141
Abstract Original Article
Evaluation of oxidative stress and homocysteine level in patients with acute myocardial infarction:
a case-control study
Masoomeh Boomi Ghoochane Atigh1, Mohammad Malekaneh2, Hamid Reza Mashreghi Moghadam3, Gholamreza Anani Sarab4
Background and Aim: Along with the development of cardiac diagnostic procedures, new risk factors ,such as homocysteine role in cardiovascular disease, have been proposed. The aim of the present study was to evaluate the levels of homocysteine and total antioxidant capacity in patients with acute myocardial infarction compared with the control group.
Materials and Methods: A case-control study was conducted on 45 patients with myocardial infarction admitted to Vali-e-asr hospital in Birjand and 45 healthy people matched with the case group.Total antioxidant capacity applying FRAP method and homocysteine levels were measured using ELISA The obtained data was analyzed by means of SPSS software at the significant level P <0.05.
Results: There was no statistically significant difference in terms of age, sex, body mass index, lipid profile and fasting blood glucose between two groups. Total antioxidant capacity in case and control groups, respectively 837.86±175.07 and 981.91±276.57 µmol/L and average level of homocysteine in the case and control groups, 15.77±8.09 and 12.19±6.75 respectively.Statistical analysis showed that the antioxidant capacity in the patient group was significantly lower than the control group (P=0.004) and no significant difference in the levels of homocysteine in both groups (P = 0.11).
Conclusion: The study showed that oxidative stress and low antioxidant capacity can be associated with the pathogenesis of MI; and more studies are required to confirm the relationship between homocysteine and cardiovascular disease.
Key Words: Oxidative stress, Homocysteine, Total Antioxidant Capacity, Stroke
Journal of Birjand University of Medical Sciences. 2016; 23(2): 141-148.
Received:February 1, 2016 Accepted: May 31, 2016
1 Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
2 Cellar and Molecular Sciences Research Centre, Birjand University of Medical Sciences, Birjand, Iran.
3 Atherosclerosis and Coronary Artery Research Centre, Birjand University of Medical Science, Birjand, Iran.
4 Corresponding Author; Member of Hepatitis Research Centre, Department Immunohaematology, Birjand University of Medical Sciences, Genomic Research Center, Birjand, Iran. Email: ghansa@yahoo.com Tel: 05632440556
زرا ﯾ ﺑﺎ ﯽ ﺴﮐا سﺮﺘﺳا ﯿ
ﺗاﺪ ﯿ ﻮ ﺳﻮﻤﻫ ﺢﻄﺳ و ﯿ
ﺌﺘﺴ ﯿ ﻦ ﺑ رد ﯿ نارﺎﻤ ﻪﺑ ﻼﺘﺒﻣ
ﺒﻠﻗ دﺎﺣ ﻪﺘﮑﺳ ﯽ
: ﯾ ﮏ درﻮﻣ ﻪﻌﻟﺎﻄﻣ -
يﺪﻫﺎﺷ
ﻣﻮﺑ ﻪﻣﻮﺼﻌﻣ ﯽ
نﺎﭼﻮﻗ ﺘﻋ ،1
ﯿ ﻖ ﻪﻧﺎﮑﻠﻣ ﺪﻤﺤﻣ ﻤﺣ ،2
ﯿ ﺪ ﻗﺮﺸﻣ ﺎﺿر مﺪﻘﻣ ﯽ
،3
ﻧﺎﻨﻋ ﺎﺿﺮﻣﻼﻏ ﯽ
4باﺮﺳ
هﺪﯿﮑﭼ
ﻪﻨﯿﻣز فﺪﻫ و ور ﺖﻓﺮﺸﯿﭘ ﺎﺑ نﺎﻣﺰﻤﻫ : ش
ﺎﻤﯿﺑ ﯽﺼﯿﺨﺸﺗ يﺎﻫ ﺮﻄﺧ ﻞﻣاﻮﻋ ،ﯽﺒﻠﻗ نار
ﻪﺑ ﻼﺘﺑا رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ نﻮﭽﻤﻫ ﺪﯾﺪﺟ ياز
يرﺎﻤﯿﺑ ﯽﺒﻠﻗ يﺎﻫ - هﺪﺷ حﺮﻄﻣ ﯽﻗوﺮﻋ ﺪﻧا
. ﻪﻌﻟﺎﻄﻣ ﻦﯾا زا فﺪﻫ
، هزاﺪﻧا ﯽﺘﻧآ مﺎﺗ ﺖﯿﻓﺮﻇ و ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ حﻮﻄﺳ يﺮﯿﮔ رد ﯽﻧاﺪﯿﺴﮐا
ﺪﻫﺎﺷ هوﺮﮔ داﺮﻓا ﺎﺑ نآ ﻪﺴﯾﺎﻘﻣ و ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ نﺎﯾﻼﺘﺒﻣ دﻮﺑ
.
شور ﻖﯿﻘﺤﺗ ﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ: ﻪ
يدرﻮﻣ ترﻮﺻ -
يور ﺮﺑ يﺪﻫﺎﺷ 45
رﺎﻤﯿﺑ ﺮﺼﻌﯿﻟو نﺎﺘﺳرﺎﻤﯿﺑ رد يﺮﺘﺴﺑ ﯽﺒﻠﻗ دﺎﺣ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺒﻣ
ﺪﻨﺟﺮﯿﺑ و 45 ﻢﻟﺎﺳ دﺮﻓ ﺪﺷ مﺎﺠﻧا . ﻢﻟﺎﺳ داﺮﻓا ﻦﺳ ﺮﻈﻧ زا
، ﺲﯾد و نﻮﺧ رﺎﺸﻓ ،ﺖﺑﺎﯾد ،ﺲﻨﺟ ﯽﻣﺪﯿﭙﯿﻟ
رﺎﻤﯿﺑ هوﺮﮔ ﺎﺑ نﺎﺴﻤﻫ
ﺪﺷ ﺪﻧ . ﻦﯾا رد
،ﻪﻌﻟﺎﻄﻣ ﯽﺘﻧآ مﺎﺗ ﺖﯿﻓﺮﻇ ﻪﺑ ﯽﻧاﺪﯿﺴﮐا
ر شو ﻪﺑ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ حﻮﻄﺳ وFRAP
هزاﺪﻧا اﺰﯾﻻا شور يﺮﯿﮔ
ﺪﺷ . هداد مﺮﻧ زا هدﺎﻔﺘﺳا ﺎﺑ ﺎﻫ راﺰﻓا
ﮏﻤﮐ ﺎﺑ وSPSS
نﻮﻣزآ يرﺎﻣآ يﺎﻫ
Kalmogorov– Smiranov
،
Mann Whitney
و
t-test
ﯽﻨﻌﻣ ﺢﻄﺳ رد يراد
05 / 0
P<
و ﻪﯾﺰﺠﺗ
ﺪﻧﺪﺷ ﻞﯿﻠﺤﺗ .
ﻪﺘﻓﺎﯾ ﺎﻫ ﯽﺘﻧآ مﺎﺗ ﺖﯿﻓﺮﻇ : ﺪﻫﺎﺷ و درﻮﻣ هوﺮﮔ ﯽﻧاﺪﯿﺴﮐا
ﻪﺑ ﺐﯿﺗﺮﺗ : 07 / 175 86± / 837 و 57 / 276 91± / 981 ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ و
ﻪﺑ ﺪﻫﺎﺷ و درﻮﻣ هوﺮﮔ داﺮﻓا ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺐﯿﺗﺮﺗ
: 09 /8 77± / 15 و 75 /6 91± / 12 دﻮﺑ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣوﺮﮑﯿﻣ .
مﺎﺗ ﺖﯿﻓﺮﻇ ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ
ﯽﺘﻧآ ﻪﺑ رﺎﻤﯿﺑ هوﺮﮔ رد ﯽﻧاﺪﯿﺴﮐا ﻨﻌﻣ رﻮﻃ
ﯽ اد ﺶﻫﺎﮐ لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ يراد ﺖﺷ
) 004 / 0 ( P=
ﯽﻣﺮﺳ ﺢﻄﺳ رد ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ توﺎﻔﺗ و
ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ رد
اﺪﻧ دﻮﺟو هوﺮﮔ ود ﺖﺷ
) 11 / 0 (.P=
ﻪﺠﯿﺘﻧ يﺮﯿﮔ ﯽﺘﻧآ ﺖﯿﻓﺮﻇ و ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا ﻪﮐ داد نﺎﺸﻧ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ : ﻦﯿﯾﺎﭘ ﯽﻧاﺪﯿﺴﮐا
ﯽﻣ ﺪﻧاﻮﺗ ﺪﺷﺎﺑ ﻂﺒﺗﺮﻣ يرﺎﻤﯿﺑ ﺰﻧژﻮﺗﺎﭘ ﺎﺑ .
