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Supplementary Table S1. Definitions of laboratory abnormalities

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(1)Supplementary Table S1. Definitions of laboratory abnormalities Laboratory abnormality. Definition. Leukopenia. White blood cell count <1500 /mm3. Thrombocytopenia. Platelet count <150 000 mm3. Anemia. Hemoglobin level <10.5 g/dL. Hyperbilirubinemia. Total bilirubin level > 3 mg/dL. Direct hyperbilirubinemia. Direct bilirubin level >2 mg/dL. Hypoalbuminemia. Albumin level <3.5 g/dL. Prolonged PT. PT >14 seconds. High INR ratio. INR ratio >1.5. PT, prothrombin time; INR, International Normalized Ratio.

(2) Supplementary Table S2. Classification of total, LDL and HDL cholesterol and tryglyceride levels in children Total cholesterol (mg/dL). LDL cholesterol (mg/dL). Low Borderline low Acceptable. <170. <110. Borderline high. 170-199. 110-129. High. ≥200. ≥130. HDL cholesterol (mg/dL) <40 40-45 >45. LDL; low-density lipoprotein; HDL, high-density lipoprotein. Triglyceride (mg/dL). <75 (1-9 years) <90 (10-19 years) 75 -99 (1-9 years) 90-129 (10-19 years) ≥100 (1-9 years) ≥130 (10-19 years).

(3) Supplementary Table S3 Clinical findings of the study population Parameter. Value. HAZ, Mean ±SD. -0.41±1.68. WAZ, Mean ±SD. -0.42±1.31. BMIZ, Mean ±SD. -0.2±1.11. Undernutrition, n (%). 92 (11). Stunting, n (%). 47 (6). Wasting, n(%). 56 (7). Hepatomegaly, n (%). 377 (47). Splenomegaly, n (%). 179 (22). Jaundice, n (%). 51 (6). Ascites, n (%). 18 (2). Palmar erythema, n (%). 11 (1). Edema, n (%). 9 (1). Spider nevus, n (%). 8 (<1). Xanthoma, n (%). 8 (<1). SD, standard deviation; HAZ, Height for age Z score; WAZ, Weight for age Z score; BMIZ, Body mass index for age Z score.

(4) Supplementary Table S4 Laboratory findings of study population Parameter. Value. White blood cell count (mm3), Mean ±SD. 8714±3564. Hemoglobin (g/dL), Mean ±SD. 12.1 ±1.8. Platelet count (mm3), Mean ±SD. 295 444 ±127 280. ALT (xULN)*. 2.7 (0.53-56.8). AST (xULN)*. 2.5 (0.35-56). GGT (xULN)*. 2.2 (1-28.7). Total bilirubin (mg/dL)*. 0.47 (0.3-31.6). Direct bilirubin (mg/dL)*. 0.16 (0.01-24.36). Albumin (g/dL), mean ±SD. 4.2 ±0.5. PT (sn) mean ±SD. 12.9±3.1. INR mean ±SD. 1.1±0.6. *Median (Range) SD, standard deviation; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γglutamyl transpeptidase;ULN, upper limit of normal, PT, prothrombin time; INR, International Normalized Ratio.

(5) Supplementary Table S5. Lipid profile of study population mg/dL * Total cholesterol. 145.7±46.2. Acceptable n, (%) 616 (76). Bordeline high n, (%) 123 (15.2). High n, (%) 71 (8.8). LDL cholesterol. 85.1±42.4. 645 (79.6). 95 (11.7). 70 (8.6). HDL cholesterol. 40.4±15.2. 268 (33). -. -. Triglyceride. 120.1±84.2. 287 (35.4). 182 (22.5). 341 (42.1). *Mean ±SD LDL; low-density lipoprotein; HDL, high-density lipoprotein. Bordeline low n, (%). Low n, (%). 174 (22). 368 (45).

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