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1- Ahmadi Zade M. Industrial Toxicology: heavy metals. Tehran: Hezaran; 2006
2- Aga M, Iwaki K, Ueda Y, Ushio S, Masaki N, Fukuda S, et al. Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice. J Ethno Pharmacol.2001; 77: 203-208.
3- Henretig FM. Gold Frank's Toxicologic Emergencies. New York: McGraw Hill; 2002.
4- Erickson L, Thompson T. A review of a preventable poison: pediatric lead poisoning. JPSN. 2005; 10 (4): 171-181 5- Farhat AS, Parizadeh SM, Balali M, Khademi GR. Comparison of blood lead levels in 1-7 year old children with and without seizure. Neurosciences. 2005;10 (3): 210-212.
6- Faranoush M, Malek M, Ghorbani R, Rahbar M, Safaei Z. Study of the blood lead levels and related factors in the 6-11 years old children in Semnan. Koomesh. 2003; 4 (3-4):182-189. [Persian].
7- Dehghan L, Ghane A. Study of the blood lead levels in the 2-12 years old children in Yazd. [dissertation]. Yazd University of Medical Science. 2000. [Persian].
8- Wong DL, Hockenberry-Eaton M, Wilson D. Wong's Essentials of Pediatric Nursing. St. Louis. Missouri. Mosby.
2001.
9- Ellis MR, Kane KY. Lightening of the lead load in children. Am Family Physician. 2002; 62: 545-554.
10- Center for Disease Control and Prevention. Children of construction workers at increased risk for lead poisoning.
Available from: www.cdc.gov/niosh/leadpoison. 2006-13-04.
11- Chan J, Sim M, Golec R, Forbes A. Predictors of lead absorption in children of lead workers. Occupational Medicine. 2000; 50 (6): 398-405.
12- Valnet J. Phytotherpie, treatment des maladies par les plantes Translated into Persian by Emami A, et al. Vol 2.
Tehran: Rah-e-Kamal Publication; 2002. pp: 146-149.
13- Zargari A. Medicinal Plants. Vol 2. Tehran: Tehran University Publication; 1996. pp. 586-590. [Persian].
14- Hosseinzadeh H. Anticonvulsant effect of Coriandrum sativum L. seed extracts in Mice. Available From:
www.amc.ac.ir/AIM/0034/hosseinzadeh0034/html
15- Wong P, Kitts DD. Studies on dual antioxidant and antibacterial properties of Parsley (Petroselinum Crispum) and Cilantro (Chinese parsley) extracts. Food Chemistry. 2006; 97 (3): 505-515.
16- Karunasagar D, Krishna MV, Rao SV, Arunachalam J. Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum Sativum. J Hazardous Materials.
2005; 118 (1-3): 133-139.
17- Suplido ML, Ong CN. Lead exposure among small-scale battery recyclers, automobile radiator mechanics and their children in Manila, the Philippine. Environmental Res Sci. 2000; 82: 231-238.
18- Shargel L, Andrew BC. Applied Biopharmaceutics & Pharmacokinetics. 4th ed. New York: McGraw Heal; 1991:
19- Canfield RL, Henderson CR Jr, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. Intellectual impairment in children with blood lead concentration below 10 microgram per deciliter. New England J Med. 2003; 348 (16): 1517- 1526.
20- Khan AH, Khan A, Ghani F, Khurshid M. Low level lead exposure and blood lead levels in children: a cross sectional survey. Arch Environmental Health. 2001; 56 (6): 501–505.
21- Lanphear BP. Cognitive deficit associated with BLL<10 in US children & adolescents. Public Health Rep. 2000;
115: 521-529.
22- Bellinger D. Lead. Pediatrics., 2004; 113 (4): 1016-1020
23- Kosnett MJ. Lead. In: Brent J. Wallace K, Burkhart K, Phillips S, Donovan J. (eds). Critical Care Toxicology. St.