ﻪﺑ ﺗ رﻮﻈﻨﻣ ﺄ يرﺎﻤﯿﺑ و ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ طﺎﺒﺗرا ﺪﯿﯾ ﯽﺒﻠﻗ يﺎﻫ
- ﯽﻗوﺮﻋ
، ﻪﺑ ﺖﺳا زﺎﯿﻧ ﺮﺘﺸﯿﺑ تﺎﻌﻟﺎﻄﻣ .
هژاو يﺪﯿﻠﮐ يﺎﻫ ﺴﮐا سﺮﺘﺳا:
ﯿ ﺗاﺪ ﯿ
،ﻮ ﺳﻮﻤﻫ ﯿ ﺌﺘﺴ ﯿ
،ﻦ ﻓﺮﻇ ﯿ ﺖ ﺘﻧآ مﺎﺗ ﯽ ﺴﮐا ﯿ ﻧاﺪ ﯽ
، ﺒﻠﻗ ﻪﺘﮑﺳ ﯽ
ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ .
1395
؛ 23 ) 2 :(
141 - 148 .
ﺖﻓﺎﯾرد : 12 / 11 / 1394 شﺮﯾﺬﭘ : 11 / 03 / 1395
،ﯽﻨﯿﻟﺎﺑ ﯽﻤﯿﺷﻮﯿﺑ هوﺮﮔ1
ناﺮﯾا ،ﺪﻨﺟﺮﯿﺑ ،ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد .
.ناﺮﯾا ،ﺪﻨﺟﺮﯿﺑ ،ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﯽﻟﻮﮑﻠﻣ و ﯽﻟﻮﻠﺳتﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ2
ﺰﮐﺮﻣ3
ﻘﺤﺗ ﯿ تﺎﻘ و زوﺮﻠﮑﺳاوﺮﺗآ
،ﺮﻧوﺮﮐ قوﺮﻋ ﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽ
ﺑﯿ
،ﺪﻨﺟﺮ ﺑﯿ
،ﺪﻨﺟﺮ اﯾ ناﺮ .
ﺑﯿﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد،يژﻮﻟﻮﺗﺎﻤﻫﻮﻧﻮﻤﯾا هوﺮﮔ ،ﺖﯿﺗﺎﭙﻫ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ :لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ4
،ﺪﻨﺟﺮ ﺑﯿ
،ﺪﻨﺟﺮ اﯾ ناﺮ .
سردآ : ﺪﻨﺟﺮﯿﺑ - ﯿﺧ يرﺎﻔﻏ نﺎﺑﺎ - مﻮﻠﻋ هﺎﮕﺸﻧاد ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ
- ﯽﮑﺷﺰﭘاﺮﯿﭘ هﺪﮑﺸﻧاد
ﻦﻔﻠﺗ : 32440556 056 ﯽﮑﯿﻧوﺮﺘﮑﻟا ﺖﺴﭘ
: ghansa@yahoo.com
ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ
هرود 23 هرﺎﻤﺷ ، 2
، نﺎﺘﺴﺑﺎﺗ 1395
ﻪﻣﺪﻘﻣ اﺪﻬﺑ ﯽﻧﺎﻬﺟ نﺎﻣزﺎﺳ رﺎﻣآ ﻖﺑﺎﻄﻣ ﯽﻣ رﺎﻈﺘﻧا ﺖﺷ
ﺗ دور لﺎﺳ ﺎ
2020 رﻮﺸﮐ رد گﺮﻣ هد ﺮﻫ زا ﺖﻔﻫ ،ﻪﻌﺳﻮﺗ لﺎﺣ رد يﺎﻫ
يرﺎﻤﯿﺑ ﻪﺑ طﻮﺑﺮﻣ گﺮﻣ ﺪﺷﺎﺑ رادﺮﯿﮔاو ﺮﯿﻏ يﺎﻫ
. زا ﯽﮑﯾ
يرﺎﻤﯿﺑ ﻦﯾﺮﺘﻤﻬﻣ ﺮﯿﻣ و گﺮﻣ ﯽﻠﺻا ﻞﻣﺎﻋ و رادﺮﯿﮔاو ﺮﯿﻏ يﺎﻫ
نﺎﻬﺟ ﺮﺳاﺮﺳ رد
، يرﺎﻤﯿﺑ ﯽﺒﻠﻗ يﺎﻫ -
ﯽﻗوﺮﻋ ﺖﺳا . ﻦﯿﻤﺨﺗ
ﯽﻣ هدز لﺎﺳ ﺎﺗ ﻪﮐ دﻮﺷ 2030
ًﺎﺒﯾﺮﻘﺗ 6 / 23 ﺮﺛا رد ﺮﻔﻧ نﻮﯿﻠﯿﻣ
يرﺎﻤﯿﺑ ﯽﺒﻠﻗ يﺎﻫ -
ﻪﺑ ﯽﻗوﺮﻋ دﻮﺧ نﺎﺟ ،ﯽﺒﻠﻗ ﻪﺘﮑﺳ صﻮﺼﺧ
ار داد ﺪﻨﻫاﻮﺧ ﺖﺳد زا .
ﺮﻄﺧ ﻞﻣاﻮﻋ زا يرﺎﻤﯿﺑ ﻦﯾا ياز
ﺎﻫ
ﯽﻣ ،ﻻﺎﺑ نﻮﺧ رﺎﺸﻓ ،ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ مﺪﻋ ،رﺎﮕﯿﺳ فﺮﺼﻣ ﻪﺑ ناﻮﺗ
ﺲﯾد ،ﺖﺑﺎﯾد هﻮﯿﺷ ،ﯽﻣﺪﯿﭙﯿﻟ
مورﺪﻨﺳ و ﯽﮔﺪﻧز ﺖﺳردﺎﻧ يﺎﻫ
دﺮﮐ هرﺎﺷا ﮏﯿﻟﻮﺑﺎﺘﻣ )1
، 2 ( .
ﯽﻠﻋ شﻼﺗ مﺎﻤﺗ ﻢﻏر مﺎﺠﻧا يﺎﻫ
لﺎﺳ رد هﺪﺷ ﺮﯿﺧا يﺎﻫ
يرﺎﻤﯿﺑ زوﺮﺑ رد ﻢﻬﻣ لاﻮﻋ ﯽﯾﺎﺳﺎﻨﺷ ياﺮﺑ ﯽﺒﻠﻗ يﺎﻫ
- ﯽﻗوﺮﻋ
ﻧآ زا يﺮﯿﮕﺸﯿﭘ و ﻪﺑ ﺎﻬ
ﻦﯾا زا ﯽﺷﺎﻧ ﺮﯿﻣ و گﺮﻣ ﺶﻫﺎﮐ رﻮﻈﻨﻣ
يرﺎﻤﯿﺑ ﻪﮐ ﯽﻧارﺎﻤﯿﺑ درﻮﻣ رد زﻮﻨﻫ ﺞﯾﺎﺘﻧ ،ﺎﻫ ﺮﻄﺧ
ياﺮﺑ ﯽﯾﻻﺎﺑ
يرﺎﻤﯿﺑ ﻦﯾا ﻪﺑ ﻼﺘﺑا ﻊﻧﺎﻗ ،ﺪﻧراد ﺎﻫ
ﻨﻨﮐ ﯽﻤﻧ هﺪ ﺪﺷﺎﺑ . ﻦﯿﻤﻫ ﻪﺑ
ﻮﺗ ﻞﯿﻟد و ﺪﯾﺪﺟ يازﺮﻄﺧ ﻞﻣاﻮﻋ ﻦﯿﯿﻌﺗ ﻪﺑ ناﺮﮕﺸﻫوﮋﭘ ﻪﺟ
ﻧآ زا يﺮﯿﮕﺸﯿﭘ ﺖﺳا هﺪﺷ ﺰﮐﺮﻤﺘﻣ ﺎﻬ
)3 ( . زوﺮﺑ رد يدﺎﯾز ﻞﻣاﻮﻋ
يرﺎﻤﯿﺑ ﯽﺒﻠﻗ يﺎﻫ -
ﺪﻧراد ﺶﻘﻧ ﯽﻗوﺮﻋ
؛ لﺎﺳ رد ﺎﻣا ﺮﯿﺧا يﺎﻫ
هداد نﺎﺸﻧ ﮏﯾژﻮﻟﻮﯿﻣﺪﯿﭘا تﺎﻌﻟﺎﻄﻣ ﺶﻘﻧ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﻪﮐ ﺪﻧا
ﻠﻗ سﻮﺘﮐرﺎﻔﻧا رد ار ﯽﻤﻬﻣ ﯽﻣ يزﺎﺑ ﯽﺒ
ﺪﻨﮐ .
