第五章 討論與結論
第四節 結論
本研究納入十三篇文獻共基因變異42筆8項SNPs與乳癌發生關聯之個體層 次研究之摘要並利用統合分析了解基因變異與乳癌的關聯性。本研究和過去的 研究相比，統合結果之p較小且更為顯著。各基因變異SNP相較於其分別沒有 變異者，乳癌發生odds增加7%~28%。
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附錄一森林圖(inverse variance heterogeneity (IVhet) model)
一、1p11.2 (EMBP1, rs11249433)
附圖 一 rs11249433與乳癌發生關聯之統合分析森林圖(IVhet)
二、3p24.1 (SLC4A7, rs4973768)
附圖 二 rs4973768與乳癌發生關聯之統合分析森林圖(IVhet)
三、5p15.33 (TERT, rs10069690)
附圖 三 rs10069690與乳癌發生關聯之次群組統合分析森林圖(IVhet)
四、8q24.21 (CASC8, POU5F1B, PCAT1, rs13281615)
附圖 四 rs13281615與乳癌發生關聯之統合分析森林圖(IVhet)
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五、10q22.3 (ZMIZ1, rs704010)
附圖 五 rs704010與乳癌發生關聯之統合分析森林圖(IVhet)
六、10q26.13 (FGFR2, rs2981579)
附圖 六 rs2981579與乳癌發生關聯之次群組統合分析森林圖(IVhet)
七、14q32.11 (CCDC88C, rs941764)
附圖 七 rs941764與乳癌發生關聯之統合分析森林圖(IVhet)
八、16q12.1 (CASC16, rs3803662)
附圖 八 rs3803662與乳癌發生關聯之統合分析森林圖(IVhet)
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附錄二 含 Michailidou et al. (2013)的森林圖(random-effects model 和 inverse variance heterogeneity (IVhet) model)
一、1p11.2 (EMBP1, rs11249433)
附圖 九 rs11249433與乳癌發生關聯之統合分析森林圖(上圖：Random Effects下圖：IVhet)
二、3p24.1 (SLC4A7, rs4973768)
附圖 十 rs4973768與乳癌發生關聯之統合分析森林圖(上圖：Random Effects下圖：IVhet)
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三、5p15.33 (TERT, rs10069690)
附圖 十一 rs10069690與乳癌發生關聯之次群組統合分析森林圖(上圖：Random Effects下圖：IVhet)
四、8q24.21 (CASC8, POU5F1B, PCAT1, rs13281615)
附圖 十二 rs13281615與乳癌發生關聯之統合分析森林圖(上圖：Random Effects下圖：IVhet)
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五、10q22.3 (ZMIZ1, rs704010)
附圖 十三 rs704010與乳癌發生關聯之統合分析森林圖(上圖：Random Effects下圖：IVhet)
六、10q26.13 (FGFR2, rs2981579)
附圖 十四 rs2981579與乳癌發生關聯之次群組統合分析森林圖(上圖：Random Effects下圖：IVhet)
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七、14q32.11 (CCDC88C, rs941764)
附圖 十五 rs941764與乳癌發生關聯之統合分析森林圖(上圖：Random Effects下圖：IVhet)
八、16q12.1 (CASC16, rs3803662)
附圖 十六 rs3803662與乳癌發生關聯之統合分析森林圖(上圖：Random Effects下圖：IVhet)