Louis: Mosby; 2005. Chapt. 78. pp: 821-835.
24- Aguilar-Garduno C, Lacasana M, Tellez-Rojo MM, Aguilar-Madrid G, Sanin-Aguirre LH, Romieu I, et al. Indirect lead exposure among children of radiator repair workers. Am J Ind Med. 2003; 43 (6):662-667.
25- Omura Y, Beckman SL. Role of mercury in resistant infections and effective treatment of Clamydia trachomatis and Herpes family viral infections by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement. Acupuncture Electrotherapeutics Res. 1995; 20:195-229.
Title: Effect of Coriandrum sativum L. extract on lead excretion in 3-7 year old children
Authors: K. Deldar1, E. Nazemi2, M. Balali Mood3, SA. Emami4, AH. MohammadPour5, M. Tafaghodi6, R. Afshari7
Abstract
Background and Aim: Lead (Pb) poisoning is the most common occupational poisoning that may affect family members of lead workers specially their children. The most important and irreversible effect of lead poisoning in children is on the developing of central nervous system and its evolution. High cost and severe side effects of chelating agents may result in incomplete treatment of lead poisoning in some cases. The aim of the present study was to assess the effect of Coriandrum Sativum l. (Cilantro) extracts on renal lead excretion in 3-7 year old children.
Materials and Methods: In this randomized, case–control clinical trial, 32 children aged 3-7 years whose parents were lead-exposed workers were randomly divided into 2 groups. The test group received Cilantro extract and the controls were given placebos for 14 days. Blood and urine lead concentrations were determined at the beginning of the study and 14 days later. Questionnaires were designed and used for data collection. The obtained data were analyzed by T-student and Paired t-test using SPSS version 11.5 Numerical data were shown as mean ± SD and P 0.05 was taken as the significant level.
Results: Mean age and weight of the children was 4.9±1.46 years and 17.32±4.74 kg respectively and 59.4%
of them were males. Duration of fathers' exposure to Pb at work was 9.14±5.63 years. Blood and urine Pb concentrations and renal lead clearance of children were 163.81±57.19, 97±48.12 g/L and .012±.009 L/day, respectively at the beginning of the study. There were no significant differences in blood (P=0.87), urine (P=0.73) Pb concentrations and renal excretion of lead (P=0.96) between the two groups. After two weeks use of Cilantro, the mean blood lead concentration decreased (P=0.006), urine lead concentration increased (P=0.038) and renal excretion of lead increased significantly (P=0.019). But similar significant changes were observed in the control group (P=0.034, 0.021 and 0.009, respectively). There were no significant differences in blood lead concentration (P=0.93), urine lead concentration (P=0.93) and renal lead clearance (P=0.77) between the two groups at the end of the study.
Conclusion: According to the results of this study, it seems that Coriandrum Sativum is not effective in lead elimination. Increasing renal lead elimination in both groups of children may be due to other factors like improvement of nutrition following the necessary educations at the beginning of this study.
Key Words: Lead poisoning; Children; Coriandrum Sativum L
1Corresponding Author; M.Sc. in Nursing, Instructor; Faculty of Nursing (Neishaboor), Mashhad University of Medical Sciences.
Neishaboor, Iran deldar.k@gmail.com
2M.Sc. in Nursing; Instructor; Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences. Mashhad, Iran.
3Professor; Department of Medical Toxicology, Faculty of Medicine, Mashhad University of Medical Sciences. Mashhad, Iran
4Assistant Professor, Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences. Mashhad, Iran
5Assistant Professor; Department of Pharmacotherapy, Faculty of Pharmacy, Mashhad University of Medical Sciences. Mashhad, Iran
6Assistant Professor; Department of Pharmaceutics, Faculty of Pharmacy, Mashhad University of Medical Sciences. Mashhad, Iran
7Assistant Professor; Department of Medical Toxicology, Faculty of Medicine, Mashhad University of Medical Sciences. Mashhad, Iran