ﺪﺣ ﻪﻨﯿﻣآ ﺪﯿﺳا ﮏﯾ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ يروﺮﺿ ﺮﯿﻏ ﻂﺳاو
ﻦﯿﺌﺘﺴﯿﺳ ﻪﺑ ﻦﯿﻧﻮﯿﺘﻣ ﻞﯾﺪﺒﺗ ﺮﯿﺴﻣ رد ﻪﮐ ﺖﺳا رﻮﻔﻟﻮﺳ يوﺎﺣ ﯽﻣ ﺪﯿﻟﻮﺗ دﻮﺷ
. مﺎﺠﻧا تﺎﻌﻟﺎﻄﻣ لﺪﻣ رد هﺪﺷ
نﺎﺸﻧ ﯽﻧاﻮﯿﺣ يﺎﻫ
هداد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ يﻻﺎﺑ حﻮﻄﺳ ﻪﮐ ﺪﻧا ﯽﻣ
ﺮﺠﻨﻣ ﺪﻧاﻮﺗ ﻪﺑ
دﺮﮑﻠﻤﻋ لﻼﺘﺧا ،ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا ﺶﯾاﺰﻓا و لﺎﯿﻠﺗوﺪﻧا
دﻮﺷ زوﺮﻠﮑﺳاوﺮﺗآ ﺶﯾاﺰﻓا ﺖﯾﺎﻬﻧ رد و ﻪﺘﯿﺴﯿﻧژﻮﺒﻣوﺮﺗ ﺶﯾاﺰﻓا )4 (.
ﺎﻘﻟا ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا ﺚﻋﺎﺑ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﻂﺳﻮﺗ هﺪﺷ
ﯽﺘﻧآ ﺖﯿﻓﺮﻇ ﺶﻫﺎﮐ مﺎﺗ ﯽﻧاﺪﯿﺴﮐا
)1
( TAC ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد
ﯽﻣ ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ دﻮﺷ
)5 .(
1 Total Antioxidant Capacity
ﺪﻌﺘﻣ تﺎﻌﻟﺎﻄﻣ مﺎﺠﻧا د
هداد نﺎﺸﻧ هﺪﺷ يﻻﺎﺑ حﻮﻄﺳ ﻪﮐ ﺪﻧا
ﺘﺴﯿﺳﻮﻤﻫ ﺎﻤﺳﻼﭘ ﻦﯿﺌ
ﺮﻄﺧ ﻞﻣاﻮﻋ ﺮﯾﺎﺳ زا ﻞﻘﺘﺴﻣ ، ﺎﺑ از
يرﺎﻤﯿﺑ ﺖﺳا هاﺮﻤﻫ ﺮﻧوﺮﮐ قوﺮﻋ يﺎﻫ )6
- 8(
. ﺖﻈﻠﻏ ﺶﯾاﺰﻓا
ﯽﻣ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﯽﯾﺎﻤﺳﻼﭘ ﻪﺑ ﺪﻧاﻮﺗ
رد ﯽﮑﯿﺘﻧژ ﺺﯾﺎﻘﻧ ﻞﯿﻟد
ﻢﯾﺰﻧآ ﺴﻣ رد ﻞﯿﺧد يﺎﻫ ،ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﯽﻤﺴﯿﻟﻮﺑﺎﺘﻣ ﺮﯿ
دﻮﺒﻤﮐ ﻪﯾﺬﻐﺗ يﺎﻫ ﻦﯿﻣﺎﺘﯾو رد يا
ﻪﺑ ﺎﻫ رﻮﺘﮐﺎﻓﻮﮐ ناﻮﻨﻋ
ﻢﯾﺰﻧآ و قﻮﻓ يﺎﻫ و رﺪﺨﻣ داﻮﻣ فﺮﺼﻣ ﺪﻨﻧﺎﻣ ﺮﮕﯾد ﻞﻣاﻮﻋ
ﺪﻫد خر ﯽﻨﯿﻟﺎﺑ ﻂﯾاﺮﺷ ﯽﺧﺮﺑ )8
( . مﺎﺠﻧا تﺎﻌﻟﺎﻄﻣ سﺎﺳاﺮﺑ هﺪﺷ
،
ﻓا يﺎﻤﺳﻼﭘ رد مﺎﺗ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﯽﻌﯿﺒﻃ هدوﺪﺤﻣ ﻢﻟﺎﺳ داﺮ
15 - 5 وﺮﮑﯿﻣ ﯽﻣ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣ ﺪﺷﺎﺑ
)9 ( . ﺶﯾاﺰﻓا 5 وﺮﮑﯿﻣ رد لﻮﻣ
ﻦﯿﻐﻟﺎﺑ رد مﺎﺗ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ رد ﺮﺘﯿﻟ ﺶﯾاﺰﻓا ﺎﺑ ،
50 يﺪﺻرد ﺮﻄﺧ
ﺶﯾاﺰﻓا و ﻪﺘﮑﺳ 30
يرﺎﻤﯿﺑ يﺪﺻرد يﺎﻫ
ﺖﺳا هاﺮﻤﻫ ﮏﯿﻤﮑﺴﯾا )
10 (.
ﻧآ زا رد ﻪﯾﺬﻐﺗ ﺖﯿﻌﺿو و ﯽﮑﯿﺘﻧژ ﻪﻨﯿﻣز ﻪﮐ ﯽﯾﺎﺠ
ﺖﯿﻌﻤﺟ حﻮﻄﺳ ﻦﯿﯿﻌﺗ ،ﺖﺳا توﺎﻔﺘﻣ ﻒﻠﺘﺨﻣ يﺎﻫ
ﺖﯿﻌﻤﺟ رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﯽﻣ ﺮﻈﻧ ﻪﺑ يروﺮﺿ ﻒﻠﺘﺨﻣ يﺎﻫ
ﺪﺳر
) 11 (
؛ ﻦﯾا زا ﻪﺑ ور و ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ حﻮﻄﺳ ﯽﺳرﺮﺑ رﻮﻈﻨﻣ
ﮐا سﺮﺘﺳا ﯽﺑﺎﯾزرا ﻪﺑ ﻮﯿﺗاﺪﯿﺴ
هزاﺪﻧا ﻪﻠﯿﺳو مﺎﺗ ﺖﯿﻓﺮﻇ يﺮﯿﮔ
آ ﯽﺘﻧ ﺖﯿﻌﻤﺟ رد ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ رد ﯽﻧاﺪﯿﺴﮐا
ﺪﻨﺟﺮﯿﺑ نﺎﺘﺳﺮﻬﺷ
، ﻦﯾا يدرﻮﻣ ﻪﻌﻟﺎﻄﻣ -
ﯽﺣاﺮﻃ يﺪﻫﺎﺷ ﺪﯾدﺮﮔ
.
شور ﻖﯿﻘﺤﺗ
ﻪﺑ ﻪﻌﻟﺎﻄﻣ ﻦﯾا يدرﻮﻣ ترﻮﺻ
- لﺎﺳ رد يﺪﻫﺎﺷ 94
-
1393 ﺖﻓﺮﮔ ترﻮﺻ ﺪﻨﺟﺮﯿﺑ نﺎﺘﺳﺮﻬﺷ رد .
ﻞﻣﺎﺷ ﻪﻧﻮﻤﻧ ﻢﺠﺣ
45 رﺎﻤﯿﺑ و ﯽﺒﻠﻗ دﺎﺣ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺒﻣ 45
ﻢﻟﺎﺳ دﺮﻓ دﻮﺑ
. داﺮﻓا
درﻮﻣ هوﺮﮔ
، ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ زا
، هدوﺪﺤﻣ رد ﯽﻨﺳ
45 - 35 لﺎﺳ ﻪﮐ دﺎﺣ ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﺺﯿﺨﺸﺗ ﺎﺑ
، ﺶﺨﺑ رد يﺎﻫ
ﺖﺒﻗاﺮﻣ و ﺐﻠﻗ ﺮﺼﻌﯿﻟو نﺎﺘﺳرﺎﻤﯿﺑ هﮋﯾو يﺎﻫ
) ﺞﻋ ( ﺪﻨﺟﺮﯿﺑ ﺮﻬﺷ
ﺑ ،ﺪﻨﺘﺷاد ﻞﯾﺎﻤﺗ ﻪﻌﻟﺎﻄﻣ رد ﺖﮐﺮﺷ ياﺮﺑ و ﺪﻧدﻮﺑ يﺮﺘﺴﺑ ﻪ
ﺪﻧﺪﺷ بﺎﺨﺘﻧا يرﺎﻤﺷﺮﺳ شور .
