinesin family member 2C

349_g_at -2,05 KIFC1 kinesin family member C1

39441_at -2,27 LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)

37985_at 1,35 LMNB1 lamin B1

34387_at -1,44 LPGAT1 lysophosphatidylglycerol acyltransferase 1

39009_at -1,81 LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 36179_at -1,67 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2

1764_s_at 1,45 MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 35312_at -1,58 MCM2 minichromosome maintenance complex component 2

982_at -1,63 MCM5 minichromosome maintenance complex component 5

419_at -1,96 MKI67 antigen identified by monoclonal antibody Ki-67 38698_at -1,23 MOBKL3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 861_g_at -1,72 MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

2003_s_at -1,26 MSH6 mutS homolog 6 (E. coli)

33877_s_at -1,26 MTDH metadherin

1854_at -1,59 MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2

35153_at -1,24 NBN nibrin

35314_at -1,70 NCAPD2 non-SMC condensin I complex, subunit D2

40041_at -2,58 NDC80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 35264_at 1,20 NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa 279_at 1,92 NR4A1 nuclear receptor subfamily 4, group A, member 1

35136_at 1,49 NXT2 nuclear transport factor 2-like export factor 2

40470_at 1,31 OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1824_s_at -1,44 PCNA proliferating cell nuclear antigen

37900_at -1,34 PEX11B peroxisomal biogenesis factor 11B

480_at -1,70 PKMYT1 protein kinase, membrane associated tyrosine/threonine 1

41253_s_at 1,28 PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 37228_at -2,10 PLK1 polo-like kinase 1 (Drosophila)

34795_at 1,57 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

32028_at 1,38 PMM2 phosphomannomutase 2

525_g_at -1,41 PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 41638_at -1,22 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 37466_at 2,35 RAB7L1 RAB7, member RAS oncogene family-like 1

781_at -1,48 RABGGTB Rab geranylgeranyltransferase, beta subunit 32026_s_at -1,24 RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1055_g_at -1,76 RFC4 replication factor C (activator 1) 4, 37kDa

36580_at -1,44 RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)

33343_at 1,57 RNF14 ring finger protein 14

33657_at -1,62 RPL34 ribosomal protein L34

36358_at -1,35 RPL9 ribosomal protein L9

36922_at -2,30 RRM2 ribonucleotide reductase M2 polypeptide 36511_at -1,58 SACM1L SAC1 suppressor of actin mutations 1-like (yeast)

34849_at 1,25 SARS seryl-tRNA synthetase

33369_at 1,41 SC4MOL sterol-C4-methyl oxidase-like

34199_at 2,03 SEC24A SEC24 related gene family, member A (S. cerevisiae) 35809_g_at -1,72 SFRS6 splicing factor, arginine/serine-rich 6

33143_s_at 1,24 SLC16A3 solute carrier family 16, member 3 (monocarboxylic acid transporter 4) 38797_at 1,26 SLC39A14 solute carrier family 39 (zinc transporter), member 14

40329_at -1,43 SLC39A7 solute carrier family 39 (zinc transporter), member 7

(3)

1649_at 1,28 SMOX spermine oxidase

35488_at -1,39 SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa

38940_at -2,22 SPC25 SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) 31670_s_at -1,43 SRP72 signal recognition particle 72kDa

37739_at -1,64 SSRP1 structure specific recognition protein 1

35861_at -2,19 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1

41354_at 1,79 STC1 stanniocalcin 1

32043_at 1,68 STC2 stanniocalcin 2

37911_at 1,24 STX4 syntaxin 4

32317_s_at -3,26 SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 40841_at -1,34 TACC1 transforming, acidic coiled-coil containing protein 1

36822_at -1,89 TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 40767_at -1,25 TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

HUMTFRR/M11507_5_at -1,20 TFRC transferrin receptor (p90, CD71)

32830_g_at 1,32 TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)

910_at -1,86 TK1 thymidine kinase 1, soluble

35000_at 1,57 TNFSF9 tumor necrosis factor (ligand) superfamily, member 9

1592_at -4,18 TOP2A topoisomerase (DNA) II alpha 170kDa

36079_at 1,40 TP53I3 tumor protein p53 inducible protein 3

39109_at -1,57 TPX2 TPX2, microtubule-associated, homolog (Xenopus laevis) 32955_at 1,24 TRIAP1 TP53 regulated inhibitor of apoptosis 1

39382_at -1,26 TRIM2 tripartite motif-containing 2

38469_at -1,36 TSPAN8 tetraspanin 8

572_at -1,98 TTK TTK protein kinase

151_s_at -1,93 TUBB tubulin, beta

38699_at 1,82 TUBB4 tubulin, beta 4

31508_at -1,47 TXNIP thioredoxin interacting protein

39425_at -1,27 TXNRD1 thioredoxin reductase 1

1505_at -1,66 TYMS thymidylate synthetase

35246_at -1,42 TYRO3 TYRO3 protein tyrosine kinase

1651_at -1,76 UBE2C ubiquitin-conjugating enzyme E2C

34827_at -1,47 ULK1 unc-51-like kinase 1 (C. elegans)

625_at 1,30 VAT1 vesicle amine transport protein 1 homolog (T. californica)

36601_at 1,28 VCL vinculin

1953_at 1,36 VEGFA vascular endothelial growth factor A

39823_at -1,87 WDR42A WD repeat domain 42A

40928_at 1,37 WSB1 WD repeat and SOCS box-containing 1

39755_at 1,24 XBP1 X-box binding protein 1

1235_at -1,36 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

35995_at -1,97 ZWINT ZW10 interactor