ﻪﻠﻤﺟ زا ﻦﻣﺰﻣ يرﺎﻤﯿﺑ ﻦﺘﺷاﺪﻧ
نﺎﻃﺮﺳ درﻮﻣ هوﺮﮔ داﺮﻓا ياﺮﺑ ﻪﻌﻟﺎﻄﻣ ﻪﺑ دورو ﻂﯾاﺮﺷ ﺮﮕﯾد زا
دﻮﺑ . تاﺮﯿﯿﻐﺗ و ماﺮﮔﻮﯾدرﺎﮐوﺮﺘﮑﻟا حﺮﺷ سﺎﺳا ﺮﺑ داﺮﻓا يرﺎﻤﯿﺑ
ﺗ ﯽﻤﯾﺰﻧآ ﺢﻄﺳ ﺄ
ﺪﯿﯾ ﺪﺷ .
و ﻦﺳ ﺮﻈﻧ زا درﻮﻣ هوﺮﮔ ﺎﺑ ﻪﮐ ﻢﻟﺎﺳ داﺮﻓا زا ﺪﻫﺎﺷ هوﺮﮔ ﺖﺑﺎﯾد ،ﺲﻨﺟ ،
رﺎﺸﻓ نﻮﺧ ﺲﯾد و ﺪﻨﺘﺷاد ﯽﻧﺎﺴﻤﻫ ﯽﻣﺪﯿﭙﯿﻟ
، ﺮﺑ
ﻪﻧﻮﻤﻧ سﺎﺳا ﺪﻧﺪﺷ بﺎﺨﺘﻧا نﺎﺳآ يﺮﯿﮔ
. ﻪﻌﻟﺎﻄﻣ ﻪﺑ دورو ﻂﯾاﺮﺷ
هوﺮﮔ ﻦﯾا رد ﻞﻣﺎﺷ
: و ﯽﻧﻮﻔﻋ ،ﯽﺑﺎﻬﺘﻟا يرﺎﻤﯿﺑ ﻪﻧﻮﮔ ﺮﻫ ﻦﺘﺷاﺪﻧ
يرﺎﻤﯿﺑ ﺮﯾﺎﺳ ﺎﯾ ﯽﻗوﺮﻋ و ﯽﺒﻠﻗ يرﺎﻤﯿﺑ ﻦﺘﺷاﺪﻧ و ﻦﻣﺰﻣ يﺎﻫ
و ﯽﮑﯿﻨﯿﻠﮐ ﺪﻫاﻮﺷ آ
يرﺎﻤﯿﺑ ﻊﻔﻧ ﻪﺑ ﯽﻫﺎﮕﺸﯾﺎﻣز ﯽﺒﻠﻗ يﺎﻫ
دﻮﺑ .
ﻪﮐ دﻮﺑ ترﻮﺻ ﻦﯾﺪﺑ رﺎﮐ شور 5
ﯽﺳ نﻮﺧ ﻪﻧﻮﻤﻧ ﯽﺳ
ﺎﺘﺷﺎﻧ ) 8 ﺎﺗ 12 ﺖﻋﺎﺳ ( ﺮﺜﮐاﺪﺣ ضﺮﻋ رد 24
زا ﺲﭘ ﺖﻋﺎﺳ
يﺮﺘﺴﺑ نﺪﺷ ) ﺖﯾﺎﻋر زا ﺪﻌﺑ ﺎﯾ و ﯽﯾﺎﺘﺷﺎﻧ ترﻮﺻ رد دورو وﺪﺑ
ﯽﯾﺎﺘﺷﺎﻧ ( ﺪﺷ ﻪﺘﻓﺮﮔ درﻮﻣ هوﺮﮔ نارﺎﻤﯿﺑ زا .
هوﺮﮔ رد يﺮﯿﮕﻧﻮﺧ
ﺪﺷ مﺎﺠﻧا ﺎﺘﺷﺎﻧ ﻂﯾاﺮﺷ رد درﻮﻣ هوﺮﮔ ﺪﻨﻧﺎﻤﻫ ﺰﯿﻧ ﺪﻫﺎﺷ .
ﺲﭙﺳ
رود ﺎﺑ ژﻮﯿﻔﯾﺮﺘﻧﺎﺳ زا هدﺎﻔﺘﺳا ﺎﺑ 3000g
تﺪﻣ ﻪﺑ ﻪﻘﯿﻗد رد
5 ﻧآ مﺮﺳ ﻪﻘﯿﻗد ﻪﺑ مﺮﺳ زا ﯽﺸﺨﺑ و ﺪﯾدﺮﮔ اﺪﺟ ﺎﻬ
رﻮﻈﻨﻣ
هزاﺪﻧا مﺎﺗ ﺖﯿﻓﺮﻇ يﺮﯿﮔ آ
ﯽﺘﻧ رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ و ﯽﻧاﺪﯿﺴﮐا
يﺎﻣد 20 - ﯽﺘﻧﺎﺳ ﻪﺟرد ﺎﺗ ﺪﺷ يراﺪﻬﮕﻧ داﺮﮔ
45 درﻮﻣ رﺎﻤﯿﺑ
ﺪﻧﻮﺷ ﻞﻣﺎﮐ ﺮﻈﻧ .
ﯿﻗﺎﺑ مﺮﺳ هﺪﻧﺎﻤ ياﺮﺑ
هزاﺪﻧا ﺳ يﺮﯿﮔ ﺮﯾﺎ
ﺎﻫرﻮﺘﮐﺎﻓ ﺪﻨﻧﺎﻣ
يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و نﻮﺧ ﺪﻨﻗ
، راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ
ﺖﻓﺮﮔ .
هداد ﺮﮔﻮﻣد تﺎﻋﻼﻃا ﻪﺑ طﻮﺑﺮﻣ يﺎﻫ زا نارﺎﻤﯿﺑ ﮏﯿﻓا
ﻧآ ﯽﮑﺷﺰﭘ هﺪﻧوﺮﭘ رد و جاﺮﺨﺘﺳا ﺎﻬ
ﺐﻟﺎﻗ ﻪﻣﺎﻨﺸﺳﺮﭘ ﮏﯾ
ﻊﻤﺟ ﺪﺷ يروآ .
ﯽﺘﻧآ مﺎﺗ ﺖﯿﻓﺮﻇ ﻪﻧﻮﻤﻧ ﯽﻧاﺪﯿﺴﮐا
شور ﺎﺑ ﺎﻫ
ﺖﻓﺮﮔ راﺮﻗ ﯽﺑﺎﯾزرا درﻮﻣ FRAP .
ور ﻦﯾا رد ﻪﻧﻮﻤﻧ ﯽﯾﺎﻧاﻮﺗ ش
نﻮﯾ يﺎﯿﺣا رد ﯽﻣ هﺪﯿﺠﻨﺳ وﺮﻓ ﻪﺑ ﮏﯾﺮﻓ يﺎﻫ
دﻮﺷ . Fe2+
ﯽﻣ ﺎﺑ ﺪﻧاﻮﺗ رد ﻪﮐ ﺪﯾﺎﻤﻧ دﺎﺠﯾا ﮓﻧر ﺶﻔﻨﺑ ﺲﮑﻠﭙﻤﮐ TPTZ
جﻮﻣ لﻮﻃ 593
هزاﺪﻧا ﻞﺑﺎﻗ ﺮﺘﻣﻮﻧﺎﻧ ﯽﻣ يﺮﯿﮔ
ﺪﺷﺎﺑ ) 12 .(
ياﺮﺑ
هزاﺪﻧا مﺮﺳ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ يﺮﯿﮔ
، زا يرﺎﺠﺗ ﺖﯿﮐ AXISR
Homocysteine EIA )
رﻮﺸﮐ ﺖﺧﺎﺳ نﺎﺘﺴﻠﮕﻧا
( ﻪﮐ زا
ﺎﻣزآ نﻮﻣرﻮﻫ ﺖﮐﺮﺷ ،ﺪﺷ يراﺪﯾﺮﺧ
ﻪﺑ ﺪﺷ هدﺎﻔﺘﺳا اﺰﯾﻻا شور .
مﺮﻧ زا هدﺎﻔﺘﺳا ﺎﺑ يرﺎﻣآ ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ راﺰﻓا
مﺎﺠﻧاSPSS
ﺪﺷ . ياﺮﺑ لﺎﻣﺮﻧ ﯽﺳرﺮﺑ
هداد ندﻮﺑ ﺎﻫ
، زا
نﻮﻣزآ Kalmogorov– Smiranov ﺪﯾدﺮﮔ هدﺎﻔﺘﺳا
.
هداد ﺪﻧدﻮﺑ لﺎﻣﺮﻧ ﻪﮐ ﯽﯾﺎﻫ
، ﺎﻔﺘﺳا ﺎﺑ ﺪﻫﺎﺷ و درﻮﻣ هوﺮﮔ ود رد هد
نﻮﻣزآ زا t-test
هداد و ﺪﻧﺪﺷ ﻪﺴﯾﺎﻘﻣ ﻢﻫ ﺎﺑ ﺎﺑ لﺎﻣﺮﻧ ﺮﯿﻏ يﺎﻫ
نﻮﻣزآ زا هدﺎﻔﺘﺳا Mann Whitney
ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ درﻮﻣ
ﺪﻨﺘﻓﺮﮔ راﺮﻗ .
نﺎﻨﯿﻤﻃا ﺐﯾﺮﺿ 95
ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ ياﺮﺑ ﺪﺻرد
هداد ﺪﺷ هدﺎﻔﺘﺳا ﺎﻫ .
ﻪﺘﻓﺎﯾ ﺎﻫ
،ﻦﺳ يﺮﺗ ،لوﺮﺘﺴﻠﮐ ،ﯽﻧﺪﺑ هدﻮﺗ ﻪﯾﺎﻤﻧ ،ﺪﯾﺮﺴﯿﻠﮔ
،LDL
ﻧ نﻮﺧ ﺪﻨﻗ و HDL ود رد ﺎﺘﺷﺎ
هوﺮﮔ
، لوﺪﺟ رد ﺶﯾﺎﻤﻧ ﮏﯾ
ﺖﺳا هﺪﺷ هداد .
مﺎﺠﻧا يرﺎﻣآ ﺰﯿﻟﺎﻧآ يور هﺪﺷ
45 هوﺮﮔ رﺎﻤﯿﺑ
و درﻮﻣ 45 ﻧ ﺪﻫﺎﺷ هوﺮﮔ ﻢﻟﺎﺳ دﺮﻓ صﻮﺼﺧ رد ﻪﮐ داد نﺎﺸ
ﺮﮐذ يﺎﻫرﺎﯿﻌﻣ هﺪﺷ
، ﻨﻌﻣ توﺎﻔﺗ هوﺮﮔ ود ﻦﯿﺑ رد ﯽ
و هدﻮﺒﻧ راد
ﺖﺷاد دﻮﺟو ﯽﻧﺎﺴﻤﻫ )
لوﺪﺟ 1 .(
لوﺪﺟ 1 -
،نﻮﺧ ﺪﻨﻗ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ ﻪﺴﯾﺎﻘﻣ ﻞﯾﺎﻓوﺮﭘ
ﺺﺧﺎﺷ ،يﺪﯿﭙﯿﻟ يﺎﻫ ﻦﺗ يﺎﻫ
هوﺮﮔ ود داﺮﻓا رد ﻦﺳ و ﯽﺠﻨﺳ
ﺮﯿﻐﺘﻣ هوﺮﮔ
ﯽﻨﻌﻣ ﺢﻄﺳ
يراد
ﺪﻫﺎﺷ درﻮﻣ
ﻦﯿﮕﻧﺎﯿﻣ رﺎﯿﻌﻣ فاﺮﺤﻧا
ﻦﯿﮕﻧﺎﯿﻣ رﺎﯿﻌﻣ فاﺮﺤﻧا
ﻦﺳ 11
/ 56 50
/ 7 87
/ 53 31
/ 8 18
/ 0
ﯽﻧﺪﺑ هدﻮﺗ ﻪﯾﺎﻤﻧ
07 / 26 97
/ 3 25
/ 25 48
/ 4 36
/ 0
ﺪﯾﺮﺴﯿﻠﮔ يﺮﺗ
20 / 153 92
/ 86 58
/ 152 52
/ 45 97
/ 0
لوﺮﺘﺴﻠﮐ 22
/ 197 43
/ 49 67
/ 195 22
/ 39 87
/ 0
04 LDL
/ 126 95
/ 42 36
/ 124 19
/ 31 83
/ 0
69 HDL
/ 39 39
/ 8 38
/ 40 26
/ 6 66
/ 0
ﺎﺘﺷﺎﻧ ﺪﻨﻗ 108
37
/ 34 95
/ 106 44
/ 33 89
/ 0
ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ
هرود 23 هرﺎﻤﺷ ، 2
، نﺎﺘﺴﺑﺎﺗ 1395
ﺑ ﺞﯾﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻪ
مﺎﺗ ﺖﯿﻓﺮﻇ ﻦﯿﮕﻧﺎﯿﻣ ،هﺪﻣآ ﺖﺳد
ﯽﺘﻧآ اﺪﯿﺴﮐا لﺮﺘﻨﮐ و ﺶﯾﺎﻣزآ هوﺮﮔ داﺮﻓا رد ﯽﻧ ﻪﺑ
ﺐﯿﺗﺮﺗ :
07 / 175 86± / 837 و 57 / 276 91± / 981 ﺮﺘﯿﻟ ﺮﺑ لﻮﻣوﺮﮑﯿﻣ
دﻮﺑ . ﺞﯾﺎﺘﻧ ﻪﺴﯾﺎﻘﻣ يرﺎﻣآ نﺎﺸﻧ داد ﻪﮐ ﺖﯿﻓﺮﻇ ﯽﺘﻧآ ﯽﻧاﺪﯿﺴﮐا
مﺎﺗ رد هوﺮﮔ درﻮﻣ ﺖﺒﺴﻧ هوﺮﮔ ﻪﺑ ﺪﻫﺎﺷ ، ﺶﻫﺎﮐ ﺖﺷاد زا ﻪﮐ
ﺮﻈﻧ يرﺎﻣآ ﯽﻨﻌﻣ راد دﻮﺑ ) 004 / 0 .(P=
ﻦﯿﻨﭽﻤﻫ نﻮﻣزآ ﺞﯾﺎﺘﻧ
ﯽﺗ داد نﺎﺸﻧ ﻞﻘﺘﺴﻣ
، ﺖﯿﻓﺮﻇ ﻦﯿﮕﻧﺎﯿﻣ مﺎﺗ
آ ﯽﺘﻧ ﯿﺴﮐا ﯽﻧاﺪ رد
داﺮﻓا ﺮﮐﺬﻣ و ﻣﺆ
ّﻧ ﺚ ود هوﺮﮔ رﺎﻤﯿﺑ و لﺮﺘﻨﮐ
، ﯽﻨﻌﻣ توﺎﻔﺗ يراد
ﺖﺷاﺪﻧ ) 05 / 0 P>
.(
لوﺪﺟ 2 - مﺎﺗ ﺖﯿﻓﺮﻇ ﻦﯿﮕﻧﺎﯿﻣ ﻪﺴﯾﺎﻘﻣ آ
ﯽﺘﻧ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ و ﯽﻧاﺪﯿﺴﮐا
هوﺮﮔ ود داﺮﻓا رد
ﯿﻐﺘﻣ ﺮ مﺎﺗ ﺖﯿﻓﺮﻇ آ
ﯽﺘﻧ ﯽﻧاﺪﯿﺴﮐا ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ
رﺎﻤﯿﺑ هوﺮﮔ 07
/ 175 86± / 837 09 /8 77± / 15
لﺮﺘﻨﮐ هوﺮﮔ
57 / 276 91± / 981 75 /6 91± / 12
ﯽﻨﻌﻣ ﺢﻄﺳ يراد 004
/ 0 11
/ 0
ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ ﻪﮐ داد نﺎﺸﻧ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ﺞﯾﺎﺘﻧ درﻮﻣ هوﺮﮔ رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ 09
/8 77± / 15 وﺮﮑﯿﻣ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣ
ﺪﻫﺎﺷ هوﺮﮔ رد و 75
/6 91± / 12 وﺮﮑﯿﻣ ﻪﮐ دﻮﺑ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣ ﺎﺑ
ﻻﺎﺑ دﻮﺟو رﺎﻤﯿﺑ هوﺮﮔ رد نآ ندﻮﺑ ﺮﺗ
، ﯽﻨﻌﻣ توﺎﻔﺗ ﻦﯾا دﻮﺒﻧ راد
) 11 / 0 .(p=
نﻮﻣزآ ﺞﯾﺎﺘﻧ ﻦﯿﻨﭽﻤﻫ Mann Whitney
ﻪﮐ داد نﺎﺸﻧ
ﻣ و ﺮﮐﺬﻣ داﺮﻓا مﺮﺳ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ رد ﺆّﻧ
ود ﺚ
هوﺮﮔ
، ﯽﻨﻌﻣ توﺎﻔﺗ ﺖﺷاﺪﻧ دﻮﺟو يراد
؛ داﺮﻓا رد نآ ناﺰﯿﻣ ﺎﻣا
ﻦﯿﮕﻧﺎﯿﻣ ﺎﺑ ﺮﮐﺬﻣ 3/
16 وﺮﮑﯿﻣ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣ ﺲﻨﺟ زا ﺮﺘﺸﯿﺑ
ﻣﺆ
ّﻧ ﻂﺳﻮﺘﻣ ﺎﺑ ﺚ 71
/ 14 دﻮﺑ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣوﺮﮑﯿﻣ .
لوﺪﺟ 3 - هوﺮﮔ ود رد يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ طﺎﺒﺗرا ﯽﺳرﺮﺑ
ﯿﻐﺘﻣ ﺮ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ
r p
يﺮﺗ ﺪﯾﺮﺴﯿﻠﮔ 02
/ 0 - 91
/ 0
لوﺮﺘﺴﻠﮐ 14
/ 0 - 36
/ 0
LDL
03 / 0 - 85
/ 0
17 HDL
/ 0 - 27
/ 0
لوﺪﺟ ﻪﮐ رﻮﻄﻧﺎﻤﻫ
3 ﯽﻣ نﺎﺸﻧ ﺪﻫد
، ﻨﻌﻣ ﻪﻄﺑار ﯽ
يراد
اﺮﻓا رد يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ ﺎﺑ نﻮﺧ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ ﻦﯿﺑ هوﺮﮔ د
اﺪﻧ دﻮﺟو درﻮﻣ ﺖﺷ
) 05 / 0 P>
.(
ﺚﺤﺑ راد دﻮﺟو ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺑا دراﻮﻣ زا ﯽﺧﺮﺑ ﺪﻗﺎﻓ دﺮﻓ ﻪﮐ د
ﺮﻄﺧ ﻞﻣاﻮﻋ ﻪﻧﻮﮔ ﺮﻫ ﯽﻣ مﻮﺳﺮﻣ زﺎﺳ
ﺪﺷﺎﺑ
؛ ﻦﯾا زا رد ور
لﺎﺳ ﻪﺑ ﻪﺘﺷﺬﮔ يﺎﻫ يرﺎﻤﯿﺑ داﺪﺧر ﺶﻫﺎﮐ رﻮﻈﻨﻣ
ﯽﺒﻠﻗ يﺎﻫ -
دﺎﯾز تﺎﻘﯿﻘﺤﺗ ،ﯽﻗوﺮﻋ ﺪﯾﺪﺟ ﻞﻣاﻮﻋ ﯽﯾﺎﺳﺎﻨﺷ ياﺮﺑ ي
ﺑ ﻼﺘﺑا هﺪﻨﻨﮐﺪﻌﺘﺴﻣ ﻦﯾا ﻪ
يرﺎﻤﯿﺑ مﺎﺠﻧا ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﻠﻤﺟ زا ﺎﻫ
ﺖﺳا هﺪﺷ )9
( .
ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد دﻮﺟو ﺎﺑ
نﺎﺴﮑﯾ ﻞﯿﺧد يﺎﻫرﻮﺘﮐﺎﻓ يزﺎﺳ
يرﺎﻤﯿﺑ رد ﯽﺒﻠﻗ يﺎﻫ
- ﻪﻘﺑﺎﺳ نوﺪﺑ هوﺮﮔ ود ﻦﯿﺑ رد ﯽﻗوﺮﻋ
ظﺎﺤﻟ ﻪﺑ ،دﺎﺣ ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺒﻣ و ﯽﺒﻠﻗ يرﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺑا ﯽﻨﻌﻣ توﺎﻔﺗ يرﺎﻣآ ﺢﻄﺳ رد يراد
وﺮﮔ ود ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ه
ﺪﺸﻧ هﺪﻫﺎﺸﻣ .
ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ ندﻮﺑﺮﺗﻻﺎﺑ لﺎﺣ ﻦﯾا ﺎﺑ
ﯽﻣ رﺎﻤﯿﺑ هوﺮﮔ رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ نﺎﺸﻧ ﺪﻧاﻮﺗ
ﺖﯿﻤﻫا هﺪﻨﻫد
ﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ نﺎﯾﻼﺘﺒﻣ رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺶﯾاﺰﻓا ﯽﻨﯿﻟﺎﺑ ﯽ
ﺪﺷﺎﺑ
ﻪﮐ ﯽﻣ دﺎﻬﻨﺸﯿﭘ ﻪﻧﻮﻤﻧ ﻢﺠﺣ ﺎﺑ هﺪﻨﯾآ تﺎﻌﻟﺎﻄﻣ عﻮﺿﻮﻣ دﻮﺷ
دﺮﯿﮔ راﺮﻗ ﺮﺘﮔرﺰﺑ .
ﺶﯾاﺰﻓا حﻮﻄﺳ ﺮﺑ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﻪﺘﻓﺎﯾ
ﻦﯿﻟوا يا لﺎﺳ رد رﺎﺑ
1969 ﻪﺑ ناﻮﻨﻋ ﺮﻄﺧ ﻞﻣﺎﻋ يرﺎﻤﯿﺑ
ﯽﺒﻠﻗ يﺎﻫ -
دﺎﻬﻨﺸﯿﭘ ﯽﻗوﺮﻋ
ﺪﺷ ) 8(
. تﺎﻌﻟﺎﻄﻣ زا ﯽﺧﺮﺑ
، ﺎﺑ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﻦﯿﺑ ﯽﺘﺒﺜﻣ طﺎﺒﺗرا
هداﺪﻧ نﺎﺸﻧ ار ﺮﻧوﺮﮐ قوﺮﻋ يرﺎﻤﯿﺑ ﺪﻧا
) 13 - 15 (
؛ ،ﻞﺑﺎﻘﻣ رد
هداد نﺎﺸﻧ ار طﺎﺒﺗرا ﻦﯾا يدﺎﯾز تﺎﻌﻟﺎﻄﻣ ﺪﻧا
) 11
، 16 - 18 ( .
ﻂﺳﻮﺘﻣ راﺪﻘﻣ 77
/ 15 ﻪﻌﻟﺎﻄﻣ ﻦﯾا نارﺎﻤﯿﺑ رد ﺮﺘﯿﻟ ﺮﺑ لﻮﻣوﺮﮑﯿﻣ
ﺮﺿﺎﺣ
، ﻪﻌﻟﺎﻄﻣ ﻪﺑﺎﺸﻣ ﻪﮐ
Marinou
،ﺖﺳا نارﺎﮑﻤﻫ و
نﺎﺸﻧ ﻧآ رد ﻒﯿﻔﺧ يﺎﯿﻤﻨﯿﺌﺘﯿﺳﻮﻤﻫﺮﭙﯾﺎﻫ دﻮﺟو هﺪﻨﻫد ﯽﻣ ﺎﻬ
ﺪﺷﺎﺑ
) 19 ( . ﺮﮕﯾد تﺎﻌﻟﺎﻄﻣ زا يرﺎﯿﺴﺑ ﺪﻨﻧﺎﻤﻫ
، ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ
ﺮﮔ ود ﺮﻫ نادﺮﻣ مﺮﺳ رد ﻫوﮋﭘ ﻦﯾا ﺪﻫﺎﺷ و درﻮﻣ هو
ﺶ ﺖﺒﺴﻧ
ﺪﺷ شراﺰﮔ ﺮﺗﻻﺎﺑ نﺎﻧز ﻪﺑ
؛ ﻪﻧﻮﮔ ﻪﺑ ﻦﯿﮕﻧﺎﯿﻣ فﻼﺘﺧا ﻪﮐ يا
ﯿﺳﻮﻤﻫ ناﺰﯿﻣ ﻪﺑ نادﺮﻣ رد ﻦﯿﺌﺘﺴ 2
وﺮﮑﯿﻣ زا ﺮﺗﻻﺎﺑ ﺮﺘﯿﻟ ﺮﺑ لﻮﻣ
دﻮﺑ نﺎﻧز
؛ ﻨﻌﻣ توﺎﻔﺗ ﻦﯾا يرﺎﻣآ ظﺎﺤﻟ ﻪﺑ ﺎﻣا ﯽ
دﻮﺒﻧ راد . رد
ﻪﻌﻟﺎﻄﻣ ﻂﺳﻮﺗ ﻪﮐ يا Jacques
ﺪﺷ مﺎﺠﻧا نارﺎﮑﻤﻫ و ﺺﺧﺎﺷ ،
ﯿﻌﺿو ،نژوﺮﺘﺳا ﺖﯿﻌﺿو ،ﯽﻧﺪﺑ هدﻮﺗ ﻦﯿﻣﺎﺘﯾو ﺖ
و نﺪﺑ يﺎﻫ ...
ﻪﺑ ناﻮﻨﻋ ﻞﯿﻟﻻد ﯽﻟﺎﻤﺘﺣا ﺑﻪ
رد ﺢﻄﺳ فﻼﺘﺧا هﺪﻧروآ دﻮﺟو
نﺎﻧز و نادﺮﻣ ﺪﺷ ﺮﮐذ
) 20 ( . يﺮﮕﯾد ﻪﻌﻟﺎﻄﻣ رد Agapakis
و
نارﺎﮑﻤﻫ )
2000 ( ا ، ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ ﺶﯾاﺰﻓ ار
ﺶﯾاﺰﻓا ﺎﺑ
ﺮﻄﺧ ﺢﻄﺳ ﯽﺑﺎﯾزرا و ﻪﺘﺴﻧاد ﻂﺒﺗﺮﻣ ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺑا
ﺑ ﻢﻟﺎﺳ داﺮﻓا رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﻪ
مورﺪﻨﺳ ﻪﺑ ﻼﺘﺒﻣ داﺮﻓا صﻮﺼﺧ
ﮏﯿﻟﻮﺑﺎﺘﻣ ار
ﻪﺑ ﺶﯿﭘ رﻮﻈﻨﻣ ﯽﻨﯿﺑ
ﺮﻄﺧ ﻪﺘﮑﺳ
، ﺘﺴﻧاد ﺪﯿﻔﻣ ﺪﻨ
) 21 ( . ﺪﯿﻟﻮﺗ و نﻮﯿﺳاﺪﯿﺴﮐاﻮﺗا ﺮﺑ هوﻼﻋ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ H2O2
،
ﻢﯾﺰﻧآ ﯽﺘﻧآ يﺎﻫ نﻮﯿﺗﺎﺗﻮﻠﮔ ﺪﻨﻧﺎﻣ ﯽﻟﻮﻠﺳ ﻞﺧاد ﯽﻧاﺪﯿﺴﮐا
ﯽﻣ رﺎﻬﻣ ار زاﺪﯿﺴﮐاﺮﭘ ﺪﻨﮐ
؛ ﻦﯾا زا لﻮﻠﺳ ﯽﯾﺎﻧاﻮﺗ ور ياﺮﺑ ﺎﻫ
ﯽﺜﻨﺧ ر ندﺮﮐ لﺎﮑﯾدا
ﯽﻣ ﺶﻫﺎﮐ نﮋﯿﺴﮐا يﺎﻫ ﺪﺑﺎﯾ
) 22 .(
ناﺪﯿﺴﮐا ﻦﯿﺑ لدﺎﻌﺗ مﺪﻋ ﻪﺠﯿﺘﻧ رد ﻪﮐ ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا يﺎﻫ
ﯽﺘﻧآ و ﺮﻀﻣ ناﺪﯿﺴﮐا
ﯽﻣ دﺎﺠﯾا ﻆﻓﺎﺤﻣ يﺎﻫ ﯽﻠﺻا ﻞﻣﺎﻋ ،دﻮﺷ
يرﺎﻤﯿﺑ ﺪﻨﻧﺎﻣ ﻒﻠﺘﺨﻣ يﺎﻫ :
يرﺎﻤﯿﺑ ﯽﺒﻠﻗ يﺎﻫ -
نﺎﻃﺮﺳ ،ﯽﻗوﺮﻋ
ﯽﻣ ﺖﺑﺎﯾد و ﺪﺷﺎﺑ
. ﻪﺑ ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا هزاﺪﻧا ﻪﻠﯿﺳو
يﺮﯿﮔ
ﯿﻌﺿو ﯽﺘﻧآ مﺎﺗ ﺖ ﯽﻧاﺪﯿﺴﮐا
، ﯽﻣ راﺮﻗ ﺶﺠﻨﺳ درﻮﻣ دﺮﯿﮔ
.
ﻪﺘﻓﺎﯾ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ يﺎﻫ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ ﻪﮐ داد نﺎﺸﻧ
دﺎﺣ ﯽﺒﻠﻗ ﻪﺘﮑﺳ
، ﻪﺑ ﺖﺒﺴﻧ يﺮﺘﺸﯿﺑ ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا ﺖﺤﺗ
ﺪﻧراد راﺮﻗ ﻢﻟﺎﺳ داﺮﻓا .
ﻪﺘﻓﺎﯾ ﺎﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ تﺎﻌﻟﺎﻄﻣ يﺎﻫ
ﺖﺳا رﺎﮔزﺎﺳ ﺮﮕﯾد
؛ ﺑﻪ ﻪﻧﻮﮔ ﻧ تﺎﻌﻟﺎﻄﻣ ﻦﯾا رد ﻪﮐ يا ﺖﯿﻓﺮﻇ ﺰﯿ
ﯽﺘﻧآ مﺎﺗ ﯽﺒﻠﻗ نارﺎﻤﯿﺑ رد ﯽﻧاﺪﯿﺴﮐا
- ﻪﺑ ﯽﻗوﺮﻋ صﻮﺼﺧ
ﺶﻫﺎﮐ ﻢﻟﺎﺳ داﺮﻓا ﻪﺑ ﺖﺒﺴﻧ ،ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ نﺎﯾﻼﺘﺒﻣ ﻨﻌﻣ ﯽ نﺎﺸﻧ يراد ﺪﻧداد
) 11 ، 23 ، 24 .(
سﺮﺘﺳا ﺮﺑ هوﻼﻋ
ﯽﺒﻠﻗ نارﺎﻤﯿﺑ رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺶﯾاﺰﻓا زا ﯽﺷﺎﻧ ﻮﯿﺗاﺪﯿﺴﮐا ﯽﺘﻧآ بﺬﺟ ﺎﯾ و فﺮﺼﻣ ﺶﻫﺎﮐ ،ﯽﻗوﺮﻋ ناﺪﯿﺴﮐا
ﺪﻨﻧﺎﻣ ﺎﻫ و
ﻦﯿﻣﺎﺘﯾ ﯽﻣ ﺎﻫ ﯽﺘﻧآ مﺎﺗ ﺖﯿﻓﺮﻇ ﺶﻫﺎﮐ رد ﺪﻧاﻮﺗ ﻣ ﯽﻧاﺪﯿﺴﮐا
ﺆّﺛ ﺮ
ﺪﺷﺎﺑ ) 23 .(
ﻪﻌﻟﺎﻄﻣ زا ﻞﺻﺎﺣ ﺞﯾﺎﺘﻧ Angeline
نارﺎﮑﻤﻫ و
ﯽﻤﻨﯿﺌﺘﺴﯿﺳﻮﻤﻫﺮﭙﯿﻫ درﻮﻣ رد ﻪﮐ داد نﺎﺸﻧ
، ﻞﻤﮑﻣ فﺮﺼﻣ يﺎﻫ
ﻦﯿﻣﺎﺘﯾو ﺖﻈﻓﺎﺤﻣ ﺮﺘﺸﯿﺑ ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا زا ﺖﺳا ﻦﮑﻤﻣB
ﺪﯾﺎﻤﻧ ) 25 .(
ﻪﺠﯿﺘﻧ يﺮﯿﮔ
ﺖﻠﻋ ﻪﻄﺑار ﮏﯾ ﺪﻨﭼ ﺮﻫ و ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﻦﯿﺑ ﯽﻟﻮﻠﻌﻣ و
ﯽﻤﻧ ار ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﯽﻟو ،دﻮﻤﻧ جﺎﺘﻨﺘﺳا ﯽﻠﻌﻓ ﻪﻌﻟﺎﻄﻣ زا ناﻮﺗ
ندﻮﺑ ﺮﺗﻻﺎﺑ 3
رد ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ يﺪﺣاو هوﺮﮔ
،لﺮﺘﻨﮐ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ نارﺎﻤﯿﺑ نﺎﺸﻧ
ﯽﻨﯿﻟﺎﺑ ﺖﯿﻤﻫا هﺪﻨﻫد
ﯽﻣ ﯽﺒﻠﻗ ﻪﺘﮑﺳ ﻪﺑ نﺎﯾﻼﺘﺒﻣ رد ﺎﻤﺳﻼﭘ ﻦﯿﺌﺘﺴﯿﺳﻮﻤﻫ ﺪﺷﺎﺑ
.
ﻪﺑ ﯾﺄﺗ رﻮﻈﻨﻣ ﻦﯾا ﺪﯿ
ﺐﻠﻄﻣ
، ﺖﺳا زﺎﯿﻧ يﺮﺘﺸﯿﺑ تﺎﻌﻟﺎﻄﻣ ﻪﺑ .
ﻪﺘﻓﺎﯾ ﻪﻌﻟﺎﻄﻣ يﺎﻫ ﺮﺿﺎﺣ
ﻪﺘﮑﺳ ﻪﺑ ﻼﺘﺒﻣ نارﺎﻤﯿﺑ ﻪﮐ داد نﺎﺸﻧ
ﯽﺒﻠﻗ
، ﻢﻟﺎﺳ داﺮﻓا ﻪﺑ ﺖﺒﺴﻧ يﺮﺘﺸﯿﺑ ﻮﯿﺗاﺪﯿﺴﮐا سﺮﺘﺳا ﺖﺤﺗ
ﺪﻧراد راﺮﻗ
؛ ﻦﯾا ضراﻮﻋ ﺶﻫﺎﮐ و يﺮﯿﮕﺸﯿﭘ ﻪﻣزﻻ ﻦﯾاﺮﺑﺎﻨﺑ
ﺮﻄﺧ ضﺮﻌﻣ رد داﺮﻓا رد يرﺎﻤﯿﺑ
، ﺶﯾاﺰﻓا ﺖﯿﻟﺎﻌﻓ ﻢﺘﺴﯿﺳ
آ ﯽﺘﻧ ﯽﻧاﺪﯿﺴﮐا ﯽﻣ نﺪﺑ
ﺪﺷﺎﺑ .
ﺮﮑﺸﺗ و ﺮﯾﺪﻘﺗ
ﻢﻧﺎﺧ ﺪﺷرا ﯽﺳﺎﻨﺷرﺎﮐ ﻪﻣﺎﻧ نﺎﯾﺎﭘ زا ﯽﺸﺨﺑ ﻪﻟﺎﻘﻣ ﻦﯾا لﺎﺳ رد ﻪﮐ ﺪﺷﺎﺑ ﯽﻣ ﻖﯿﺘﻋ نﺎﭼﻮﻗ ﯽﻣﻮﺑ ﻪﻣﻮﺼﻌﻣ 1393
هرﺎﻤﺷ ﺎﺑ و ﺐﯾﻮﺼﺗ 774
قﻼﺧا ﺪﮐ و IR.BUMS.1393-
11-10 دﺮﮔ بﻮﺼﻣ
ﯾﺪ . ﺖﻧوﺎﻌﻣ زا ﻪﻟﺎﻘﻣ ﻦﯾا نﺎﮔﺪﻨﺴﯾﻮﻧ
ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﺸﻫوﮋﭘ و ﯽﺷزﻮﻣآ صﻮﺼﺧ رد
ﺰﮐﺮﻣ و زوﺮﻠﮑﺳاوﺮﺗآ و ﺐﻠﻗ تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ و ﻪﺟدﻮﺑ ﻦﯿﻣﺎﺗ ﻦﯾا ياﺮﺟا و ﺎﻫ ﻪﻧﻮﻤﻧ يروآ ﻊﻤﺟ رد ﻪﮐ ﺖﯿﺗﺎﭙﻫ تﺎﻘﯿﻘﺤﺗ يرﺎﮑﻤﻫ ﻖﯿﻘﺤﺗ ﺪﻧراد ار ﯽﻧادرﺪﻗ و ﺮﮑﺸﺗ لﺎﻤﮐ ﺪﻨﺘﺷاد
.
ﻊﺑﺎﻨﻣ :
1- Kazemi T, Sharifzadeh GR, Zarban A, Fesharakinia A. Comparison of components of metabolic syndrome in premature myocardial infarction in an Iranian population: a case-control study. Int J Prev Med. 2013; 4(1): 110-4.
2- Kazemi T, Sharifzadeh GR, Zarban A, Fesharakinia A, Rezvani MR, Moezy SA. Risk factors for premature myocardial infarction: a matched case-control study. JRes Health Sci. 2011;11(2): 77-82.
ﺪﻨﺟﺮﯿﺑ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ
هرود 23 هرﺎﻤﺷ ، 2
، نﺎﺘﺴﺑﺎﺗ 1395
3- Schaffer A, Verdoia M, Cassetti E, Marino P, Suryapranata H, De Luca G, et al. Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study. Thromb Res. 2014; 134(2): 288-93.
4- Khosravi M, Shohrati M, Falaknazi K. Does N-Acetyl Cysteine Have a Dose-Dependent Effect on Plasma Homocysteine Concentration in Patients Undergoing Hemodialysis? Nephrourol Mon. 2009; 1(1): 27-32.
5- Angeline T, Aruna RM, Rama Devi K, Jeyaraj N. Homocysteine and total antioxidant status in acute myocardial infarction patients among Tamil population. Integrative Biosciences. 2007; 11(2): 161-4.
6- Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995; 274(13): 1049-57.
7- Chambers JC, Obeid OA, Refsum H, Ueland P, Hackett D, Hooper J, et al. Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men. Lancet. 2000; 355(9203): 523-7.
8- Eftychiou C, Antoniades L, Makri L, Koumas L, Costeas PA, Kyriakou E, et al. Homocysteine levels and MTHFR polymorphisms in young patients with acute myocardial infarction: A case control study. Hellenic J Cardiol. 2012;
53(3): 189-94.
9- Angeline T, Aruna RM, Ramadevi K, Mohan G, Jeyaraj N. Homocysteine status and acute myocardial infarction among Tamilians. Indian J Clin Biochem. 2005; 20(1): 18-20.
10- Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta- analysis. BMJ. 2002; 325: 1202.
11- Puri A, Gupta OK, Dwivedi RN, Bharadwaj RP, Narain VS, Singh S. Homocysteine and lipid levels in young patients with coronary artery disease. J Assoc Physicians India. 2003; 51: 681-5.
12- Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 1996; 239(1): 70-6
13- Mehrabi MR, Huber K, Serbecic N, Wild T, Wojta J, Tamaddon F, et al. Elevated homocysteine serum level is associated with low enrichment of homocysteine in coronary arteries of patients with coronary artery disease. Thromb.
Res. 2002; 107(5): 189-96.
14- Snehalatha C, Ramachandran A, Satyavani K, Sivasankari S, Sathyamurthy I, Viswanathan V. Plasma homocysteine concentration and coronary artery disease in Asian Indians. J Assoc Physicians India. 2002; 50: 1229-31.
15- Wilcken DE, Reddy SG, Gupta VJ. Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria. Metabolism. 1983; 32(4): 363-70.
16- Anderson JL, Muhlestein JB, Horne BD, Carlquist JF, Bair TL, Madsen TE, et al. Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease. Circulation. 2000; 102(11): 1227-32.
17- Guthikonda S, Haynes WG. Homocysteine as a novel risk factor for atherosclerosis. Curr Opin Cardiol. 1999;
14(4): 283-91.
18- Verhoef P, Kok FJ, Kruyssen DA, Schouten EG, Witteman JC, Grobbee DE, et al. Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 1997; 17(5): 989-95.
19- Marinou K, Antoniades C, Tousoulis D, Pitsavos C, Goumas G, Stefanadis C. Homocysteine: A Risk Factor for Coronary Artery. Hellenic J Cardiol. 2005;46(1): 59-67.
20- Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW, et al. Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 1999; 69(3): 482-9.
21- Agapakis D, Ntaios G, Massa E, Savopoulos C, Kaiafa G, Hatzitolios A. Tu-P10: 401 Hyperhomocysteinemia as a risk factor for stroke. Atheroscler Suppl. 2006;7(3): 272.
22- Upchurch GR Jr, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr, et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997; 272(27): 17012-7.
23- Bashar T, Akhter N. Oxidative Stress and Antioxidant Status in Patients of acute Myocardial Infarction before and after Regular Treatment. University Heart Journal. 2015; 10(2): 60-5.
24- Srivastava L, Kankra M, Manocha A, Bhargava S. Evaluation of antioxidant status in the critically ill with special reference to patients of cardiovascular disorders. Clin Biochem Lab Medicine. 2003:600-4.
25- Angeline T, Jeyaraj N, Tsongalis GJ. MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients. Exp Mol Pathol. 2007; 82(3): 227-33.
